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CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye seon kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee Brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

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Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study

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World Journal of Gastroenterology 2022年第17期28卷 1845-1859页

作者： seong Ji Choi Hong Sik Lee Jiyeong kim Jung Wan Choe Jae Min Lee Jong Jin Hyun Jai Hoon Yoon Hyo Jung kim Jae seon kim Ho Soon Choi Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841South Korea Lab of Biostatistical Consulting and Research Medical Research Collaborating CenterIndustry-University Cooperation FoundationHanyang UniversitySeoul 04763South Korea

BACKGROUND Ampullary adenoma is a rare premalignant lesion,but its incidence is *** papillectomy has become the first treatment of choice for ampullary adenomas due to its safety and effectiveness,thereby replacing surgical ***,recurrence rates and adverse events after endoscopic papillectomy were reported in up to 30%of *** To review the long-term outcomes of endoscopic papillectomy and investigate the factors that affect these *** We retrospectively analyzed the data of patients who underwent endoscopic papillectomy for ampullary adenoma at five tertiary hospitals between 2013 and *** evaluated clinical outcomes and their risk *** definitions of outcomes were as follow:(1)curative resection:complete endoscopic resection without recurrence;(2)endoscopic success:treatment of ampullary adenoma with endoscopy without surgical intervention;(3)early recurrence:reconfirmed adenoma at the first endoscopic surveillance;and(4)late recurrence:reconfirmed adenoma after the first endoscopic *** A total of 106 patients were included for *** the included patients,81(76.4%)underwent curative resection,99(93.4%)had endoscopic success,showing that most patients with noncurative resection were successfully managed with *** patients(15.1%)had piecemeal resection,22 patients(20.8%)had shown positive/uncertain resection margin,11 patients(16.1%)had an early recurrence,13 patients(10.4%)had a late recurrence,and 6 patients(5.7%)had a *** multivariate analysis,a positive/uncertain margin[Odds ratio(OR)=4.023,P=0.048]and piecemeal resection(OR=6.610,P=0.005)were significant risk factors for early and late recurrence,*** resection was also a significant risk factor for non-curative resection(OR=5.424,P=0.007).Twenty-six patients experienced adverse events(24.5%).CONCLUSION Endoscopic papillectomy is a safe and effective treatment for ampullary ***

关键词： Endoscopic papillectomy Ampullary adenoma Clinical outcome Recurrence Adverse event

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Microstructural evolution and mechanical properties of binary Mg-xBi(x=2,5,and 8 wt%)alloys

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Journal of Magnesium and Alloys 2021年第3期9卷 983-994页

作者： Hui Yu Shaoda Fan Shuaiju Meng Jae Ok Choi Zhongjie Li Yohan Go Young Min kim Weimin Zhao Bong Sun You Kwang seon Shin School of Materials Science and Engineering Hebei University of TechnologyXiping Road 5340Tianjin 300130China

The microstructures and mechanical properties of Mg-x Bi(x=2,5,and 8 wt%)were investigated compared with pure *** ascast Mg-Bi billets consist of dendriticα-Mg grain matrix,divorced eutectic Mg_(3)Bi_(2) phase and secondary precipitated Mg_(3)Bi_(2) *** homogenization,secondary precipitated Mg_(3)Bi_(2) particles were all dissolved into the matrix,while most of the divorced eutectic Mg_(3)Bi_(2) intermetallic compounds *** the as-extruded samples exhibit fully dynamic recrystallization(DRX)and the average grain size decreases and the amount of nano-scale Mg_(3)Bi_(2) precipitates increases with increasing Bi ***,Bi alloying has little influence on the texture of the as-extruded pure Mg,with all the samples showing typical basal *** the results of grain refinement and precipitation hardening,the strengths of the as-extruded samples increase under both tensile and compressive ***,the yield asymmetry significantly decreases with Bi ***,all the as-extruded samples represent similar ductility under compression,while the tensile elongation first increases and then decreases with more Bi *** as-extruded Mg-5Bi alloy demonstrates good combination of strength and ***,Mg-8Bi alloy displays lower tensile ductility than that of Mg-5Bi alloy due to the presence of abundant undissolved coarse Mg_(3)Bi_(2) particles,which act as cracking sources during tensile ***,the strain hardening rate,strain hardening exponent n,and hardening capacity Hc are greatly reduced by Bi addition,mainly owing to the enhanced synergy effects of grain refinement and numerous Mg_(3)Bi_(2) precipitates.

关键词： Mg-Bi Mechanical properties Microstructure Strain hardening

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Seroprevalence of anti-HAV among patients with chronic viral liver disease

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World Journal of Gastroenterology 2011年第2期17卷 236-241页

作者： Hyun Chin Cho Seung Woon Paik Yu Jin kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung Chul Yoo Hee Jung Son seon Woo kim Division of Gastroenterology Samsung Medical CenterSungkyunkwan University School of Medicine Division of Gastroenterology Center for Health PromotionSamsung Medical CenterSungkyunkwan University School of Medicine Biostatics Team Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in *** also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December ***:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health *** anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver *** anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of *** analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus.

关键词： Chronic hepatitis B Chronic hepatitis C Hepatitis A virus Korea Seroprevalence

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Impact of statin usage patterns on outcomes after percutaneous coronary in-tervention in acute myocardial infarction：Korea Working Group on Myocar-dial Infarction registry （KorMI） study

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Journal of Geriatric Cardiology 2014年第2期11卷 93-99页

作者： Chan-Hee Lee Sang-Hee Lee Jong-seon Park Young-Jo kim Kee-Sik kim Shung-Chull Chae Hyo-Soo kim Dong-Ju Choi Myeong-Chan Cho Seung-Woon Rha Myung-Ho Jeong Department of Cardiology Yeungnam University Hospital 170 Hyeonchung-ro Nam-gu Daegu 705-717 South Korea Department of Internal Medicine Daegu Catholic University Hospital 33 Duryugongwon-ro 17-gil Nam-gu Daegu 705-718 South Korea Department of Internal Medicine Kyungpook National University Hospital 130 Dongdeok-ro Jung-gu Daegu 700-721 South Korea Department of Internal Medicine Seoul National University Hospital 101 Daehak-ro Jongno-gu Seoul 110-744 South Korea Department of Internal Medicine Seoul National University Bundang Hospital 82 Gumi-ro 173-gil Bundang-gu Seongnam 463-707 South Korea Department of Internal Medicine Chungbuk National University Hospital 776 1sunhwan-ro Heungdeok-gu Cheongju 361-711 South Korea Department of Internal Medicine Korea University Guro Hospital 148 Gurodong-ro Guro-gu Seoul 152-703 South Korea Department of Internal Medicine Chonnam National University Hospital 42 Jebong-ro Dong-gu Gwangju 501-757 South Korea

Background The benefit of statin use after acute ST-segment elevation myocardial infarction （STEMI） has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention （PCI）. Methods This analysis of the Korea Working Group on Myocardial Infarction registry （KorMI） study included 3,584 STEMI patients （mean age, 63 ±13 years;male, 2,684, 74.9%） undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events （MACE：all-cause death, recurrent MI, and target lesion revascularization） were compared among patients grouped according to statin therapy timing：I, both during and after hospitalization （n=2,653, 74%）;II, only during hospita-lization （n=309, 8.6%）;III, only after discharge （n=157, 4.4%）;and IV, no statin therapy （n=465, 13%）. Mean follow-up duration was 234 ± 113 days. Results Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups Ⅲ and Ⅳ had the highest MACE rates （2.3%, 3.9%, 5.1%, and 4.9%for groups I-IV, respectively, P=0.004）. After adjusting for confounders, groups Ⅱ-Ⅳ had a higher MACE risk than group Ⅰ [hazard ratio （HR）：3.20, 95%confidence interval （95%CI）：1.31-7.86, P=0.011;HR：3.84, 95%CI：1.47-10.02, P=0.006;and HR：3.17, 95%CI：1.59-6.40, P=0.001;respectively]. Conclusions This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical prac-tice.

关键词： Statins Acute myocardial infarction Treatment omcome

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计算超导螺线管磁体中电磁应力的解析方法

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Acta Mechanica Sinica 2024年第4期40卷 4-20页

作者： Jeonghwan Park Kibum Choi Yufan Yan Jaemin kim Seungyong hahn Department of Electrical and Computer Engineering Seoul National UniversitySeoul08826Republic of Korea Applied Superconductivity Center and Electric Power Institute Seoul National UniversitySeoul08826Republic of Korea

在高场磁体中,压缩磁径向应力比拉伸应力更受青睐,原因是它能降低磁体绕组内的整体峰值磁应力.这对于无绝缘高温超导(NI HTS)磁体尤为重要,因为压缩径向应力能够产生良好的匝间接触,这对于无绝缘高温超导线圈中的电流共享以及随之而来... 详细信息

在高场磁体中,压缩磁径向应力比拉伸应力更受青睐,原因是它能降低磁体绕组内的整体峰值磁应力.这对于无绝缘高温超导(NI HTS)磁体尤为重要,因为压缩径向应力能够产生良好的匝间接触,这对于无绝缘高温超导线圈中的电流共享以及随之而来的自保护行为至关重要.根据关键磁体设计参数(如目标中心场、背景磁场、内外绕组直径和外部径向堆叠),我们给出了可以从解析上确定高场超导磁体具有压缩径向应力的电磁-力学条件.本文提出的方法可以识别干绕线圈中径向匝间接触行为的3种不同模式:(1)完全分离;(2)完全接触;以及(3)混合模式(即部分分离和接触).文章随后提出一种使用完全压缩径向应力电磁-力学条件来计算干绕线圈中应力分布的解析方法.并通过有限元分析示例验证了解析方法与数值方法的良好一致性.文章结果可以帮助磁体工程师在早期设计阶段更好地概览高场超导磁体的电磁-力学行为.

关键词：高温超导背景磁场径向应力力学条件拉伸应力匝间接触行为混合模式

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Optimal postoperative surveillance strategies for stage III colorectal cancer

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1012-1024页

作者： Min Young Park In Ja Park Hyo seon Ryu Jay Jung Minsung kim Seok-Byung Lim Chang Sik Yu Jin Cheon kim Colon and Rectal Surgery Asan Medical CenterSeoul 05505South Korea Colon and Rectal Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Optimal surveillance strategies for stage III colorectal cancer(CRC)are lacking,and intensive surveillance has not conferred a significant survival *** To examine the association between surveillance intensity and recurrence and survival rates in patients with stage III *** Data from patients with pathologic stage III CRC who underwent radical surgery between January 2005 and December 2012 at Asan Medical Center,Seoul,Korea were retrospectively *** consisted of abdominopelvic computed tomography(CT)every 6 mo and chest CT annually during the 5 year follow-up period,resulting in an average of three imaging studies per *** who underwent more than the average number of imaging studies annually were categorized as high intensity(HI),and those with less than the average were categorized as low intensity(LI).RESULTS Among 1888 patients,864(45.8%)were in HI ***,sex,and location were not different between *** group had more advanced T and N stage(P=0.002,0.010,each).Perineural invasion(PNI)was more identified in the HI group(21.4%vs 30.3%,P<0.001).The mean overall survival(OS)and recurrence-free interval(RFI)was longer in the LI group(P<0.001,each).Multivariate analysis indicated that surveillance intensity[odds ratio(OR)=1.999;95%confidence interval(CI):1.680–2.377;P<0.001],pathologic T stage(OR=1.596;95%CI:1.197–2.127;P=0.001),PNI(OR=1.431;95%CI:1.192–1.719;P<0.001),and circumferential resection margin(OR=1.565;95%CI:1.083–2.262;P=0.017)in rectal cancer were significantly associated with *** mean post-recurrence survival(PRS)was longer in patients who received curative resection(P<0.001).Curative resection rate of recurrence was not different between HI(29.3%)and LI(23.8%)groups(P=0.160).PRS did not differ according to surveillance intensity(P=0.802).CONCLUSION Frequent surveillance with CT scan do not improve OS in stage III CRC *** need to evaluate role of other surveillance method rather tha

关键词： Colorectal cancer Surveillance intensity Survival Recurrence

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Pinch Point Calculations and Its Implications on Robust Distillation Design

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Chinese Journal of Chemical Engineering 2011年第6期19卷 911-925页

作者： Daniel A. Beneke seon B. kim Andreas A. Linninger Laboratory for Product and Process Design Department of Chemical and Bio Engineering University of Illinois at Chicago Chicago IL 60607 USA Centre of Materials and Process Synthesis （COMPS） School of Process and Materials Engineering University of the Witwatersrand Johannesburg South Africa

Rising energy costs and growing environmental awareness motivate a critical revision of the design of distillation units. Systematic design techniques, such as the rectification body, column profile map, and temperature collocation methods, require exact knowledge of all pinch points in a particular system, because these stationary points delineate the possible composition trajectories realizable in separation columns. This paper demonstrates novel methods for rigorously determining all pinch points for the constant relative volatility, ideal and non-ideal systems. Constant relative volatility and ideal solution systems are transformed into one-dimensional polynomial and nonlinear functions, regardless of the number of the components. A deflation method is proposed to locate all zeros in ideal and non-ideal zeotropic problems. For more challenging non-ideal problems, a novel hybrid sequential niche algorithm is used to solve hard azeotropic problems successfully. Finally, the design implications of these pinch point locations are investigated to show how new separation configurations can be devised. Methodically the paper points out the use of rigorous pinch point computations in conjunction with continuous composition profiles for robust distillation design.

关键词： pinch point column profile map phase equilibrium model temperature collocation

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Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 619-625页

作者： Chan Sun Park Hee Seok Jeong Ki Bae kim Joung-Ho Han Hee Bok Chae Sei Jin Youn seon Mee Park Department of Internal Medicine Chungbuk National University College of Medicine

BACKGROUND： Acute cholangitis in old people is a cause of mortality and prolonged hospital stay. We evaluated the effects of methods and timing of biliary drainage on the outcomes of acute cholangitis in elderly and very elderly patients. METHODS： We analyzed 331 patients who were older than 75 years and were diagnosed with acute calculous cholangitis. They were admitted to our hospital from 2009 to 2014. Patients＇ demographics, severity grading, methods and timing of biliary drainage, mortality, and hospital stay were retrospectively obtained from medical records. Clinical parameters and outcomes were compared between elderly （75-80 years, n= 156） and very elderly （≥81 years, n=175） patients. We analyzed the effects of methods [none, endoscopic retrograde cholangio- pancreatography （ERCP）, percutaneous transhepatic biliary drainage, or failure] and timing （urgent or early） of biliary drainage on mortality and hospital stay in these patients. RESULTS： Acute cholangitis in older patients manifested as atypical symptoms characterized as infrequent Charcot＇s triad （4.2%） and comorbidity in one-third of the patients. Patients were graded as mild, moderate, and severe cholangitis in 104 （31.4%）, 175 （52.9%）, and 52 （15.7%）, respectively. Urgent bili-ary drainage （≤24 hours） was performed for 80.5% （247/307） of patients. Very elderly patients tended to have more severe grades and were treated with sequential procedures of transient hiliary drainage and stone removal at different sessions. Hospital stay was related to methods and timing of biliary drainage. Mortality was very low （1.5%） and not related to patient age but rather to the success or failure of biliary drainage and severity grading of the acute cholangitis. CONCLUSIONS： The methods and timing used for biliary drainage and severity of cholangitis are the major determinants of mortality and hospital stay in elderly and very elderly patients with acute cholangitis. Urgent successful ERCP is mandatory for favorable

关键词： acute cholangitis biliary drainage prognosis elderly very elderly

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Enzyme-treated date plum leave extract ameliorates atopic dermatitis-like skin lesion in hairless mice

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Asian Pacific Journal of Tropical Biomedicine 2020年第6期10卷 239-247页

作者： Byoung Ok Cho Jae Young Shin Ji-Su kim Denis Nchang Che Hyun Ju Kang Hyeon Jin Kang Hyeonhwa Oh Young-Soo kim seon Il Jang Research Institute Ato Q&A Co.LtdJeonju-siJeonbuk 54840Republic of Korea Department of Health Management Jeonju UniversityJeonju-siJeonbuk 55069Republic of Korea Department of Agro-Bio and Food Industry Jeonju UniversityJeonju-siJeonbuk 55069Republic of Korea Department of Food Science and Technology Chonbuk National UniversityJeonju-siJeonbuk 54896Republic of Korea

Objective: To evaluate the effect of different extracts of Diospyros lotus leaves in atopic dermatitis Methods: Diospyros lotus leaves were extracted in ethanol and treated with or without hydrochloric acid or α-rhamnosidase to obtain three different extracts-ethanol, acid-hydrolyzed, and enzyme-hydrolyzed leaf extracts of date plum. The myricitrin content in all samples was measured using HPLC analysis. In vitro antioxidant and anti-inflammatory activities of the extracts were determined by measuring DPPH radical scavenging activities and nitric oxide production in RAW264.7 cells, respectively. Sevenweek-old male hairless mice were used to evaluate the anti-atopic dermatitis effects of three extracts in vivo. Splenocytes and mast cells were used to further determine the anti-atopic dermatitis effects of the major compound in the ethanol leaf ***: Enzyme-hydrolyzed leaf extract showed significant in vitro antioxidant and anti-inflammatory activities, and attenuated atopic dermatitis-like skin symptoms and clinical signs more significantly than ethanol and acid-hydrolyzed leaf extracts in 1-fluoro-2,4-dinitrobenzene and house dust mite antigen-treated hairless mice. Enzyme-hydrolyzed leaf extract also suppressed the serum level of immunoglobulin E, interleukin(IL)-4, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, thymic stromal lymphopoietin, and thymus and activation-regulated chemokine in mice with atopic dermatitis. Furthermore, histological analysis revealed that enzymehydrolyzed leaf extract suppressed the increased epidermal thickness, dermal infiltration of inflammatory cells, and infiltration and degranulation of mast cells more markedly than the other two extracts in atopic dermatitis-like skin lesions. In addition, this extract effectively inhibited the production of IFN-γ, IL-4, and thymus and activation-regulated chemokine compared with the other two extracts in concanavalin A-stimulated splenocytes. Myricitrin, a major compound of enzyme-hy

关键词： Date plum leaves Enzyme Atopic dermatitis Inflammation Cytokine

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