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Diagnostic challenges in alcohol use disorder and alcoholic liver disease

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World Journal of Gastroenterology 2014年第25期20卷 8024-8032页

作者： Luisa Vonghia Peter Michielsen Geert dom Sven Francque Department of Gastroenterology and Hepatology University Hospital Antwerp Wilrijkstraat 10 2650 Edegem Belgium Department of Basic Medical Sciences Neuroscience and Sensory OrgansUniversity of BariPoliclinicoPiazza Giulio Cesare70100 BariItaly Collaborative Antwerp Psychiatric Research Institute (CAPRI) Antwerp University Universiteitsplein 12610 Antwerp Belgium

Alcohol use disorders represent a heterogeneous spectrum of clinical manifestations that have been defined by the Diagnostic and Statistical Manual of Mental Disorders-5. Excessive alcohol intake can lead to damage of various organs, including the liver. Alcoholic liver disease includes different injuries ranging from steatosis to cirrhosis and implicates a diagnostic assessment of the liver disease and of its possible complications. There is growing interest in the possible different tools for assessing previous alcohol consumption and for establishing the severity of liver injury, especially by noninvasive methods.

关键词： Alcoholic liver disease Alcohol use disorder Diagnosis Diagnostic and Statistical Manual of Mental Disorders-5 Screening tests Markers of previous alcohol consumption Non-invasive fibrosis assessment

Effect of low level laser therapy on dental pulp during orthodontic movement

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World Journal of Methodology 2013年第2期3卷 19-26页

作者： ngela domínguez Rosa Emilia Ballesteros Jairo Hernán Viáfara Oscar Mario Tamayo Department of Orthodontics Faculty of DentistryUniversidad del ValleCali 76001000Colombia Histology and Anatomy Medicine DepartmentUniversidad Santiago de CaliCali 76001000Colombia

AIM: To validate the protocol described here to be used in future clinical trials related to the effect of laser therapy on dental pulp. METHODS: Histologically treated samples from eight human healthy premolar teeth obtained from the middle root level were distributed in four groups: group 1(G1) absolute control; group 2(G2) only laser irradiation; group 3(G3) exposed only to orthodontics; and group 4(G4) treated with orthodontics and laser. Laser treatment was performed at 830 nm wavelength, 100 mW(energy 80 J/cm2, 2.2 J), for 22 s in the vestibular surface and 22 s in the palatal surface, 1 mm away from the dental root mucosa. Three staining methods were performed: hematoxylin-eosin(HE), Masson's Trichrome method and Gomori's ***: The pulp histology parameters were evaluated and the results classified in to 3 parts: an inflammatory response, soft tissue response(dental pulp) and hard tissue response(dentin and predentin). There was no inflammation(chronic or acute) in any of the evaluated groups. The zones of pulp necrosis were found in one premolar of G3 and in one of G4; in groups G2 and G4 there was higher angiogenesis than in the other two groups. G4 group presented the highest level of vascularization. A reduced nerve density was observed in G3. A G2 specimen showed increased nerve density. A higher rate of calcification was observed in G1 compared to G2. Denticles, either real or false, were observed in G1, G2 and G3. Sclerosis of dentin and focal dentin loss was observed among all the groups. Secondary dentin was present in one sample in G1 and G2. A necrosis zone was found in one sample of G3 and G4. No differences between groups were observed in the odontoblast irregularity layer but the layer was wider in the group treated with laser only. A notable difference was detected in reduction of the cell-free layer between the groups G1 and G4. The findings in pulp tissue favor its adaptative response against dental movement induced by orthodontics.

关键词： Low level laser therapy Pulpal Orthodontic movement Histological protocol Dentin

NDT-Suite: A Methodological Tool Solution in the Model-Driven Engineering Paradigm

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Journal of Software Engineering and Applications 2014年第4期7卷 206-217页

作者： Julián Alberto García-García María José Escalona Francisco José domínguez-Mayo Alberto Salido Web Engineering and Early Testing Research Group University of Seville Seville Spain

Although the Model-Driven paradigm is being accepted in the research environment as a very useful and powerful option for effective software development, its real application in the enterprise context is still a challenge for software engineering. Several causes can be stacked out, but one of them can be the lack of tool support for the efficient application of this paradigm. This paper presents a set of tools, grouped in a suite named NDT-Suite, which under the Model-Driven paradigm offer a suitable solution for software development. These tools explore different options that this paradigm can improve such as, development, quality assurance or requirement treatment. Besides, this paper analyses how they are being successfully applied in the industry.

关键词： Model-Driven Web Engineering Model-Based Suite Tools Practical Experiences NDT NDT-Suite

PET/CT with <sup>18</sup>F-PSMA in Patients with Prostate Cancer, Review of the Initial Experience

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Open Journal of Urology 2021年第4期11卷 158-175页

作者： Jhonatan Gómez domínguez Jorge Martin Schalch Ponce de León Jose Luis Criales Cortés Department of PET/CT in CT Scanner San Angel Mexico City Mexico

METHOD: We carry out an observational study where reviewed the PET/CT studies with PSMA marked with Fluor-18 (18F) carried out from February 2019 to September 2020. We analyzed the average value of hepatic uptake SUV lean average (SUVlave), acquisition time, age, reason from the study, focal, multifocal and diffuse prostate uptake, analysis of the location of metastases, level of prostate specific antigen (PSA), we describe uptakes of non-prostate origin and focal uptakes in ribs without anatomical representation. RESULTS: The average hepatic SUVlave was 9.7, the acquisition times were variable (52 - 183 minutes) without alterations in the white-background relationship, the most frequent indication for the study was staging, the uptake in ribs without anatomical representation were considered benign with certain characteristics, PET/CT has the ability to detect neoplastic activity with low PSA levels in lymph nodes CONCLUSION: PET/CT with 18F-PSMA has advantages over bone scan and computed tomography of the abdomen and pelvis for the staging of prostate cancer.

关键词： 18F-PSMA Prostate Cancer Non-Prostatic Uptakes

Mechanical Properties of Composite Mortars Using Flurogypsum and PVC Particles

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Materials Sciences and Applications 2014年第4期5卷 212-222页

作者： Luisa Maria Flores-Vélez Hector Valle Gabriel García Roberto Torres Martha Lomelí Octavio domínguez Facultad de Química-UASLP Salvador México Instituto de Metalurgia-UASLP San Luis Potosí México Mexichem Flúor San Luis Potosí México

The present work describes the viability of a mortar binder based on two industrial by-products: poly(vinyl chloride) (PVC) particles from scrap and anhydrite (CaSO4) from fluorgypsum. Mortar composites were made incorporating different amounts of PVC particles and cured at constant room temperature during various periods of time. From X-ray diffraction, it was possible to follow the hydration process and to estimate the effect of the PVC particles on anhydrite transformation to gypsum (CaSO4·2H2O). Compressive strength from uniaxial testing was measured from stress-strain curves carried out at room temperature. According to these results, the hydration rates of the composites depend on the concentration of PVC particles and there is an enhancement in their compressive strength as particle content increases, reaching values of 36 MPa after 28 days.

关键词： Compressive Strength Recycled PVC Hydraulic Binder Alternative Building Materials Gypsum-Composite

Safety of digoxin in nonagenarian patients with atrial fibrillation:lessons from the Spanish Multicenter Registry

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Journal of Geriatric Cardiology 2021年第10期18卷 809-815页

作者： Pablo domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi María Cespón-Fernández David Alonso-Rodríguez Santiago Jesús Camacho-Freire Naiara Cubelos-Fernández Álvaro López-Masjuán Ríos María Melendo-Viu AndrésÍñiguez-Romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain Department of Cardiology University Hospital of LeónLeónSpain Department of Cardiology University Hospital Juan Ramón JiménezHuelvaSpain

BACKGROUND The association between digoxin and mortality is an unclear *** older patients with atrial fibrillation(AF),where use of digoxin is frequent,the evidence of its safety is *** aim is to assess the safety of digoxin in nonagenarian patients with *** We evaluated data from 795 nonagenarian patients with non-valvular AF from the Spanish Multicenter *** analyzed the relationship between digoxin and all-cause mortality with the Cox proportional-hazards *** Follow-up was 27.7±18.3 *** age was 92.5±3.8 years,and 71%of nonagenarian patients were *** was not associated with increased risk of mortality[adjusted hazard ratio(aHR)=1.16,95%CI:0.96−1.41,P=0.130].However,we found a significant increase in mortality in the subgroup with estimated glomerular filtration rate(eGFR)<30 mL/min per 1.73 m^(2)(aHR=2.01,95%CI:1.13−3.57,P=0.018),but not in the other subgroups of eGFR(30−59 mL/min per 1.73 m^(2) and≥60 mL/min per 1.73 m^(2)).When exploring the risk of mortality according to sex,male subgroup was associated with an in-crease in mortality(aHR=1.48,95%CI:1.02−2.14,P=0.041).This was not observed in females subgroup(aHR=1.03,95%CI:0.81−1.29,P=0.829).Based on the presence or absence of heart failure,we did not find significant differences(aHR=1.20,95%CI:0.87−1.65,P=0.268 ***=1.15,95%CI:0.90−1.47,P=0.273,respectively).CONCLUSIONS In our large registry of nonagenarian patients with AF,we did not find an association between digoxin and mortality in the total ***,in the subgroup analyses,we found an increase in mortality with the use of digoxin in men and in patients with an eGFR<30 mL/min per 1.73 m^(2).

关键词： patients digoxin fibrillation

Simulaccion Processes of a Mathematical Model to Determine the Growth of Tomato under Plastic Cover

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Agricultural Sciences 2015年第12期6卷 1532-1537页

作者： Luz Elva Marín Vaca Martha Lilia domínguez Patino Nadia Lara Ruiz Miguel Aguilar Cortes Centro de Investigacion en Ingenieria y Ciencias Aplicadas Universidad Autonoma del Estado de MorelosCuernavacaMexico Facultad de Ciencias Quimicas e Ingenieria Universidad Autonoma del Estado de MorelosCuernavacaMexico

The tomato is one of the horticultural crops of the greatest economic value;for this reason, flexibility of management is usable. The population density in a crop of vegetables is determined by the distance between the plants and so it is necessary to choose the number of plants per square meter since the saturation of plants will lead to competition between sunlight, nutrients and weed. The objective of this work is to make the appropriate investigation for the use of the model proposed in order to describe the growth of tomato in greenhouse to high density of two plants per container to two bunches per plant, resulting in eight plants per square meter to grow, by means of a simulator of growth by computer. Of this work, it is concluded that it is possible to use the model to describe the growth of plants, and in the near future it will be possible to develop a simulator by computer of the growth of these crops in order to improve their quality and increase their production.

关键词： Simulation Plastic Cover Tomato

Global Standards and Local Policies for School Diabetes Care

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Health 2015年第12期7卷 1642-1650页

作者： María J. Miranda Velasco Maria Gloria Solís Galán Enma domínguez Martín Department of Educational Sciences University of Extremadura Coordinator of Research Group Education and Health Innovation Cáceres Spain Department of Educational Sciences University of Extremadura Research Group Education and Health Innovation Cáceres Spain Research Group Education and Health Innovation Cáceres Spain

Objectives: The purpose of this study is to analyse the practical implementation of regional and na-tional policies through the Protocol of Care of Children and Adolescents in School (2010) in Extremadura Region (Spain), and to compare its contents with the international standards of diabetes care at school defined by American Diabetes Association and International Diabetes Federation. The measures not only affect the security and diabetes care, but also inclusion and the right to health. Methods: A documental comparative analysis between the local and international standards about diabetes care in school setting is carried out. This analysis is framed in a larger project focused on the study of health promoting school and diabetes education, in which perceptions of children and adolescents with diabetes, their parents and school staff were studied. Results: The Protocol of Care of Children and Adolescents in School (2010) contains some international recommendations about the care of T1DM at school, but in other cases the measures are non-specific. The distribution of responsibilities for care at school is unclear and no monitoring and evaluation indicators are defined. Some elements are identified to be implemented in the tool to favour the security, management of T1DM care and wellbeing. In general, these elements refer to school plan for diabetes care, school organization and teachers, and school community training. Conclusion: It is required to develop specific policies and decisive action to ensure the right to health of children with diabetes and the full application of international standards for diabetes care at school.

关键词： Health Policy Childhood and Adolescents Diabetes Care School Setting Inclusion

Aggregation properties of a therapeutic peptide for rheumatoid arthritis:A spectroscopic and molecular dynamics study

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ChemPhysMater 2022年第1期1卷 62-70页

作者： Rita Cimino Marco Savioli Noemi Ferrante Carrante Ernesto Placidi Hilda Garay-Perez Matilde López-Abad Alexis Musacchio Lasa Maria Del Carmen domínguez-Horta Emanuela Gatto Francesca Cavalieri Gianfranco Bocchinfuso Mariano Venanzi PEPSA-LAB Department of Chemical Sciences and TechnologyUniversity of Rome Tor VergataVia della Ricerca Scientifica 100133RomeItaly Department of Physics University of Rome‘Sapienza’P.le A.Moro 500185 RomeItaly Centre for Genetic Engineering and Biotechnology PO Box 616210600HavanaCuba School of Science RMIT UniversityMelbourneVIC 3001Australia

The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation ***,we studied the aggregation properties of a therapeutic peptide(CIGB-814),currently in phase 2 clinical trial,for the treatment of rheumatoid arthritis over a wide range of concentrations(μM-mM).We applied spectroscopic techniques(fluorescence,circular dichro-ism,resonance,and dynamic light scattering),atomic force microscopy,and molecular dynamics simulations to determine the aggregation mechanism of *** found that the hierarchical aggregation of CIGB-814 at micromolar concentrations was initiated by the formation of peptide ***,the peptide oligomers trigger the nucleation and growth of peptide nanostructures(cac=123μM),ultimately leading to the fibrillization of CIGB-814(cac’=508μM).These results pave the way for a deeper understanding of the CIGB-814 therapeutic activity and may give important insights on its pharmacokinetics.

关键词： Molecular dynamics of peptide oligomers Peptide aggregation Peptide fibrils Peptide nanostructures Therapeutic peptides Treatment of rheumatoid arthritis