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Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

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World Journal of Gastroenterology 2005年第14期11卷 2072-2079页

作者： seung oe lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-Taek Jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park School of Biological Sciences Seoul National University SeoulKorea Hepatology Center and Laboratory of Hepatocarcinogenesis Bundang Jesaeng General Hospital KyungkidoKorea School of Chemistry Seoul National University SeoulKorea Department of Pathology Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea General Surgery Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea Internal Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea

AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related ***: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically ***: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic ***: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis.

关键词： Heat shock protein Hepatocellular carcinoma Dysplastic nodule Hepatocarcinogenesis Immunohisto-chemistry Dot immunoblot analysis

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Novel N-doped multichannel carbon nanofiber architecture with porous CoS nanoprisms for high-performance potassium-ion batteries

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Rare Metals 2024年第3期43卷 971-983页

作者： Jae Bong lim seung-Keun Park Department of Advanced Materials Engineering Chung-Ang UniversityGyeonggi-do17546Republic of Korea Department of Intelligence Energy and Industry Chung-Ang UniversitySeoul06974Republic of Korea Western Seoul Center Korea Basic Science InstituteSeoul03759Republic of Korea

Potassium-ion batteries(PIBs)have gained significant attention as an alternative to lithium-ion batteries(LIBs)due to the abundance of potassium(K)and low ***,the difficulty in finding appropriate electrode materials that can efficiently store the larger K ions has hindered their practical ***,we report a novel anode material,N-doped multichannel carbon nanofibers embedded with porous CoS nanoprisms(CSP@NMCNF),for high-performance *** CSP@NMCNF was synthesized using a two-step strategy comprising of the electrospinning of Co acetate hydroxide nanoprism/binary polymer blend and a subsequent heat *** porous CoS nanoprisms with an anisotropic morphology were well aligned along the length axis of the N-doped multichannel carbon nanofibers,thus ensuring their structural stability during the repeated charge-discharge *** addition,numerous pores facilitated the transport of electrons and ***,the CSP@NMCNF anode exhibited excellent electrochemical performance,delivering a high specific capacity of 368 mAh·g^(-1)at 0.5 A·g^(-1)after 200 cycles and excellent rate capability(232 mAh·g^(-1)at 2.0 A·g^(-1)).

关键词： K-ion batteries Cobalt sulfide Multichannel structured composite Electrospinning Nanoprism Porous structure

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Anticipating the lifespan: Predicting the durability of an anode-supported solid oxide fuel cell short stack over 50,000 h

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Progress in Natural Science:Materials International 2024年第3期34卷 606-613页

作者： Muhammad Zubair Khan Amjad Hussain seung-Bok Lee Tak-Hyoung lim Rak-Hyun Song Department of Materials Science & Engineering Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology Hydrogen Energy Research Division Korea Institute of Energy Research Department of Advanced Energy and System Engineering Korea University of Science and Technology (UST)

In the present study, the operational lifetime of a solid oxide fuel(SOFC) short stack is predicted by investigating the performance degradation of both the short stack and its cells throughout 1000 h at 800°C. The short stack and integral cell voltages are continuously measured during the long-term test, with electrochemical impedance spectroscopy(EIS) conducted every 200 h. The short stack voltage decreased rapidly for the initial 200–300 h and afterwards, it decreased at a slow rate due to the increase in the Ohmic and polarization resistances in the same manner. Scanning electron microscopy results show that there is no delamination or cracking among constituent layers of the short-stack cells. The single degradation effects of the Ni coarsening in the anode, cation migration and surface segregation in cathode and oxide scale growth in metallic interconnect mesh are successfully integrated into a comprehensive lifetime prediction model. The experimentally measured voltage degradation data of the short stack fits well with the developed mathematical model and allows the successful prediction of the lifetime up to 50,000 h.

关键词： Degradation Impedance Lifetime SOFC Stack

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Efficacy of chemotherapy containing bevacizumab in patients with metastatic colorectal cancer according to programmed cell death ligand 1

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3521-3528页

作者： Shin Woo Kang Sung Hee lim Min-Ji Kim Jeeyun Lee Young Suk Park Ho Yeong lim Won Ki Kang seung Tae Kim Division of Hematology Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Samsung Biomedical Research Institute Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Bevacizumab,an anti-vascular endothelial growth factor(VEGF)monoclonal antibody,inhibits angiogenesis and reduces tumor *** VEGF-C,lactate dehydrogenase,and inflammatory markers have been reported as predictive markers related to bevacizumab *** cell death ligand 1(PD-L1)could act upon VEGF receptor 2 to induce cancer cell angiogenesis and *** To investigate the efficacy of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer(CRC)according to the expression of *** This analysis included CRC patients who received bevacizumab plus FOLFOX or FOLFIRI as first-line therapy between June 24,2014 and February 28,2022,at Samsung Medical Center(Seoul,South Korea).Analysis of patient data included evaluation of PD-L1 expression by the combined positive score(CPS).We analyzed the efficacy of bevacizumab according to PD-L1 expression status in patients with *** A total of 124 patients was included in this *** all patients were treated with bevacizumab plus FOLFIRI or FOLFOX as the first-line *** 77%of patients received FOLFOX,23%received FOLFIRI as backbone first-line *** numbers of patients with a PD-L1 CPS of 1 or more,5 or more,or 10 or more were 105(85%),64(52%),and 32(26%),*** results showed no significant difference in progression-free survival(PFS)and overall survival(OS)with bevacizumab treatment between patients with PDL1 CPS less than 1 and those with PD-L1 CPS of 1 or more(PD-L1<1%vs PD-L1≥1%;PFS:P=0.93,OS:P=0.33),between patients with PD-L1 CPS less than 5 and of 5 or more(PD-L1<5%vs PD-L1≥5%;PFS:P=0.409,OS:P=0.746),and between patients with PD-L1 CPS less than 10 and of 10 or more(PD-L1<10%vs PD-L1≥10%;PFS:P=0.529,OS:P=0.568).CONCLUSION Chemotherapy containing bevacizumab can be considered as first-line therapy in metastatic CRC irrespective of PD-L1 expression.

关键词： Bevacizumab Colorectal cancer Programmed cell death ligand 1 expression First-line chemotherapy Metastatic colorectal cancer

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Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae lim Dong Guk Kang Hyeon Gyu Lee Yen Hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling

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Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae Han Joong Hoon Lee Gwan‑Jin Ko seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon lim Chan‑Hwi Eom Amay J.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

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Discreteness of Flux Groups

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Acta Mathematica Sinica,English Series 2006年第1期22卷 115-122页

作者： Yong seung CHO Myung Im lim Department of Mathematics Ewha Women's-University Seoul 120-750 Korea

Let （M, ω） be a closed symplectic 2n-dimensional manifold. Donaldson in his paper showed that there exist 2m-dimensional symplectie submanifolds （V^2m,ω） of （M,ω）, 1 ≤m ≤ n - 1, with （m - 1）-equivalent inclusions. On the basis of this fact we obtain isomorphic relations between kernel of Lefschetz map of M and kernels of Lefschetz maps of Donaldson submanifolds V^2m, 2 ≤ m ≤ n - 1. Then, using this relation, we show that the flux group of M is discrete if the action of π1 （M） on π2（M） is trivial and there exists a retraction r ： M→ V, where V is a 4-dimensional Donaldson submanifold. And, in the symplectically aspherical case, we investigate the flux groups of the manifolds.

关键词： Symplectic diffeomorphisms Flux Symplectically aspherical manifold Donaldson submanifold

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Automatic Discontinuity Classification of Wind-turbine Blades Using A-scan-based Convolutional Neural Network

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Journal of Modern Power Systems and Clean Energy 2021年第1期9卷 210-218页

作者： Jiyeon Choung Sun lim seung Hwan lim Su Chung Chi Mun Ho Nam Korea Electronics Technology Institute 401-402Bucheon Technopark655Pyeongcheon-roWonmi-guBucheon-siGyeonggi-do 14502Korea Sam Yong Inspection Engineering Co.Ltd.

Recent development trends in wind power generation have increased the importance of the safe operation of wind-turbine blades(WTBs). To realize this objective, it is essential to inspect WTBs for any defects before they are placed into operation. However, conventional methods of fault inspection in WTBs can be rather difficult to implement, since complex curvatures that characterize the WTB structures must ensure accurate and reliable inspection. Moreover, it is considered useful if inspection results can be objectively and consistently classified and analyzed by an automated system and not by the subjective judgment of an inspector. To address this concern,the construction of a pressure-and shape-adaptive phased-array ultrasonic testing platform, which is controlled by a nanoengine operation system to inspect WTBs for internal defects, has been presented in this paper. An automatic classifier has been designed to detect discontinuities in WTBs by using an A-scanimaging-based convolutional neural network(CNN). The proposed CNN classifier design demonstrates a classification accuracy of nearly 99%. Results of the study demonstrate that the proposed CNN classifier is capable of automatically classifying the discontinuities of WTB with high accuracy, all of which could be considered as defect candidates.

关键词： Wind-turbine blade(WTB) blade inspection platform convolutional neural network(CNN) discontinuity phased-array ultrasonic testing(PAUT) A-scan

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Ultimate strength of single shear bolted connections with cold-formed ferritic stainless steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第2期14卷 120-136页

作者： Jin-seong lim Tae-soo KIM seung-hun KIM Department of Architectural Engineering Hanbat National UniversityDaejeon 305-719Korea

This paper is focused on the structural behavior of the single shear bolted connections with thin-walled ferritic stainless *** purpose of this study is to investigate the ultimate behaviors,such as ultimate strength and fracture mode of the single shear bolted connections of thin-walled ferritic stainless steel(low cost steel) rather than austenitic stainless steel(high cost steel).Bolt arrangement and end distance parallel to the direction of applied load are considered as main variables of the test specimens for bolted *** have a constant dimension of edge distance perpendicular to the loading direction,bolt diameter,pitch,and gauge.A monotonic tensile test for specimens has been carried out and some bolted connections with long end distance showed curling(out of plane deformation) occurrence which led to strength *** ultimate behaviors such as fracture mode,ultimate strength are compared with those predicted by current design ***,conditions of curling occurrence and the strength reduction due to curling are investigated and modified strength equations are suggested considering the curling effect.

关键词： Cold-formed ferritic stainless steel Bolted connection Bolt arrangement End distance Curling Strength reduction

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Environmental friendly synthesis of hierarchical mesoporous platinum nanoparticles templated by fucoidan biopolymer for enhanced hydrogen evolution reaction

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Journal of Materials Science & Technology 2020年第11期42卷 185-190页

作者： seung Man lim Kyunglee Kang Hongje Jang Jung Tae Park Department of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea Department of Chemistry Kwangwoon University20 Cwangwoon-roNowon-guSeoul 01897Republic of Korea

Researching novel hydrogen evolution reaction(HER)catalysts with enhanced electrocatalytic activity,excellent stability,and cost-efficiency is of great significance for the large-scale hydrogen production from industrial electrolysis *** report the preparation of hierarchical mesoporous-Pt nanoparticles(HM-Pt NPs)with coral-like rough surface morphologies using environmental friendly and biocompatible fucoidan(Fu)biopolymer as a surface engineering compound and its application to electrocatalysts for *** designed HM-Pt NPs yields better mass activity of electrocatalysts compared to a commercial Pt/***-Pt NPs showed an overpotential of 33 mV at 10 mA cm-2 for the HER in 0.5 MH2SO4,which was highly comparable to that of the commercial Pt/C catalysts(29 mV).However,the amount of HM-Pt NPs loaded in glassy carbon electrode(0.033 mg mL-1)was approximately 20 times lower than that of the commercial Pt/C(0.64 mg *** HM-Pt NPs also maintained high catalytic stability with a consistent HER current density after 1000 continuous *** excellent HER performance is attributed to the improved electrochemical surface area,highly porous structure,and good surface wettability of the HM-Pt NPs,which results in enhanced electrocatalytic activity,decreased resistance at the electrode/electrolyte interface,and facile penetration of the electrolytes inside the electrode.

关键词： Mesoporous Fucoidan Biopolymer Low Pt content Hydrogen evolution reaction

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