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Human retinal secretome:A cross-link between mesenchymal and retinal cells

World Journal of Stem Cells 2023年第7期15卷 665-686页

作者： Luigi Donato Concetta Scimone Simona Alibrandi sergio zaccaria scalinci Domenico Mordà Carmela Rinaldi Rosalia D'Angelo Antonina Sidoti Department of Biomedical and Dental Sciences and Morphofunctional Imaging University of MessinaMessina 98125Italy Department of Biomolecular Strategies Genetics and Cutting-Edge TherapiesEuro-Mediterranean Institute of Science and TechnologyPalermo 90139Italy Department of Chemical BiologicalPharmaceutical and Environmental SciencesUniversity of MessinaMessina 98125Italy Department of Medical and Surgical Sciences University of BolognaBologna 40121Italy

In recent years,mesenchymal stem cells(MSC)have been considered the most effective source for regenerative medicine,especially due to released soluble paracrine bioactive components and extracellular *** factors,collectively called the secretome,play crucial roles in immunomodulation and in improving survival and regeneration capabilities of injured ***,there has been a growing interest in the secretome released by retinal cytotypes,especially retinal pigment epithelium and Müller glia *** latter trophic factors represent the key to preserving morphofunctional integrity of the retina,regulating biological pathways involved in survival,function and responding to ***,these factors can play a pivotal role in onset and progression of retinal diseases after damage of cell secretory *** this review,we delineated the importance of cross-talk between MSCs and retinal cells,focusing on common/induced secreted factors,during experimental therapy for retinal *** cross-link between the MSC and retinal cell secretomes suggests that the MSC secretome can modulate the retinal cell secretome and vice *** example,the MSC secretome can protect retinal cells from degeneration by reducing oxidative stress,autophagy and programmed cell ***,the retinal cell secretome can influence the MSC secretome by inducing changes in MSC gene expression and phenotype.

关键词： Secretome Mesenchymal stem cells Retinal cells Extracellular vesicles Retinal diseases

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