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Operando electrochemical SERS monitors nanoparticle reactions by capping agent fingerprints

Nano Research 2022年第5期15卷 4517-4524页

作者： Kevin Wonner Steffen Murke serena RAlfarano Pouya Hosseini Martina Havenith Kristina Tschulik Chair of Analytical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany Chair of Physical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany

Nanomaterials are frequently employed in daily life goods,including health,textile,and food industry.A comprehensive picture is lacking on the role of the capping agents,added ligand molecules,in case of nanoparticle reactions and degradation in aqueous solutions,like surface waters or ***,we aim to elucidate the capping agent influence on nanoparticle reactivity probing two commonly employed capping agents citrate and polyvinylpyrrolidone(PVP).Their influence on silver nanoparticle(AgNP)transformation is studied,which is particularly important due to its application as an antimicrobial *** induce oxidation and reduction processes of AgNPs in halide solutions and we monitor the associated transformations of particles and capping agents by spectro-electrochemical surface-enhanced Raman spectroscopy(SERS).Raman bands of the capping agents are used here to track chemical changes of the nanoparticles under operando *** sparingly soluble and non-plasmon active silver salts(AgBr and AgCl)are formed under potential *** addition,we spectroscopically observe plasmon-mediated structural changes of citrate to cis-or trans-aconitate,while PVP is *** different behavior of the capping agents implies a change in the physical properties on the surface of AgNPs,in particular with respect to the surface ***,we showcase that reactions of the capping agents induced by different external stimuli,such as applied bias or laser irradiation,can be *** results demonstrate how SERS of capping agents can be exploited to operando track nanoparticle conversions in liquid *** approach is envisaged to provide a more comprehensive understanding of nanoparticle fates in complex liquid environments and varied redox conditions.

关键词： capping agent electrochemical surface-enhanced Raman spectroscopy silver nanoparticle nanoparticle reaction

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The effect of temperature on the wear behaviour of dental composites

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Biosurface and Biotribology 2022年第4期8卷 329-336页

作者： Joseph A.Arsecularatne serena Tran Mark J.Hoffman School of Materials Science and Engineering UNSW SydneySydneyNew South WalesAustralia School of Mechanical and Manufacturing Engineering UNSW SydneySydneyNew South WalesAustralia School of Engineering University of NewcastleCallaghanNew South WalesAustralia

Despite numerous published studies on the wear of dental composites,few have considered the influence of temperature on the two-body wear ***,no previous work has considered the influence of temperature on dominant wear mecha-nisms during the consumption of hot substances,hence the focus of this ***-rocating wear tests were carried out at varying artificial saliva lubricant temperatures(37 and 57℃)and material loss was quantified using *** wear tracks were analysed using FIB/SEM/*** reveal that the wear rate of a dental composite can significantly increase with temperature,with fatigue/delamination and ploughing acting as dominant mechanisms.

关键词： dental composite temperature tribological performance wear mechanism

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Stakeholder analysis of the governance framework of a national SDI dataset-whose needs are met in the buildings and address register of the Netherlands?

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International Journal of Digital Earth 2020年第3期13卷 355-373页

作者： serena Coetzee Martijn Odijk Bastiaan van Loenen Janette Storm Jantien Stoter Centre for Geoinformation Science Department of GeographyGeoinformatics and MeteorologyUniversity of PretoriaPretoriaSouth Africa Ministerie van Binnenlandse Zaken en Koninkrijksrelaties Den Haagthe Netherlands Knowledge Centre Open Data OTB Research for the Built EnvironmentFaculty of Architecture and the Built EnvironmentDelft University of TechnologyDelftthe Netherlands Kadaster Apeldoornthe Netherlands Department of Urbanism Delft University of TechnologyDelftthe Netherlands

National spatial data infrastructures are key to achieving the Digital Earth *** many cases,national datasets are integrated from local datasets created and maintained by *** are address,building and topographic *** of local datasets may result in a dataset satisfying the needs of users of national datasets,but is it productive for those who create and maintain the data?This article presents a stakeholder analysis of the Basisregistratie Adressen en Gebouwen(BAG),a collection of base information about addresses and buildings in the *** information is captured and maintained by municipalities and integrated into a national base register by Kadaster,the Cadastre,Land Registry and Mapping Agency of the *** stakeholder analysis identifies organisations involved in the BAG governance framework,describes their interests,rights,ownerships and responsibilities in the BAG,and maps the relationships between *** results indicate that Kadaster and the municipalities have the highest relative importance in the governance framework of the *** study reveals challenges of setting up a governance framework that maintains the delicate balance between the interests of all *** results provide guidance for SDI role players setting up governance frameworks for national or global datasets.

关键词： Address data data governance spatial data infrastructure SDI stakeholder analysis Netherlands

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Capacitating local governments for the digital earth vision:lessons learnt from the role of municipalities in the South African spatial data infrastructure

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International Journal of Digital Earth 2021年第12期14卷 1897-1917页

作者： Lindy-Anne Siebritz Ahmad Desai serena Coetzee Antony K.Cooper National Geo-Spatial Information Department of AgricultureRural Development and Land ReformCape TownSouth Africa Department of Geography Geoinformatics and MeteorologyUniversity of PretoriaPretoriaSouth Africa Smart Places CSIRPretoriaSouth Africa

The Digital Earth vision foresees the availability and accessibility of geospatial information to achieve the goals of sustainable development,economic growth and social *** the case of urban areas,upto-date geospatial information is essential for managing a city towards achieving these *** rapid shift from rural to urban areas globally puts pressure on local governments and they often struggle to find and organise the resources required to collect and maintain geospatial information that can help to address urban growth challenges.A spatial data infrastructure(SDI)can facilitate the availability and accessibility of geospatial information towards addressing national objectives,however,the involvement of local governments in an SDI can be a *** this paper,we critique the role of municipalities against the backdrop of the developments of the South African SDI(SASDI)to *** critique identifies five high-level shortcomings of the SASDI that have led to the limited participation of *** on the shortcomings,we provide recommendations for capacitating municipalities through SASDI so that the Digital Earth vision can also be achieved for *** recommendations are aimed at involving the local sphere of government in a national SDI and are equally applicable to other countries.

关键词： SDI SASDI municipalities service delivery data governance

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Concomitant medications and circulating tumor cells:friends or foes?

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Cancer Drug Resistance 2023年第1期6卷 30-34页

作者： serena Di Cosimo Vera Cappelletti Department of Advanced Diagnostics Fondazione IRCCS Istituto Nazionale dei TumoriMilano 20133Italy

The use of concomitant medications by patients with cancer is observed almost globally;however,little attention has been paid to this topic in the medical *** clinical studies do not describe the type and duration of drugs used at the time of inclusion and during treatment or how these drugs may affect the experimental and/or standard *** less information has been published on the potential interaction between concomitant medications and tumor ***,we do know that concomitant drugs can complicate cancer clinical trials and biomarker development,thus contributing to their interaction,leading to side effects,and resulting in suboptimal adherence to anticancer *** the basis of these premises and moving from the study by Jurisova et al.,which reported the effect of commonly used drugs on the prognosis of women with breast cancer and the detection of circulating tumor cells(CTCs),we comment on the role of CTCs as an emerging diagnostic and prognostic tool for breast *** also report the known and hypothesized mechanisms of CTC interplay with other tumor and blood components,possibly modulated by widespread drugs,including over-the-counter compounds,and discuss the possible implications of commonly used concomitant medications on CTC detection and *** considering all these points,it is conceivable that concomitant drugs are not necessarily a problem,but on the contrary,their virtuous mechanisms can be exploited to reduce tumor spread and enhance the effect of anticancer therapies.

关键词： Breast cancer concomitant medications circulating tumor cells

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Comparison of radiation degradation induced by x-ray and 3-MeV protons in 65-nm CMOS transistors

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Chinese Physics B 2016年第9期25卷 468-473页

作者：丁李利 Simone Gerardin Marta Bagatin Dario Bisello serena Mattiazzo Alessandro Paccagnella State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear Technology RREACT group Department of Information EngineeringPadova University INFN

The total ionizing dose（TID） response of 65-nm CMOS transistors is studied by 10-ke V x-ray and 3-Me V protons up to 1 Grad（SiO_2） total *** degradation levels induced by the two radiation sources are different to some *** main reason is the interface dose enhancement due to the thin gate oxide and the low energy *** holes＇ recombination also contributes to the *** to these two mechanisms,the influence of the dose rate is negligible.

关键词： total ionizing dose(TID) effects grad dose x-ray and protons 65-nm CMOS transistors

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CRISPR/Cas system: An emerging technology in stem cell research

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World Journal of Stem Cells 2019年第11期11卷 937-956页

作者： Maria Teresa Valenti Michela serena Luca Dalle Carbonare Donato Zipeto Department of Medicine Section of Internal Medicine DUniversity of VeronaVerona 37134Italy Department of Biochemistry University of OxfordOxford OX13QUUnited Kingdom Department of Neurosciences Biomedicine and Movement SciencesLaboratory of Molecular BiologyVerona 37134Italy

The identification of new and even more precise technologies for modifying and manipulating the genome has been a challenge since the discovery of the DNA double *** ability to modify selectively specific genes provides a powerful tool for characterizing gene functions,performing gene therapy,correcting specific genetic mutations,eradicating diseases,engineering cells and organisms to achieve new and different functions and obtaining transgenic animals as models for studying specific *** regularly interspaced short palindromic repeats(CRISPR)/Cas9 technology has recently revolutionized genome *** application of this new technology to stem cell research allows disease models to be developed to explore new therapeutic *** possibility of translating new systems of molecular knowledge to clinical research is particularly appealing for addressing degenerative *** this review,we describe several applications of CRISPR/Cas9 to stem cells related to degenerative *** addition,we address the challenges and future perspectives regarding the use of CRISPR/Cas9 as an important technology in the medical sciences.

关键词： Gene editing CRISPR/Cas9 Stem cells Degenerative diseases

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Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone

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Neural Regeneration Research 2020年第10期15卷 1773-1783页

作者： Giancarlo Poiana Roberta Gioia serena Sineri Silvia Cardarelli Giuseppe Lupo Emanuele Cacci Department of Biology and Biotechnology "C.Darwin" Sapienza University of Rome

In rodents,well characterized neurogenic niches of the adult brain,such as the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampus,support the maintenance of neural/stem progenitor cells(NSPCs)and the production of new neurons throughout the *** adult neurogenic process is dependent on the intrinsic gene expression signatures of NSPCs that make them competent for self-renewal and neuronal *** the same time,it is receptive to regulation by various extracellular signals that allow the modulation of neuronal production and integration into brain circuitries by various physiological stimuli.A drawback of this plasticity is the sensitivity of adult neurogenesis to alterations of the niche environment that can occur due to aging,injury or *** the core of the molecular mechanisms regulating neurogenesis,several transcription factors have been identified that maintain NSPC identity and mediate NSPC response to extrinsic ***,we focus on REST,Egr1 and Dbx2 and their roles in adult neurogenesis,especially in the subventricular *** review recent work from our and other laboratories implicating these transcription factors in the control of NSPC proliferation and differentiation and in the response of NSPCs to extrinsic influences from the *** also discuss how their altered regulation may affect the neurogenic process in the aged and in the diseased ***,we highlight key open questions that need to be addressed to foster our understanding of the transcriptional mechanisms controlling adult neurogenesis.

关键词： adult neurogenesis aging extracellular signaling gene regulation neural stem/progenitor cells transcription factors

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Prevalence of functional dyspepsia and its subgroups in patients with eating disorders

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World Journal of Gastroenterology 2012年第32期18卷 4379-4385页

作者： Antonella Santonicola Monica Siniscalchi Pietro Capone serena Gallotta Carolina Ciacci Paola Iovino Department of Clinical and Experimental Medicine University of NaplesFederico II80131 NaplesItaly Department of Medicine and Surgery University of Salerno84081 SalernoItaly

AIM:To study the prevalence of functional dyspepsia(FD)(Rome Ⅲ criteria) across eating disorders(ED),obese patients,constitutional thinner and healthy ***:Twenty patients affected by anorexia nervosa,6 affected by bulimia nervosa,10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders,4th edition,nine constitutional thinner subjects and,thirtytwo obese patients were recruited from an outpatients clinic devoted to eating behavior *** healthy volunteers matched for age and gender were enrolled as healthy *** participants underwent a careful clinical *** and anthropometric characteristics were obtained from a structured *** presence of FD and,its subgroups,epigastric pain syndrome and postprandial distress syndrome(PDS) were diagnosed according to Rome Ⅲ *** intensity-frequency score of broader dyspeptic symptoms such as early satiety,epigastric fullness,epigastric pain,epigastric burning,epigastric pressure,belching,nausea and vomiting were studied by a standardized questionnaire(0-6).Analysis of variance and post-hoc Sheffè tests were used for ***:90% of patients affected by anorexia nervosa,83.3% of patients affected by bulimia nervosa,90% of patients affected by ED not otherwise specified,55.6% of constitutionally thin subjects and 18.2% healthy volunteers met the Postprandial Distress Syndrome Criteria(χ 2,P < 0.001).Only one bulimic patient met the epigastric pain syndrome *** fullness intensity-frequency score was significantly higher in anorexia nervosa,bulimia nervosa and ED not otherwise specified groups compared to the score calculated in the constitutional thinner group(4.15 ± 2.08 vs 1.44 ± 2.35,P = 0.003;5.00 ± 2.45vs 1.44 ± 2.35,P = 0.003;4.10 ± 2.23vs 1.44 ± 2.35,P = 0.002,respectively),the obese group(4.15 ± 2.08vs 0.00 ± 0.00,P < 0.001;5.00 ± 2.45vs 0.00 ± 0.00,P < 0.001;4.10 ± 2.23

关键词： Eating disorders Functional dyspepsia Post prandial distress syndrome Epigastric pain sindrome Rome Ⅲ criteria Upper abdominal symptoms Anorexia nervosa Bulimia nervosa Eating disorders not otherwise specified Constitutional thinness

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Sexual outcome of patients undergoing thulium laser enucleation of the prostate for benign prostatic hyperplasia

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Asian Journal of Andrology 2015年第5期17卷 802-806,I0009页

作者： Luca Carmignani Giorgio Bozzini Alberto Macchi serena Maruccia Stefano Picozzi Stefano Casellato Academic Department of Urology IRCCS Policlinico San Donato University of Milan Milan Italy

Treatment of patients with lower urinary tract symptoms （LUTS） secondary to benign prostatic hyperplasia （BPH） may affect the quality of sexual function and ejaculation. The effect of new surgical procedures, which are currently available to treat BPH, on erection and ejaculation, has been poorly studied. This study aimed to assess the effect of thulium laser enucleation of the prostate （ThuLEP） on sexual function and retrograde ejaculation in patients with LUTS secondary to BPH. We performed a prospective study in 110 consecutive patients who had undergone ThuLEP to analyze changes in sexual function and urinary symptoms. To evaluate changes in erection and ejaculation, and the effect of urinary symptoms on the quality of life （QoL）, five validated questionnaires were used： the ICIQ-MLUTSsex, MSHQ-EjD, International Index of Erectile Function 5, International Prognostic Scoring System （IPSS） questionnaire, and QoL index of the intraclass correlation coefficients. Patients also underwent IPSS and flowmetry to assess the outcome of flow. Patients were evaluated before surgery and 3-6 months after ThuLEP, whereas those with previous abdominal surgery were excluded. The patients＇ mean age was 67.83 years. Postoperative urinary symptoms improved after surgery. No significant differences in erectile function before and after surgery were observed. As compared with other techniques described in the literature, the percentage of patients with conserved ejaculation increased by 52.7% after ThuLEP. ThuLEP positively affects urinary symptoms and their effect on the QoL of patients as assessed by questionnaire scores. While endoscopic management of BPH （e.g. transurethral resection of the prostate） causes retrograde ejaculation in most patients, those who undergo ThuLEP have conserved ejaculation and erectile function.

关键词： antegrade ejaculation benign prostatic hyperplasia sexual function thulium laser enucleation of the prostate

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