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Clinical outcomes of hospitalized patients with chikungunya fever: A retrospective analysis

Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 183-186页

作者： Lucas Lobo Mesquita Enio Simas Macedo sergio Luiz Arruda Parente filho Francisca Lillyan Christyan Nunes Beserra Evelyne Santana Girao Juliana Mandato Ferragut Roberto da Justa Pires Neto Geraldo Bezerra da Silva Junior Elizabeth De Francesco Daher School of Medicine Federal University of CearaFortalezaCearaBrazil Hospital Regional da Unimed FortalezaCearaBrazil Intensive Care Unit Hospital Sao CarlosFortalezaCearaBrazil Department of Public Health School of MedicineFederal University of CearaFortalezaCearaBrazil Public Health and Medical Sciences Post-Graduation Programs School of MedicineHealth Sciences CenterUniversity of Fortaleza.FortalezaCearaBrazil Medical Sciences Post Graduate Program Department of Internal MedicineSchool of MedicineFederal University of Ceara.FortalezaCearáBrazil

Objective:To describe the prognostic and clinical profile of hospitalized patients with chikungunya virus(CHIKV)infection focusing on renal ***:This is a cross-sectional study including all patients with confirmed chikungunya fever(CHIKF)admitted to 3 different highcomplexity hospitals in Fortaleza,Brazil between January 2016 and June *** analysis was carried out to evaluate correlation between clinical profile and ***:Fifty-five patients were included,with a median age of 77(IQR=21)years,and 23(41.82%)were ***-five patients(45.45%,25/55)developed acute kidney injury(AKI),and 15(60.00%,15/25)were classified as KDIGO 1,1(4.00%)as KDIGO 2,and 9(36.00%)as KDIGO *** overall mortality was 34.54%whilst AKI-related mortality was 64.00%(16/25).Both AKI and encephalitis were associated with higher *** who died were significantly older[82(IQR=12)years vs.70(IQR=28.75)years,P<0.001].In the multivariate analysis,abdominal pain was associated with an increased risk of severe AKI(OR=5.33,95%CI=1.11–25.64,P=0.037)and AKI was an independent risk factor of death(OR=12.06,95%CI=2.55–57.15,P=0.002).Recovery of renal function was similar among the different age ***:AKI is present in half of the study population and is an independent risk factor of ***,renal function should be carefully monitored in hospitalized patients with CHIKV infection.

关键词： Arbovirus infections Chikungunya fever Acute kidney injury Elderly Mortality

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Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis

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World Journal of Gastroenterology 2023年第22期29卷 3440-3468页

作者： Henrique Inhauser Riceti Magalhães Felipe Alexandre Machado Roberta Figueiroa Souza Marcos Antônio Ferreira caetano Vanessa Ribeiro Figliuolo Robson Coutinho-Silva Patricia Castelucci Department of Surgery School of Veterinary Medicine and Animal SciencesUniversity of São PauloSão Paulo 05508-270Brazil Department of Anatomy University of São PauloSão Paulo 05508-000Brazil Biophysics Institute Carlos Chagas filho Federal University of Rio de JaneiroRio de Janeiro 21941-902Brazil

BACKGROUND The literature indicates that the enteric nervous system is affected in inflammatory bowel diseases(IBDs)and that the P2X7 receptor triggers neuronal ***,the mechanism by which enteric neurons are lost in IBDs is *** To study the role of the caspase-3 and nuclear factor kappa B(NF-κB)pathways in myenteric neurons in a P2X7 receptor knockout(KO)mouse model of *** Forty male wild-type(WT)C57BL/6 and P2X7 receptor KO mice were euthanized 24 h or 4 d after colitis induction by 2,4,6-trinitrobenzene sulfonic acid(colitis group).Mice in the sham groups were injected with *** mice were divided into eight groups(n=5):The WT sham 24 h and 4 d groups,the WT colitis 24 h and 4 d groups,the KO sham 24 h and 4 d groups,and the KO colitis 24 h and 4 d *** disease activity index(DAI)was analyzed,the distal colon was collected for immunohistochemistry analyses,and immunofluorescence was performed to identify neurons immunoreactive(ir)for calretinin,P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,and total NF-κ*** analyzed the number of calretinin-ir and P2X7 receptor-ir neurons per ganglion,the neuronal profile area(μm^(2)),and corrected total cell fluorescence(CTCF).RESULTS Cells double labeled for calretinin and P2X7 receptor,cleaved caspase-3,total caspase-3,phospho-NF-κB,or total NF-κB were observed in the WT colitis 24 h and 4 d *** number of calretinin-ir neurons per ganglion was decreased in the WT colitis 24 h and 4 d groups compared to the WT sham 24 h and 4 d groups,respectively(2.10±0.13 vs 3.33±0.17,P<0.001;2.92±0.12 vs 3.70±0.11,P<0.05),but was not significantly different between the KO *** calretinin-ir neuronal profile area was increased in the WT colitis 24 h group compared to the WT sham 24 h group(312.60±7.85 vs 278.41±6.65,P<0.05),and the nuclear profile area was decreased in the WT colitis 4 d group compared to the WT sham 4 d group(104.63±2.49 vs 117.41±1.14,P<0.01).The number of

关键词： Cell death Enteric nervous system Gastroenterology Inflammatory bowel diseases P2X7 receptor Purinergic signaling

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Periodic Modulation of Nonlinearity in a Fiber Bragg Grating:A Numerical Investigation

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Journal of Electromagnetic Analysis and Applications 2012年第2期4卷 53-59页

作者： Antonio Francisco Gomes Furtado filho Jose Rubens Rodrigues de Sousa Apiano Ferreira de Morais Neto Jose Wally Mendonca Menezes Antonio sergio Bezerra Sombra Teleinformatics Engineering Department Federal University of CearaFortaleza-CeBrazil Telecommunications and Materials Science and Engineering Laboratory(LOCEM) Campus do PiciFortaleza-CEBrazil Department of Infrastructure Telecommu-nications Systems Specialist Laboratory and TeachingEastFederal Institute of CearaFortaleza CampusFortalezaBrazil

We present numerical studies on the switching characteristics of a fiber Bragg grating (FBG) with modulation in the third order nonlinear index of refraction along it’s length. The FBG is operating in a continuous wave regime (CW). This study was done taking into account the possible asymmetry brought by the non harmonic modulation of the nonlinearity, leading to different reflection and transmission characteristics, that depend on the direction of propagation along the modulated nonlinear FBG. This phenomenon may be useful for applications like an optical isolator. It was found that for a set of values of the modulation parameter, the FBG can exhibit multistable states. The numerical studies were obtained starting from the coupled-mode equations solved from the coupled-mode theory and simulated using the fourth-order Runge-Kutta method.

关键词： Bragg Gratings Nonlinearity Modulation Optical Bistability Nonlinear Switching

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Biliary tract reconstruction using jejunal tube:an experimental study in dogs

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 179-185页

作者： Eliane Anrain Trentini Eduardo Crema Juan Carlos Llanos Mauro Masson Lerco Luiz Alberto Magna Luiz sergio Leonardi State University of Campinas Faculty of Medical SciencesDepartment of Surgery Federal University of Triangulo Mineiro So Paulo State University "Júlio de Mesquita filho" Faculty of Medicine of BotucatuDepartment of Surgery and Orthopedics

BACKGROUND:To physiologically reconstruct the biliary tract,Crema et al suggested the application of the Monti principle to the biliary tract,already used in humans for the urinary *** this technique,a jejunal segment is transversely *** study aimed to evaluate the efficacy of jejunal tube interposition between the common bile duct and duodenum in ***:Thirteen dogs underwent a laparoscopic common bile duct ligature,followed by a biliodigestive connection by jejunal tube interposition after one *** levels of glutamic-pyruvic and glutamic-oxalacetic transaminases,total bilirubins,alkaline phosphatase and gamma-glutamyltransferase were assessed before surgery and thereafter weekly until euthanasia,which was performed 6 weeks after biliodigestive ***:Data on 9 dogs were analyzed *** dogs presented with obstructive jaundice after common bile duct ligature,as confirmed by biochemical *** showed a statistically significant reduction in cholestasis after biliodigestive connection by jejunal tube interposition and were healthy until the end of the ***:A statistically significant reduction was seen in total bilirubin and canalicular enzymes(alkaline phosphatase and gamma-glutamyltransferase)in the 9 dogs 6 weeks after biliodigestive connetion by jejunal tube interposition.

关键词： biliary tract surgical procedures monti principle obstructive jaundice

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Association between mucosal surface pattern under near focus technology and Helicobacter pylori infection

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World Journal of Gastrointestinal Endoscopy 2021年第10期13卷 518-528页

作者： Felipe Fiuza Fauze Maluf-filho Edson Ide Carlos Kiyoshi Furuya Jr Sonia Nadia Fylyk Jennifer Nakamura Ruas Luciana Stabach Gabriela Albuquerque Araujo sergio Eiji Matuguma Ricardo Sato Uemura Christiano Makoto Sakai Kendi Yamazaki sergio Shiguetoshi Ueda Paulo Sakai Bruno Costa Martins Department of Endoscopy Hospital Alemão Oswaldo CruzSão Paulo 01323-020Brazil

BACKGROUND Many studies evaluated magnification endoscopy(ME)to correlate changes on the gastric mucosal surface with Helicobacter pylori(***)***,few studies validated these concepts with high-definition endoscopy without *** To access the association between mucosal surface pattern under near focus technology and *** infection status in a western *** Cross-sectional study including all patients referred to routine upper *** exams were performed using standard high definition(S-HD)followed by near focus(NF-HD)*** of erythema,erosion,atrophy,and nodularity were recorded during S-HD,and surface mucosal pattern was classified using NF-HD in the gastric *** were taken for rapid urease test and *** One hundred and eighty-seven patients were analyzed from August to November *** those,47(25.1%)were ***+,and 42(22.5%)had a previous *** *** the examination with S-HD,erythema had the best sensitivity for *** detection(80.9%).Exudate(99.3%),nodularity(97.1%),and atrophy(95.7%)demonstrated better specificity values,but with low sensitivity(6.4%-19.1%).On the other hand,the absence of erythema was strongly associated with ***-(negative predictive value=92%).With NF-HD,56.2%of patients presented type 1 pattern(regular arrangement of collecting venules,RAC),and only 5.7%of RAC+patients were ***+.The loss of RAC presented 87.2%sensitivity for *** detection,70.7%specificity,50%positive predictive value,and 94.3%negative predictive value,indicating that loss of RAC was suboptimal to confirm *** infection,but when RAC was seen,*** infection was *** The presence of RAC at the NF-HD exam and the absence of erythema at S-HD were highly predictive of *** negative *** the other hand,the loss of RAC had a suboptimal correlation with the presence of ***.

关键词： Diagnosis Endoscopy Gastric infection Gastritis Helicobacter pylori Sensitivity and specificity

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Meningococcal disease, a clinical and epidemiological review

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1019-1029页

作者： Rodrigo Siqueira Batista Andreia Patricia Gomes Jorge Luiz Dutra Gazineo Paulo sergio Balbino Miguel Luiz Alberto Santana Lisa Oliveira Mauro Geller Laboratorio de Agentes Patogenicos Departamento de Medicina e Enfermagem Universidade Federal de VicosaVicosaMGBrazil Curso de Medicina Faculdade Dinamica do Vale do PirangaPonte NovaMGBrazil Hospital Universitario Clementino Fraga filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Curso de Medicina Centro Universitario Serra dos Orgaos (UNIFESO)TeresopolisRJBrazil School of Medicine New York University–NYUNew YorkUSA Departamento de Genetica Medica Universidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroRJBrazil

Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C. Serogroups B, C and Y represent the majority of cases in Europe, the Americas and Australia. However, there has been a growing increase in serogroup W in some areas. The pathogen transmission happens for respiratory route(droplets) and clinically can lead to meningitis and sepsis(meningococcemia). The treatment is made with antimicrobial and supportive care. For successful prevention, we have some measures like vaccination, chemoprophylaxis and droplets' precautions. In this review, we have described and clarify clinical features of the disease caused by N. meningitidis regarding its relevance for healthcare professionals.

关键词： Neisseria meningitidis Bacterial infection Meningococcal disease

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Growth and Quality of Clonal Plantlets of Conilon Coffee(Coffea canephora Pierre ex ***)Influenced by Types of Cuttings

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American Journal of Plant Sciences 2014年第14期5卷 2148-2153页

作者： Abraao Carlos Verdin filho Aldo Luiz Mauri Paulo sergio Volpi Aymbire Francisco Almeida da Fonseca Romario Gava Ferrao Maria Amelia Gava Ferrao Wagner Nunes Rodrigues Saul de Andrade Júnior Tafarel Victor Colodetti Instituto Capixaba de Pesquisa Assistencia Técnica e Extensao Rural(Incaper) MarilandiaBrazil Empresa Brasileira de Pesquisa Agropecuaria(Embrapa Cafe) BrasiliaBrazil Centro de Ciencias Agrarias Universidade Federal do Espírito Santo(CCA-UFES)AlegreBrazil Escola Estadual Rural de Colatina(EECOR) ColatinaBrazil

To achieve high crop yieldin agriculture, the production of plantlets of superior quality is one of thebasic prerequisites. For conilon coffee, the current recommendation in theproduction of clonal plantlets through vegetative propagation is to usediagonal cuttings, in bevel form. However, there are indications that othertypes of cutting have been successfully used to produce plantlets. In thiscontext, this experiment was conducted with the objective of studying thedevelopment of plantlets of conilon coffee obtained by different types ofcuttings. The experiment was conducted in a greenhouse. The cuttings wereobtained from the middle portion of orthotropic stems of standardized *** experiment followed a split plot in time design, with three types ofcuttings (bevel, sharp bevel and straight) and two times of evaluation, withfour repetitions. At 30 and 120 days after planting, plantlets were collectedand evaluated. The results show the increase occurred in the variables due tothe straight cut when compared to the others, except for stem *** in this context, the straight cut promoted an increase in seedlingheight, production of biomass and in the Dickson’s quality index when comparedto cuttings in bevel and sharp bevel.

关键词： Coffea canephora Asexual Propagation Vegetative Propagation Multiplication

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粉末冶金高速钢在汽车零件--气门座圈中的应用

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粉末冶金技术 2011年第2期29卷 149-153页

作者： Rossi J.L.Salgado L. Jesus filho E.S. Jesus E.R.B. Ambrozio filho F. Santos J.C. Colosio M.A. Instituto de Pesquisas Energ6ticas e Nucleares-IPEN Powder Processing Centre-CPP P.O.Box 11049-CEP 05422-970-Sao Paulo General Motors do Brasil Materials and Fastening Engineering P.O.Box 197-CEP 09501-970-Sgo Caetano do Sul-SP巴西

这篇文章介绍了关于高速钢用于气门座圈的情况。评定了两种材料:一种是研发的高速钢M3/2粉、Fe粉及NbC的混合粉制造的材料;一种是为了比较,由Fe-Co合金制造的气门座圈。用SEM对研制的气门座圈的显微组织进行了鉴定。对研发的高速钢的物... 详细信息

这篇文章介绍了关于高速钢用于气门座圈的情况。评定了两种材料:一种是研发的高速钢M3/2粉、Fe粉及NbC的混合粉制造的材料;一种是为了比较,由Fe-Co合金制造的气门座圈。用SEM对研制的气门座圈的显微组织进行了鉴定。对研发的高速钢的物理-力学性能将分别介绍密度、硬度、径向压溃强度及切削加工性。

关键词：粉末冶金高速钢汽车零件气门座圈

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Rheumatoid arthritis: Nuclear medicine state-of-the-art imaging

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World Journal of Orthopedics 2014年第3期5卷 312-318页

作者： Paulo Henrique Rosado-de-Castro sergio Augusto Lopes de Souza Dangelo Alexandre Lea Mirian Barbosa da Fonseca Bianca Gutfilen Departamento de Radiologia Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-913Brazil Instituto Nacional de Traumatologia e Ortopedia Rio de Janeiro 20940-070Brazil

Rheumatoid arthritis(RA)is an autoimmune disease,which is associated with systemic and chronic inflammation of the joints,resulting in synovitis and pannus *** several decades,the assessment of RA has been limited to conventional radiography,assisting in the diagnosis and monitoring of ***,conventional radiography has poor sensitivity in the detection of the inflammatory process that happens in the initial stages of *** the past years,new drugs that significantly decrease the progression of RA have allowed a more efficient *** Medicine provides functional assessment of physiological processes and therefore has significant potential for timely diagnosis and adequate follow-up of *** single photon emission computed tomography(SPECT)and positron emission tomography(PET)radiopharmaceuti-cals have been developed and applied in this *** use of hybrid imaging,which permits computed tomography(CT)and nuclear medicine data to be acquired and fused,has increased even more the diagnostic accuracy of Nuclear Medicine by providing anatomical localization in SPECT/CT and PET/CT *** recently,fusion of PET with magnetic resonance imaging(PET/MRI)was introduced in some centers and demonstrated great *** this article,we will review studies that have been published using Nuclear Medicine for RA and examine key topics in the area.

关键词： Rheumatoid arthritis Nuclear medicine Scintigraphy Single photon emission computed tomography Positron emission tomography

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Changes in Muscle and Collagen Fibers of Fish after Exposure to Urban Pollutants and Biodegradable Detergents

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Microscopy Research 2015年第3期3卷 33-40页

作者： Cynthia Medina Ciamarro Bruno Fiorelini Pereira Rebeca Mamede da Silva Alves Joao Rodolfo Tuckumantel Valim Dimitrius Leonardo Pitol Flavio Henrique caetano Instituto de Biociencias Universidade Estadual Paulista“Julio de Mesquita Filho”—UNESPCampus Rio ClaroRio ClaroBrazil Centro de Ciencias Biologicas e da Saude Universidade Federal do Oeste da Bahia—UFOBCampus BarreirasBarreirasBrazil Faculdade de Odontologia de Ribeirao Preto Universidade de Sao Paulo—FORP/USPCampus Ribeirao PretoRibeirao PretoBrazil

Fish populations are sensitive to environmental impact resulting from many factors, as an introduction of exotic species, industrial or residual waste, oil spills, pesticides or other agents that can directly affect the ecology and species survival. Astyanax altiparanae is pelagic and active swimmer specie and can have serious implications on its way of life as changes in muscle structure of fish may occur since the presence of pollutants in the water. In this study we analyze the alterations in Muscle and collagen fibers of the pectoral muscles and pollutants exposed flows contained in water with biodegradable detergents, and water coming from the Blue Lake, River clear-SP (2o24'39"S, 47o33'39"E) diluted. Effects of these exposures were analyzed during the period of seven and thirty days. Compared with acclimatized fish (Astyanax altiparanae) with pure water from an artesian well, the muscle fibers morphology and collagen concentration on them have changed due to the exposure to urban pollutants and biodegradable detergents.

关键词： Astyanax altiparanae Biodegradable Detergents Pollutants

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