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Clinicopathologic features of surgically resected primary gastric lymphoma

World Journal of Gastroenterology 2004年第8期10卷 1103-1109页

作者： seong-HoKong Do-JoongPark Hyuk-JoonLee Han-KwangYang Kuhn-UkLee Kuk-JinChoe Min-AKim Hye-SeungLee Chul-wooKim Dae-SeogHeo Chul-woo Kim Dae-Seog Heo Department of Surgery Seoul National University College of MedicineSeoulKorea Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Pathology Seoul National University College of MedicineSeoulKorea Tumor Immunity Medical Research Center and Cancer Research Institute Seoul National University College of MedicineSeoulKorea Department of Internal Medicine Seoul National University College of MedicineSeoulKorea

AIM:To analyze the clinicopathologic characteristics of surgically resected gastric lymphoma patients. METHODS:We retrospectively analyzed 57 surgically resected gastric lymphoma patients,dividing them into 2 subgroups:Low grade MALToma (the LG group),High grade MALToma and Diffuse large B cell lymphoma (the HG group). RESULTS:The numbers of patients were:20 in the LG group, 37 in the HG *** diagnostic rate of gastroscopy was 34.8% at primary diagnosis and 50% including differential *** positive rates of Hpyloriwere similar between the 2 groups (68% vs77%).Multiple lesions were found in 19.3%.The proportion of mucosal and submucosal lesions was 80.0%(16/20) in the LG group,and 24.3%(9/37) in the HG group (P<0.001).Lymph node invasion rates were 10.5%(2/19) in the LG group and 44.1%(15/34) in the HG group (P=0.031).The numbers of recurred patients were none in the LG group,and 8 in the HG *** univariant analysis,group (P=0.024) and TNM stage (stage Ⅰ,Ⅱ vs stages Ⅲ,Ⅳ,P=0.002) were found to be the significant risk *** was a tendency of higher recurrence rate in the subtotal gastrectomy group than in the total gastrectomy group (P=0.50). CONCLUSION:The HG groups had a more advanced stage and a higher recurrence rate than the LG *** there was no difference between subtotal and total gastrectomies,more careful assessments of multiplicities and radical resections with lymph node dissections seem to be needed because of multiplicity and LN invasion even in LG group.

关键词： Adenocarcinoma Adult Aged Disease-Free Survival Female Gastrectomy Helicobacter Infections Humans Lymphoma, B-Cell Lymphoma, Large-Cell, Diffuse Male Middle Aged Retrospective Studies Stomach Neoplasms Treatment Outcome

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Switching-on of serotonergic calcium signaling in activated hepatic stellate cells

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World Journal of Gastroenterology 2011年第2期17卷 164-173页

作者： Kyu-Sang Park Pyo-Jin Sin Dong Hyeon Lee Seung-Kuy Cha Min-Jeong Kim Na-Hyun Kim Soon-Koo Baik seong-woo Jeong In Deok Kong Department of Physiology and Institute of Lifelong Health Yonsei University Wonju College of Medicine Department of Physiology College of MedicinePochon CHA University Department of Basic Nursing Science Keimyung University College of Nursing Department of Internal Medicine Yonsei University Wonju College of Medicine

AIM:To investigate serotonergic Ca 2+ signaling and the expression of 5-hydroxytryptamine(5-HT) receptors,as well as Ca 2+ transporting proteins,in hepatic stellate cells(HSCs) . METHODS:The intracellular Ca 2+ concentration([Ca 2+ ]i) of isolated rat HSCs was measured with a fluorescence microscopic imaging *** PCR was per-formed to determine the transcriptional levels of 5-HT receptors and endoplasmic reticulum(ER) proteins involved in Ca 2+ storage and release in cultured rat HSCs. RESULTS:Distinct from quiescent cells,activated HSCs exhibited[Ca 2+ ]i transients following treatment with 5-HT,which was abolished by U-73122,a phospholipase C *** of 5-HT2A and 5-HT2B receptors,but not 5-HT3,was prominent during trans-differentiation of *** with ritanserin,a 5-HT2 antagonist,inhibited[Ca 2+ ]i changes upon application of *** of type 1 inositol-5'-triphosphate receptor and type 2 sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase were also increased during activation of HSCs and serve as the major isotypes for ER Ca 2+ storage and release in activated *** 2+ binding chaperone proteins of the ER,including calreticulin,calnexin and calsequestrin,were up-regulated following activation of HSCs. CONCLUSION:The appearance of 5-HT-induced[Ca 2+ ]i response accompanied by upregulation of metabotropic 5-HT2 receptors and Ca 2+ transporting/chaperone ER proteins may participate in the activating process of HSCs.

关键词： Hepatic stellate cells 5-hydroxytryptamine Intracellular Ca 2+ transient Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase Inositol-5’-triphosphate receptor Endoplasmic reticulum chaperone

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Multiplanar reformations and minimum intensity projections using multi-detector row CT for assessing anomalies and disorders of the pancreaticobiliary tree

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World Journal of Gastroenterology 2007年第31期13卷 4177-4184页

作者： Hyun Cheol Kim Dal Mo Yang wook Jin Chang woo Ryu Jung Kyu Ryu Sung Il Park seong Jin Park Hyeong Cheol Shin Il Young Kim Department of Radiology East-West Neo Medical Center Kyung-Hee University Seoul Republic of Korea Department of Diagnostic Radiology Kwandong University Myongji Hospital Goyang Republic of Korea Department of Diagnostic Radiology Soonchunhyang University Bucheon Hospital Bucheon Republic of Korea Department of Diagnostic Radiology Soonchunhyang University Cheonan Hospital Cheonan Republic of Korea

CT scan is regarded as the imaging modality of choice in patients with pancreaticobiliary ductal abnormalities. However, the axial orientation of the CT images provides only limited anatomical view of pancreaticobiliary ductal abnormalities. The technological advances of multi-de-tector row CT and three-dimensional image processing in workstations allows rapid image acquisition and a short postprocessing time. In particular, multiplanar reforma-tions (MPR) and minimum intensity projections (MinIP) offer rapid and accurate images of the anatomy and ab-normalities of the pancreaticobiliary tree. Moreover, MPR and MinIP help determine the relationship between the pancreaticobiliary ductal anatomy and the surrounding structures. This pictorial review illustrates the wide spec-trum of images obtained by the MPR and MinIP of the anomalies and disorders of the pancreaticobiliary tree.

关键词： Multi-detector CT Bile Ducts Biliary System Pancreas Computer Applications-3D

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Relationship between physicochemical characteristics of Korean wheat flour and quality attributes of steamed bread

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Journal of Integrative Agriculture 2019年第11期18卷 2652-2663页

作者： Ji-Eun Kim Byung-Kee Baik Chul Soo Park Jae-Han Son Chang-Hyun Choi Youngjun Mo Tae-Il Park Chon-Sik Kang seong-woo Cho Department of Crop Science&Biotechnology Chonbuk National UniversityJeonju 54896Korea USDA-ARS CSWQRU Soft Wheat Quality LaboratoryWoosterOH 44691USA National Institute of Crop Science Rural Development AdministrationWanju 55365Korea

The purpose of this study is to identify major factors affecting the manufacture and quality of steamed bread,consumed in Southeast Asia including China,Japan,and ***,flours of 11 Korean wheat cultivars were used to evaluate quality attributes of two different styles of steamed bread,Korean style steamed bread(KSSB)and northern-style Chinese steamed bread(NSCSB).KSSB prepared more ingredients and higher optimum water absorption of dough than NSCSB because Korean consumers prefer white and glossy surface and soft *** showed lower height,larger diameter and volume of steamed bread,higher stress relaxation,and softer texture of crumb than *** correlation between flour characteristics and quality of steamed bread was different in KSSB and *** 90%of variability in the height and volume of KSSB could be predicted from protein content,mixing tolerance of Mixograph,average particle size of flour,final viscosity and solvent retention *** content and quality parameters also could explain the variation of steamed bread height in *** wheat carrying Glu-A3c allele produced higher volume of steamed bread(704.7 mL)than Glu-A3d allele(645.8 mL)in KSSB,although there was no significant difference in volume of NSCSB by glutenin ***-D1d and Glu-A3c alleles had softer texture of crumb than Glu-D1f and Glu-A3d alleles in KSSB,Glu-B3i allele also showed lower hardness of crumb than their counterpart allele in *** wheat showed higher height and volume of steamed bread,and lower stress relaxation and hardness of crumb than soft wheat in KSSB.

关键词： steamed bread quality wheat flour evaluation

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Endoscopic resection of co-existing severe dysplasia and a small esophageal leiomyoma

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World Journal of Gastroenterology 2013年第1期19卷 137-140页

作者： Sun Young Ahn seong woo Jeon Division of Gastroenterology and Hepatology Department of Internal MedicineKyungpook National University HospitalDaegu 700-721South Korea

Leiomyoma is the most common benign mesenchymal tumor of the esophagus.A small leiomyoma covered with endoscopically normal mucosa has a characteristic endoscopic ultrasonographic appearance,slow growth rate,and negligible risk of malignant transformation;therefore the histology does not need to be *** tumors such as an epithelial tumor and small subepithelial tumor in the upper gastrointestinal tract are *** describe a case with a coexisting small leiomyoma and severe dysplasia in the esophagus which were completely resected by endoscopic mucosal resection.

关键词： Synchronous tumor Leiomyoma Dysplasia

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Neuroprotective Effect of Chunghyuldan(Qing Xue Dan)on Hypoxia-Reoxygenation Induced Damage of Neuroblastoma 2a Cell Lines

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Chinese Journal of Integrative Medicine 2013年第12期19卷 940-944页

作者： Chang-Nam Ko In-Seo Park seong-Uk Park woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chulhun Kang Ki-Ho Cho Department of Cardiology and Neurology Diseases College of Korean MedicineKyung Hee University Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University

Objectives： Chunghyuldan （CHD）, a combinatorial drug that has anti-hyperlipidemic and anti inflammatory activities, has been shown to reduce infarct volume in a focal ischemia-reperfusion rat model. To explore the molecular basis of CHD＇s neuroprotective effect, we examined whether CHD shows a cell-protective activity and has a regulatory effect on Bax and/or B-cell leukemia/lymphoma 2 （Bcl-2） expression in mouse neuroblastoma 2a （N2a） cells subjected to hypoxia-reoxygenation （H/R）. Methods： In order to evaluate the effects of CHD on the cytotoxicity induced from hypoxia or H/R condition, lactate dehydrogenase （LDH） assay was performed. To explore whether the suppression of neural damage when pre-treated with CHD is associated with its anti-apoptotic effect, the CHD effect on the expression of Bcl-2 and Bax was analyzed by Western blotting analysis. Results： Cytotoxicity of N2a cell line was slightly increased in 42 h hypoxia condition and dramatically increased under the H/R condition. CHD treatment markedly decreased the cytotoxicity in both conditions （P〈0.01, P〈0.05）. H/R markedly increased the expression of the pro-apoptotic protein, Bax, but slightly increased the expression of the anti-apoptotic protein, Bcl-2, compared with the normoxia or hypoxia group. CHD significantly decreased Bax expression （P〈0.01） and slightly decreased Bcl-2 expression （P〉0.05）, resulted in a reduction of Bax/Bcl-2 ratio in N2a cells subjected to H/R. Conclusion： CHD has neuroprotective effect in N2a cells subjected to H/R, which might be derived at least in part from its ability to decrease the expression of the pro-apoptotic protein, Bax.

关键词： apoptosis stroke Chunghyuldan herbal

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Effect of the herbal medicine Danggui Sini plus Wuzhuyu Shengjiang Tang on erythrocyte deformability in normal subjects: a cross-over trial

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Journal of Traditional Chinese Medicine 2018年第5期38卷 769-772页

作者： JiEun Lee Seung-Yeon Cho seong-Uk Park woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ki-Ho Cho Seungwon Kwon Department of Cardiology and Neurology College of Korean Medicine Kyung Hee University

OBJECTIVE: To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang(DSWST) has any transient effect on erythrocyte deformability in normal ***: A total of 25 subjects [mean age(27.8± 1.8) years] was enrolled in this study. The study was designed as a cross-over trial in which the subjects took part for 2 d. On the first day, blood samples were collected at baseline and 1-2 h after administration of water, whereas, on the second day, instead of water, the subjects were administered DSWST after the baseline blood sampling. The blood samples collected at baseline and after the administration water or DSWST, were examined for erythrocyte ***: The elongation index increased significantly after 2 h(P = 0.009) compared to the baseline after DSWST intake. However, after water intake, there was no significant differenceobserved. When comparing the percent change of erythrocyte deformability between DSWST and water, we found that after 2 h of administration,DSWST improved erythrocyte deformability significantly compared to water(P < 0.001).CONCLUSION: DSWST has a transient effect on erythrocyte deformability in normal subjects.

关键词： Erythrocyte deformability Peptide elongation factors Raynaud disease Coldness of hands and feet Cross-over studies Danggui Sini plus Wuzhuyu Shengjiang Tang

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Uhwang Chungsim Won Decreases Blood Oxygen Level-Dependent fMRI Signal Response to A Motor Stimulation Task

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Chinese Journal of Integrative Medicine 2015年第7期21卷 493-499页

作者： woo-Sang Jung Jong-Man Ryu Young-Jee Kim seong-Uk Park Geon-Ho Jahng Jung-Mi Park Sang-Kwan Moon Chang-Nam Ko Ki-Ho Cho Department of Cardiovascular&Neurologic Diseases(Stroke Center) College of Oriental MedicineKyung Hee University Department of Radiology College of MedicineKyung Hee University

Objectives： TO evaluate the effect of Uhwang Chungsim Won [UC, Niuhuang Qingxin Pill （牛黄清心丸] on the blood oxygen level-dependent （BOLD） functional magnetic resonance imaging （fMRI） signal response to a motor stimulation task using a hand grasping paradigm. Methods： Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC. Results： With the administration of UC, BOLD responses to the right hand motor task showed a decrease in both hemispheres including the right cerebellar culmen, right and left medial frontal gyrus, right parahippocampal gyrus, right and left sublobar insula, right and left posterior cingulate, left precuneus, and right precentral gyrus. Decreased BOLD responses to the left hand motor task were shown in the right lingual gyrus, right cerebellar culmen, left superior temporal gyrus, right and left middle frontal gyrus, and right precentral gyrus after UC administration. Increased BOLD responses to the left hand motor task were shown in the left and right posterior cingulate, while there was no increased response to the right hand motor task after UC administration. Conclusions： UC administration significantly decreased fMRI BOLD signal responses to hand grasping in most of the brain areas including the primary motor cortex, but it is not clear whether these decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to the cerebral vasodilatory effects of UC. Further studies using positron emission tomography or single photon emission computed tomography are needed to fully elucidate these findings.

关键词： Uhwang Chungsim Won Niuhuang Qingxin Pfll pharmacological fMRI cerebral blood flow

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Preoperative colonoscopy through the colonic stent in patients with colorectal cancer obstruction

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World Journal of Gastroenterology 2014年第30期20卷 10570-10576页

作者： Jin Su Kim Kang Moon Lee Sang woo Kim Eun Jung Kim Chul Hyun Lim seong Taek Oh Myung Gyu Choi Kyu Yong Choi Division of Gastroenterology Department of Internal MedicineCatholic University of Korea College of MedicineSeoul 137-701South Korea Department of surgery Catholic University of Korea College of MedicineSeoul 137-701South Korea

AIM: To evaluate the feasibility of a preoperative colonoscopy through a self-expendable metallic stent (SEMS) and to identify the factors that affect complete colonoscopy.

关键词： Colon cancer Stent Preoperative colonoscopy Complete colonoscopy

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Brain Activity Associated with Memory and Cognitive Function During Jaw-Tapping Movement in Healthy Subjects Using Functional Magnetic Resonance Imaging*

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Chinese Journal of Integrative Medicine 2013年第6期19卷 409-417页

作者： Seung-Yeon Cho Ae-Sook Shin Byung-Jo Na Geon-Ho Jahng seong-Uk Park woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Department of Cardiovascular and Neurological Diseases College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Internal Medicine Kang-Nam Korean HospitalKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongSchool of MedicineKyuna Hee UniversitySeoulKorea

Objective： TO determine whether jaw-tapping movement, a classically described as an indication of personal well-being and mental health, stimulates the memory and the cognitive regions of the brain and is associated with improved brain performance. Methods： Twelve healthy right-handed female subjects completed the study. Each patient performed a jaw-tapping task and an n-back task during functional magnetic resonance imaging （fMRI）. The subjects were trained to carry out the jaw-tapping movement at home twice a day for 4 weeks. The fMRI was repeated when they returned. Results： During the first and second jaw-tapping session, both sides of precentral gyrus and the right middle frontal gyrus （BA 6） were activated. And during the second session of the jaw-tapping task, parts of frontal lobe and temporal lobe related to memory function were more activated. In addition, the total percent task accuracy in n-beck task significantly increased after 4 weeks of jaw- tapping movement. After jaw-tapping training for 4 weeks, brain areas related to memory showed significantly increased blood oxygen level dependent signals. Conclusion： Jaw-tapping movement might be a useful exercise for stimulating the memory and cognitive regions of the brain.

关键词： Jaw-tapping movement functional magnetic resonance imaging memory cognitive function dementia

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