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Asian Journal of Andrology 2008年第2期10卷 177-187页

作者： Khaled Hamden Dorothee Silandre Christelle Delalande Abdefattah El Feki serge Carreau Animal Ecophysiology Faculty of Sciences Sfax-3018 Tunisia USC 20061NRA- EA 2608 Biochemistry Caen-14032 France

Aim： To examine the effects on rat aging of caloric restriction （CR1） and undernutrition （CR2） on the body and on testicular weights, on two enzymatic antioxidants （superoxide dismutase and catalase）, on lipid peroxidation and on the expression of testicular aromatase and estrogen receptors （er）. Methods： CR was initiated in 1-month-old rats and carried on until the age of 18 months. Results： In control and CR2 rats an age-related decrease of the aromatase and of er （α and β） gene expression was observed; in parallel a diminution of testicular weights, and of the total number and motility of epididymal spermatozo was recorded. In addition, aging in control and CR2 rats was accompartied by a significant decrease in testicular superoxide dismutase, catalase activities, and an increase in lipid peroxidation level （thiobarbituric acid reactive substance）, associated with alterations of spermatogenesis. Conversely, caloric restriction-treatment exerted a protective effect and all the parameters were less affected by aging. Conclusion： These results indicate that during aging, a low caloric diet （not undernutrition） is beneficial for spermatogenesis and likely improves the protection of the cells via an increase of the cellular antioxidant defense system in which aromatase/ er could play a role. （Asian J Andro12008 Mar; 10： 177-187）

关键词： aging low caloric diet rat testis aromatase estrogen receptors antioxidants

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Antagonism between ambient ozone increase and urbanization-oriented population migration on Chinese cardiopulmonary mortality

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The Innovation 2023年第6期4卷 48-58页

作者： Haitong Zhe Sun Junchao Zhao Xiang Liu Minghao Qiu Huizhong Shen serge Guillas Chiara Giorio Zosia Staniaszek Pei Yu Michelle W.L.Wan Man Mei Chim Kim Robin van Daalen Yilin Li Zhenze Liu Mingtao Xia Shengxian Ke Haifan Zhao Haikun Wang Kebin He Huan Liu Yuming Guo Alexander T.Archibald lYusuf Hamied Department of Chemistry University of CambridgeCambridge CB21EWUK Department of Earth Sciences University of CambridgeCambridge CB23EQUK Department of Environmental Health and Engineering Johns Hopkins Bloomberg School of Public HealthBaltimoreMD 21205USA State Key Joint Laboratory of ESPC State Environmental Protection Key Laboratory of Sources and Control of Air Pollution ComplexSchool of EnvironmentTsinghua UniversityBejing 100084China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Department of Earth System Science Stanford UniversityStanfordCA 94305USA School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518p55China Department of Statistical Science University College LondonLondon WC1E 6BTUK The Alan Turing Institute London NW12DBUK School of Public Heath and Preventive Medicine Monash UniversityMelboumeVIC 3004Australia British Heart Foundation Cardiovascular Epidemiology Unit Department of Public Health and Primary CareUniversity of CambridgeCambridge CB18RNUK Heart and Lung Research Institute University of CambridgeCambridge CB20BDUK Baroelona Supercomputing Center Department of Earth Sciences08034 BarcelonaSpain School of Environmental Science and Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Department of Mathematics University of CaliformiaLos AngelesLos AngelesCA 90095USA State Key Laboratory of New Ceramics and Fine Processing KeyLaboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Engineering University of CambridgeCambridge CB21PZUK National Centre for Atmospheric Science Cambridge CB21EWUK

Everincreasing ambient ozone(O3)pollution in China has been exacerbating cardiopulmonary premature ***,the urban-rural exposure inequity has seldom been ***,we assess populationcale 03 exposure and mortality burdens between 1990 and 2019 based on integrated pollution tracking and epidemiological *** find Chinese population have been suffering from climbing 03 exposure by 4.3±2.8 ppb per decade as a result of rapid urbanization and growing prosperity of socioeconomic *** residents are broadly exposed to 9.8±4.1 ppb higher ambient O3 than the adjacent urban citizens,and thus urbaniza-tion-oriented migration compromises the exposure-associated mortality on total *** excess premature deaths attributable to longterm 03 exposure,373,500(95%uncertainty interval[U]:240,600-510,900)in 2019,is underestimated in previous studies due to ignorance of cardiovascular *** 03 pollution policy should focus more on rural population who are facing an aggravating threat of mortality risks to ameliorate environmental health injustice.

关键词： ambient urban urbanization

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