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Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms

Journal of Environmental Sciences 2015年第9期27卷 115-127页

作者： jin Wuk Lee Eun-Ji Won Sheikh Raisuddin Jae-seong Lee Department of Biological Science College of Science Sungkyunkwan University Department of Medical Elementology and Toxicology Hamdard University

In environmental risk assessments（ERA）, biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes（e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function）. To mitigate these limitations, the concept of adverse outcome pathways（AOPs） was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event（MIE） to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo（a）pyrene（Ba P）, silver nanoparticles（Ag NPs）, and selenium（Se）. Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population ***, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural *** development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem.

关键词： Adverse outcome pathway Biomarker Omics Environmental risk assessment Aquatic organisms Interspecific difference

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Actinomycosis of the appendix mimicking appendiceal tumor:A case report

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World Journal of Gastroenterology 2010年第3期16卷 395-397页

作者： Sang-Yun Lee Hee-jin Kwon jin-Han Cho Jong-Young Oh Kyung-jin Nam jin-Hwa Lee seong-Kuk Yoon Myong-jin Kang jin-Sook Jeong Department of Radiology Dong-A University Hospital Department of Pathology Dong-A University Hospital

Actinomycosis is an uncommon chronic infectious disease. Common sites of involvement include the cervicofacial, thoracic and abdominopelvic regions. In abdominopelvic actinomycosis, the ileocecal region, including the appendix, is the most commonly involved site. In some reports, limited appendiceal actinomycosis has revealed a thickened appendiceal wall with peri-appendiceal inflammation as acute appendicitis or perforated appendicitis. We experienced pathologically confirmed intraluminal limited appendiceal actinomycosis without peri-appendiceal infiltration. Here, we report the computed tomography and ultrasound findings.

关键词： Actinomyces Actinomycosis Appendiceal neoplasms Appendicitis

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Ultrasensitive and Highly Stretchable Multiple‑Crosslinked Ionic Hydrogel Sensors with Long‑Term Stability

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Nano-Micro Letters 2023年第4期15卷 85-96页

作者： jin‑Young Yu Seung Eon Moon Jeong Hun Kim seong Min Kang Department of Mechanical Engineering Chungnam National UniversityDaejeon 34134Korea Emerging Nano‑Materials Research Section Electronics and Telecommunications Research InstituteDaejeon 305‑700Republic of Korea

Flexible hydrogels are receiving significant attention for their application in wearable ***,most hydrogel materials exhibit weak and one-time adhesion,low sensitivity,ice crystallization,water evaporation,and poor self-recovery,thereby limiting their application as *** issues are only partly addressed in previous ***,a multiplecrosslinked poly(2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide-co-acrylamide)(P(SBMA-co-AAm))multifunctional hydrogel is prepared via a one-pot synthesis method to overcome the aforementioned ***,ions,glycerol,and 2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide are incorporated to reduce the freezing point and improve the moisture retention *** proposed hydrogel is superior to existing hydrogels because it exhibits good stretchability(a strain of 2900%),self-healing properties,and transparency through effective energy dissipation in its dynamic crosslinked ***,2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide as a zwitterion monomer results in an excellent gauge factor of 43.4 at strains of 1300-1600%by improving the ion transportability and achieving a strong adhesion of 20.9 kPa owing to the dipole-dipole *** proposed hydrogel is promising for next-generation biomedical applications,such as soft robots,and health monitoring.

关键词： Hydrogel sensors Biocompatibility Multifunction High-sensitivity sensors Multiple-crosslink association

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Assembly of charged aerosols on non-conducting substrates via ion-assisted aerosol lithography （IAAL）

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Particuology 2017年第4期15卷 17-23页

作者： Seunghyon Kang Wooik Jung Dae seong Kim Sei jin Park Mansoo Choi School of Mechanical and Aerospace Engineering Seoul National University Seou 108826 Republic of Korea Global Frontier Center for Multiscale Energy Systems Seoul National University Seou108826 Republic of Korea

The development of ion-assisted aerosol lithography （IAAL） has enabled fabrication of complex three- dimensional nanoparticle （NP） structures on conducting substrates. In this work, the applicability of the IAAL technique was investigated on non-conducting substrates. The NP structure growth process on a non-conducting substrate was found to self-terminate and the structures subsequently repel incoming charged NPs and scatter them away. Electric field calculations supported the experimental findings and confirmed that the electric field distortions owing to charge build-up within the structures prevented additional NP deposition thereon. To regulate the charge build-up without compromising the number of NPs available for assembly, a corona discharger and an ion trap were implemented. By varying the number of ions available in the assembly process, an optimum level of ion injection was found that allowed for a prolonged （〉120 rain） assembly of NP structures on non-conducting substrates without the unwanted scattering of NPs.

关键词： Nanoparticle assembly Non-conducting substrate Ion-assisted aerosol lithography Ion trap

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Atomic Diffusion in Cu/Si （111） and Cu/SiO2/Si （111） Systems by Neutral Cluster Beam Deposition

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Chinese Physics Letters 2008年第4期25卷 1400-1402页

作者：曹博李公平陈熙萌 CHO seong—jin KIM Hee School of Nuclear Science and Technology Lanzhou University Lanzhou 730000 Department of physics Kyungsung University Pusan 608-736 South Korea

The Cu films are deposited on two kinds of p-type Si （111） substrates by ionized duster beam （ICB） technique. The interface reaction and atomic diffusion of Cu/Si （111） and Cu/SiO2/Si （111） systems are studied at different annealing temperatures by x-ray diffraction （XRD） and Rutherford backscattering spectrometry （RBS）. Some significant results are obtained： For the Cu/Si （111） samples prepared by neutral dusters, the interdiffusion of Cu and Si atoms occurs when annealed at 230℃. The diffusion coefficients of the samples annealed at 230℃ and 500℃ are 8.5 ×10^-15 cm^2.s^-1 and 3.0 ×10^-14 cm^2.s^-1, respectively. The formation of the copper-silicide phase is observed by XRD, and its intensity becomes stronger with the increase of annealing temperature. For the Cu/SiO2//Si （111） samples prepared by neutral dusters, the interdiffusion of Cu and Si atoms occurs and copper silicides are formed when annealed at 450℃. The diffusion coefficients of Cu in Si are calculated to be 6.0 ×10^-16 cm^2.s^-1 at 450℃, due to the fact that the existence of the SiO2 layer suppresses the interdiffusion of Cu and Si.

关键词： supernova explosion proto-neutron star shock wave

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Another new variant of Bouveret's syndrome

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World Journal of Gastroenterology 2009年第3期15卷 378-379页

作者： seong-Heum Park Sang-Woo Lee Tae-jin Song Department of Surgery Korea UniversityAnsan Hospital516Gojan-dongDanwon-guAnsanGyeonggi-do 425-707South Korea Department of Gastroenterology Korea UniversityAnsan Hospital516Gojan-dongDanwon-guAnsanGyeonggi-do 425-707South Korea

Although Bouveret's syndrome,*** outlet obstruction by a large gallstone impacted in the proximal duodenum secondary to a cholecystoduodenal fistula,is rare,its pathogenesis and clinical features are well ***,existence of variant forms of the syndrome are not well known,and as far as we know,only two cases of variant Bouveret's syndrome have been described in the English-language *** present a case of another new variant of Bouveret's syndrome in a 54-year-old Korean woman.

关键词： Duodenal obstruction Biliary fistula Gallstones

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A Regional Economy's Resistance to the COVID-19 Shock: Sales Revenues of Micro-, Small-, and Medium-Sized Enterprises in South Korea

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International Journal of Disaster Risk Science 2022年第2期13卷 190-198页

作者： seong-jin Lee Joong-Hoo Park Seung-Min Cha Donghyun Kim Department of Public Policy and Management.Pusan National University Busan 46241South Korea Department of Urban Planning and Engineering Pusan National UniversityBusan 46241South Korea

The coronavirus disease 2019(COVID-19) is a global pandemic that has heavily impacted not only the health sector, but also the economic sector in *** countries have projected a negative economic impact, and the effect on micro-, small-, and medium-sized enterprises(MSMEs) is predicted to be significantly *** study estimated the regional resistance of MSME sales revenues and identified the regional economic factors that affect resistance by analyzing South Korea, a country with one of the lowest economic impact projections from COVID-19. Resistance was estimated by comparing sales revenues and changes in resistance observed during the early COVID-19 period to those recorded in the same weeks(weeks 6 to 9) of 2019. The factors that affect regional resistance were determined by conducting robust regression and spatial regression analyses. The results show that the number of confirmed COVID-19 cases, a direct risk factor, is negatively related to regional resilience, while diversity is positively related to regional resistance. To improve the regional resistance against uncertain events, this study recommends increased diversity among regional industrial structures to reduce the duration of the early shock of an unexpected adverse event.

关键词： COVID-19 Economic resistance MSMEs South Korea

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Adenoma arising from xanthoma in the transverse colon:a case report

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Gastroenterology Report 2023年第1期11卷 542-544页

作者： Yu jin Jung Jun Lee seong Jung Kim Ran Hong Department of Internal Medicine College of MedicineChosun UniversityGwangjuRepublic of Korea Department of Pathology College of MedicineChosun UniversityGwangjuRepublic of Korea

Introduction A xanthoma is a benign lesion consisting of foamy cells characterized by a highly vacuolated *** lesions can develop anywhere in the gastrointestinal tract but most often occur in the stomach,duodenum,or esophagus and very rarely in the colon[1].Gastric xanthoma shows a high incidence in gastric cancer patients and is reportedly an independent predictor of gastric cancer[2].Although adenomas associated with colorectal xanthoma were first reported in 1997,clear evidence supporting an association between xanthoma and colorectal adenoma or cancer is lacking[3].Furthermore,the association between adenoma and lipid deposits is unproven,and although adenoma has been found adjacent to or around xanthoma,this is more likely coincidental.

关键词： colon stomach adenoma

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Connection between inflammation and carcinogenesis in gastrointestinal tract: Focus on TGF-β signaling

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World Journal of Gastroenterology 2010年第17期16卷 2080-2093页

作者： Suntaek Hong Ho-Jae Lee seong jin Kim Ki-Baik Hahm Laboratory of Cancer Cell Biology Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Chemoprevention Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Cell Regulation and Carcinogenesis Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Translational Medicine Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Department of Gastroenterology Gachon Graduate School of MedicineIncheon 406-840South Korea

Inflammation is a primary defense process against various extracellular stimuli,such as viruses,pathogens,foods,and environmental *** cells respond to stimuli for short periods of time,it results in acute or physiological ***,if the stimulation is sustained for longer time or a pathological state occurs,it is known as chronic or pathological *** studies have shown that tumorigenesis in the gastrointestinal (GI) tract is closely associated with chronic inflammation,for which abnormal cellular alterations that accompany chronic inflammation such as oxidative stresses,gene mutations,epigenetic changes,and inflammatory cytokines,are shared with carcinogenic processes,which forms a critical cross-link between chronic inflammation and *** growth factor (TGF)-β is a multi-potent cytokine that plays an important role in regulation of cell growth,apoptosis and *** importantly,TGF-β is a strong anti-inflammatory cytokine that regulates the development of effector ***-β has a suppressive effect on carcinogenesis under normal conditions by inhibiting abnormal cell growth,but on the other hand,many GI cancers originate from uncontrolled cell growth and differentiation by genetic loss of TGF-β signaling molecules or perturbation of TGF-β *** a tumor has developed,TGF-β exerts a promoting effect on the tumor itself and stromal cells to enhance cell growth,alter the responsiveness of tumor cells to stimulate invasion and metastasis,and inhibited immune ***,novel development of therapeutic agents to inhibit TGF-β-induced progression of tumor and to retain its growth inhibitory activities,in addition to anti-inflammatory actions,could be useful in *** this review,we discuss the role of TGF-β in inflammation and carcinogenesis of the GI tract related to abnormal TGF-β signaling.

关键词： Inflammation Carcinogenesis Transforming growth factor-β Gastrointestinal tract

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Synthesis and characterization of metallic Pd embedded TiO_2 nanoparticles by reverse micelle and sol-gel processing

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中国有色金属学会会刊：英文版 2009年第B9期19卷 96-99页

作者： Jeoung-Ho jin Min-Cheol CHU seong-Jai CHO Dong-Sik BAE School of Nano & Advanced Materials Science Engineering Changwon National University Division of Industrial Metrology Korea Research Institute of Standards and Science

Metallic Pd clusters were embedded into TiO2 nanoparticles that were synthesized within reverse micelle via a solution reduction of Pd(NO3)2 by hydrazine hydrate. The size of the particles can be controlled by manipulating the relative rates of the hydrolysis and condensation reactions of titanium tetra-isopropoxide within the micro-emulsion. The spherical equivalent size for the Pd clusters formed in TiO2 matrix was estimated to be around (3±1) nm. The presence of Pd in the matrix was demonstrated by EDS spectroscopy. The effects of synthesis parameters, such as the concentration of Pd solution, the molar ratio of water to TIP, and the molar ratio of water to surfactant, were discussed.

关键词： TiO2纳米粒子金属钯反胶束溶胶凝胶法二氧化钛纳米粒子嵌入合成表征

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