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Association of low muscle strength with metabolic dysfunctionassociated fatty liver disease:A nationwide study

World Journal of Gastroenterology 2023年第45期29卷 5962-5973页

作者： Gyu Bae Lee Youn Huh Sang Hyun Lee Byoungduck Han Yang-Hyun kim Do-Hoon kim seon mee kim Youn seon Choi Kyung Hwan Cho Ga Eun Nam Department of Family Medicine Korea University College of MedicineSeoul 02841South Korea Department of Family Medicine Uijeongbu Eulji Medical CenterEULJI UniversityDaejeon 11759South Korea School of Electrical Engineering Korea UniversitySeoul 02841South Korea

BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAFLD in the general population in *** This nationwide representative cross-sectional study included 31649 individuals aged≥19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and *** ratios(ORs)and 95%confidence intervals(95%CIs)for MAFLD according to sex-specific quartiles of muscle strength,defined by relative handgrip strength,were calculated using multivariable logistic regression ***,multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with *** Of all the participants,29.3%had *** prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants,sexes,and age groups(P<0.001).A 1.92-fold(OR=1.92,95%CI:1.70–2.16)and 3.12-fold(OR=3.12,95%CI:2.64–3.69)higher risk of MAFLD was observed in the lowest quartile(Q1)group than in the other groups(Q2–Q4)and the highest quartile(Q4)group,*** ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner(P for trend<0.001).These associations persisted in both *** inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age,obesity,and diabetes *** patients with MAFLD,the odds of severe liver fibrosis were higher in Q1(OR=1.83,95%CI:1.25–2.69)than in other groups(Q2–Q4).CONCLUSION Among Korean adults,low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD.

关键词： Muscle strength Handgrip strength Metabolic dysfunction-associated fatty liver disease Liver fibrosis Korea National Health and Nutrition Examination Survey

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Effect of organic mineral supplementation in reducing oxidative stress in Holstein calves during short‑term heat stress and recovery conditions

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Journal of Animal Science and Biotechnology 2024年第2期15卷 812-825页

作者： A-Rang Son seon-Ho kim Mahfuzul Islam Michelle Miguel Ye Pyae Naing Sang-Suk Lee Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon 57922Korea Department of Microbiology and Parasitology Sher-e-Bangla Agricultural UniversityDhaka 1207Bangladesh

Background This study investigated the effects of inorganic and organic minerals on physiological responses,oxidative stress reduction,and rumen microbiota in Holstein bull calves(123.81±9.76 kg;5 months old)during short-term heat stress(HS)and recovery *** Holstein calves were randomly assigned to four treatment groups:no mineral supplementation(Con),inorganic minerals(IM),organic minerals(OM),and high-concentration organic minerals(HOM)and two thermal environments(HS and recovery)using 4×2 factorial arrangement in a crossover design of four periods of 35 *** were maintained in a temperature-controlled *** experimental period consisted of 14 d of HS,14 d of recovery condititon,and a 7-d washing *** Body temperature and respiration rate were higher in HS than in the recovery conditions(P0.05).The principal coordinate analysis represented that the overall rumen microbiota was not influenced by mineral supplementation;however,temperature-induced microbial structure shifts were indicated(PERMANOVA:P<0.05).At the phylum level,Firmicutes and Actinobacteria decreased,whereas Fibrobacteres,Spirochaetes,and Tenericutes increased(P<0.05),under HS *** genus Treponema increased under HS conditions,while Christensenella was higher in recovery conditions(P<0.05).Conc

关键词： Antioxidant status Heat stress Holstein bull calves Organic mineral supplementation Oxidative stress

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Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-seon kim Jeongeun Park Hyun-Su Ha Sewoom Baek Chan Hee Lee Kyubae Lee Suji Park Jueun kim Se Won Yi Hak-Joon Sung Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea TMD LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are *** membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur *** elastomer became moldable upon a temperature shift above T_(m).The structure can then be fixed as the temperature *** a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

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Bone Research 2024年第2期12卷 407-420页

作者： Minhee kim Jin Hee Park Miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong kim Hyunil Ha Taesoo kim Myeong seon Jeong Suree kim Taesoo kim Han Sung kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye seon kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee Brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

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Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： seon Yeong Ji EunJin Bang Hyun Hwangbo Min Yeong kim Da Hye kim Su Hyun Hong Shin-Hyung Park Chang-Young Kwon Gi-Young kim You-Jin Jeon Suengmok Cho Yung Hyun Choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

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Ear keloid and epidermal cyst following auricular cartilage harvest for rhinoplasty:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4434-4439页

作者： Jun Mo kim Ji seon Cheon Woo Young Choi Department of Plastic Reconstructive Surgery Chosun University College of MedicineGwangju 61453South Korea Department of Plastic and Reconstructive Surgery Chosun University College of MedicineGwangju 61453South Korea

BACKGROUND This case report highlights a rare instance of concurrent keloid and epidermal cyst development at an ear cartilage harvest site following rhinoplasty in a 25-year-old *** conditions,which typically stem from skin trauma,seldom occur together,demonstrating the exceptional characteristics of this *** SUMMARY The patient underwent successful surgical removal of both the keloid and the epidermal *** treatment included the use of silicone sheets,gel,and oral tranilast to reduce *** recurrence was observed over a 6-mo follow-up period,indicating effective management of the *** The effective management of complex skin trauma cases underscores the need for individualized treatment strategies in plastic surgery.

关键词： Ear keloids Epidermal cysts Auricular cartilage harvesting Rhinoplasty complications Case report

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Complicated calcified alloplastic implants in the nasal dorsum:A clinical analysis

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World Journal of Clinical Cases 2024年第18期12卷 3351-3359页

作者： Yong-seon Hwang Taek-Kyun kim Dong-Jun Yang Si-Hyong Jang Da-Woon Lee Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-Si 31151South Korea Department of Plastic Surgery The PLUS Plastic Surgery ClinicSeoul 06035South Korea Department of Plastic Surgery CDU Plastic Surgery ClinicSeoul 06067South Korea Department of Pathology College of MedicineSoonchunhyang UniversityCheonan 31151Chungcheongnam-doSouth Korea

BACKGROUND In rhinoplasty,calcification around silicone implants is frequently observed in the tip dorsum(TD)***,based on a review of various literature,it is presumed that calcification in silicone implants occurs due to both inflammatory chemical reactions and physical friction against the *** calcification of nasal silicone implants not only results in the functional loss of the implants,but also leads to material ***,there is a lack of research on calcification of nasal silicone implants in the current *** To elucidate various clinical characteristics of calcification around nasal silicone implants,using histological and radiological *** This study analyzed data from 16 patients of calcified nasal implants,who underwent revision rhinoplasty for various reasons after undergoing augmentation rhinoplasty with silicone *** collected data included information on implant duration,implant types,location of calcification,presence of inflammatory reactions,and computed tomography(CT)*** The most common location of calcification,as visually analyzed,was in the TD area,accounting for 56%.Additionally,the analysis of CT scans revealed a trend of increasing Hounsfield Unit values for calcification with the duration of implantation,although this trend was not statistically significant(P=0.139).CONCLUSION Our study shows that reducing the frequency of calcification may be achievable by using softer silicone implants and by minimizing the damage to perioperative tissues.

关键词： Silicone implants Rhinoplasty Calcification Complication Hounsfield unit

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Enhancing the Prediction of User Satisfaction with Metaverse Service Through Machine Learning

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Computers, Materials & Continua 2022年第9期72卷 4983-4997页

作者： seon Hong Lee Haein Lee Jang Hyun kim Department of Applied Artificial Intelligence/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Department of Interaction Science/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea

Metaverse is one of the main technologies in the daily lives of several people,such as education,tour systems,and mobile application ***,the number of users of mobile metaverse applications is increasing owing to the merit of accessibility *** provide an improved service,it is important to analyze online reviews that contain user *** previous studies have utilized traditional methods,such as the structural equation model(SEM)and technology acceptance method(TAM)for exploring user satisfaction,using limited survey *** methods may not be appropriate for analyzing the users of mobile *** overcome this limitation,several researchers perform user experience analysis through online reviews and star ***,some online reviews occasionally have inconsistencies between the star rating and the sentiment of the *** variation disturbs the performance of machine *** alleviate the inconsistencies,Valence Aware Dictionary and sEntiment Reasoner(VADER),which is a sentiment classifier based on lexicon,is *** current study aims to build a more accurate sentiment classifier based on machine learning with *** this study,five sentiment classifiers are used,such as Naïve Bayes,K-Nearest Neighbors(KNN),Logistic Regression,Light Gradient Boosting Machine(LightGBM),and Categorical boosting algorithm(Catboost)with three embedding methods(Bag-of-Words(BoW),Term Frequency-Inverse Document Frequency(TF-IDF),Word2Vec).The results show that classifiers that apply VADER outperform those that do not apply VADER,excluding one classifier(Logistic Regression with Word2Vec).Moreover,LightGBM with TF-IDF has the highest accuracy 88.68%among other models.

关键词： Metaverse ubiquitous computing user satisfaction online review big data VADER machine learning natural language processing

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Information Extraction Based on Multi-turn Question Answering for Analyzing Korean Research Trends

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Computers, Materials & Continua 2023年第2期74卷 2967-2980页

作者： seongung Jo Heung-seon Oh Sanghun Im Gibaeg kim seonho kim School of Computer Science and Engineering KOREATECHCheonan31253Korea Korea Institute of Science and Technology Information KISTIDaejeon34141Korea

Analyzing Research and Development(R&D)trends is important because it can influence future decisions regarding R&D *** typical trend analysis,topic or technology taxonomies are employed to compute the popularities of the topics or codes over *** it is simple and effective,the taxonomies are difficult to manage because new technologies are introduced ***,recent studies exploit deep learning to extract pre-defined targets such as problems and *** on the recent advances in question answering(QA)using deep learning,we adopt a multi-turn QA model to extract problems and solutions from Korean R&D *** the previous research,we use the reports directly and analyze the difficulties in handling them using QA style on Information Extraction(IE)for sentence-level benchmark *** investigating the characteristics of Korean R&D,we propose a model to deal with multiple and repeated appearances of targets in the ***,we propose a model that includes an algorithm with two novel modules and a prompt.A newly proposed methodology focuses on reformulating a question without a static template or pre-defined *** show the effectiveness of the proposed model using a Korean R&D report dataset that we constructed and presented an in-depth analysis of the benefits of the multi-turn QA model.

关键词： Natural language processing information extraction question answering multi-turn Korean research trends

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