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Bioactive Materials 2022年第8期7卷 182-205页

作者： Hwa seung han Song Yi Koo Ki Young Choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health ***,they are a significant resource for drug discovery in the development of modern *** many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to *** have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of *** review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and *** review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic ***,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound Nanoformulation Drug delivery Phototherapy

Structural identification of active moiety in anti-tumor metastatic polysaccharide purified from fermented barley by sequential enzymatic hydrolysis

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Food Bioscience 2022年第6期50卷 139-149页

作者： seung-U Son han Wool Kim Kwang-Soon Shin Department of Food Science and Biotechnology Kyonggi UniversitySuwon16227Republic of Korea Transdisciplinary Major in Learning Health System Department of Integrated Biomedical and Life ScienceKorea UniversitySeoul02841Republic of Korea

The potent anti-cancer metastatic effects induced by the immunostimulatory activities of intravenously administered BF–I,an active polysaccharide purified from fermented barley,were previously *** study aimed to evaluate the anti-cancer metastatic effect of orally administered BF–I and elucidated the microstructure and active moiety of BF–I using sequential enzymatic *** experiments using Colon26-M3.1 carcinoma,prophylactic oral administration of BF–I potently suppressed lung cancer ***,gas chromatography-mass spectrometry analysis of partially methylated alditol acetate showed that BF–I comprised 15 different glycosyl linkages,including 4-linked Xylp(16.1%),terminal Araf(12.4%),4-linked Glcp(32.8%),3-linked Glcp(13.5%),3,6-linked Glcp(1.5%),and 3,6-linked Galp(5.3%).These glycosyl linkage combinations are typical for arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II *** clarify the microstructure,BF–I was sequentially degraded via linkage-specific enzymatic hydrolysis using five ***,the sugar composition,glycosyl linkage,and reactivity with theβ-glucosyl Yariv reagent were analyzed,along with sequencing based on tandem mass spectra of partially degraded fragment *** results confirmed that BF–I comprises a mixture of four different types of polysaccharides(arabinoxylan,yeast-derivedβ-glucan,barley-derivedβ-glucan,and type II arabinogalactan)with similar molecular ***,different polysaccharides contribute significantly to cytokine(interleukin-6,-12,and tumor necrosis factor-α)secretion by peritoneal ***,the potent anti-cancer metastatic activity of BF–I is proposed to be related to the immunostimulatory activities of the four different types of polysaccharides.

关键词： Barley Polysaccharide structure Anti-cancer Enzymatic hydrolysis

Selecting suitable sites for mountain ginseng(Panax ginseng)cultivation by using geographically weighted logistic regression

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Journal of Mountain Science 2017年第3期14卷 492-500页

作者： han Hee JANG Kwang-min CHUNG Joo-sang Department of Forest Engineering Resources and ManagementCollege of ForestryOregon State UniversityCorvallisOR 97331USA Department of Forest Sciences College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research Institute for Agriculture and Life Sciences Seoul National UniversitySeoul 08826Republic of Korea

With the well-being trends to pursue a healthy life, mountain ginseng(Panax ginseng) is rising as one of the most profitable forest products in South Korea. This study was aimed at evaluating a new methodology for identifying suitable sites for mountain ginseng cultivation in the country. Forest vegetation data were collected from 46 sites and the spatial distribution of all sites was analyzed using GIS data for topographic position, landform, solar radiation, and topographic wetness. The physical and chemical properties of the soil samples, including moisture content, p H, organic matter, total nitrogen, exchangeable cations, available phosphorous, and soil texture, were analyzed. The cultivation suitability at each site was assessed based on the environmental conditions using logistic regression(LR) and geographically weighted logistic regression(GWLR) and the results of both methods were compared. The results show that the areas with northern aspect and higher levels of solar radiation, moisture content, total nitrogen, and sand ratio are more likely to be identified as suitable sites for ginseng cultivation. In contrast to the LR, the spatial modeling with the GWLR results in an increase in the model fitness and indicates that a significant portion of spatialautocorrelation in the data decreases. A higher value of the area under the receiver operating characteristic(ROC) curve presents a better prediction accuracy of site suitability by the GWLR. The geographically weighted coefficient estimates of the model are nonstationary, and reveal that different site suitability is associated with the geographical location of the forest stands. The GWLR increases the accuracy of selecting suitable sites by considering the geographical variations in the characteristics of the cultivation sites.

关键词： Panax ginseng Site suitability Logistic regression Geographically weighted logistic regression Geographic Information System South Korea

Rademacher Complexity in Neyman-Pearson Classification

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Acta Mathematica Sinica,English Series 2009年第5期25卷 855-868页

作者： min han Di Rong CHEN Zhao Xu SUN Department of Applied Mathematics Beijing University of Technology Beijing 100124 P. R. China Department of Mathematics and LMIB Beijing University of Aeronautics and Astronautics Beijing 100083 P. R. China School of Applied Mathematics Central University of Finance and Economics Beijing 100081 P. R. China

Neyman-Pearson（NP） criterion is one of the most important ways in hypothesis testing. It is also a criterion for classification. This paper addresses the problem of bounding the estimation error of NP classification, in terms of Rademacher averages. We investigate the behavior of the global and local Rademacher averages, and present new NP classification error bounds which are based on the localized averages, and indicate how the estimation error can be estimated without a priori knowledge of the class at hand.

关键词： Neyman-Pearson lemma VC classes Rademacher complexity Neyman-Pearson classification

Improved Method of Contention-Based Random Access in LTE System

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Journal of Electronic Science and Technology 2018年第2期16卷 175-183页

作者： han-Song Su min Zhang Gao-Hua Liu School of Electronic and Information Engineering Tianjin UniversityTianjin 300072

Random access is the necessary process to establish the wireless link between the user equipment （UE） and network. The performance of the random access directly affects the performance of the network. In this work, we propose a method on the basis of the existing alternatives. In this method, we estimate the system load in advance to adjust the number of terminals. An access threshold is set to control the number of terminals which want to access the base station at an acceptable level. At the same time, we havean improvement on the existing power climbing strategy. We suppose that the power ramping is not always necessary for the re-access. And the selection ofpower ramping steps is studied in this paper. Simulations based on MATLAB are employed to evaluate the effectiveness of the proposed solution and to make comparisons with existing alternatives.

关键词： Access threshold long-term evolution(LTE) power ramping steps random access

Long-term culture-induced phenotypic difference and efficient cryopreservation of small intestinal organoids by treatment timing of Rho kinase inhibitor

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World Journal of Gastroenterology 2017年第6期23卷 964-975页

作者： Sung-Hoon han Sehwan Shim min-Jung Kim Hye-Yun Shin Won-Suk Jang Sun-Joo Lee Young-Woo Jin seung-Sook Lee seung Bum Lee Sunhoo Park Laboratory of Radiation Exposure and Therapeutics National Radiation Emergency Medical CenterKorea Institute of Radiological and Medical ScienceSeoul 01812South Korea

To investigate a suitable long-term culture system and optimal cryopreservation of intestinal organoid to improve organoid-based therapy by acquiring large numbers of *** were isolated from jejunum of C57BL/6 mouse. Two hundred crypts were cultured in organoid medium with either epidermal growth factor/Noggin/R-spondin1 (ENR) or ENR/CHIR99021/VPA (ENR-CV). For subculture, organoids cultured on day 7 were passaged using enzyme-free cell dissociation buffer (STEMCELL Technologies). The passage was performed once per week until indicated passage. For cryopreservation, undissociated and dissociated organoids were resuspended in freezing medium with or without Rho kinase inhibitor subjected to different treatment times. The characteristics of intestinal organoids upon extended passage and freeze-thaw were analyzed using EdU staining, methyl thiazolyl tetrazolium assay, qPCR and time-lapse live cell *** established a three-dimensional culture system for murine small intestinal organoids using ENR and ENR-CV media. Both conditions yielded organoids with a crypt-villus architecture exhibiting Lgr5+ cells and differentiated intestinal epithelial cells as shown by morphological and biochemical analysis. However, during extended passage (more than 3 mo), a comparative analysis revealed that continuous passaging under ENR-CV conditions, but not ENR conditions induced phenotypic changes as observed by morphological transition, reduced numbers of Lgr5+ cells and inconsistent expression of markers for differentiated intestinal epithelial cell types. We also found that recovery of long-term cryopreserved organoids was significantly affected by the organoid state, i.e., whether dissociation was applied, and the timing of treatment with the Rho-kinase inhibitor Y-27632. Furthermore, the retention of typical morphological characteristics of intestinal organoids such as the crypt-villus structure from freeze-thawed cells was observed

关键词： intestinal organoid Rho kinase inhibitor three-dimensional culture cryopreservation long-term culture

Electrochemical characteristics of stainless steel using impressed current cathodic protection in seawater

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中国有色金属学会会刊：英文版 2009年第4期19卷 930-934页

作者： Seok-Ki JANG min-Su han Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University

Stainless steels such as STS 304,316 and 630 are frequently used as shaft materials in small fiber reinforced polymer(FRP) fishing *** the shaft material is exposed to a severely corrosive environment such as seawater,it should be protected using appropriate *** impressed current cathodic protection was used to inhibit corrosion in shaft *** anodic polarization,passivity was remarkably more evident in STS 316 stainless steel than in STS 304 and STS *** pitting potentials of STS 304,316,and 630 stainless steels were 0.30,0.323,and 0.260 V,*** concentration polarization due to oxygen reduction and activation polarization due to hydrogen generation were evident in the cathodic polarization trends of all three stainless *** 316 had the lowest current densities in all potential ranges,and STS 630 had the *** analysis showed that STS 316 was the most noble in the *** addition,the corrosion current density was the lowest for STS 316.

关键词：外加电流阴极保护 316不锈钢电化学特性海水腐蚀电流密度材料腐蚀阳极极化 STS

Nitrogen-skinned carbon nanocone enables non-dynamic electrochemistry of individual metal particles

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Science China Chemistry 2022年第10期65卷 2031-2037页

作者： Chen Liu Jianan Xu han Gao min Zhou Lehui Lu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130000China University of Science and Technology of China Hefei 230026China

Nano-impact electrochemistry is an efficient way to probe the physical and chemical properties of individual ***,limited by the weak adsorption between particles and a microelectrode(ME),the particle collision events evolve randomly to be elastic or *** events occur intermittently to produce unmarked transient signal sets that seriously interfere with single particle ***,we report a nitrogen-skinned carbon nanocone electrode(NS-CNCE) to enhance its adsorption capacity greatly towards metal particles and thus realize non-dynamic(i.e.,inelastic impacts) single particle *** surface of NS-CNCEs characteristic of excellent adhesion,smoothness,and conductivity can effectively capture the landing metal particles to form a stable contact for efficient electronic *** superior NS-CNCEs,we investigated electrochemical oxidation of Ag(or Au) particles and electrocatalytic amplification of Pt particles,respectively,under non-dynamic *** determined particle size is highly consistent with the physical *** analysis of transient signals confirms the strong adhesion of NS-CNCEs to metal particles,which is also in line with the prediction of a particle-electrode adsorption energy *** proposed strategy has effectively solved the major challenge of general single metal particle collision analysis.

关键词： non-dynamic electrochemistry inelastic impacts single particle collisions nitrogen-skinned carbon

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Shexiang Tongxin Dropping Pill Allieviates Heart Failure via Extracellula Matrix-Receptor Interaction Pathways Based on RNA-Seq Transcriptomics and Experimental Studies

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Chinese Journal of Integrative Medicine 2023年第7期29卷 600-607页

作者： TAN Ya-fang FU Yu-han ZhanG min-zhou Intensive Care Research Team of Traditional Chinese Medicine Guangdong Province Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510006China School of Life Sciences and Biopharmaceutics Guangdong Pharmaceutical UniversityGuangzhou510006China

Objective:To investigate the protective mechanisms of Chinese medicine Shexiang Tongxin Dropping Pills(STDP) on heart failure(HF).Methods:Isoproterenol(ISO)-induced HF rat model and angiotensin Ⅱ(Ang Ⅱ)-induced neonatal rat cardiac fibroblast(CFs) model were used in the present *** rats were treated with and without STDP(3 g/kg).RNA-seq was performed to identify differentially expressed genes(DEGs).Cardiac function was evaluated by *** and eosin and Masson’s stainings were taken to assess cardiac *** levels of collagen Ⅰ(Col Ⅰ) and collagen Ⅲ(Col Ⅲ) were detected by immunohistochemical ***8 kit and transwell assay were implemented to test the CFs’ proliferative and migratory activity,*** protein expressions of α-smooth muscle actin(α-SMA),matrix metalloproteinase-2(MMP-2),MMP-9,Col I,and Col Ⅲ were detected by Western ***:The results of RNA-seq analysis showed that STDP exerted its pharmacological effects on HF via multiple signaling pathways,such as the extracellular matrix(ECM)-receptor interaction,cell cycle,and B cell receptor *** from in vivo experiments demonstrated that STDP treatment reversed declines in cardiac function,inhibiting myocardial fibrosis,and reversing increases in Col Ⅰ and Col Ⅱ expression levels in the hearts of HF ***,STDP(6,9 mg/mL) inhibited the proliferation and migration of CFs exposed to Ang Ⅱin vitro(P<0.05).The activation of collagen synthesis and myofibroblast generation were markedly suppressed by STDP,also the synthesis of MMP-2 and MMR-9,as well as ECM components Col Ⅰ,Col Ⅲ,and α-SMA were decreased in Ang Ⅱ-induced neonatal rats’ ***:STDP had anti-fibrotic effects in HF,which might be caused by the modulation of ECM-receptor interaction *** the management of cardiac fibrosis,STOP may be a compelling candidate for improving prognosis of HF.

关键词： Shexiang Tongxin Dropping Pill heart failure RNA-seq extracellular matrix isoproterenol-induced

Edge sulfurized graphene nanoplatelets via vacuum mechano-chemical reaction for lithium–sulfur batteries

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Journal of Energy Chemistry 2017年第3期26卷 522-529页

作者： Longlong Yan min Xiao Shuanjin Wang Dongmei han Yuezhong Meng The Key Laboratory of Low-Carbon Chemistry&Energy Conservation of Guangdong Province/State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275GuangdongChina Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082GuangdongChina

Lithium–sulfur batteries have great potential for high energy applications due to their high capacities,low cost and eco-friendliness. However, the particularly rapid capacity decay owing to the dissolution and diffusion of polysulfide intermediate into the electrolyte still hamper their practical *** the reported preparation procedures to sulfur based cathode materials are often complex, and hence are rather difficult to produce at large scale. Here, we report a simple mechano-chemical sulfurization methodology in vacuum environment applying ball-milling method combined both the chemical and physical interaction for the one-pot synthesis of edge-sulfurized grapheme nanoplatelets with 3D porous foam structure as cathode materials. The optimal sample of 70%S–Gn Ps-48 h(ball-milled 48 h) obtains 13.2 wt% sulfur that chemically bonded onto the edge of Gn Ps. And the assembled batteries exhibit high initial discharge capacities of 1089 mAh/g at 0.1 C and 950 mAh/g at 0.5 C, and retain a stable discharge capacity of 776 mAh/g after 250 cycles at 0.5 C with a high Coulombic efficiency of over 98%. The excellent performance is mainly attributed to the mechano-chemical interaction between sulfur and grapheme nanoplatelets. This definitely triggers the currently extensive research in lithium–sulfur battery area.

关键词： Lithium sulfur batteries Graphene nanoplatelets Edge-functionalized with sulfur 3D porous foam structure Mechano-chemical interaction