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Journal of Molecular Cell Biology 2018年第3期10卷 180-194页

作者： Daebeom Park Ho-Sung Lee Jun Hyuk Kang seon-Myeong kim Jeong-Ryeol Gong Kwang-Hyun Cho Laboratory for Systems Biology and Bio-inspired Engineering Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Graduate School of Medical Science and Engineering KAIST Daejeon 34141 Republic of Korea

Apoptosis and hypertrophy of cardiomyocytes are the primary causes of heart failure （HF）, a global leading cause of death, and are regulated through the complicated intracellular signaling network, limiting the development of effective treatments due to its complexity. To identify effective therapeutic strategies for HF at a system level, we develop a large-scale comprehensive mathematical model of the cardiac signaling network by integrating all available experimental evidence. Attractor landscape analysis of the network model identifies distinct sets of control nodes that effectively suppress apoptosis and hypertrophy of cardiomyocytes under ischemic or pressure overload-induced HF, the two major types of HF. Intriguingly, our system-level analysis suggests that intervention of these control nodes may increase the efficacy of clinical drugs for HF and, of most importance, different combinations of control nodes are suggested as potentially effective candidate drug targets depending on the types of HF. Our study provides a systematic way of developing mechanism-based therapeutic strategies for HF.

关键词： heart failure mathematical modeling cardiac signaling network systems analysis disease mechanism mechanism-based therapeutic strategy systems biology

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation

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Cellular & Molecular Immunology 2017年第9期14卷 748-757页

作者： Beom K Choi Do Y Lee Don G Lee Young H kim seon-Hee kim Ho S Oh Chungyong Han Byoung S Kwon Cancer Immunology Branch Division of Cancer BiologyNational Cancer CenterGoyangGyeonggi 10408Korea Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752Korea Immune Cell Production Unit Program for Immunotherapeutic ResearchNational Cancer CenterGyeonggi 10408Korea Eutilex Catholic University School of MedicineSeoul 06591Korea Department of Medicine Tulane University Health Sciences CenterNew OrleansLA 70112USA

4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T *** these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid *** found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and *** with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid ***-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty *** also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB *** increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,*** conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.

关键词： AMPK CD8^(+)T cells 4-1BB(CD137) LKB1 metabolism

Ileal polypoid lymphangiectasia bleeding diagnosed and treated by double balloon enteroscopy

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World Journal of Gastroenterology 2013年第45期19卷 8440-8444页

作者： Min seon Park Beom Jae Lee Dae Hoe Gu Jeung-Hui Pyo Kyeong Jin kim Yun Ho Lee Moon Kyung Joo Jong-Jae Park Jae seon kim Young-Tae Bak Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospitial Seoul 152-703 South Korea

Intestinal lymphangiectasia is a rare disease characterized by focal or diffuse dilated enteric lymphatics with impaired lymph *** causes protein-losing enteropathy and may lead to gastrointestinal ***,lymphangiectasia presents as whitish spots or *** our knowledge,small bowel bleeding resulting from polypoid intestinal lymphangiectasia has not been ***,we report a rare case of active bleeding from the small bowel caused by polypoid lymphangiectasia with a review of the relevant *** 80-year-old woman was hospitalized for *** could not identify the source of *** colonoscopy showed fresh bloody material gushing from the small *** abdominal-pelvic contrast-enhanced computed tomography scan did not reveal any abnormal *** capsule endoscopy showed evidence of active and recent bleeding in the *** localize the bleeding site,we performed double balloon enteroscopy by the anal approach.A small,bleeding,polypoid lesion was found in the distal ileum and was successfully removed using endoscopic snare electrocautery.

关键词： Intestinal lymphangiectasia Small bowel bleeding Double balloon endoscopy Solitary ileal polypoid lesion Endoscopic polypectomy

Usefulness of CA 19–9 for pancreatic cancer screening in patients with new-onset diabetes

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Hepatobiliary & Pancreatic Diseases International 2018年第3期17卷 263-268页

作者： Jung Wan Choe Hyo Jung kim Jae seon kim Jaehyung Cha Moon Kyung Joo Beom Jae Lee Jong-Jae Park Young-Tae Bak Department of Internal Medicine Korea University College of MedicineSeoul 08308Korea Department of Biostatistics Korea University Medical CenterSeoul 08308Korea

Background： Generally, carbohydrate antigen 19–9 （CA 19–9） is not useful for screening pancreatic cancerin the asymptomatic general population. This study aimed to evaluate the utility of CA 19–9 level as a scre... 详细信息

关键词： Diabetes mellitus Pancreatic neoplasms Early detection of cancer Carbohydrate antigen 19-9 Bilirubin

Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress

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Animal Nutrition 2022年第4期11卷 87-101页

作者： Jun Sik Eom Da Som Park Sang Jin Lee Bon-Hee Gu Shin Ja Lee Sang-Suk Lee seon-Ho kim Byeong-Woo kim Sung Sill Lee Myunghoo kim Institute of Agriculture and Life Science Gyeongsang National UniversityJinju52828Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang50463Republic of Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang50463Republic of Korea University-Centered Labs Gyeongsang National UniversityJinju52828Republic of Korea Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon57922Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju52828Republic of Korea

Heat stress(HS)damages livestock by adversely affecting physiological and immunological ***,fundamental understanding of the metabolic and immunological mechanisms in animals under HS remains elusive,particularly in *** understand the changes on metabolic and immune responses in steers under HS condition,we performed RNA-sequencing and proton nuclear magnetic resonance spectroscopy-based metabolomics on HS-free(temperature humidity index[THI]value:64.92±0.56)and HS-exposed(THI value:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study clarifies the metabolic changes in 3 biofluids(rumen fluid,serum,and urine)and the immune responses observed in the peripheral blood mononuclear cells of HS-exposed *** integrated approach allowed the discovery of HS-sensitive metabolic and immunological *** metabolomic analysis indicated that HS-exposed steers showed potential HS biomarkers such as isocitrate,formate,creatine,and riboflavin(P<0.05).Among them,there were several integrative metabolic pathways between rumen fluid and ***,HS altered mRNA expression and immune-related signaling pathways.A meta-analysis revealed that HS decreased riboflavin metabolism and the expression of glyoxylate and dicarboxylate metabolism-related ***,metabolic pathways,such as the hypoxia-inducible factor-1 signaling pathway,were downregulated in immune cells by HS(P<0.05).These findings,along with the datasets of pathways and phenotypic differences as potential biomarkers in steers,can support more in-depth research to elucidate the interrelated metabolic and immunological *** would help suggest new strategies to ameliorate the effects of HS,including disease susceptibility and metabolic disorders,in Jersey steers.

关键词： Heat stress Jersey steer Metabolome Transcriptome Immunity Metabolism

Effect of intra-arterial infusion with triolein emulsion on rabbit liver

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World Journal of Gastroenterology 2014年第39期20卷 14442-14449页

作者： Yong-Woo kim Young Mi Park Sik Yoon Hak Jin kim Do Yoon Park Byung Mann Cho seon Hee Choi Department of Radiology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Pusan National University College of Medicine Yangsan 626-770 South Korea Department of Radiology Busan Paik Hospital Inje University Pusan 614-735 South Korea Department of Anatomy Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Radiology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Department of Pathology Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Preventive Medicine Pusan National University College of Medicine and Biomedical Research Institute Pusan 602-739 South Korea Pusan National University Postgraduate School Pusan National University Pusan 602-739 South Korea

AIM: To determine whether intra-arterial infusion of triolein emulsion has biochemical and histopathologic effect on rabbit liver.

关键词： Triolein Emulsions Hepatology Liver dysfunction Histopathology

Microstructure and compressive deformation of hypereutectic Al-Si-Fe based P/M alloys fabricated by spark plasma sintering

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Transactions of Nonferrous Metals Society of China 2014年第7期24卷 2346-2351页

作者： Jewoosoo kim Gwang-seon JANG Mok-Soon kim Jeong-Keun LEE Division of Materials Science and Engineering Inha University R&D Center Dong Yang Piston Co. Ltd

Al-Si-Fe based alloys are attractive light-weight structural materials for automotive engine components because of their high wear resistance, low density and low thermal expansion. Al-17Si 5Fe-2Cu-lMg-lNi-lZr alloys were produced in compact form by a spark plasma sintering （SPS） technique using gas atomized powders. The mean grain size of the compact was 530 nm, and fine equiaxed grains and uniformly distributed precipitates were observed in the compact. The compressive deformation behavior of the SPSed materials was examined at various temperatures and strain rates. All the true stress-true strain curves showed steady state flow after reaching peak stress. The peak stress decreased with increasing test temperature and decreasing strain rate. In the deformed specimens, the equiaxed grain morphology and the dislocation microstructure within the equiaxed grains were observed. These facts strongly indicated the occurrence of dynamic recrystallization during high temperature deformation of the present alloy.

关键词： Al-Si-Fe alloy powder metallurgy spark plasma sintering, microstructure deformation

Cytomegalovirus colitis induced segmental colonic hypoganglionosis in an immunocompetent patient: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5631-5636页

作者： Ban Seok kim seon-Young Park Dong Hyun kim Nah Ihm kim Jae Hyun Yoon Jae Kyun Ju Chang Hwan Park Hyun Soo kim Sung Kyu Choi Department of Gastroenterology Chonnam National University HospitalGwangju 501-757South Korea Department of Pathology Chonnam National University HospitalGwangju 501-757South Korea Department of Surgery Chonnam University HospitalGwangju 501-757South Korea

BACKGROUND Cytomegalovirus(CMV)colitis is usually seen in immunocompromised patients with risk factors such as human immunodeficiency virus infection,solid organ transplant,inflammatory bowel disease,or ***,many clinicians usually do not consider the possibility of CMV colitis in immunocompetent *** reported a rare case of segmental colonic hypoganglionosis associated with CMV colitis in an immunocompetent *** SUMMARY A 48-year-old woman with no underlying disease was admitted to our hospital for severe abdominal pain and *** tomography of the abdomen showed diffuse dilatation of the small intestine and the entire *** sigmoidoscopic findings and result of polymerase chain reaction(PCR)for CMV revealed the compatible findings of CMV colitis,the patient was treated with intravenous *** treatment,sigmoidoscopic findings and CMV PCR results *** the patient continued to suffered from *** months after the initial admission,patient visited the emergency department with severe abdominal pain and imaging revealed aggravation of fecal impaction and bowel *** performed subtotal colectomy to control patient’s *** examination of the resected specimen showed significantly reduced number of mature ganglion cells in the sigmoid colon compared to that in the proximal *** Our case demonstrates that CMV colitis can develop even in patients with no other underlying disease,and that CMV colitis can be one of the causes for developing colonic hypoganglionosis.

关键词： Colonic pseudo-obstruction Colitis Cytomegalovirus Ganglia Case report

A squamous metaplasia in a gastric ulcer scar of the antrum

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World Journal of Gastroenterology 2008年第8期14卷 1296-1298页

作者： Young-Seok Cho Jin-Soo kim Hyung-Keun kim Jeong-seon Ji Byung-Wook kim Hiun-Suk Chae Sok-Won Han Kyu-Yong Choi In-Sik Chung Department of Internal Medicine College of Medicine The Catholic University of Korea Uijeongbu St. Mary's Hospital Gyeonggi-do 480-717 Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Our Lady of Mercy Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Holy Family Hospital Gyeonggi-do Korea Department of Internal Medicine College of Medicine The Catholic University of Korea Kangnam St. Mary’s Hospital Seoul Korea

An 81-year-old man presented with epigastric pain and weight loss for one month. He had a past history of pulmonary tuberculosis, 10 years ago. We performed a gastroscopy, which showed a linear depressed whitish gastric ulcer scar (0.8 cm in length) in the posterior wall of the prepyloric antrum. The result of biopsy was reported as squamous epithelium. Immunohistochemical staining using an antibody to high molecular weight cytokeratin (HMC) revealed positive staining in the squamous epithelium. Two years later, the lesion was followed up. The lesion remained at same site endoscopically, but no squamous epithelium could be seen microscopically.

关键词： Squamous metaplasia Gastric ulcer scar High molecular weight cytokeratin

Primary signet ring cell carcinoma of the appendix:A rare case report and our 18-year experience

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World Journal of Gastroenterology 2008年第37期14卷 5763-5768页

作者： Yoon Ho Ko Chan-Kwon Jung Soon Nam Oh Tae Hee kim Hye Sung Won Jin Hyoung Kang,Hyung Jin kim, Won Kyung Kang, seong Taek Oh, Young seon Hong Jin Hyoung Kang Hyung Jin kim Won Kyung Kang seong Taek Oh Young seon Hong Departmentof Internal Medicine Kangnam St. Mary's hospital CatholicUniversity Seoul 137-701 South Korea Department of Hospital Pathology Kangnam St. Mary's hospital Catholic University Seoul137-70 l South Korea Department of Radiology Kangnam St. Mary'shospital Catholic University Seoul 137-701 South Korea Department of General Surgery Kangnam St. Mary's hospitalCatholic University Seoul 137-701 South Korea

Primary adenocarcinoma of the appendix is a rare malignancy that constitutes 〈 0.5% of all gastrointestinal neoplasms. Moreover, primary signet ring cell carc noma of the appendix is an exceedingly rare entity. We have encountered 15 cases of primary appendiceal cancer among 3389 patients who underwent appen- dectomy over the past 18 years. In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastases and unresectable peritoneal dissemination occurring in a 67-year-old female patient. She underwent ap- pendectomy and bilateral salpingo-oophorectomy with a laparoscopy procedure. She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin （FOIFOX-4）. The patient currently is well without progression of disease 12 mo after beginning chemotherapy.

关键词： Appendiceal neoplasms Carcinoma Signet ring cell Chemotherapy