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Heterogeneous population of macrophages in the development of non-alcoholic fatty liver disease

Liver Research 2023年第1期7卷 16-25页

作者： Ye Eun Cho Yong Seong Kwon seonghwan hwang Department of Manufacturing Pharmacy College of Pharmacy and Research Institute for Drug DevelopmentPusan National UniversityBusanRepublic of Korea

Non-alcoholic fatty liver disease(NAFLD)is characterized by a spectrum of hepatic diseases,including fatty liver,non-alcoholic steatohepatitis,cirrhosis,and hepatocellular *** is a hepatic manifestation of metabolic syndrome and has become the leading cause of liver transplantation,necessitating an in-depth understanding of its underlying pathogenic mechanisms and the identification of viable drug *** fatty liver is benign and does not exert marked liver damage or inflammation,NAFLD progression involves inflammatory processes facilitated by immune *** and monocytes constitute the pool of innate immune cells that contribute to NAFLD development in association with other cell types,such as neutrophils,T cells,and natural killer *** concept that macrophages contribute to the inflammatory processes in NAFLD development has long been debated;however,the remarkable advances in experimental techniques have rapidly uncovered new subpopulations of macrophages and monocytes,whose functions need to be comprehensively *** current review focuses on the recent expansion of our knowledge of the heterogeneous population of macrophages crucially involved in NAFLD *** addition,the present paper discusses ongoing efforts to target macrophages and inflammatory processes to develop optimal therapeutic agents against non-alcoholic steatohepatitis.

关键词： Fatty liver Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) Inflammation Macrophages Chemokines

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Immunopathobiology and therapeutic targets related to cytokines in liver diseases

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Cellular & Molecular Immunology 2021年第1期18卷 18-37页

作者： Yong He seonghwan hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro Fouad Lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMD 20892USA Universite Paris-Est UMR-S955UPECF-94000 CreteilFrance Department of Medicine and Department of Surgery School of MedicineUniversity of CaliforniaSan DiegoCA 92093USA Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMAUSA INSERM U955F-94000 CreteilFrance Institut Universitaire de France(IUF) Paris F-75231 Cedex 05France

Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular *** progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut *** the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family *** can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly *** cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described.

关键词： T helper ALD NAFLD Fibrosis Inflammation

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