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Prognostic value of ^(18)F-FDG PET/CT in liver transplantation for hepatocarcinoma

World Journal of Gastroenterology 2015年第10期21卷 3049-3054页

作者： Olivier Detry Laurence Govaerts Arnaud Deroover Morgan Vandermeulen Nicolas Meurisse serge Malenga Noella Bletard Charles Mbendi Anne Lamproye Pierre Honoré Paul Meunier Jean Delwaide roland Hustinx Department of Abdominal Surgery and Transplantation CHU LiegeB4000 LiegeBelgium Department of Nuclear Medicine CHU Liege University of Liege ULg CHU B4000 LiegeBelgium Department of Radiology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium Department of Pathology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium Department of Hepato-Gastroenterology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium

AIM:To evaluate the prognostic value of pretreatment F D G p o s i t r o n e m i s s i o n t o m o g ra p h y c o m p u t e d tomography(PET-CT) in patients with hepatocarcinoma treated by liver transplantation(LT).METHODS:The authors retrospectively analyzed the data of 27 patients(mean age 58 ± 9 years) who underwent FDG PET-CT before LT for *** follow-up was 26 ± 18 *** FDG PET/CT was performed according to a standard clinical protocol:4 MBq FDG/kg body weight,uptake 60 min,low-dose non-enhanced *** authors measured the SUVmax and SUVmean of the tumor and the normal *** tumor/liver activity ratios(RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors:MILAN,CLIP,OKUDA,TNM stage,alphafoetoprotein level,portal thrombosis,size of the largest nodule,tumor differentiation,microvascular invasion,underlying cirrhosis and liver ***:Overall and recurrence free survivals were80.7%and 67.4%at 3 years,and 70.6%and 67.4%at 5 years,*** to a multivariate Cox model,only FDG PET/CT RSUVmax predicted recurrence free *** though the MILAN criteria alone were not predictive,it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 ***:FDG PET/CT with an RSUVmax cutoff value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective *** prospectivestudies should test whether this metabolic index should be systematically included in the preoperative assessment.

关键词： Cancer Hepatoma Hepatocellular cancer Liver transp

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Monitoring dioxins and PCBs in eggs as sensitive indicators for environmental pollution and global contaminated sites and recommendations for reducing and controlling releases and exposure

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Emerging Contaminants 2022年第1期8卷 254-279页

作者： Jindrich Petrlik Lee Bell Joe DiGangi serge Molly Allo'o Allo'o Gilbert Kuepouo Griffins Ochieng Ochola Valeriya Grechko Nikola Jelinek Jitka Strakova Martin Skalsky Yuyun Ismawati Drwiega Jonathan N.Hogarh Eric Akortia Sam Adu-Kumi Akarapon Teebthaisong Maria Carcamo Bjorn Beeler Peter Behnisch Claudia Baitinger Christine Herold roland Weber International Pollutants Elimination Network(IPEN) GooteborgSweden Arnika e Toxics and Waste Programme Delnicka 13PragueCzech Republic National Toxics Network(NTN) PerthAustralia National SAICM Focal Point President of the Tenth Conference of the Parties to the Rotterdam ConventionMinistry of ForestryFisheries and EnvironmentLibrevilleGabon Centre de Recherche et d‘Education pour le Developpement(CREPD) YaoundeCameroon Centre for Environmental Justice and Development(CEJAD) NairobiKenya University of Chemistry and Technology Technicka 5PragueCzech Republic Arnika e Citizens'Support Center Delnicka 13PragueCzech Republic Nexus3 Foundation Denpasar80223Indonesia Department of Environmental Science Kwame Nkrumah University of Science and TechnologyKumasiGhana Ghana Atomic Energy Commission National Nuclear Research InstituteAccraRepublic of Ghana Chemicals Control and Management Centre Environmental Protection AgencyAccraGhana Ecological Alert and Recovery e Thailand(EARTH) NonthaburiThailand La Red de Accion en Plaguicidas y sus Alternativas para America Latina MontevideoUruguay BioDetection Systems BV(BDS) Science Park 4061098 XHAmsterdamthe Netherlands Bund für Umwelt und Naturschutz(BUND) Germany POPs Environmental Consulting D-73527Schw€abisch GmündGermany

This review compiles information on PCDD/F-and PCB-contaminated eggs from 20 years of global egg monitoring around emission sources in four continents conducted by the International Pollutants Elimination Network(IPEN)and Arnika as well as a compilation of data from scientific *** monitored 127 pooled egg samples including samples from 113 chicken flocks at potential PCDD/F-and PCB-contaminated sites around priority sources listed in the Stockholm Convention(*** incinerators,metal industries,cement plants,and open burning).99(88%)of pooled egg samples were above the EU maximum limits for PCDD/Fs(2.5 pg PCDD/F-TEQ/g fat)or the sum of PCDD/Fs and dioxinlike PCBs(5 pg PCDD/F-PCB-TEQ/g fat).Children consuming such eggs exceed the tolerable weekly intake(TWI).This demonstrates that close to 90%of these areas were not safe for the production of free-range *** out of the 113 egg samples(14%)were contaminated above 50 pg TEQ/g fat and exceeded the EU maximum limit more than 10 *** the 26 pooled egg samples around incinerators 24(92%)exceeded the limit with a mean of 43.1 pg TEQ/g fat(2.6e234 pg TEQ/g).All 21 egg samples around metal industries(4.4e112.6 pg TEQ/g fat)were above limits with mean concentration of 26.0 pg TEQ/g *** all 7 egg samples measured at e-waste recycling sites were above limits(mean 308 pg TEQ/g fat).In 58(51%)pooled egg samples the PCB-TEQ was above 5 pg TEQ/g fat exceeding the EU maximum limit with dioxin-like PCBs *** highlights the role of commercial PCBs for global contamination with dioxin-like *** was discovered that around metal industries,shredder plants,open burning sites of e-waste and dump sites,a high share of contamination was caused by *** clearly shows severe PCB release from the end-of-life management of PCB-containing equipment in developing *** highly contaminated eggs were found at many sites where plastic was *** highest contaminated egg sample ev

关键词： PCDD/PCDF dl-PCBs PBDD/PBDF Contaminated sites Monitoring Egg DR CALUX

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Bacteriological and Physico-Chemical Characterisation of Liquid Wastes: The Case of the University Hospital Centre (UHC) of Yaoundé-Cameroon

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Journal of Geoscience and Environment Protection 2022年第6期10卷 170-190页

作者： Luciane Marlyse Moungang Blandine Pulchérie Tamatcho Kweyang Lisyane Merveille Betyi roland Ndifor Ache Yves Poutoum Yogne Mouhama Sani Adams Ibn Rabiou Golda Reine Zame Meva’a Aurélie Dzenga Njeunkam Claire Stephane Metsopkeng serge Hubert Zebaze Togouet Laboratory of Hydrobiology and Environment Department of Animal Biology and Physiology Faculty of Sciences University of Yaoundé I Yaoundé Cameroon Department of Microbiology Faculty of Sciences University of Yaoundé I Yaoundé Cameroon Department of Organic Chemistry Faculty of Sciences University of Yaoundé I Yaoundé Cameroon Higher Technical Teachers Training College University of Bamenda Bamenda Cameroon

The untreated effluents generated by hospital activities contribute to the dissemination of pathogenic germs and multi-resistant bacteria, thus presenting a great potential danger for health and the environment. The objective of this study was to evaluate the microbiological and physico-chemical quality of the effluents of the Yaoundé University Hospital Centre and their impact on the environment. It was a prospective and analytical study on three sites where hospital effluents from the intensive care unit (Station A), the upstream of the wastewater treatment plant (Station B), and the gynaecology, surgery and hospitalisation departments (Station C) were sampled. Samples were collected in sterile glass bottles for bacteriological analyses and polyethylene bottles for physico-chemical analyses. The bacteriological parameters measured showed that the density of the bacterial species sought was very high at Station B with a predominance of the species Escherichia coli (57.36%). At Station A, total coliforms were very abundant (50.12%) and at Station C, the genus Pseudomonas was predominant (14.69%). Bacteria of the genus Streptococcus were represented by three species, namely: Streptococcus agalactiae, Streptococcus faecalis, and Streptococcus pneumoniae. The Pseudomonas genus was also represented by 3 species, namely Pseudomonas aeruginosa, Pseudomonas maltophilia and Pseudomonas putida. The physico-chemical parameters showed that apart from temperature and conductivity, which were in compliance with the standards, the other had values higher than these standards. This study shows that untreated hospital effluent contains most of the bacteria involved in community, nosocomial infections and would be a potential source of risk to the surrounding population.

关键词： Characterisation University Hospital Centre Effluents Bacteriology of Effluents Physico-Chemistry of Wastewater

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加工食品与心血管疾病发生风险:前瞻性队列研究(NutriNet-Santé)

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英国医学杂志中文版 2020年第1期23卷 3-4页

作者： Méjean Caroline Bernard Srour Léopold K Fezeu Emmanuelle Kesse-Guyot Benjamin Allès Caroline Méjean roland M Andrianasolo Eloi Chazelas Melanie Deschasaux serge Hercberg Pilar Galan Carlos A Monteiro Chantal Julia Mathilde Touvier 霍永丰(译) 不详中华医学杂志编辑部

目的评估食用超加工食品与心血管疾病发生风险的前瞻性关联。方法基于人群的队列研究。背景NutriNet-Santé队列,法国2009—2018年。参与者年龄≥18岁的105159位受试者。应用重复24小时的膳食记录(平均每人5.7小时)收集受试者饮食摄入情... 详细信息

目的评估食用超加工食品与心血管疾病发生风险的前瞻性关联。方法基于人群的队列研究。背景NutriNet-Santé队列,法国2009—2018年。参与者年龄≥18岁的105159位受试者。应用重复24小时的膳食记录(平均每人5.7小时)收集受试者饮食摄入情况,用以记录受试者日常对于3300种食品的摄入情况。根据加工程度利用NOVA分级将这些食品进行分类。主要结局测量在校正已知风险因素后,利用多变量Cox比例风险模型评估食用超加工食品与总体心血管疾病及冠状动脉性心脏病、脑血管疾病发生风险的关系。结果研究的中位随访时间为5.2年,其间食用超加工食品与总体心血管疾病[1409例患病,超加工食品在饮食中所占百分比绝对增加10%的危险比为1.12(95%可信区间为1.05~1.20);P<0.01,518208人年;食用超加工食品量最多的受试者(Q4)其总体心血管疾病发病率为277/10万人年,而在食用量最少的受试者(Q1)中为242/10万人年]、冠状动脉心脏病[665例患病;危险比1.13(1.02~1.24);P=0.02,520319人年;在超加工食品食用量最多和最少者的发病率分别为124/10万人年和109/10万人年]及脑血管疾病[829例患病;危险比1.11(1.01~1.21);P=0.02,520023人年;超加工食品食用量最多和最少者的发病率分别为163/10万人年和144/10万人年]的发病高风险有关。在校正了数种膳食营养质量标记(饱和脂肪酸、钠与糖摄入量、膳食纤维或者是来自主成分分析的健康饮食模式)的影响及大范围灵敏度分析后,这些结果仍存在统计学显著性。结论这项大型观察性研究发现,食用大量超加工食品与心血管疾病、冠状动脉性心脏病及脑血管疾病的高发病风险相关。这些结果仍需要在其他人群或研究单位进行验证,并且因果关系仍待确定。食品加工中的多种因素,如终产品的营养成分、添加剂、接触材料和新污染物,可能在这种联系中发挥某种作用,其各自作用的大小仍需要进一步研究。同时,几个国家的公共卫生当局近期已经开始鼓励人们食用未经加工或者经简单加工的食品,并且限制超加工食品的摄入。研究注册*** NCT03335644。

关键词： Cox比例风险模型冠状动脉心脏病观察性研究心血管疾病摄入情况脑血管疾病食用量接触材料

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