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New C-13 Norisoprenoids and Flavonoids from Lannea kerstingii

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Journal of Materials Science and Chemical Engineering 2022年第10期10卷 10-19页

作者： Jean-Michel Kouamé Koffi Philomène Akoua Yao-Kouassi chardin seri seri Abdulmagid Alabdul Magid Zachée Louis Evariste Akissi Laurence Voutquenne-Nazabadioko Université Félix Houphouë t-Boigny Laboratoire de Constitution et Réaction de la Matière UFR Sciences des Structures de la Matière et de Technologie Abidjan C&#244 te d’Ivoire Université de San Pedro San Pedro C&#244 te d’Ivoire Université de Reims Champagne-Ardenne CNRS Reims France

Lannea kerstingii is known for its multiple therapeutic and biological activities. Despite of many traditional uses of this plant, scientific research on the content of its chemical compounds is still limited. This study aims to isolate the chemical compounds contained in the n-butanol fraction of Lannea kerstingii leaves. The chemical investigation of the leaves of Lannea kerstingii led to isolation of three undescribed C-13 norisoprenoids, lankerstinol A-C (1-3), together with six (4-9) known flavonoid glycosides. The structures of these compounds were established by spectroscopic analyses.

关键词： Lannea kerstingii Anacardiaceae Flavonoids C-13 Norisoprenoids Structure Elucidation

Effectiveness of sensory integration therapy in children,focusing on Korean children:A systematic review and meta-analysis

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World Journal of Clinical Cases 2024年第7期12卷 1260-1271页

作者： seri Oh Jong-Sik Jang A-Ra Jeon Geonwoo Kim Mihwa Kwon Bahoe Cho Narae Lee Department of Occupational Therapy Kangwon National University Graduate SchoolSamcheok 25949South Korea Department of Occupational Therapy Kangwon National UniversitySamcheok 25949South Korea Department of Occupational Therapy Ju-Ju Children Development CenterNonsansi 32985Chungcheongnam-doSouth Korea Department of Occupation Therapy Suwon Women’s UniversityGyeonggi-do 16632South Korea Hijam Center for Development of Children Ochang 28117South Korea Department of Occupational Therapy U1 UniversityChung-cheong bukdo 25949South Korea

BACKGROUND Sensory integration intervention is highly related to the child's effective interaction with the environment and the child's ***,various sensory integration interventions are being applied,but research methodological problems are arising due to unsystematic *** study aims to present the optimal intervention protocol by presenting scientific standards for sensory integration intervention through *** To prove the effectiveness of sensory integration therapy,examine the latest trend of sensory integration studies in Korea,and provide clinical evidence for sensory integration *** The database of Korean search engines,including RISS,KISS,and DBpia,was used to search for related literature published from 2001 to October *** keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this ***,a meta-analysis was conducted on 24 selected studiesRISS,KISS,and DBpia,was used to search for related literature published from 2001 to October *** keywords,“Children”,“Sensory integration”,“Integrated sensory”,“Sensorymotor”,and“Sensory stimulation”were used in this ***,a meta-analysis was conducted on 24 selected *** Sensory integration intervention has been proven effective in children with cerebral palsy,autism spectrum disorder,attention deficit/hyperactivity disorder,developmental disorder,and intellectual disability in relation to the diagnosis of *** sensory integration therapies,1:1 individual treatment with a therapist or a therapy session lasting for 40 min was most *** terms of dependent variables,sensory integration therapy effectively promoted social skills,adaptive behavior,sensory processing,and gross motor and fine motor *** The results of this study may be used as therapeutic evidence for sensory integration intervention in the clinical field of occupational therapy for

关键词： Children Meta-analysis Occupational therapy Sensory integration Sensory processing Social skills

Phytochemical Constituents of the Stem Barks of Uvaria tortilis , an Endemic Annonaceae from Côte d’Ivoire

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Mercury Levels Assessment in the Population of Aby and Frambo Villages in the Vinicity of Aby Lagoon in Côte d’Ivoire (West Africa)

Open Journal of Applied Sciences（应用科学） 2023年第6期

作者： Aboua Timothée Okpekon seri chardin seri Maxime Eric Joel Dade Akpa Salemon Agnes Yao San Yao Landry Kouakou

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Journal of Water Resource and Protection 2024年第3期16卷 219-232页

作者： Stéphane Jean Claon Serge Kouakou Kouassi Nina Laurette Ahouéfa Laurent Kipré seri Arsène M’bassidjé Seka Joseph Allico Djaman Luc Kouakou Kouadio Analytical Sciences and Public Health Department University of Félix Houphou&eumlt-Boigny Abidjan C&ocircte d'Ivoire Water Quality Control and Analysis Laboratory (LACQUE) Office National de l’Eau Potable (ONEP) Abidjan C&ocircte d’Ivoire Biology and Health Laboratory University of Félix Houphou&eumlt-Boigny Abidjan C&ocircte d’Ivoire Laboratory of Nutrition and Food Safety Department of Science and Food Technology Nangui Abrogoua University Abidjan C&ocircte d'Ivoire Department of Medical and Fundamental Biochemistry Institut Pasteur of C&ocircte d'Ivoire Abidjan C&ocircte d’Ivoire Laboratory of Environmental Sciences (LSE) University of Nangui Abrogoua Abidjan C&ocircte d’Ivoire

The Minamata Convention in the aim to protect human life and the environment, seeks to reduce mercury (Hg) by monitoring it concentrations in the environment. Artisanal and Small-scale Gold Mining (ASGM) has been identified as the most important anthropogenic source of human exposure to Hg. In this context, the main goal of this study was to assess the level of mercury in hair of two (2) populations living along two lagoons respectively Aby and Tendo, in Ivory Coast. To reach this goal, hair samples of 138 residents were collected and analyzed by using Cold Vapor Atomic Fluorescence Spectrophotometry (CV-AFS) technique for mercury concentration. Results showed that for the entire population the Hg mean was 2.34 μg/g. Also, they were ranged between 0.15 to 8.53 μg/g and presented substantial differences amongst the villages. In Aby village, we observed the highest Hg concentrations (Mean = 2.62 μg/g). Our findings showed that almost the entire sample group (82%) exceed the USEPA recommended limit, furthermore 56% of them exceed the normal level of WHO and 2% of the respondent has the unhealthy levels of mercury (≥6 μg Hg/g) of hair by WHO standards. Gender differences in hair mercury varies greatly among reports. Lower levels in women’s hair compared to men were reported in the both village. Considering age, the lowest concentrations were observed with children. However, when we take in account the age groups, data suggested that the most exposed sub-population of [18-29] years old is from Aby village in opposite at Frambo village, the same case those who were ≥ 40 years old. It’s convenient to note that, the proportion of Mercury levels would not to be neglected among studied population especially with the resident from Aby village. So, some measures need to be taken at the political level to control mercury contamination.

关键词： Mercury Hair ASGM Population Exposure Côte d’Ivoire

尿酸盐转运蛋白-1抑制剂治疗痛风临床研发审评考虑

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中国新药杂志 2024年第8期33卷 768-773页

作者：色日格楞艾星赵伯媛李远红赵田张杰国家药品监督管理局药品审评中心北京100076

痛风是一种单钠尿酸盐(monosodium urate,MSU)沉积在关节所致的晶体相关性关节病,其与嘌呤代谢紊乱和/或尿酸排泄减少所致的高尿酸血症直接相关。随着人们物质生活水平的不断提高以及越来越多的含嘌呤类食物的摄入,痛风的患病率呈逐年... 详细信息

痛风是一种单钠尿酸盐(monosodium urate,MSU)沉积在关节所致的晶体相关性关节病,其与嘌呤代谢紊乱和/或尿酸排泄减少所致的高尿酸血症直接相关。随着人们物质生活水平的不断提高以及越来越多的含嘌呤类食物的摄入,痛风的患病率呈逐年上升的趋势。目前国内常用的降尿酸药物包括抑制尿酸合成(别嘌醇和非布司他)和促进尿酸排泄(苯溴马隆)2类,虽然现有的药物可以减轻痛风发作和痛风的负担,但其仍然有一定的局限性,需要研发新的有效、安全痛风治疗药物。目前以尿酸盐转运蛋白-1(urate transporter 1,URAT1)为靶向的药物设计是抗痛风药物研发的热点。本文综述了URAT1抑制剂的临床应用现状以及URAT1品种临床试验申报日益增多的情况,结合审评中遇到的相关问题,阐述目前URAT1抑制剂药物治疗痛风临床试验的一般性设计与审评考虑,期望为企业研发人员在痛风临床试验设计方面提供参考,从而提高研发效率,使患者早日获益。

关键词：痛风尿酸盐转运蛋白-1抑制剂临床研发审评考虑

Discovery of an unknown conduction mechanism in insulating polymers

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High Voltage 2020年第4期5卷 403-408页

作者： Gian Carlo Montanari Paolo seri Leonard A.Dissado Center for Advanced Power Systems Florida State University2000 Levy AvenueFL 32310USA DEI University of BolognaViale del Risorgimento2–40136BolognaItaly Department of Engineering University of LeicesterUniversity RoadLeicesterLE17RHUK

Polymer dielectrics are widely used in electrical and electronic apparatus and devices because of their capability to insulate conductors,withstand high fields and suffer negligible conductive *** near-to-zero conductivity has been explained in terms of long-accepted theories of electronic and ionic transport that lead to the accumulation of local net charge regions at high electric *** the authors describe a previously unknown conduction mechanism consisting of small bipolar ultra-fast charge pulses crossing the polymer with the mobility,as large as,4 to 5 orders of magnitude greater than that of the previously *** authors show that this motion is a consequence of molecular relaxation processes triggered by the electric field locally enhanced by the pulses *** accumulation at the electrodes increases interface field and thus contributes substantially towards premature failure in insulating dielectrics in DC fields.

关键词： conduction mechanism negligible

Ageing and reliability of electrical insulation: the risk of hybrid AC/DC grids

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High Voltage 2020年第5期5卷 620-627页

作者： Gian Carlo Montanari Peter Morshuis Paolo seri Riddhi Ghosh CAPS Florida State UniversityTallahasseeUSA School of Electrical Engineering Xi'an Jiaotong UniversityXi'anPeople's Republic of China University of Bologna BolognaItaly

With an impetuous growth of DC links and future grids that will be often hybrid,providing AC and DC supply to nearby or the same customer,an important element is often neglected,that is,electrical *** are no doubts that overhead lines will step back compared to insulated cables,for known reasons of environmental impact,right of way and reliability,especially in an urban or harsh *** the other hand,while AC insulation systems have been investigated and used for decades,there is no analogue experience for DC polymeric insulation,nor for insulation systems subjected to power electronics *** study aims at enhancing the attention on this topic,focusing on insulation ageing mechanisms and models of relevance for hybrid AC/DC assets and *** and life models for AC,DC and power electronics supply are discussed and compared to experimental data,focusing on partial discharge and space *** is shown how these two phenomena affect lifetime for different AC,DC and transient operating *** main drivers for insulation design and material selection are discussed,showing that insulation reliability can be achieved only if operating stresses,ageing mechanisms and life models are known and accounted for properly by insulation designers.

关键词： insulation electrical properly

Characterization of a-Si:H/SiN multilayer waveguide polarization using an optical pumping application—LED

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第10期10卷 1421-1427页

作者： Mohd Saiful Dzulkefly ZAN Isamu KATO Mohammad Syuhaimi AB-RAHMAN seri Mastura MUSTAZA Department of Electrical Electronic and System EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia Department of Electrical Engineering and Bioscience Waseda University

This paper describes the fabrication of a waveguide and the analysis of its polarization characteristics by applying light-emitting diode(LED) pumping lights to its *** using double tubed coaxial line(DTCL) microwave plasma chemical vapor deposition(MPCVD) equipment,an a-Si:H/SiN multilayer waveguide was fabricated whose thickness could be controlled at nanometer *** main structural material of the waveguide sample consisted of a combination of layers of amorphous silicon hydrogen and silicon *** the sample was ready,another major objective of the experiment was to analyze the polarization characteristics of the fabricated *** idea of the experiment was to analyze how the waveguide reacts when three types of LED(blue,yellow,and red) are radiated onto its *** results showed that the fabrication of the a-Si:H/SiN sample is *** effective transmission results,which accord with the polarization characteristics analysis,were obtained.

关键词： Waveguide Multilayer Optical pumping Light-emitting diode (LED) Double tubed coaxial line microwave plasma chemical vapor deposition (DTCL-MPCVD)

Establishment of various biliary tract carcinoma cell lines and xenograft models for appropriate preclinical studies

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World Journal of Gastroenterology 2016年第40期22卷 9035-9038页

作者： Hidenori Ojima seri Yamagishi Kazuaki Shimada Tatsuhiro Shibata Division of Molecular Pathology National Cancer Center Research InstituteTokyo Department of Pathology Keio University School of MedicineTokyo Division of Cancer Genomics National Cancer Center Research InstituteTokyo Hepatobiliary and Pancreatic Surgery Division National Cancer Center HospitalTokyo

We recently reported several driver genes of biliary tract carcinoma(BTC) that are known to play important roles in oncogenesis and disease progression. Although the need for developing novel therapeutic strategies is increasing, there are very few BTC cell lines and xenograft models currently available for conducting preclinical studies. Using a total of 88 surgical BTC specimens and 536 immunodeficient mice, 28 xenograft models and 13 new BTC cell lines, including subtypes, were established. Some of our cell lines were found to be resistant to gemcitabine, which is currently the first choice of treatment, thereby allowing highly practical preclinical studies to be conducted. Using the aforementioned cell lines and xenograft models and a clinical pathological database of patients undergoing BTC resection, we can establish a preclinical study system and appropriate parameters for drug efficacy studies to explore new biomarkers for practical applications in the future studies.

关键词： Biliary tract carcinoma Cell line Xenograft model Preclinical study