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Targeted approaches for HER2 breast cancer therapy: News from nanomedicine?

World Journal of Pharmacology 2014年第4期3卷 72-85页

作者： serena mazzucchelli Marta Truffi Luisa Fiandra Luca Sorrentino Fabio Corsi "L. Sacco" University Hospital 20157 Milan Italy Department of Biomedical and Clinical Sciences "L. Sacco" University of Milan 20157 Milan Italy Surgery Division "Luigi Sacco" Hospital 20157 Milan Italy

About 30% of human breast cancers are human epidermal growth factor receptor 2 （HER2）＋. This particular biological portrait is characterized by the overexpression of HER2 receptor with the subsequent deregulation of downstream pathways, which control cellular survival and proliferation. The most effective treatment for HER2＋ cancer is represented by therapy with HER2-targeted agents. Anti-HER2 therapy dramatically improves clini-cal outcomes, although it shows some limitations in achieving a proper treatment. These drawbacks of HER2-targeted therapy may be overcome with the develop-ment of HER2-targeted drug delivery nanodevices. These nanoparticles possess an internal three-dimensional com-partimentalization, which allows to combine the specifc target recognition with their capability to act as a drug reservoir for the selective delivery of chemotherapics to tumor sites. Moreover, nanoparticles useful in photo-thermal ablation or in photodynamic therapy have been functionalized in order to match specifcity in tumor cell recognition and suitable chemical properties. Here, we summarize the state of the art concerning the HER2＋ breast cancer and anti-HER2 therapy, in particular deep-ening the contribution of the nanomedicine. Description of preclinical studies performed with HER2-targeted nanoparticles for HER2＋ breast cancer therapy will be preceded by an overview on HER2-targeting molecules and nano-conjugation strategies. Further investigation will be necessary to introduce these nano-drugs in clinical prac-tice; however promising results encourage an upcoming translation of this research for the next future.

关键词： Human epidermal growth factor receptor 2 Human epidermal growth factor receptor 2^+-breast cancer Nanomedicine Nanoparticle Targeted-therapy

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Antiretroviral Therapy through Barriers： A Prominent Role for Nanotechnology in HIV-1 Eradication from Sanctuaries

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Journal of Pharmacy and Pharmacology 2016年第7期4卷 328-340页

作者： Fabio Corsi Luca Sorrentino serena mazzucchelli Marta Truffi Amedeo Capetti Giuliano Rizzardini Luisa Fiandra Universit3 degli Studi di Milano Dipartimento di Scienze Biomediche e Cliniche "L. Sacco" via G.B. Grassi 74 20157 Milanltalia Ospedale L. Sacco via G.B. Grassi 74 20157 Milan Italia University of the Witwatersrand Faculty of Health Science School of Clinical Medicine 7 York Rd & Carse O'Gowrie RoadJohannesburg South Africa

Abstract： In HIV-1 management, eradication of the virus from sanctuaries represents a major and challenging goal. The genital tract, gut associated lymphoid tissue, lymph nodes, central nervous system, macrophages and latently infected CD4＋ T lymphocytes are typical sites where H1V-1 compartmentalizes. To circumvent this problem, a consistent number of studies have focused on improving ARVs （antiretroviral drugs） delivery into sanctuary sites and different nanoteehnological approaches have been developed. Cellular HIV-1 sanctuaries （i.e. macrophages） can be reached by nanoformulation of ARVs or by activation of latently infected cells. Anatomical sanctuaries （i.e. brain or male genital tract） can be addressed by increasing the permeation of ARVs across tissue barriers, such as the blood-brain barrier or the blood-testis barrier, while ARVs concentration in lymph nodes can be enhanced by drug encapsulation in CD4-targeted nanoparticles.

关键词： Nanotechnology HIV-1 antiretrovirals sanctuaries delivery.

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