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COVID-19 Vaccine Priority Access for Adults and Children with Congenital Heart Disease: A Statement of the Italian Society of Pediatric Cardiology

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Congenital Heart Disease 2021年第5期16卷 427-431页

作者： Gabriele Egidy Assenza Biagio Castaldi serena flocco Giovanni Battista Luciani Giovanni Meliota Gabriele Rinelli Ugo Vairo Silvia Favilli Board of the Italian Society of Pediatric Cardiology Department of Cardio-Thoracic and Vascular Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Women’s and Children’s Health University of PadovaPadovaItaly Health Professions Research and Development Unit IRCCS Policlinico San DonatoMilanoItaly Department of Surgery DentistryPediatrics and GynecologyUniversity of VeronaVeronaItaly Pediatric Cardiology ‘Giovanni XXIII’Pediatric HospitalBariItaly Department of Pediatric Cardiology and Cardiac Surgery ‘Ospedale Pediatrico Bambino Gesu’RomaItaly Pediatric Cardiology ‘A.Meyer’Pediatric HospitalFirenzeItaly 不详

COVID-19 pandemic continues to strike across the world with increasing number of infected patients,severe morbidity and mortality,social life and economy *** access to vaccine prophylaxis will be pivotal in controlling this infection and providing individual level ***,mismatch between vaccine request and vaccine availability,as well as constraints in logistics of vaccine campaign is creating a transition phase of progressive but still incomplete inclusion of group of individuals in the vaccination *** patients living with chronic and multisystemic disease may present increased propensity of adverse outcome,should Sars-Cov-2 infection *** these patients,expedite access to COVID-19 vaccination may be *** Italian Society of Pediatric Cardiology National Board is providing a viewpoint to inform policy makers and public authorities during vaccine allocation strategies development,to consider higher priority and expedite access for selected groups of patients living with congenital heart disease.

关键词： COVID-19 vaccine congenital heart disease

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The Effects of Laser Therapy in Treating Hypertrophic Scars and Keloids after Median Sternotomy:A Scoping Review

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Congenital Heart Disease 2024年第4期19卷 363-374页

作者： Laura Schianchi Fabrizio Vaira Massimo Chessa serena Francesca flocco Arianna Magon Gianluca Conte Karina Geraldina Zuniga Olaya Giacomo Bortolussi Erika Cioffi Matteo Riccardo Di Nicola Santo Raffaele Mercuri Rosario Caruso Adult Congenital Heart Disease Unit IRCCS Policlinico San DonatoSan Donato MilaneseMilan20097Italy Dermatology and Cosmetology Unit IRCCS Ospedale San RaffaeleMilan20132Italy Faculty of Medicine and Surgery Vita-Salute San Raffaele UniversityMilan20132Italy Health Professions Research and Development Unit IRCCS Policlinico San DonatoSan Donato MilaneseMilan20097Italy Department of Congenital Cardiac Surgery IRCCS Policlinico San DonatoSan Donato MilaneseMilan20097Italy Cardiac Surgery IRCCS Policlinico San DonatoSan Donato MilaneseMilan20097Italy Department of Biomedical Sciences for Health University of MilanMilan20133Italy

Background:Hypertrophic scars and keloids,common complications following median sternotomy for cardiac surgery,signiﬁcantly impact patient quality of life due to their aesthetic and symptomatic *** advancements in laser therapy have made it a prominent option for managing these complex scars,yet a com-prehensive understanding of its efﬁcacy is *** aim of this scoping review is to explore the effects of laser therapy in managing hypertrophic scars and keloids after median ***:This scoping review ana-lyzed studies up to February 2024 from databases including PubMed,EMBASE,CINAHL,Scopus,Web of Science,and the Cochrane *** included any study that assessed laser therapy’s effects on hypertrophic scars and keloids following median *** were selected based on predeﬁned inclusion criteria with-out publication year,design,or origin ***:Six studies met the inclusion criteria,involving a total ofﬁve RCTs and one *** studies primarily tested 585 and 595-nm pulsed dye laser(PDL)treatments,focusing on scar appearance,patient symptoms,and treatment *** studies reported signiﬁcant improvements in scar height reduction and patient symptom relief after treatment,with mixed results for scar erythema and *** events were generally mild and ***:Laser therapy offers a beneﬁcial approach for improving the appearance and symptoms of hypertrophic scars and keloids post-median ***,further research is necessary to optimize treatment parameters and explore the long-term psychosocial impacts of this *** review highlights the need for more comprehensive studies to establish standardized treatment protocols and evaluate their effectiveness.

关键词： Laser therapy hypertrophic scars keloids median sternotomy cardiac surgery pulsed dye laser scar management

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Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano serena Boccella Carmela Belardo Andrea Maria Morace Francesca Guida Sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

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Genetic signatures of ERCC1 and ERCC2 expression,along with SNPs variants,unveil favorable prognosis in SCLC patients undergoing platinum-based chemotherapy

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Oncology Research 2025年第1期33卷 45-55页

作者： ENRICO CALIMAN SARA FANCELLI FEDERICO SCOLARI ADRIANO PASQUI CLARA MANNESCHI DANIELE LAVACCHI FRANCESCA MAZZONI FRANCESCA GENSINI VALERIA PASINI CAMILLA EVA COMIN LUCA VOLTOLINI serena PILLOZZI LORENZO ANTONUZZO Clinical Oncology Unit Careggi University HospitalFlorence50134Italy Department of Experimental and Clinical Medicine University of FlorenceFlorence50134Italy Department of Health Sciences University of FlorenceFlorence50134Italy Medical Oncology Unit Careggi University HospitalFlorence50134Italy Department of Experimental and Clinical Biomedical Sciences“Mario Serio” University of FlorenceFlorence50134Italy Section of Anatomic Pathology Department of Health SciencesUniversity of FlorenceFlorence50139Italy Section of Surgery Histopathology and Molecular PathologyUniversity of FlorenceFlorence50139Italy Thoracic Surgery Unit Careggi University HospitalFlorence50134Italy

Background:Platinum chemotherapy(CT)remains the backbone of systemic therapy for patients with smallcell lung cancer(SCLC).The nucleotide excision repair(NER)pathway plays a central role in the repair of the DNA damage exerted by platinum *** in this repair mechanism may affect patients’*** and Methods:We conducted a retrospective analysis of data from 38 patients with extensive disease(ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit,Careggi University Hospital,Florence(Italy),from 2015 to *** expression analysis and single nucleotide polymorphism(SNP)characterization of three NER pathway genes—namely ERCC1,ERCC2,and ERCC5—were performed on patient tumor ***:Overall,elevated expression of ERCC genes was observed in SCLC patients compared to healthy *** with low ERCC1 and ERCC5 expression levels exhibited a better median progression-free survival(mPFS=7.1 vs.4.9 months,p=0.39 for ERCC1 and mPFS=6.9 vs.4.8 months,p=0.093 for ERCC5)and overall survival(mOS=8.7 vs.6.0 months,p=0.4 for ERCC1 and mOS=7.2 vs.6.2 months,p=0.13 for ERCC5).Genotyping analysis of five SNPs of ERCC genes showed a longer survival in patients harboring the wild-type genotype or the heterozygous variant of the ERCC1 rs11615 SNP(p=0.24 for PFS and p=0.14 for OS)and of the rs13181 and rs1799793 ERCC2 SNPs(p=0.43 and p=0.26 for PFS and p=0.21 and p=0.16 for OS,respectively)compared to patients with homozygous mutant ***:The comprehensive analysis of ERCC gene expression and SNP variants appears to identify patients who derive greater survival benefits from platinum-CT.

关键词： Small cell lung cancer(SCLC) Nucleotide excision repair(NER)pathway ERCC genes Single nucleotide polymorphisms(SNPs) Platinumchemotherapy(CT)

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The Role of PIN Auxin Efflux Carriers in Polar Auxin Transport and Accumulation and Their Effect on Shaping Maize Development

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Molecular Plant 2012年第4期5卷 787-798页

作者： Cristian Forestan serena Varotto Department of Environmental Agronomy and Crop Science--University of Padova Viale dell'Universita 16 35020 Legnaro (PD) Italy

In plants, proper seed development and the continuing post-embryonic organogenesis both require that dif- ferent cell types are correctly differentiated in response to internal and external stimuli. Among internal stimuli, plant hormones and particularly auxin and its polar transport （PAT） have been shown to regulate a multitude of plant phys- iological processes during vegetative and reproductive development. Although our current auxin knowledge is almost based on the results from researches on the eudicot Arabidopsis thaliana, during the last few years, many studies tried to transfer this knowledge from model to crop species, maize in particular. Applications of auxin transport inhibitors, mutant characterization, and molecular and cell biology approaches, facilitated by the sequencing of the maize genome, allowed the identification of genes involved in auxin metabolism, signaling, and particularly in polar auxin transport. PIN auxin efflux carriers have been shown to play an essential role in regulating PAT during both seed and post-embryonic development in maize. In this review, we provide a summary of the recent findings on PIN-mediated polar auxin transport during maize development. Similarities and differences between maize and Arabidopsis are analyzed and discussed, also considering that their different plant architecture depends on the differentiation of structures whose development is con- trolled by auxins.

关键词： auxin PIN-formed auxin efflux carrier PAT Polar Auxin Transport kernel development meristem organ-ogenesis Zea mays.

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Vitamin C as a promoter of γδ T cells

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Cellular & Molecular Immunology 2021年第2期18卷 510-512页

作者： serena Meraviglia Francesco Dieli Central Laboratory of Advanced Diagnosis and Biomedical Research(CLADIBIOR) University of PalermoPalermoItaly Department of Biomedicine Neurosciences and Advanced DiagnosisUniversity of PalermoPalermoItaly

HumanγδT cells are a small CD3+subset exhibiting features of both innate and adaptive immune cell.1 The majorγδT cell population in peripheral blood expresses the Vγ9 and Vδ2 chains and recognizes phosphoantigens(PAgs)that are overexpressed by tumor cells in the absence of genetic *** and expansion of Vγ9Vδ2 T cells is also achieved by aminobisphosphonates(n-BPs),which promote the intracellular accumulation of *** of their potent cytotoxic and antitumor activity,Vγ9Vδ2 T cells are particularly indicated for use in cancer immunotherapy,even against tumors with low mutational burdens.

关键词： γδT chains absence

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Brain-derived neurotrophic factor in main neurodegenerative diseases

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Neural Regeneration Research 2023年第3期18卷 554-555页

作者： serena Camuso Sonia Canterini Division of Neuroscience Department of PsychologyUniversity La SapienzaRomeItaly PhD Program in Behavioral Neuroscience Sapienza University of RomeRomeItaly

Discovered in pig brains in 1982,the brain-derived neurotrophic factor(BDNF)is one of the most studied and characterized neurotrophins in the central nervous *** recent years,BDNF has received considerable attention for its importance in the development and maintenance of normal brain *** is because BDNF plays an important role in crucial functions of the nervous system,such as the survival,differentiation,and maturation of neurons and glial cells as well as the actions of neuroprotection in adverse conditions,such as glutamatergic overstimulation,cerebral ischemia,hypoglycemia,and neurotoxicity(Kowiański et al.,2018).

关键词： stimulation diseases

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Clonal expansion shapes the human Vδ1T cell receptor repertoire

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Cellular & Molecular Immunology 2018年第2期15卷 96-98页

作者： serena Meraviglia Francesco Dieli Central Laboratory of Advanced Diagnosis and Biomedical Research(CLADIBIOR)and Department of Biopathology and Medical Biotechnologies(DIBIMED) University of PalermoPalermo90129Italy

Theγδcells are a unique population of T lymphocytes that combine innate-like features and adaptive-type responses and play an important role in the early host response to infections and *** fromαβT cells,γδT cells recognize a limited set of antigens,which are shared by a variety of microbial pathogens and tumor cells in a non-MHC restricted manner;1 thus,these cells use the TCR in a manner similar to a pattern recognition receptor(PRR).Moreover,whereasαβT cells require antigen-and cytokine-driven clonal expansion,γδT cells are equipped with immediate effector functions.1 However,the potentialγδrepertoire with junctional diversity is estimated at∼10^(18),which is much greater than theαβrepertoire(∼10^(16)),thus raising questions concerning the forces governing the selection of such a huge TCR repertoire during ontogeny and whether and how theγδTCR repertoire is shaped under physiological and pathological conditions.

关键词： expansion equipped concerning

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Mapping the quality of prenatal and postnatal care and demographic differences on child mortality in 26 low to middle-income countries

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World Journal of Pediatrics 2023年第9期19卷 835-850页

作者： Kelly Lin serena Chern Jing Sun School of Medicine and Dentistry Griffith UniversityParkland DriveGold CoastQLD4215Australia Institute for Integrated and Intelligent Systems Griffith UniversityGold Coast4222Australia Menzies Health Institute Queensland Griffith UniversityGold CoastAustralia

Background Closing the gap between child mortality in low-and middle-income countries(LMICs)and high-income countries is a priority set by the WHO in sustainable development goals(SDGs).We aimed to examine poor nutrition and prenatal and postnatal care that could increase the risk of child mortality in *** The Demographic and Health Survey(DHS)was used to examine data from 26 countries to compare prenatal,postnatal,nutritional,and demographic factors across *** of child death was classified into death before one month of age,between 1 to 11 months,between one to two years,between three to five years,and overall death before five ***-square analyses identified differences in prenatal care,postnatal care,nutrition,and demographic factors between children who died and those who *** regression identified factors that increased child mortality *** The majority of deaths occurred before the ages of one month and one *** poorer quality of prenatal care,postnatal care,and nutrition were found in low-income and low-middle-income countries in the contemporary *** child mortality and poor quality of prenatal and postnatal care coincide with low *** in LMICs were exposed to less vitamin A-rich foods than children in higher-middle-income *** use of intestinal parasite drugs and the absence of postpartum maternal vitamin A supplementation significantly increased child mortality *** socio-demographic risk factors were associated with an increased mortality rate in children,including lack of education,maternal marital status,family wealth index,living rurally,and financial problems hindering access to *** Poor nutrition remains a vital factor across all LMICs,with numerous children being exposed to foods low in iron and vitamin ***,most deaths occur in neonates and infants,indicating an urgent need to address risk factors associated with early chil

关键词： Child mortality Low-and middle-income countries Postnatal care Prenatal care

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PML nuclear bodies:new players in familial amyotrophic lateral sclerosis-frontotemporal dementia?

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Neural Regeneration Research 2024年第9期19卷 1875-1876页

作者： Anand Goswami serena Carra Institute of Neuropathology RWTH Aachen University HospitalAachenGermany Department of Neurology Eleanor and Lou Gehrig ALS CenterColumbia UniversityNew YorkNYUSA Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly

Amyotrophi c lateral s c lerosis(ALS)and frontotemporal dementia(FTD)are two closely related disorders with overlapping clinical,genetic,and neuropathological features,forming a continuous disease spectrum(Ling et al.,2013).The major pathological hallmark of ALS and FTD are the depletion from the nucleus of the RNA-binding proteins TAR DNA‐binding protein 43(TDP-43)and FUsed in Sarcoma(FUS)and their abnormal accumulation in ubiquitin-positive cytoplasmic inclusions(Ling et al.,2013).

关键词： clinical familial

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