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Role of multidetector computed tomography in patients with acute infectious colitis

World Journal of Clinical Cases 2022年第12期10卷 3686-3697页

作者： seung jung yu Jae Hyuk Heo Eun Jeong Choi Jong Hyuk Kim Hong Sub Lee Sun Young Kim Jae Hoon Lim Department of Internal Medicine Inje University Busan Paik HospitalBusan 47392South Korea Department of Radiology Myongji HospitalHanyang University College of MedicineGoyang 10475South Korea Department of Cancer Control and Population Health National Cancer CenterGoyang 10408South Korea

BACKGROUND The role of multidetector computed tomography(MDCT)in patients with acute infectious colitis is still *** To examine the usefulness of MDCT in distinguishing the etiology of acute infectious *** Overall,244 patients who met the criteria for acute infectious colitis and visited the Hospital from February 2015 to 2018 were retrospectively enrolled and divided into two groups(bacterial:204,viral:40)according to causes of acute colitis,based on stool *** MDCT parameters,including wall thickening,submucosal edema,mucosal enhancement,serosa involvement,empty colon sign,small bowel involvement,comb sign,continuous distribution,accordion sign,mucosal thickening,and lymph node enlargement,were constructed in a blinded *** MDCT parameters of wall thickening(OR:13.60;95%CI:5.80–31.88;P<0.001),submucosal edema(OR:36.08;95%CI:13.54–96.13;P<0.001),mucosal enhancement(OR:22.55;95%CI:9.28–54.81;P<0.001),serosal involvement(OR:14.50;95%CI:3.33–63.23;P<0.001),empty colon sign(OR:6.68;95%CI: 2.44–18.32;P < 0.001), continuous distribution (OR: 24.09;95%CI: 9.38–61.90;P < 0.001), accordionsign (OR: 9.02;95%CI: 1.12–72.35;P = 0.038), mucosal thickening (OR: 46.41;95%CI: 10.38–207.51;P< 0.001), and lymph node enlargement (OR: 4.39;95%CI: 1.22–15.72;P = 0.023) were significantlyassociated with bacterial colitis. At least one positive finding in four CT outcomes (submucosaledema, mucosal enhancement, continuous distribution, mucosal thickening) in summer showed ahigh probability of bacterial colitis (sensitivity, 41.67;specificity, 92.50;OR: 24.95).CONCLUSIONMDCT provides many clues that can be useful in suggesting a specific etiology of acute infectiouscolitis.

关键词： Colitis Multidetector computed tomography Differential diagnosis Bacterial infections Viral infections

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Effect of music on colonoscopy performance: A propensity scorematched analysis

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 397-406页

作者： Eun Jeong Choi Sam Ryong Jee Sang Heon Lee Jun Sik Yoon seung jung yu Jong Hyun Lee Han Byul Lee Sang Wook Yi Myeong Pyo Kim Byung Cheol Chung Hong Sub Lee Department of Internal Medicine Inje University College of MedicineBusan Paik HospitalBusan 47392South Korea Department of Public Health Ajou University Graduate School of Public HealthSuwon 16499South Korea Department of Preventive Medicine and Public Health Catholic Kwandong University College of MedicineGangneung 25601South Korea

BACKGROUND Music has been used to reduce stress and improve task performance during medical *** To assess the effects of music on colonoscopy performance *** We retrospectively reviewed patients who underwent colonoscopy performed by four endoscopists with popular *** performance outcomes,such as insertion time,adenoma detection rate(ADR),and polyp detection rate(PDR),were compared between the music and non-music *** reduce selection bias,propensity score matching was *** After one-to-one propensity score matching,169 colonoscopies were selected from each *** significant differences in insertion time(4.97 vs 5.17 min,P=0.795)and ADR(39.1%vs 46.2%,P=0.226)were found between the two *** analysis showed that the insertion time(3.6 vs 3.8 min,P=0.852)and ADR(51.1%vs 44.7%,P=0.488)did not significantly differ between the two groups in ***,in trainees,PDR(46.9%vs 66.7%,P=0.016)and ADR(25.9%vs 47.6%,P=0.006)were significantly lower in the music than in the nonmusic *** The current study found that listening to music during colonoscopy did not affect procedure ***,it suggested that music may distract trainees from appropriately detecting adenomas and polyps.

关键词： Music Colonoscopy Performance Adenoma Colonic polyps Cecal insertion time

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Depth perception on fundus images using a single-channel stereomicroscopy

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 68-76页

作者： Edalat Radfar Hyunseon yu Tien Son Ho seung Ho Choi Byungjo jung Department of Biomedical Engineering Yonsei University Wonju-siGangwon-do 26493 Republic of Korea Research Center for Science and Technology in Medicine Tehran University of Medical Sciences Tehran 14185-615Iran Institute of Metabolism and Systems Research University of Birmingham Edgbaston Birmingham B152TTUK

Typical fundus photography produces a two-dimensional *** makes it difficult to observe the microvascular and neural abnormalities,because the depth of the image is *** provide depth appreciation,we develop a single-channel stereoscopic fundus video imaging sys-tem based on a rotating *** respect to the pupil center,the rotating refractor laterally displaces the optical path and the *** allows standard monocular fundus cameras to generate stereo-parallax and image disparity through sequential image *** opti-mize our imaging system,characterize the stereo-base,and image an eyeball model and a rabbit *** virtual realities are considered,our imaging system can be a simple yet efficient technique to provide depth perception in a virtual space that allows users to perceive abnor-malities in the eye fundus.

关键词： Imaging systems ophthalmic optics and devices refraction vision-binocular and stereopsis

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer: a phase II trial of pembrolizumab

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Oncology research 2025年第1期33卷 57-65页

作者： Ryul Kim Joo Kyung Park Minsuk Kwon Minae An jung Yong Hong Joon Oh Park Sung Hee Lim seung Tae Kim Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea. Department of Hematology-Oncology Ajou University School of Medicine Suwon-si Gyeonggi-do Korea. Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of Medicine Seoul Korea.

Background:Immune checkpoint inhibitors (ICIs) are effective in a subset of patients with metastatic solid tumors. However, the patients who would benefit most from ICIs in biliary tract cancer (BTC) are still controversial.Materials and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line therapy.Results:All patients had microsatellite stable (MSS) type tumors. Three of the 32 patients achieved partial response (PR), with an objective response rate (ORR) of 9.4% (95% confidence interval [CI], 2.0-25.2) and nine showed stable disease (SD), exhibiting a disease control rate (DCR) of 37.5% (95% CI, 21.1-56.3). For the 31 patients who had access to PD-1 ligand 1 (PD-L1) combined positive score (CPS) testing (cut-off value ≥1%), the ORR was not different between those who had PD-L1-positive (PD-L1+; 1/11, 9.1%) and PDL1-(2/20, 10.0%) tumors ( = 1.000). The tumor mutational burden (TMB) of PD-L1+ BTC was comparable to that of PD-L1-BTC ( = 0.630). TMB and any exonic somatic mutations were also not predictive of pembrolizumab response. Molecular analysis of blood and tumor samples demonstrated a relatively high natural killer (NK) cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor response. Moreover, the tumors of these patients presented high enrichment scores for NK cells, antitumor cytokines, and Th1 signatures, and a low enrichment score for cancer-associated fibroblasts.Conclusions:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Biliary tract cancer Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing

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Adverse effects of early-life stress:focus on the rodent neuroendocrine system

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Neural Regeneration Research 2024年第2期19卷 336-341页

作者： seung Hyun Lee Eui-Man jung Department of Molecular Biology College of Natural SciencesPusan National UniversityBusanRepublic of Korea

Early-life stress is associated with a high prevalence of mental illnesses such as post-traumatic stress disorders,attention-deficit/hyperactivity disorder,schizophrenia,and anxiety or depressive behavior,which constitute major public health *** the early stages of brain development after birth,events such as synaptogenesis,neuron maturation,and glial differentiation occur in a highly orchestrated manner,and external stress can cause adverse long-term effects throughout *** body utilizes multifaceted mechanisms,including neuroendocrine and neurotransmitter signaling pathways,to appropriately process external *** individuals first exposed to early-life stress deploy neurogenesis as a stress-defense mechanism;however,in adulthood,early-life stress induces apoptosis of mature neurons,activation of immune responses,and reduction of neurotrophic factors,leading to anxiety,depression,and cognitive and memory *** process involves the hypothalamus-pituitary-adrenal axis and neurotransmitters secreted by the central nervous system,including norepinephrine,dopamine,and *** rodent early-life stress model is generally used to experimentally assess the effects of stress during *** paper reviews the use of the early-life stress model and stress response mechanisms of the body and discusses the experimental results regarding how early-life stress mediates stress-related pathways at a high vulnerability of psychiatric disorder in adulthood.

关键词： early-life stress hypothalamic-pituitary-adrenergic axis maternal separation mental illness neurodevelopmental disorder neuroendocrine system neurotransmitter

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Long cycle-life aqueous Zn battery enabled by facile carbon nanotube coating on Cu current collector

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Carbon Energy 2024年第6期6卷 151-164页

作者： Beom-Keun Cho Sung-Ho Huh So Hee Kim seungho yu Jong-Seong Bae jung-Keun Yoo seung-Ho yu Department of Chemical and Biological Engineering Korea UniversitySeoulRepublic of Korea Advanced Analysis Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Energy Storage Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST School Division of Energy and Environment TechnologyKorea University of Science and TechnologySeoulRepublic of Korea Busan Center Korea Basic Science Institute(KBSI)BusanRepublic of Korea Carbon Composites Department Composites Research DivisionKorea Institute of Materials Science(KIMS)ChangwonRepublic of Korea

As an alternative to Li-ion batteries,aqueous Zn batteries have gained attention due to the abundance of Zn metal,low reduction potential(-0.76 V *** hydrogen electrode),and high theoretical capacity(820 mAh g^(-1))of multivalent Zn2+***,the growth of Zn dendrites and the formation of irreversible surface reaction byproducts pose challenges for ensuring a long battery lifespan and ***,the Cu foil coated with a single-walled carbon nanotube(SWCNT)layer using a facile doctor blade casting method is *** SWCNT-coated Cu foil demonstrates a significantly longer battery lifespan compared to the bare Cu in the half-cell *** operando optical microscopy imaging,we are able to provide intuitive evidence that Zn deposition occurs between the carbon nanotube(CNT)coating and Cu substrate,in agreement with the computational ***,with various imaging techniques,the flat morphology and homogeneous distribution of Zn beneath the SWCNT layer are *** addition,the full-cell using CNT-coated Cu exhibits a long cycle life compared to the control group,thereby demonstrating improved electrochemical performance with limited Zn for the cycling process.

关键词： aqueous Zn battery carbon nanotube operando imaging surface coating

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A new damage quantification approach for shear-wall buildings using ambient vibration data

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 17-25页

作者： seung-Hun SUNG Hyung-Jo jung Department of Civil and Environmental Engineering Korea Advanced Institute of Science and Technology Daejeon 305- 701 Korea

This paper presents a new approach to estimate damage seventy tor slaear-wall DUlltllngs using alagona~ terms of a modal flexibility matrix estimated from dynamic properties. This study aims to provide a fundamental concept for quantifying the damage of realistic buildings by investigating an idealized shear-wall building. Numerical studies were performed on a 5-story shear-wall building model to validate the applicability of the presented approach, using two damage patterns. With the numerical simulations, the proposed approach accurately determined the damage ratio of the specimens. Experiments were also conducted on a 5-story shear-wall building model for which the system parameters were almost the same as those in numerical simulations. The estimated damage-quantification results from the experimental validations demonstrated that the performance of the presented method for shear-wall buildings was both suitable and accurate.

关键词： damage identification modal flexibility damage quantification shear-wall buildings

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Fossil-Winged Fruits of Fraxinus(Oleaceae) and Liriodendron(Magnoliaceae) from the Duho Formation,Pohang Basin,Korea

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Acta Geologica Sinica(English Edition) 2009年第5期83卷 845-852页

作者： seung-Ho jung Seong-Joo LEE Department of Geology Kyungpook National UniversityDaegu 702-701Korea

A total of 16 specimens of fossil-winged fruits were found from the Middle Miocene marine deposits, Duho Formation, Pohang Basin, Korea. They were identified into two structurally different groups： 15 specimens into a winged fruit of Fraxinus, and one specimen of Liriodendron. The most samaras （13 specimens） were identified as Fraxinus oishii, which is characterized by narrowly ovate or ovate-elliptic shapes that are 2.7-3.6 cm in length and 0.7-1 cm in width （i/w ratio=3.4-4）. The apexes of the Fraxinus oishii samara are round or slightly emarginated, and a seed of the samara is always located at the base, of which the general shape is narrow rhombic-ellipsoidal. The seed is 1.2-2 cm long and 0.5-0.7 cm wide. Two specimens are different from the samara of Fraxinus oishii. They have a 6.6 length/width ratio （3.3 cm long and 0.5 cm wide）, and thus, are temporarily classified into the Fraxinus sp. One specimen was recognized as a winged seed of Liriodendron meisenense. The wing is broadly lanceolate to elliptic in shape, has a smooth, acute apex, and is approximately 3 cm long and 0.7 cm wide. Samaras of Fraxinus oishii and Liriodendron meisenense were early reported from the Middle Miocene deposits from North Korea, but these specimens are the first discovery in South Korea. Further study of the Duho Formation may connect flora relationships between North and South Korea.

关键词： winged fruits Fraxinus Liriodendron Middle Miocene Pohang Basin Korea

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Stick-and-play system based on interfacial adhesion control enhanced by micro/nanostructures

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Nano Research 2021年第9期14卷 3143-3158页

作者： jung II Yoo seung Hyun Kim Heung Cho Ko School of Materials Science and Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea

The evolution of membrane-type electronics has facilitated the development of stick-and-play systems,which confer diverse electrical functions to various planar or arbitrary curvilinear *** stick-and-play concept is based on the development of thin electronic devices in a printable format and their subsequent transfer to target *** development of this technology requires control of the interfacial adhesion of the electronic prints for retrieval from a carrier and transfer to the target ***,we discuss the transfer printing for membrane-type electronics,starting from an overview of materials available for flexible substrates,transfer printing of electronic prints for retrieval,and assembly for further ***,we explain the stick-and-play concept based on fabricated membrane-type electronics;"stick" and “play"refer to the transfer of electronic devices and the performance of their electronic functions,*** particular,we broadly survey various methods based on micro/nanostructures,including gecko-inspired,interlocking,cephalopod-sucker-inspired,and cilia structures,which can be employed to stick-and-play systems for enhancing interfacial adhesion with complex target surfaces under dynamic and wet ***,we highlight the stick-and-play system application of micro/nanostructures for skin-attachable biomedical electronics,e-textiles,and environmental monitoring electronics.

关键词： transfer printing interfacial adhesion flexible electronics stick-and-play system bioinspired adhesive

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Environmental friendly synthesis of hierarchical mesoporous platinum nanoparticles templated by fucoidan biopolymer for enhanced hydrogen evolution reaction

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Journal of Materials Science & Technology 2020年第11期42卷 185-190页

作者： seung Man Lim Kyunglee Kang Hongje Jang jung Tae Park Department of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea Department of Chemistry Kwangwoon University20 Cwangwoon-roNowon-guSeoul 01897Republic of Korea

Researching novel hydrogen evolution reaction(HER)catalysts with enhanced electrocatalytic activity,excellent stability,and cost-efficiency is of great significance for the large-scale hydrogen production from industrial electrolysis *** report the preparation of hierarchical mesoporous-Pt nanoparticles(HM-Pt NPs)with coral-like rough surface morphologies using environmental friendly and biocompatible fucoidan(Fu)biopolymer as a surface engineering compound and its application to electrocatalysts for *** designed HM-Pt NPs yields better mass activity of electrocatalysts compared to a commercial Pt/***-Pt NPs showed an overpotential of 33 mV at 10 mA cm-2 for the HER in 0.5 MH2SO4,which was highly comparable to that of the commercial Pt/C catalysts(29 mV).However,the amount of HM-Pt NPs loaded in glassy carbon electrode(0.033 mg mL-1)was approximately 20 times lower than that of the commercial Pt/C(0.64 mg *** HM-Pt NPs also maintained high catalytic stability with a consistent HER current density after 1000 continuous *** excellent HER performance is attributed to the improved electrochemical surface area,highly porous structure,and good surface wettability of the HM-Pt NPs,which results in enhanced electrocatalytic activity,decreased resistance at the electrode/electrolyte interface,and facile penetration of the electrolytes inside the electrode.

关键词： Mesoporous Fucoidan Biopolymer Low Pt content Hydrogen evolution reaction

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