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World Journal of Gastroenterology 2024年第26期30卷 3198-3200页

作者： sergio Pérez-Holanda Office of Regional Viceministry of Health Regional Viceministry of HealthOviedo 33005AsturiasSpain

The Agatsuma et al’s study shows that despite the evidence of the benefits of an early colorectal cancer(CRC)diagnosis,through screening in asymptomatic subjects,up to 50%of candidates reject this option and many of those affected are diagnosed later,in advanced *** efficacy of screening programs has been well-established for several years,which reduces the risk of CRC morbidity and mortality,without taking into account the test used for screening,or other ***,a significant proportion of patients remain unscreened,so understanding the factors involved,as well as the barriers of the population to adherence is the first step to possibly modify the participation *** barriers could include a full range of social and political aspects,especially the type of financial provision of each health *** Japan,health services are universal,and this advantageous situation makes it easier for citizens to access to these services,contributing to the detection of various diseases,including ***,the symptomatic CRC group had a lower early-stage diagnosis rate than the patients detected during follow-up for other comorbidities,and symptomatic and cancer screening groups showed similar early-stage diagnosis.

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

Evaluating the influence of air pollution on solar radiation observations over the coastal region of Alicante(Southeastern Spain)

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Journal of Environmental Sciences 2023年第4期126卷 633-643页

作者： Igor Gómez sergio Molina Juan JoséGaliana-Merino Department of Applied Physics Faculty of SciencesUniversity of AlicanteSection 99E-03080 AlicanteSpain Multidisciplinary Institute for Environmental Studies(MIES)“Ramón Margalef” University of AlicanteSection 99E-03690 AlicanteSpain Department of Physics Systems Engineering and Signal TheoryUniversity of AlicanteSection 99E-03080 AlicanteSpain University Institute of Physics Applied to Sciences and Technologies University of AlicanteSection 99E-03080 AlicanteSpain

The present study evaluates ground-based downward surface shortwave radiation (Rs) over the coastal region of Alicante (Southeastern Spain).Hourly measurements collected over the eleven-year period 2010-2020 are *** weather stations located over the region capital,Alicante,have been selected as representative of urban and suburban *** additional weather stations far from the city have been selected representing rural *** is significantly reduced over the urban station during the morning hours within the winter season compared to the observations recorded over the suburban and rural stations,with a global mean difference of-81 and-120 W/m^(2)at 10 LT,***,no significant differences are obtained during the midday sun,with a global mean difference of-20 W/m^(2)between the urban and rural *** the aim of explaining these differences,the current paper investigates the relationship between Rsand different air pollutants:NOx,SO_(2),and fine particulate matter (PM_(2.5)and PM_(10)) as well as the wind field measured at the urban and suburban *** results found in this work point towards a close relationship between Rsand NOxconcentrations annual cycles,which are also influenced by the prevailing wind circulations observed over the study area.A global mean NOxconcentration of 107μg/m^(3)is observed over the urban station at 10 LT during the winter *** contrast,these high concentrations are significantly reduced over the suburban station,with global mean value of 40μg/m^(3)at 10 LT,for this period of the year.

关键词： Solar radiation Air pollution Weather-concentration relationship Coastal cities Atmospheric conditions Wind field

Kinematics ofmandibular advancement devices(MADs):Why do some MADs move the lower jaw backward duringmouth opening?

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Bio-Design and Manufacturing 2024年第5期7卷 637-650页

作者： Juan A.Cabrera Alex Bataller sergio Postigo Marcos García Mechanical Engineering Department University of Malaga29071 MalagaSpain

Mandibular advancement devices(MADs)are widely used treatments for obstructive sleep *** function by advancing the lower jaw to open the upper *** increase patient comfort,most patients allow the mouth to be ***,not all systems maintain the lower jaw in a forward position during mouth opening,which results in the production of a retrusion that favors the collapse of the upper ***,the kinematic behavior of the mechanism formed by the mandible-device assembly depends on jaw *** means that,during mouth opening,some devices cause lower jaw protrusion in some patients,but cause its retraction in *** this study,we report the behavior of well-known devices currently on *** do so,we developed a kinematic model of the lower jawdevice *** validated for all devices analyzed using a high-resolution camera *** results show that some of the devices analyzed here did not produce the correct behavior during patient mouth opening.

关键词： Mandibular advancement devices Lower jaw kinematics Sleep apnea

CAD and CAE Integration Through Scientific Visualization Techniques for Illumination Design

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Tsinghua Science and Technology 2008年第S1期13卷 26-33页

作者： Tiago Martinuzzi Buriol sergio Scheer Graduate Program in Numerical Methods for Engineering Civil Engineering Research Center Federal University of Parana

Engineers tend to use different software to perform tasks such as geometry modeling, database management, numerical analysis, and visualization. This may cause decrease of productivity and loss of information during the conversion process between different data file formats. This paper presents a computer aided design (CAD) and computer aided engineering (CAE) system integration using scientific visualization tools and techniques. It deals with the development of a 3D CAD add-in for lighting analysis which uses the CAD model as 3D interface for creating a lighting scheme, processing, and visualizing 2D or 3D illuminance fields. Visualization features as color and contour mapping were developed using the visualization toolkit (VTK) toolkit. The application integrates all functionalities of the 3D CAD with tools for light sources database management, pre-processing, processing, and post-processing of illuminance fields in a single environment. This approach increases productivity and eliminates the need for different software.

关键词： illumination design scalar fields post-processing 3D computer aided design (CAD) visualization toolkit (VTK) systems integration

Recent progress in conical shock wave/boundary layer interaction with spanwise pressure gradient

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Propulsion and Power Research 2024年第3期13卷 295-318页

作者： Feng-Yuan Zuo sergio Pirozzoli State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Dipartimento di Ingegneria Meccanica e Aerospaziale Sapienza Universitàdi RomaVia Eudossiana 18Roma 00184Italy

A common denominator between conical-symmetry and conical shock interaction is the spanwise pressure gradient,which perform more non-uniformity and its interactionflow is more complicated than the spanwise-homogeneous planar shock *** advances in conical-symmetry and conical shock interactions with turbulent boundary layer are reviewed in specific areas:(i)quasi-conical swept interactions due to compression ramps and sharpfins,(ii)impinging conical shock wave with interactions of plate wall,(iii)laminar double cone in-teractions with consideration of real-gas *** success has been achieved in describing the phenomena of the time averaged and instantaneousflow features and the low-frequency unsteadiness,including correlations and coherent structures in the separation bubble,through complementary experimental and numerical studies of swept shock *** available observations are here scrutinized to infer underlying mechanisms of interactions in conicalflow,and provide theoretical foundation and hints forfluidic control ***-parison with high-fidelity direct numerical simulations is used to quantified the uncertainty of RANS turbulence models in complex *** heat transfer,extensive studies of hypersonicflow over double cone geometries have shown that those can be predicted with reasonable accuracy,even in the presence of high-temperature effects.

关键词： Conical shock Boundary layer Separatedflows Unsteadiness Viscous-inviscid interactions

Separation and recovery of critical metal ions using ionic liquids

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Advances in Manufacturing 2016年第1期4卷 33-46页

作者： Terence Makanyire sergio Sanchez-Segado Animesh Jha Institute for Materials Research University of LeedsLeeds LS2 9JT UK

Separation and purification of critical metal ions such as rare-earth elements （REEs）, scandium and niobium from their minerals is difficult and often deter- mines if extraction is economically and environmentally feasible. Solvent extraction is a commonly used metal-ion separation process, usually favored because of its sim- plicity, speed and wide scope, which is why it is often employed for separating trace metals from their minerals. However, the types of solvents widely used for the recovery of metal ions have adverse environmental impact. Alternatives to solvent extraction have been explored and advances in separation technologies have shown commer- cial establishment of liquid membranes as an alternative to conventional solvent extraction for the recovery of metals and other valuable materials. Liquid membrane transport incorporates solvent extraction and membrane separation in one continuously operating system. Both methods con- ventionally use solvents that are harmful to the environ- ment, however, the introduction of ionic liquids （ILs） over the last decade is set to minimize the environmental impact of both solvent extraction and liquid membrane separation processes. ILs are a family of organic molten salts with low or negligible vapour pressure which may be formed below 100 ~C. Such liquids are also highly thermally stable and less toxic. Their ionic structure makes them thermody- namically favorable solvents for the extraction of metallic ions. The main aim of this article is to review the current achievements in the separation of REE, scandium, niobium and vanadium from their minerals, using ILs in eithersolvent extraction or liquid membrane processes. The mechanism of separation using ILs is discussed and the engineering constraints to their application are identified.

关键词： Critical metals Ionic liquids (ILs) -Niobium Tantalum Rare-earth elements (REEs)Vanadium Scandium

Phenotypic heterogeneity in amyotrophic lateral sclerosis type 8 and modifying mechanisms of neurodegeneration

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Neural Regeneration Research 2021年第9期16卷 1776-1778页

作者： Danyllo Oliveira sergio Verjovski-Almeida Mayana Zatz Human Genome and Stem Cell Research Center Department of Genetics and Evolutionary BiologyInstitute of BiosciencesUniversity of São PauloSão PauloSPBrazil Laboratório de Expressão Gênica em Eucariotos Instituto Butantan Departmento de Bioquímica Instituto de QuímicaUniversidade de São PauloSão PauloSPBrazil

In his accounts "On longevity and shortness of life", Aristotle considered how diseased states could be interchangeably associated with long and short lifespans. He believed that the presence of opposite elements and ... 详细信息

关键词： opposite elements states

Invasive strategy in elderly patients with acute coronary syndrome in 2018: close to the truth?

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Journal of Geriatric Cardiology 2019年第2期16卷 114-120页

作者： sergio García-Blas Clara Bonanad Juan Sanchis Servei de Cardiologia Hospital Clínic Universitari de València INCLIVA Universitat de ValènciaCIBERCV

Elderly population constitutes an increasingly larger proportion of patients admitted for acute coronary syndromes(ACS).The optimal management of ACS in these patients is still a challenge due to their clinical peculiarities and the paucity of specific data,and they have been traditionally managed more conservatively mainly based on subjective *** ST^segment elevation acute myocardial infarction urgent reperfusion is the standard of care and there is no upper age *** non-ST segment elevation acute myocardial infarction evidence is controversial,incomplete and mainly focused on chronological *** a strict conservative strategy should be avoided,routine invasive strategy may reduce the occurrence of myocardial infarction and need for revascularization at follow-up with no established benefit in terms of *** characteristics associated with aging,such as comorbidities and frailty,further discriminate patient's risk beyond *** is scarce,but it suggests that these features may modulate the benefit of invasive strategy in this *** trials should clarify the optimal management of ACS based on these parameters.

关键词： Acute coronary syndromes Comorbidity Frailty Percutaneous coronary intervention The elderly

Comparison of Cellular Automaton and Phase Field Models to Simulate Dendrite Growth in Hexagonal Crystals

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Journal of Materials Science & Technology 2012年第2期28卷 137-146页

作者： Mohsen Asle Zaeem Hebi Yin sergio D. Felicelli Center for Advanced Vehicular Systems Mississippi State University Starkville MS 39759 USA Mechanical Engineering Department Mississippi State University Starkville MS 39759 USA Materials Processing Group Oak Ridge National Laboratory Oak Ridge TN 37831 USA

A cellular automaton （CA）-finite element （FE） model and a phase field （PF）-FE model were used to simulate equiaxed dendritic growth during the solidification of hexagonal metals. In the CA-FE model, the conservation equations of mass and energy were solved in order to calculate the temperature field, solute concentration, and the dendritic growth morphology. CA-FE simulation results showed reasonable agreement with the previously reported experimental data on secondary dendrite arm spacing （SDAS） vs cooling rate. In the PF model, a PF variable was used to distinguish solid and liquid phases similar to the conventional PF models for solidification of pure materials. Another PF variable was considered to determine the evolution of solute concentration. Validation of both models was performed by comparing the simulation results with the analytical model developed by Lipton-Glicksman-Kurz （LGK）, showing quantitatively good agreement in the tip growth velocity at a given melt undercooling. Application to magnesium alloy AZ91 （approximated with the binary Mg-8.9 wt% AI） illustrates the difficulty of modeling dendrite growth in hexagonal systems using CA-FE regarding mesh-induced anisotropy and a better performance of PF-FE in modeling multiple arbitrarily-oriented dendrites growth.

关键词： Dendrite growth Cellular automaton Phase-field model Finite element~ Magnesium alloy

Neural functions of small heat shock proteins

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Neural Regeneration Research 2022年第3期17卷 512-515页

作者： Teresa de los Reyes sergio Casas-Tintó Instituto Cajal CSICMadridSpain

Stress response is a cellular widespread mechanism encoded by a common protein program composed by multiple cellular factors that converge in a defense reaction to protect the cell against *** many mechanisms described,heat shock proteins were proposed as universally conserved protective factors in the stress core proteome,coping with different stress stimuli through its canonical role in protein ***,emerging evidences reveal non-canonical roles of heat shock proteins relevant for physiological and pathological ***,we review the implications of inducible heat shock proteins in the central nervous system *** particular,we discuss the relevance of heat shock proteins in the maintenance of synapses,as a balanced protective mechanism in central nervous system development,pathological conditions and aging.

关键词： aging central nervous system chaperones environment neuroprotection pathology stress synapses