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Magnetic resonance imaging-guided focused ultrasound thalamotomy launch with remote telemedicine international proctorship

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Chronic Diseases and Translational Medicine 2024年第1期10卷 40-50页

作者： Igor V.Buzaev Rezida M.Galimova Dinara I.nabiullina sergey n.illarioshkin naufal Sh.Zagidullin Shamil M.Safin Department of Surgery Bashkir State Medical UniversityUfaRussia Intelligent neurosurgery Clinic Ltd.International Medical Center V.S.Buzaev memorialUfaRussia Directorate Research Center of NeurologyVolokolamskoye ShosseMoscowRussia

Background: COVID-19 limitations have hindered the implementation of new technologies by preventing proctors from coming to the *** share our first experience of magnetic resonance imaging(MRI)-guided focused ultrasound(MRgFUS)treatment with an international remote online proctorship,and develop and evaluate the methodology of remote MRgFUS ***: This single-center,nonrandomized controlled prospective study included 94 patients:27 with essential tremor(ET)and 67 with tremor-dominant Parkinson's disease(PD).The coming of proctors was impossible,so we arranged for the remote participation of proctors from the United Kingdom,Spain,and Israel.A total of 38 patients(40.4%)received telemedicine-proctored treatment(proctor group)and 56 received their treatment independently(solo group).We used the Clinical Rating Scale for Tremor(CRST)for ET patients and the Unified Parkinson's Disease Rating Scale(UPDRS)Part III for PD ***: In patients with ET,success rates were 81.8%(proctor group)and 100%(solo group)(p=0.22).CRST reduction on the treated side was 71.43%[65.83%;80.56%](proctor group)versus 60.87%[53.99;79.58](solo group)(p=0.19).none of the patients showed worsening of tremors within 1 *** patients with PD,the success rates were 92.6%(proctor group)and 100%(solo group)(p=0.08).The UPDRS Part III improvement was 30.1%(proctor group)versus 39.9%(solo group)(p=0.003).The 1-year recurrence rate was 40%(proctor group)and 17.5%(solo group)(p=0.04).no complications were observed at 6 ***: We developed a feasible and safe methodology for telemedicine remote online-proctored MRgFUS *** significant difference was observed between the solo and developed remote proctor protocols in terms of complication rate,effect,and long-term results;however,UPDRS Part III improvement was better in the PD solo *** study demonstrated that the MRgFUS international proctorship can be performed successfully remotely.

关键词： essential tremor MRgFUS Parkinson's disease proctor telemedicine

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A note on Transition Kernels for the Most UnfavourableMixed Strategies of the Market

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Journal of the Operations Research Society of China 2024年第1期12卷 35-50页

作者： sergey n.Smirnov Faculty of Computational Mathematics and Cybernetics Lomonosov Moscow State UniversityMoscowRussian Federation 119991

We consider a deterministic model of market evolution with trading constraints andapply a game-theoretic approach to the superhedging *** obtain sufﬁcientconditions for the game equilibrium and prove under these conditions the existenceof a Borel-measurable transition kernel describing dependence on price prehistory ofthe most unfavourable mixed strategy of the market.

关键词： Superhedging Guaranteed deterministic approach Optimal mixedstrategies of the market Borel-measurable transition kernel Game equilibrium

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Structural Stability of the Financial Market Model: Continuity of Superhedging Price and Model Approximation

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Journal of the Operations Research Society of China 2024年第1期12卷 215-241页

作者： sergey n.Smirnov Faculty of Computational Mathematics and Cybernetics Lomonosov Moscow State UniversityMoscow119991Russian Federation

The present paper continues the topic of our recent paper in the same journal,aiming to show the role of structural stability in financial *** the context of financial market modeling,structural stability means that a specific“no-arbitrage”property is unaffected by small(with respect to the Pompeiu–Hausdorff metric)perturbations of the model’s *** formulate,based on our economic interpretation,a new requirement concerning“no arbitrage”properties,which we call the“uncertainty principle”.This principle in the case of no-trading constraints is equivalent to structural *** demonstrate that structural stability is essential for a correct model approximation(which is used in our numerical method for superhedging price computation).We also show that structural stability is important for the continuity of superhedging prices and discuss the sufficient conditions for this continuity.

关键词： Uncertainty Structural stability no arbitrage Continuity of superhedging price Compact-valued multifunction Financial market model approximation Trading constraints

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Design of Resilient Sensor networks Balancing Resilience and Efficiency

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International Journal of Disaster Risk Science 2024年第1期15卷 107-115页

作者： sergey n.Vecherin Kiril D.Ratmanski Luke Hogewood Igor Linkov Cold Regions Research and Engineering Laboratory Engineering Research and Development CenterHanoverNH 03755USA Environmental Laboratory Engineering Research and Development CenterVicksburgMS 39180USA

In recent years,the notion of resilience has been developed and applied in many technical areas,becoming exceptionally pertinent to disaster risk *** a disaster situation,accurate sensing information is the key to efficient recovery *** general,resilience aims to minimize the impact of disruptions to systems through the fast recovery of critical functionality,but resilient design may require redundancy and could increase *** this article,we describe a method based on binary linear programming for sensor network design balancing efficiency with *** application of the developed framework is demonstrated for the case of interior building surveillance utilizing infrared sensors in both twoand three-dimensional *** method provides optimal sensor placement,taking into account critical functionality and a desired level of resilience and considering sensor type and *** problem formulation,resilience requirements,and application of the optimization algorithm are described in *** of sensor locations with and without resilience requirements shows that resilient configuration requires redundancy in number of sensors and their intelligent *** tasks are successfully solved by the described method,which can be applied to strengthen the resilience of sensor networks by *** proposed methodology is suitable for large-scale optimization problems with many sensors and extensive coverage areas.

关键词： Binary linear programming Optimal sensor placement Redundant networks Resilience and efciency Resilient sensor networks

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Hypoxia-inducible factor-1αin myocardial infarction

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World Journal of Cardiology 2024年第4期16卷 181-185页

作者： IvanaŠkrlec sergey n Kolomeichuk Faculty of Dental Medicine and Health Josip Juraj Strossmayer University of OsijekOsijek 31000Croatia Institute of Biology Karelia Research Center of Russian Academy of SciencesPetrozavodsk 185910Russia Laboratory for Genomics Proteomicsand MetabolomicsResearch Institute of Biomedicine and Biomedical TechnologiesTyumen State Medical UniversityTyumen 625023Russia

Hypoxia-inducible factor 1(HIF1)has a crucial function in the regulation of oxygen levels in mammalian cells,especially under hypoxic *** importance in cardiovascular diseases,particularly in cardiac ischemia,is because of its ability to alleviate cardiac *** oxygen-responsive subunit,HIF1α,plays a crucial role in this process,as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival,angiogenesis,and ***,HIF1αexpression induced reperfusion in the ischemic skeletal muscle,and hypoxic skin wounds in diabetic animal models showed reduced HIF1α*** expression of HIF1αhas been shown to reduce apoptosis and oxidative stress in cardiomyocytes during acute myocardial *** variations in HIF1αhave also been found to correlate with altered responses to ischemic cardiovascular *** addition,a link has been established between the circadian rhythm and hypoxic molecular signaling pathways,with HIF1αfunctioning as an oxygen sensor and circadian genes such as period circadian regulator 2 responding to changes in *** editorial analyzes the relationship between HIF1αand the circadian rhythm and highlights its significance in myocardial adaptation to *** the changes in molecular signaling pathways associated with diseases,specifically cardiovascular diseases,provides the opportunity for innovative therapeutic interventions,especially in low-oxygen environments such as myocardial infarction.

关键词： Cardiovascular pathologies Circadian genes Hypoxia-inducible factor 1 Hypoxia Gene-gene interaction

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Reactivation of hepatitis B virus infection – an important aspect of multifaceted problem

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World Journal of Gastroenterology 2024年第26期30卷 3193-3197页

作者： sergey Morozov sergey Batskikh Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Hepatology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia

In this editorial we comment on the article published in the recent issue of the W orld Journal of *** focus specifically on the problem of occult hepatitis B virus(HBV)infection,that is a result of previous hepatitis B(PHB)and a source for reactivation of *** prevalence of PHB is underestimated due to the lack of population testing ***,this condition not only com-plicate anticancer treatment,but may be responsible for the development of other diseases,like cancer or autoimmune *** we unveil possible mecha-nisms responsible for realization of these processes and suggest practical approa-ches for diagnosis and treatment.

关键词： Occult hepatitis B virus infection Hepatitis B virus reactivation Previous hepatitis B Cancer Autoimmune disorders

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Early selective enteral feeding in treatment of acute pancreatitis: A case report

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World Journal of Clinical Cases 2024年第3期12卷 637-642页

作者： Aleksei A Kashintsev sergey V Anisimov Anastasya nadeeva Vitali Proutski sergey V Anisimov Anastasya NadeevaVitali ProutskiPANDICA LTDLondon WC1N 3ESUnited Kingdom

BACKGROUnD Early initiation of enteral feeding is recognized to play a crucial role in improving the outcomes of treatment of acute ***,the method of adminis-tration of enteral nutrition remains *** present the experience of treating a patient with moderate-severe acute pancreatitis,at high risk of progressing to a severe or fatal condition,using a novel method of selective feeding with duodenal *** SUMMARY A 27-year-old female patient presented to the emergency unit of the hospital with a typical manifestation of acute *** a conventional treatment,the patient’s condition deteriorated by day 2 of *** an endoscopic approach,a novel catheter PandiCathffwas placed to the duodenum of the patient,isolating its segment between the duodenal bulb and the ligament of *** the isolated area created,a negative pressure was applied,followed by introduction of early selective enteral *** patient’s condition subsequently improved in a rapid manner,and no complications often associated with moderate-to-severe acute pancreatitis *** Within 48 h of starting treatment with the novel method,it can prevent the development of multiple organ failure and,when combined with minimally invasive drainage methods,help prevent infection.

关键词： Acute pancreatitis Enteral feeding Infectious complications Systemic inflammatory response syndrome MODS

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Porous Shish-Kebab Structure Prepared from Oriented UHMWPE Films by Processing in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： sergey A.Lermontov Aleksey V.Maksimkin nataliya A.Sipyagina Tarek Dayyoub Alena n.Malkova Evgeniy A.Kolesnikov Elena A.Straumal Inna O.Gozhikova Saidkhodzha G.nematulloev Dmitry V.Telyshev Institute of Physiologically Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia national University of Science and Technology"MISIS"Moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHMWPE) films, which provided special conditions for the crystallization of dissolved UHMWPE macromolecules on the surface of oriented UHMWPE crystals. The prepared porous materials were investigated by scanning electron microscopy(SEM) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHMWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHMWPE macromolecules using supercritical CO_(2) gives the possibility to control the size of both lamellar disks and pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

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Ballistic performance of titanium-based layered composites made using blended elemental powder metallurgy and hot isostatic pressing

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Defence Technology（防务技术） 2024年第9期39卷 1-14页

作者： Pavlo Markovsky Jacek Janiszewski Dmytro Savvakin Oleksandr Stasyuk Bartosz Fikus Victor Samarov Vianey Ellison sergey V.Prikhodko G.V.Kurdyumov Institute for Metal Physics of n.A.S.of Ukraine 36Academician Vernadsky BoulevardUA-03142 KyivUkraine Jarosław Dabrowski Military University of Technology 2Gen.Sylwester Kaliski Str.00e908 Warsaw 46Poland Synertech Inc. 11711 Monarch Street Garden GroveLos AngelesCA 92841USA Department of Materials Science and Engineering University of California Los AngelesLos AngelesCA 90095USA

Metal matrix composites tiles based on Ti-6Al-4V(Ti64)alloy,reinforced with 10,20,and 40(vol%)of either TiC or TiB particles were made using press-and-sinter blended elemental powder metallurgy(BEPM)and then bonded together into 3-layer laminated plates using hot isostatic pressing(HIP).The laminates were ballistically tested and demonstrated superior *** microstructure and properties of the laminates were analyzed to determine the effect of the BEPM and HIP processing on the ballistic properties of the layered *** effect of porosity in sintered composites on further diffusion bonding of the plates during HIP is analyzed to understand the bonding features at the interfaces between different adjacent layers in the *** ballistic performance of fabricated structures was explained by a significant reduction in the residual porosity of the BEPM products by their additional processing using HIP,which provides an unprecedented increase in the hardness of the layered *** is argued that the combination of the used two technologies,BEPM and HIP is principally complimentary for the materials in question with the abilities to solve the essential problems of each used individually.

关键词： Metal matrix composites Powder metallurgy Titanium hydride powder Master alloy Titanium carbide Titanium boride Hot isostatic pressing Ballistic tests

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Recent Ventures in Interdisciplinary Arctic Research:The ARCPATH Project

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Advances in Atmospheric Sciences 2024年第8期41卷 1559-1568页

作者： Astrid E.J.OGILVIE Leslie A.KInG noel KEEnLYSIDE François COUnILLOn Brynhildur DAVIÐSDÓTTIR níels EInARSSOn sergey GULEV Ke FAn Torben KOEnIGK James R.MCGOODWIn Marianne H.RASMUSSOn Shuting YAnG Institute of Arctic and Alpine Research(InSTAAR) University of ColoradoBoulder CO 80303USA Stefansson Arctic Institute AkureyriÍS-600Iceland Royal Roads University BC V9B 5Y2Canada University of Bergen Bergen N-5007Norway nansen Environmental and Remote Sensing Centre Bergen N-5007Norway University of Iceland Reykjavík 102Iceland Shirshov Institute of Oceanology Moscow 117218Russia Moscow State University Moscow 11991Russia Chinese Academy of Sciences Beijing 100045China Swedish Meteorological and Hydrological Institute SE-60176 NorrköpingSweden Danish Meteorological Institute CopenhagenØ2100Denmark Obukhov Institute of Atmospheric Physics RAS119017MoscowRussia

This paper celebrates Professor Yongqi GAO's significant achievement in the field of interdisciplinary studies within the context of his final research project Arctic Climate Predictions: Pathways to Resilient Sustainable Societies-ARCPATH(https://***/en/projects/finished-projects/arcpath). The disciplines represented in the project are related to climatology, anthropology, marine biology, economics, and the broad spectrum of social-ecological studies. Team members were drawn from the nordic countries, Russia, China, the United States, and Canada. The project was transdisciplinary as well as interdisciplinary as it included collaboration with local knowledge holders. ARCPATH made significant contributions to Arctic research through an improved understanding of the mechanisms that drive climate variability in the Arctic. In tandem with this research, a combination of historical investigations and social, economic, and marine biological fieldwork was carried out for the project study areas of Iceland, Greenland, norway, and the surrounding seas, with a focus on the joint use of ocean and sea-ice data as well as social-ecological drivers. ARCPATH was able to provide an improved framework for predicting the near-term variation of Arctic climate on spatial scales relevant to society, as well as evaluating possible related changes in socioeconomic realms. In summary, through the integration of information from several different disciplines and research approaches, ARCPATH served to create new and valuable knowledge on crucial issues, thus providing new pathways to action for Arctic communities.

关键词： Recent Ventures in Interdisciplinary Arctic Research:The ARCPATH Project

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