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Electrochemical biosensors for point-of-care testing

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Bio-Design and Manufacturing 2024年第4期7卷 548-565页

作者： Jinsol Kim Juho Jeong seung hwan Ko Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversitySeoul 08826Republic of Korea

Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely in a medical laboratory or other clinical *** has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical ***,recent growth has occurred in this field due to advances in diagnostic technologies,device miniaturization,and progress in wearable *** these developments,electrochemical sensors have attracted interest in the POCT field due to their high sensitivity,compact size,and *** are used in various applications,from disease diagnosis to health status *** this paper we explore recent advancements in electrochemical sensors,the methods of fabricating them,and the various types of sensing mechanisms that can be ***,we delve into methods for immobilizing specific biorecognition elements,including enzymes,antibodies,and aptamers,onto electrode surfaces and how these sensors are used in real-world POCT settings.

关键词： Point-of-care testing(POCT) Electrochemical sensor Enzyme Antibody Health care

Advances in wearable and implantable bioelectronics for precision medicine

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Bio-Design and Manufacturing 2024年第4期7卷 383-387页

作者： Kaichen Xu seung hwan Ko Jun Chen State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China Applied Nano and Thermal Science Lab Department of Mechanical EngineeringSeoul National UniversitySeoul 08826Republic of Korea Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095-1599USA

The continuous pursuit for a better quality of life promotes continuous advancements in intelligent *** wearable and implantable bioelectronics have emerged as an innovative complement to rigid material-based electronic devices[1-3].Due to their distinct advantages in terms of ductile,ultrathin,and biocompatible features,these elastic and soft bioelectronic devices can be seamlessly mounted onto various real or artificial tissues and organs.

关键词： wear mounted pursuit

Machine-learned wearable sensors for real-time hand-motion recognition: toward practical applications

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National Science Review 2024年第2期11卷 231-263页

作者： Kyung Rok Pyun Kangkyu Kwon Myung Jin Yoo Kyun Kyu Kim Dohyeon Gong Woon-Hong Yeo seungyong Han seung hwan Ko Department of Mechanical Engineering Seoul National University IEN Center for Human-Centric Interfaces and Engineering Institute for Electronics and NanotechnologyGeorgia Institute of Technology School of Electrical and Computer Engineering Georgia Institute of Technology Department of Chemical Engineering Stanford University Department of Mechanical Engineering Ajou University George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National University

Soft electromechanical sensors have led to a new paradigm of electronic devices for novel motion-based wearable applications in our daily lives. However, the vast amount of random and unidentified signals generated by complex body motions has hindered the precise recognition and practical application of this technology. Recent advancements in artificial-intelligence technology have enabled significant strides in extracting features from massive and intricate data sets, thereby presenting a breakthrough in utilizing wearable sensors for practical applications. Beyond traditional machine-learning techniques for classifying simple gestures, advanced machine-learning algorithms have been developed to handle more complex and nuanced motion-based tasks with restricted training data sets. Machine-learning techniques have improved the ability to perceive, and thus machine-learned wearable soft sensors have enabled accurate and rapid human-gesture recognition, providing real-time feedback to users. This forms a crucial component of future wearable electronics, contributing to a robust human–machine interface. In this review, we provide a comprehensive summary covering materials, structures and machine-learning algorithms for hand-gesture recognition and possible practical applications through machine-learned wearable electromechanical sensors.

关键词： wearable sensor soft electronics artificial intelligence machine learning human–machine interfaces gesture recognition

Structural insights on anti-biofilm mechanism of heated slightly acidic electrolyzed water technology against multi-resistant Staphylococcus aureus biofilm on food contact surface

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Food Science and Human Wellness 2024年第3期13卷 1556-1566页

作者： Pianpian Yan Ramachandran Chelliah Kyoung Hee Jo Xiuqin Chen Akanksha Tyagi Hyeon Yeong Jo Fazle Elahi Nam Chan Woo Min seung Wook Deog hwan Oh Department of Food Science and Biotechnology College of Agriculture and Life SciencesKangwon National UniversityChuncheon 24341South Korea Kangwon Institute ofInclusive Technology(KIIT) Kangwon National UniversityChuncheon 24341South Korea Saveetha School of Engineering (SIMATS)UniversitySriperumbudur 600124India Seoulin Bioscience Company Seongnam-si 13488South Korea

Slightly acidic electrolyzed water(SAEW)has proven to be an efficient and novel sanitizer in food and agriculture *** study assessed the efficacy of SAEW(30 mg/L)at 40℃on the inactivation of foodbome pathogens and detachment of multi-resistant Staphylococcus aureus(MRSA)*** underlying mechanism of MRS A biofilm under heated SAEW at 40℃treatment on metabolic profiles was *** results showed that the heated SAEW at 40℃significantly effectively against foodbome pathogens of 1.96-7.56(lg(CFU/g))reduction in pork,chicken,spinach,and *** heated SAEW at 40℃treatment significantly reduced MRS A biofilm cells by 2.41(lg(CFU/cm^(2))).The synergistic effect of SAEW treatment showed intense anti-biofilm activity in decreasing cell density and impairing biofilm cell *** metabolic response of MRSA biofilms,treated by SAEW at 40℃,revealed the alterations of intracellular metabolites,including amino acids,organic acid,fatty acid,and ***,signaling pathways involved in amino acid metabolism,energy metabolism,nucleotide synthesis,carbohydrate metabolites,and lipid biosynthesis were functionally disrupted by the SAEW at 40℃*** per our knowledge,this is the first research to uncover the potential mechanism of heated SAEW treatment against MRSA biofilm on food contact surface.

关键词： Multi-resistant Staphylococcus aureus Metabolic profile SAEW Biofilm Hurdle technology Electrode material

Real-Time Tunable Gas Sensing Platform Based on SnO_(2) Nanoparticles Activated by Blue Micro-Light-Emitting Diodes

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Nano-Micro Letters 2024年第12期16卷 103-119页

作者： Gi Baek Nam Jung-El Ryu Tae Hoon Eom seung Ju Kim Jun Min Suh seungmin Lee Sungkyun Choi Cheon Woo Moon Seon Ju Park Soo Min Lee Byungsoo Kim Sung Hyuk Park Jin Wook Yang Sangjin Min Sohyeon Park Sung hwan Cho Hyuk Jin Kim Sang Eon Jun Tae Hyung Lee Yeong Jae Kim Jae Young Kim Young Joon Hong Jong-In Shim Hyung-Gi Byun Yongjo Park Inkyu Park Sang-Wan Ryu Ho Won Jang Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Research Laboratory of Electronics Department of Mechanical EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139USA Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Display Materials Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang University ERICAAnsan 15588Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok 25913Republic of Korea Advance Institute of Convergence Technology Seoul National UniversitySuwon 16229Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Physics Chonnam National UniversityGwangju 500-757Republic of Korea

Micro-light-emitting diodes(μLEDs)have gained significant interest as an activation source for gas sensors owing to their advantages,including room temperature operation and low power ***,despite these benefits,challenges still exist such as a limited range of detectable gases and slow *** this study,we present a blueμLED-integrated light-activated gas sensor array based on SnO_(2)nanoparticles(NPs)that exhibit excellent sensitivity,tunable selectivity,and rapid detection with micro-watt level power *** optimal power forμLED is observed at the highest gas response,supported by finite-difference time-domain ***,we first report the visible light-activated selective detection of reducing gases using noble metal-decorated SnO_(2)*** noble metals induce catalytic interaction with reducing gases,clearly distinguishing NH3,H2,and ***-time gas monitoring based on a fully hardwareimplemented light-activated sensing array was demonstrated,opening up new avenues for advancements in light-activated electronic nose technologies.

关键词： Micro-LED Gas sensor array Low power consumption Metal decoration Real-time detection

Biliary reflux detection in anomalous union of the pancreaticobiliary duct patients

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World Journal of Gastroenterology 2012年第9期18卷 952-959页

作者： Suk Keu yeom seung Wha Lee Sang Hoon Cha hwan Hoon Chung Bo Kyung Je Baek Hyun Kim Jong Jin Hyun Department of Radiology Korea University Ansan Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Ansan HospitalGyeonggi-do 425-707South Korea

AIM： To demonstrate the imaging findings of biliopan creatic and pancreatico-biliary reflux in patients with anomalous union of the pancreatico biliary duct （AUPBD） on gadoxetic acidenhanced functional magnetic res... 详细信息

关键词： Bile reflux Choledochal cyst Encoscopicretrograde cholangio-pancreatography Gadolinium-eth-oxybenzyl-diethylenetriamine penta-acetic acid Magneticresonance imaging

Ultrafast synthesis of gold nanoparticles on cellulose nanocrystals via microwave irradiation and their dyes-degradation catalytic activity

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Journal of Materials Science & Technology 2020年第6期41卷 168-177页

作者： Madhusudhan Alle seung-hwan Lee Jin-Chul Kim Institute of Forest Science Kangwon National UniversityChuncheon 24341Republic of Korea Department of Forest Biomaterials Engineering Kangwon National UniversityChuncheon 24341Republic of Korea Department of Medical Biomaterials Engineering College of Biomedical Science and Institute of Bioscience and BiotechnologyKangwon National University192-1Hyoja 2 dongChuncheonKangwon-do 200-701Republic of Korea

This study represents a well-dispersed gold nanoparticles(AuNPs)synthesis process via cellulose nanocrystals(CNC)which acts as both reducing and supporting *** synthesis process was ultrafast and completed in a few seconds using microwave *** entire synthesis process was cost-effective,sustainable and *** synthesized(AuNPs/CNC)nanocomposite was investigated by transmission electron microscopy,selected area electron diffraction,Fourier transform infrared spectroscopy,energy dispersive X-ray analysis,X-ray diffraction,and UV–vis *** obtained AuNPs were well accumulated on the CNC surface and had a uniform spherical shape with an average diameter of 8±5.3 *** diameter of AuNPs could be altered by tuning the concentration of CNC *** synthesized AuNPs/CNC nanocomposite film exhibited excellent degradation properties against various organic dyes,namely,Allura red,Congo red,Rhodamine B and *** ultrafast degradation reactions followed pseudo first order *** the catalytic degradation reaction,AuNPs/CNC was transmitting electrons from a donor(NaBH4)to an acceptor(a dye).

关键词： Cellulose nanocrystals Gold nanoparticles Microwave synthesis Catalytic degradation of dyes

Endoscopic repair of delayed stomach perforation caused by penetrating trauma:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1228-1236页

作者： Jae Hyun Yoon Chung hwan Jun Jae Pil Han Ji-Woong yeom seung-Ku Kang Hyun Yi Kook Sung KyuChoi Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea Department of Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Cardiothoracic Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Nursing Chonnam National University Hospitaland College of NursingGwangju 61469South Korea

BACKGROUND Primary endoscopic closure of a perforated gastric wall during endoscopic procedures is mostly effective and well-tolerated;however,there are very few studies on the efficacy of endoscopic management of delayed traumatic gastric ***,we report a novel case of a patient who was successfully treated for delayed traumatic stomach perforation using an alternative endoscopic *** SUMMARY A 39-year-old woman presented with multiple penetrating traumas in the back and left abdominal *** imaging studies revealed left diaphragmatic disruption and peri-splenic hemorrhage without gastric *** emergency primary repair of the disrupted diaphragm with omental reduction and suturing of the lacerated lung was performed;however,delayed free perforation of the gastric wall was noted on computed tomography after 3 *** an emergency abdominal surgery for the primary repair of the gastric wall,re-perforation was noted 15 d *** high risk associated with re-surgery prompted an endoscopic intervention using 2 endoloops and 11 endoscopic clips using a novel modified purse-string suture *** free perforated gastric wall was successfully repaired without additional surgery or *** patient was discharged after 46 d without any *** Endoscopic closure with endoloops and clips can be a useful therapeutic alternative to re-surgery for delayed traumatic gastric perforation.

关键词： Surgical endoscopy Trauma Stomach Re-perforation Endoloop Case report

Nanoscale resistive switching devices for memory and computing applications

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Nano Research 2020年第5期13卷 1228-1243页

作者： seung hwan Lee Xiaojian Zhu Wei D.Lu Department of Electrical Engineering and Computer Science The University of MichiganAnn ArborMichigan 48109USA

With the slowing down of the Moore’s law and fundamental limitations due to the von-Neumann bottleneck,continued improvements in computing hardware performance become increasingly more *** switching(RS)devices are being extensively studied as promising candidates for next generation memory and computing applications due to their fast switching speed,excellent endurance and retention,and scaling and three-dimensional(3D)stacking *** particular,RS devices offer the potential to natively emulate the functions and structures of synapses and neurons,allowing them to efficiently implement neural networks(NNs)and other in-memory computing systems for data intensive applications such as machine learning *** this review,we will examine the mechanisms of RS effects and discuss recent progresses in the application of RS devices for memory,deep learning accelerator,and more faithful brain-inspired computing *** and possible solutions at the device,algorithm,and system levels will also be discussed.

关键词： resistive switching oxygen vacancy metal cation memory application in-memory computing bio-inspired application