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Local inflammatory response to gastroesophageal reflux:Association of gene expression of inflammatory cytokines with esophageal multichannel intraluminal impedance-pH data

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World Journal of Clinical Cases 2022年第26期10卷 9254-9263页

作者： sergey Morozov Tatyana Sentsova Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Hospital Pediatrics no.2 Russian National Research Medical University named after N.I.PirogovMoscow 117997Russia

BACKGROUnD Gene expression of inflammatory cytokines may take part in the pathophysiology of different forms of gastroesophageal reflux disease(GERD).AIM To explore gene expression of inflammatory cytokines in esophageal mucosa in patients with erosive esophagitis(EE)and non-erosive forms of GERD(nERD)and its association with data of esophageal multichannel intraluminal impedancepH(MII-pH)*** This was a single-center prospective *** mucosa samples were taken from the lower part of the esophagus during *** of interleukin(IL)-1β,IL-10,IL-18,tumor necrosis factorα(TnFA),toll-like receptor 4(TLR4),GATA binding protein 3(GATA3),differentiation cluster 68(CD68)andβ-2 microglobulin genes in esophageal mucosa was assessed with ImmunoQuantex ***-pH measurements were performed on all the *** of GERD was confirmed by the results of the MII-pH *** on the endoscopy,patients were allocated to the groups of EE and *** control group consisted of non-symptomatic subjects with normal endoscopy and MII-pH *** used nonparametric statistics to compare the differences between the *** of expression of the mentioned genes with the results of the MII-pH data was assessed with Spearman’s rank *** Data from 60 patients with GERD and 10 subjects of the control group were available for the *** expression of IL-18(5.89±0.4 vs 5.28±1.1,P=0.04)and GATA3(2.92±0.86 vs 2.23±0.96,P=0.03)was found in the EE group compared to *** of IL-1β,IL-18,TnFA,and TLR4 was lower(Pn the control group compared to EE and *** acid exposure correlated with the expression of IL-1β(Spearman’s rank r=0.29),IL-18(r=0.31),TnFA(r=0.35),GATA3(r=0.34),TLR4(r=0.29),and CD68(r=0.37).Mean esophagealрНcorrelated inversely with the expression of IL-18,TnFA,GATA3,TLR4,and *** association of gene expression with the number of gastroesophageal refluxes was ***

关键词： Gastroesophageal reflux disease Gene expression Cytokines Erosive esophagitis non-erosive gastroesophageal reflux disease Esophageal multichannel intraluminal impedance-pH Gastroesophageal reflux

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Previous hepatitis B viral infection–an underestimated cause of pancreatic cancer

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World Journal of Gastroenterology 2022年第33期28卷 4812-4822页

作者： sergey Batskikh sergey Morozov Alexey Dorofeev Zanna Borunova Dmitry Kostyushev sergey Brezgin Anastasiya Kostyusheva Vladimir Chulanov Department of Hepatology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Scientific and Clinical Laboratory Research Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Laboratory of Genetic Technologies Sechenov UniversityMoscow 119435Russia Division of Biotechnology Scientific Center for Genetics and Life SciencesSirius University of Science and TechnologySochi 354340Russia Laboratory of Genetic Technologies and Translational Research National Medical Research Center for Tuberculosis and Infectious Diseases of Ministry of Health of RussiaMoscow 127994Russia

BACKGROUnD The etiology of pancreatic cancer remains unclear. This limits the possibility of prevention and effective treatment. Hepatitis B virus(HBV) is responsible for the development of different types of cancer, but its role in pancreatic cancer is still being *** To assess the prevalence of previous HBV infection and to identify viral biomarkers in patients with pancreatic ductal adenocarcinoma(PDAC) to support the role of the virus in etiology of this *** The data of 130 hepatitis B surface antigen-negative subjects were available for the final analysis,including 60 patients with PDAC confirmed by cytology or histology and 70 sex-and age-matched controls. All the participants were tested for HBV biomarkers in blood [antibody to hepatitis B core antigen(anti-HBc), antibody to hepatitis B surface antigen(anti-HBs) and HBV DnA], and for those with PDAC, biomarkers in resected pancreatic tissues were tested(HBV DnA, HBV pregenomic RnA and covalently closed circular DnA). We performed immunohistochemistry staining of pancreatic tissues for hepatitis B virus X antigen and Ki-67 protein. non-parametric statistics were used for the *** Anti-HBc was detected in 18/60(30%) patients with PDAC and in 9/70(13%) participants in the control group(P = 0.029). Accordingly, the odds of PDAC in anti-HBc-positive subjects were higher compared to those with no previous HBV infection(odds ratio: 2.905, 95% confidence interval: 1.191-7.084, standard error 0.455). HBV DnA was detected in 8 cases of PDAC and in 6 of them in the pancreatic tumor tissue samples only(all patients were anti-HBc positive). Blood HBV DnA was negative in all subjects of the control group with positive results of the serum anti-HBc test. Among 9 patients with PDAC, 5 revealed signs of replicative competence of the virus(covalently closed circular DnA with or without pregenomic RnA) in the pancreatic tumor tissue samples. Hepatitis B virus X antigen expression and active cell

关键词： Hepatitis B virus Previous hepatitis B Occult hepatitis B virus infection Pancreatic cancer Pancreatic ductal adenocarcinoma

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An efficient descriptor model for designing materials for solar cells

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npj Computational Materials 2015年第1期1卷 38-46页

作者： Fahhad H Alharbi sergey n Rashkeev Fedwa El-Mellouhi Hans P Lüthi nouar Tabet Sabre Kais College of Science and Engineering Hamad Bin Khalifa UniversityDohaQatar Qatar Environment and Energy research Institute(QEERI) Hamad Bin Khalifa UniversityDohaQatar Department of Chemistry and Applied Bioscience ETH ZurichZurichSwitzerland

An efficient descriptor model for fast screening of potential materials for solar cell applications is *** works for both excitonic and non-excitonic solar cells materials,and in addition to the energy gap it includes the absorption spectrum(α(E))of the *** charge transport properties of the explored materials are modelled using the characteristic diffusion length(Ld)determined for the respective family of *** presented model surpasses the widely used Scharber model developed for bulk heterojunction solar *** published experimental data,we show that the presented model is more accurate in predicting the achievable *** model both excitonic and non-excitonic systems,two different sets of parameters are used to account for the different modes of *** analysis of the presented descriptor model clearly shows the benefit of includingα(E)and Ld in view of improved screening results.

关键词： material. designing model

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Rodent burrow network dynamics under human-induced landscape transformation from desert to steppe in Kalmykian rangelands

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Integrative Zoology 2019年第4期14卷 410-420页

作者： Elena SURKOVA sergey POPOV Andrey TCHABOVSKY A.n.Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscowRussia Department of Vertebrate Zoology Lomonosov Moscow State UniversityMoscowRussia

Rodents play an important role in rangelands through the engineering of extensive burrow systems,which provides key habitats for many animal and plant *** have analyzed the long-term variation in the abundance and distribution of rodent burrows in grazing ecosystems of southern Russia(Kalmykia)under the landscape change from desert to steppe caused by the drastic reduction of livestock after the collapse of the USSR in the early *** conducted burrow surveys in the“desert”(1980)and“steppe”(2017)periods on 193-km *** found considerable changes in burrow abundance and distribution,as well as evidence of desert habitat fragmentation and isolation caused by the expansion of tall-grass *** of the open-dwelling diurnal ground squirrel(Spermophilus pygmaeus),the dominant and the keystone species during the“desert”period,almost completely disappeared from the rodent burrow network by 2017,indicating significant habitat *** contrast,the burrows of the folivorous social vole(Microtus socialis)which was rare in the 1980s,became abundant and ubiquitously *** burrow density of the desert-dwelling psammophilous midday gerbil(Meriones meridianus)decreased,while the distances between occupied patches increased,indicating desert habitat fragmentation and loss of population *** of the folivorous tamarisk gerbils(***)were recorded only sporadically in both 1980 and *** observed changes in the rodent burrow network,the key component of grazing ecosystems,correlate with rodent species ecology and can have long-term and important consequences for ecosystem functioning.

关键词： burrows fragmentation grazing impact keystone species rodents

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A new insight into the nature of seasonal variations in coordinate time series of GPS sites located near active faults

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Frontiers of Earth Science 2016年第3期10卷 560-569页

作者： sergey V. TROFIMEnKO Victor G. BYKOV nikolay V. SHESTAKOV nikolay n. GRIB Hiroaki TAKAHASHI Institute of Tectonics and Geophysics Far Eastern Branch Russian Academy of Sciences Khabarovsk 680000 Russia north-Eastern Federal University Neryungri 678960 the Republic of Sakha (Yakutia) Russia Institute for Applied Mathematics Far Eastern Branch Russian Academy of Sciences Vladivostok 690041 Russia Far Eastern Federal University Vladivostok 690041 Russia Institute of Seismology and Volcanology Graduate School of Science Hokkaido University Sapporo 060-0810 Japan

This study provides new insights into the nature of seasonal variations in coordinate time series of GPS sites located near active faults and methods of their modeling. Monthly averaged coordinate time series were analyzed for several pairs of collocated GPS sites situated near the active fault intersection area, in close proximity to the central part of the northern boundary of the Amurian plate and the vicinity of the San Andreas Fault zone. It is concluded that the observed seasonal variations are best described by a breather function which is one of the solutions of the well-known sine-Gordon equation. The obtained results suggest that, in this case, the source of seasonal variations may be caused by the appearance of solitary strain waves in the fault intersection system, which may be qualitatively treated as standing waves of compression-extension of the geological medium. Based on statistical testing, the limits of applicability of the suggested model have been established.

关键词： space geodetic surveys oscillatory move-ments of crustal blocks seasonal variations Amurianmicroplate

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Ilizarov bone transport combined with the Masquelet technique for bone defects of various etiologies (preliminary results)

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World Journal of Orthopedics 2022年第3期13卷 278-288页

作者： Dmitry Y Borzunov sergey n Kolchin Denis S Mokhovikov Tatiana A Malkova Department of Taumatology and Orthopedics Ural State Medical UniversityEkaterinburg 620109Russia Orthopaedic Department 4 Ilizarov National Medical Research Center for Traumatology and OrthopaedicsKurgan 640014Russia Department of Medical Information and Analysis Ilizarov National Medical Research Center for Traumatology and OrthopaedicsKurgan 640014Russia

BACKGROUnD The Ilizarov bone transport(IBT)and the Masquelet induced membrane technique(IMT)have specific merits and shortcomings,but numerous studies have shown their efficacy in the management of extensive long-bone defects of various etiologies,including congenital *** their strong benefits seems a promising strategy to enhance bone regeneration and reduce the risk of refractures in the management of post-traumatic and congenital defects and nonunion that failed to respond to other *** To combine IBT and IMT for the management of severe tibial defects and pseudarthrosis,and present preliminary results of this technological *** Seven adults with post-traumatic tibial defects(subgroup A)and nine children(subgroup B)with congenital pseudarthrosis of the tibia(CPT)were treated with the combination of IMT and IBT after the failure of previous *** mean number of previous surgeries was 2.0±0.2 in subgroup A and 3.3±0.7 in subgroup *** 1 included Ilizarov frame placement and spacer introduction into the defect to generate the induced membrane which remained in the interfragmental gap after spacer *** 2 was an osteotomy and bone transport of the fragment through the tunnel in the induced membrane,its compression and docking for consolidation without *** outcomes were retrospectively studied after a mean follow-up of 20.8±2.7 mo in subgroup A and 25.3±2.3 mo in subgroup *** The“true defect”after resection was 13.3±1.7%in subgroup A and 31.0±3.0%in subgroup B relative to the contralateral *** completion of treatment,defects were filled by 75.4±10.6%and 34.6±4.2%,*** duration of external fixation was 397±9.2 and 270.1±16.3 d,including spacer retention time of 42.4±4.5 and 55.8±6.6 d,in subgroups A and B,*** infection was not *** complications were several cases of pin-tract infection and regenerate deformity in both *** regener

关键词： Ilizarov bone transport Induced membrane technique Post-traumatic tibial defect Congenital pseudarthrosis of the tibia Distraction osteogenesis Regeneration

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Phase Transformations in ZrO_2 after Shock Loading

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Journal of Materials Science & Technology 1993年第1期9卷 32-36页

作者： sergey n.Kulkov Alexander G.Melnikov Institute of Strength Physics and Materials Science.

The effects of shock loading on the morphology,grain growth during heating and phase transforma- tion of ZrO_2 have been *** is shown that shock loading may be efficiently used to modify submicron ceramic powders with nanocrystalline *** shock loading,the critical diameter of ZrO_2 particles transformed from tetragonal to monoclinic decreased due to stored strain energy. Annealing of powders resulted in reversible transformation to the tetragonal without considerable grain growth up to 1200℃.

关键词： submicron ceramics nanocrystalline shock loading phase transformation

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Structure Mechanism of Ordinary Matter Mass Formation

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Journal of Modern Physics 2016年第9期7卷 875-891页

作者： sergey n. Golubev Laboratory of Quantum Standards All-Russian Research Institute of Metrological Service Moscow Russia

The famous paradoxes of quantum mechanics are created by the fact that elementary particles exist as the alternation between two structural states with different properties. This leads to probabilistic behavior, uncertainty principle, quantum tunneling, etc. The alternation of states plays the role of the frequency generator or clock. But for the objective character of quantum interactions the length standard also should exist in nature. Such analog of the rule must be physically real and in direct sense have to participate in the of particles interactions. Just this is the main role of physical vacuum. For such role vacuum should have quasi-crystalline geometry structure. Its symmetry requires in standard views only one fundamental change. In the quasicrystalline structure of the vacuum, the virtual shells of the real particles and atomic nuclei are not diffuse “clouds”, as is assumed today. Virtual environments are clearly structured and rigidly quantised shells with the geometric structure similar to fullerenes. Such shells are forming for greater than 99% of the known substance mass. Virtual particles forming such shells belong to the group of bosons and probably are just Higgs bosons existing in the ordinary matter. Chemical fullerenes form a series of discrete geometric structures. In a similar manner virtual analogues of fullerenes form a series of discrete masses, which really exist in the nature as a set of elementary particles and atomic nuclei masses.

关键词： Quantum Mechanics Physical Vacuum Quasi-Crystalline Structure Mass Formation Dark Matter Higgs Bosons Gravitation

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On-chip excitation of single germanium vacancies in nanodiamonds embedded in plasmonic waveguides

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Light(Science & Applications) 2018年第1期7卷 446-454页

作者： Hamidreza Siampour Shailesh Kumar Valery A.Davydov Liudmila F.Kulikova Viatcheslav n.Agafonov sergey I.Bozhevolnyi Centre for nano Optics University of Southern DenmarkCampusvej 55Odense M DK-5230Denmark L.F.Vereshchagin Institute for High Pressure Physics Russian Academy of SciencesTroitskMoscow 142190Russia GREMAn Universitéde ToursUMR CNRS CEA 615737200 ToursFrance

Monolithic integration of quantum emitters in nanoscale plasmonic circuitry requires low-loss plasmonic configurations capable of confining light well below the diffraction *** demonstrated on-chip remote excitation of nanodiamond-embedded single quantum emitters by plasmonic modes of dielectric ridges atop colloidal silver *** nanodiamonds were produced to incorporate single germanium-vacancy(GeV)centres,providing bright,spectrally narrow and stable single-photon sources suitable for highly integrated *** electron-beam lithography with hydrogen silsesquioxane(HSQ)resist,dielectric-loaded surface plasmon polariton waveguides(DLSPPWs)were fabricated on single crystalline silver plates to contain those of deposited nanodiamonds that are found to feature appropriate single GeV *** low-loss plasmonic configuration enabled the 532-nm pump laser light to propagate on-chip in the DLSPPW and reach to an embedded nanodiamond where a single GeV centre was *** remote GeV emitter was thereby excited and coupled to spatially confined DLSPPW modes with an outstanding figure-of-merit of 180 due to a~six-fold Purcell enhancement,~56%coupling efficiency and~33μm transmission length,thereby opening new avenues for the implementation of nanoscale functional quantum devices.

关键词： excitation silver thereby

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Possible therapeutic targets and promising drugs based on unsymmetrical hetaryl-substituted porphyrins to combat SARS-CoV-2

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Journal of Pharmaceutical Analysis 2021年第6期11卷 691-698页

作者： Yury A.Gubarev natalya Sh.Lebedeva Elena S.Yurina sergey A.Syrbu Aleksey n.Kiselev Mikhail A.Lebedev G.A.Krestov Institute of Solution Chemistry of the Russian Academy of Sciences 153045IvanovoRussia Ivanovo State University of Chemistry and Technology 153000IvanovoRussia

Coronavirus disease 2019 is a serious disease that causes acute respiratory syndrome and negatively affects the central nervous *** acute respiratory syndrome coronavirus 2(SARS-CoV-2)crosses the blood-brain barrier due to the spike(S) protein on the surface of the viral ***,it is important to develop compounds that not only have an inhibitory effect but are also capable of completely deactivating the S protein *** study describes the purposeful modification of porphyrins and proposes compounds,asymmetrically hetaryl-substituted porphyrins with benzothiazole,benzoxazole,and n-methylbenzimidazole residues,to deactivate the S protein *** docking of SARS-CoV-2 proteins with hetaryl-substituted porphyrins showed that the viral S protein,nucleocapsid(n) protein,and non-structural protein 13(nsp13) exhibited the highest binding ***-substituted porphyrins form strong complexes(13-14 kcal/mol) with the receptor-binding domain of the S protein,while the distance from the porphyrins to the receptor-binding motif(RBM)does not exceed 20 ?;therefore,RBM can be oxidized by ^(1)O_(2),which is generated by *** porphyrins interact with the n protein in the serine/arginine-rich region,and a number of vulnerable amino acid residues are located in the photooxidation *** damage complicates the packaging of viral RnA into new ***-energy binding of hetaryl-substituted porphyrins with the n-and C-terminal domains of nsp13 was *** binding blocks the action of nsp13 as an enzyme of exoribonuclease and methyltransferase,thereby preventing RnA replication and processing.A procedure for the synthesis of hetaryl-substituted porphyrins was developed,new compounds were obtained,their structures were identified,and their photocatalytic properties were studied.

关键词： Porphyrins SARS-CoV-2 Molecular docking Photoinactivation

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