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Influence of Alternating and Static Magnetic Fields on Drug Release from Hybrid Hydrogels Containing Magnetic Nanoparticles

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Journal of Biomaterials and Nanobiotechnology 2014年第2期5卷 116-127页

作者： Marianna Uva Daniela Pasqui Lorenzo Mencuccini serena Fedi Rolando Barbucci Department of Biotechnology Chemistry and Pharmacy University of Siena Via Aldo Moro 2 Siena Italy Interuniversity Research Centre for Advanced Medical Systems (C.R.I.S.M.A.) Viale Giacomo Matteotti Colle di Val d’Elsa Siena Italy

Hybrid hydrogels of carboxymethylcellulose (CMC), containing two different amounts of CoFe2O4 magnetic nanoparticles (50% and 70% in relation to the quantity of the polymer) as crosslinkers, were prepared. The hybrid hydrogels were chemically and morphologically characterized and their viscoelastic properties and swelling degrees were analyzed. The hydrogels were tested as controlled drug delivery systems by applying one static and two different alternating magnetic fields. The application of the two alternating magnetic fields (AMF) to the hybrid hydrogels induced a higher release of methylene blue (MB), used as a model drug, than without the application of any magnetic field, especially at low frequency (4 Hz) and high magnetic intensity (0.5 T). In contrast, when the hybrid hydrogels were exposed to a static magnetic field (SMF) the release of MB was slowed down. Furthermore the two different amounts of magnetic nanoparticles induce different responses to the magnetic field. The greater number of nanoparticles in the CMC-NP-70 hydrogel leads to the formation of some NPs clusters limiting the drug release;conversely, the CMC-NP-50 hydrogel, containing a lower amount of nanoparticles, shows a higher release of MB vs. time. In conclusion, we were able to get a potential system for modulation of the drug delivery: the release behaviour of hybrid hydrogels can be modulated by applying alternating and static magnetic fields cyclically. A possible explanation for the release mechanism is about the structural modification of the polymeric chains that occurs when the hybrid hydrogels are exposed to the magnetic fields.

关键词： Magnetic Hydrogels Alternating Magnetic Field Static Magnetic Field Controlled Release Cobalt Ferrite Nanoparticles

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彩色小威

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网球大师 2008年第10期 58-65页

作者： serena

在离天美网冠军领奖台72个月之后,在离开世界第一的宝座61个月之后,小威廉姆斯终于完成了一次漂亮的回归,九月的网球场成为小威的天下。和九月的网球场一样,九月的秀场也是小威一个人的舞台。在法拉盛夺魁之后,小威一袭红衣来到时代广... 详细信息

在离天美网冠军领奖台72个月之后,在离开世界第一的宝座61个月之后,小威廉姆斯终于完成了一次漂亮的回归,九月的网球场成为小威的天下。和九月的网球场一样,九月的秀场也是小威一个人的舞台。在法拉盛夺魁之后,小威一袭红衣来到时代广场展示自己的第9个大满贯奖怀;在纽约时装周上,小威一身素净惊艳全场。从黑到白,从红到绿。

关键词：网球场彩色回归冠军红衣法拉夺魁舞台世界广场

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Targeted approaches for HER2 breast cancer therapy: News from nanomedicine?

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World Journal of Pharmacology 2014年第4期3卷 72-85页

作者： serena Mazzucchelli Marta Truffi Luisa Fiandra Luca Sorrentino Fabio Corsi "L. Sacco" University Hospital 20157 Milan Italy Department of Biomedical and Clinical Sciences "L. Sacco" University of Milan 20157 Milan Italy Surgery Division "Luigi Sacco" Hospital 20157 Milan Italy

About 30% of human breast cancers are human epidermal growth factor receptor 2 （HER2）＋. This particular biological portrait is characterized by the overexpression of HER2 receptor with the subsequent deregulation of downstream pathways, which control cellular survival and proliferation. The most effective treatment for HER2＋ cancer is represented by therapy with HER2-targeted agents. Anti-HER2 therapy dramatically improves clini-cal outcomes, although it shows some limitations in achieving a proper treatment. These drawbacks of HER2-targeted therapy may be overcome with the develop-ment of HER2-targeted drug delivery nanodevices. These nanoparticles possess an internal three-dimensional com-partimentalization, which allows to combine the specifc target recognition with their capability to act as a drug reservoir for the selective delivery of chemotherapics to tumor sites. Moreover, nanoparticles useful in photo-thermal ablation or in photodynamic therapy have been functionalized in order to match specifcity in tumor cell recognition and suitable chemical properties. Here, we summarize the state of the art concerning the HER2＋ breast cancer and anti-HER2 therapy, in particular deep-ening the contribution of the nanomedicine. Description of preclinical studies performed with HER2-targeted nanoparticles for HER2＋ breast cancer therapy will be preceded by an overview on HER2-targeting molecules and nano-conjugation strategies. Further investigation will be necessary to introduce these nano-drugs in clinical prac-tice; however promising results encourage an upcoming translation of this research for the next future.

关键词： Human epidermal growth factor receptor 2 Human epidermal growth factor receptor 2^+-breast cancer Nanomedicine Nanoparticle Targeted-therapy

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太阳照在南窗台上

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花木盆景(花卉园艺) 2016年第12期 19-24页

作者： serena

我从小就喜欢花花草草,记得小时候家里露台摆满了各种各样的花。每个仲夏的夜晚,我们都会围坐在露台听父亲讲故事,那时周围经常散发着茉莉淡淡的清香,沁人心脾,至今令我难以忘怀。温暖的父爱和清香无比的茉莉,成为了我童年美好的记忆。... 详细信息

我从小就喜欢花花草草,记得小时候家里露台摆满了各种各样的花。每个仲夏的夜晚,我们都会围坐在露台听父亲讲故事,那时周围经常散发着茉莉淡淡的清香,沁人心脾,至今令我难以忘怀。温暖的父爱和清香无比的茉莉,成为了我童年美好的记忆。我的花园刚好一岁。去年9月底我无意在网上看到一张组合多肉图片,立即被多肉美丽的色

关键词：花花草草阳台玻璃窗花儿民歌

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从IN到OUT

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网球大师 2008年第8期 60-67页

作者： serena

6月7日,伊万诺维奇赢得法网公开赛女单冠军,第一次登上了世界排名榜首位。6月27日,伊万作为温网头号种子意外止步第三轮、挥别温网,爆出本届温网的最大冷门。时间仅仅相隔20日,从最IN到最OUT,但这丝毫没有影响伊万的人气,接受采访、拍... 详细信息

6月7日,伊万诺维奇赢得法网公开赛女单冠军,第一次登上了世界排名榜首位。6月27日,伊万作为温网头号种子意外止步第三轮、挥别温网,爆出本届温网的最大冷门。时间仅仅相隔20日,从最IN到最OUT,但这丝毫没有影响伊万的人气,接受采访、拍写真、上杂志、她美丽的身影充斥在每个网球迷眼中。

关键词：法网冠军世界排名种子最大采访网球冷门写真意外

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在洒满阳光的阳台上做一个花园梦

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花木盆景(花卉园艺) 2020年第3期 46-51页

作者： serena

大约三年前,我的阳台还是空荡荡的,和大多城市里的青年人一样,平时只有晒个衣服才会去趟阳台。直到某天无意中在网上看到一张种满多肉植物的阳台图片,人生就好像打开了另一扇门,藏在我心里多年的花园梦就这样开启了。养花的起初走了很... 详细信息

大约三年前,我的阳台还是空荡荡的,和大多城市里的青年人一样,平时只有晒个衣服才会去趟阳台。直到某天无意中在网上看到一张种满多肉植物的阳台图片,人生就好像打开了另一扇门,藏在我心里多年的花园梦就这样开启了。养花的起初走了很多弯路,付出了不少心血,都打了水漂。比如担心台风太大,花儿们经不住摧残,又怕冬天太冷影响我赏花,于是请人给阳台封上了双层隔音玻璃,结果通风光照不足每盆花都生病了,那一刻才认识到养花通风特别重要。为了种上更多喜欢的花儿,我又请来师傅把家里的窗户全部改成凸窗。改成凸窗后,每天睡觉醒来就能看到充满阳光的向日葵,心里美美滴。

关键词：凸窗瓷砖建筑陶瓷

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奖牌背后

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网球大师 2008年第9期 60-67页

作者： serena

北京奥运会,费德勒来了、纳达尔来了、威廉姆斯姐妹也来了。7天过后,他们战胜者如意,战败者失意,奥运奖牌的背后,有如意者的忘形和失意者的黯然。胜败之间,他们无声的表情语言、刹那的激情进发,都泄漏出真实情感,让人感同身受。

关键词：奥运奖牌北京奥运会战败者真实情感失意者泄漏俄罗斯语言红粉胜败

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Open Innovation, Chinese Style

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博鳌观察 2016年第3期 41-44页

作者： Larry Downes Paul F.Nunes serena Jing Qiu the Georgetown Center for Business and Public Policy Accenture Institute for High Performance

Open innovation trades control,secrecy,and full ownership of technical solutions for significant increases in speed of development,reduced risk and lower capital costs for the *** of the company’s organizational and product weaknesses may be exposed in the process,but those risks are more than compensated by the enhanced exposure to potential collaborators who might otherwise never appear on the company’s radar.

关键词：英语阅读理解中国模式

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Targeting α-synuclein by PD03 AFFITOPE■ and Anle 138b rescues neurodegenerative pathology in a model of multiple system atrophy:clinical relevance

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Translational Neurodegeneration 2020年第3期9卷 484-497页

作者： Miguel Lemos serena Venezia Violetta Refolo Antonio Heras-Gavin Sabine Schmidhuber Armin Giese Andrei Leonov Sergey Ryazanov Christian Griesinger Gergana Galabova Guenther Safer Gregor Karl Wenning Nadia Stefanova Division of Neurobiology Department of NeurologyInnsbruck Medical University6020 InnsbruckAustria AFFIRIS AG ViennaAustria Center for Neuropathology and Prion Research Ludwig-Maximilians-UniversityMunichGermany Max Planck Institute for Biophysical Chemistry GottingenGermany Present Address:Origenis GmbH MunichGermany

Background:Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of a-synucleinopathies including Parkinson's disease and multiple system atrophy,and its detection parallels activation of microglia and a loss of neurons in the substantia nigra pars *** we aimed to analyze the therapeutic efficacy of PD03,a new AFFITOPE■ immunotherapy approach,either alone or in combination with Anle138b,in a PLP-α-syn mouse ***:The PLP-α-syn mice were treated with PD03 immunotherapy,Anle138b,or a combination of *** months after study initiation,the mice underwent behavioral testing and were sacrificed for neuropathological *** treatment groups were compared to the vehicle group with regard to motor performance,nigral neuronal loss,microglial activation and α-synuclein ***:The PLP-α-syn mice receiving the PD03 or Anle138b single therapy showed improvement of gait deficits and preservation of nigral dopaminergic neurons associated with the reduced α-synuclein oligomer levels and decreased microglial *** combined therapy with Anle138b and PD03 resulted in lower lgG binding in the brain as compared to the single immunotherapy with ***:PD03 and Anle138b can selectively target oligomeric α-synuclein,resulting in attenuation of neurodegeneration in the PLP-α-syn *** approaches are potential therapies that should be developed further for disease modification in α-synucleinopathies.

关键词： α-Synuclein Immunotherapy Oligomer modulation Target engagement Substantia nigra Microglia

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Cardiovascular magnetic resonance of cardiac tumors and masses

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World Journal of Cardiology 2021年第11期13卷 628-649页

作者： Marco Gatti Tommaso D’Angelo Giuseppe Muscogiuri serena Dell'aversana Alessandro Andreis Andrea Carisio Fatemeh Darvizeh Davide Tore Gianluca Pontone Riccardo Faletti Radiology Unit Department of Surgical SciencesUniversity of TurinTurin 10126Italy Department of Biomedical Sciences and Morphological and Functional Imaging “G.Martino”University Hospital MessinaMessina 98100Ita Department of Radiology IRCCS Istituto Auxologico ItalianoSan Luca HospitalMilan 20149Italy Department of Radiology S.Maria Delle Grazie HospitalPozzuoli 80078Italy Department of Medical Sciences University of TurinTurin 10126Italy School of Medicine Vita-Salute San Raffaele UniversityMilan 20121Italy Department of Cardiovascular Imaging Centro Cardiologico MonzinoIRCCSMilan 20138Italy

Cardiac masses diagnosis and treatment are a true challenge,although they are infrequently encountered in clinical *** encompass a broad set of lesions that include neoplastic(primary and secondary),non-neoplastic masses and *** clinical presentation of cardiac tumors is highly variable and depends on several factors such as size,location,relation with other structures and *** presumptive diagnosis is made based on a preliminary non-invasive diagnostic work-up due to technical difficulties and risks associated with biopsy,which is still the diagnostic gold *** findings should always be interpreted in the clinical context to avoid misdiagnosis,particularly in specific conditions(e.g.,infective endocarditis or thrombi).The modern multi-modality imaging techniques has a key role not only for the initial assessment and differential diagnosis but also for management and surveillance of the cardiac *** magnetic resonance(CMR)allows an optimal non-invasive localization of the lesion,providing multiplanar information on its relation to surrounding ***,with the additional feature of tissue characterization,CMR can be highly effective to distinguish pseudomasses from masses,as well as benign from malignant lesions,with further differential diagnosis of the *** histopathological assessment is important to make a definitive diagnosis,CMR plays a key role in the diagnosis of suspected cardiac masses with a great impact on patient *** literature review aims to provide a comprehensive overview of cardiac masses,from clinical and imaging protocol to pathological findings.

关键词： Cine magnetic resonance imaging Multiparametric magnetic resonance imaging Heart neoplasm Multimodal imaging Late-gadolinium enhancement Early gadolinium enhancement

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