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Evaluating the benefit of adjuvant chemotherapy in patients with ypT0-1 rectal cancer treated with preoperative chemoradiotherapy

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1000-1011页

作者： Ye Won Jeon In Ja Park Jeong Eun Kim Jin-Hong Park seok-byung lim Chan Wook Kim Yong Sik Yoon Jong Lyul Lee Chang Sik Yu Jin Cheon Kim Department of Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea Department of Colon and Rectal Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea Department of Oncology Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea Department of Radiation Oncology Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Adjuvant chemotherapy(ACTx)is recommended in rectal cancer patients after preoperative chemoradiotherapy(PCRT),but its efficacy in patients in the early post-surgical stage who have a favorable prognosis is *** To evaluate the long-term survival benefit of ACTx in patients with ypT0–1 rectal cancer after PCRT and surgical *** We identified rectal cancer patients who underwent PCRT followed by surgical resection at the Asan Medical Center from 2005 to *** with ypT0–1 disease and those who received ACTx were *** 5-year overall survival(OS)and 5-year recurrence-free survival(RFS)were analyzed according to the status of the *** Of 520 included patients,413 received ACTx(ACTx group)and 107 did not(no ACTx group).No significant difference was observed in 5-year RFS(ACTx group,87.9%vs no ACTx group,91.4%,P=0.457)and 5-year OS(ACTx group,90.5%vs no ACTx group,86.2%,P=0.304)between the *** stage was associated with RFS and OS in multivariate analysis[hazard ratio(HR):2.57,95%confidence interval(CI):1.07–6.16,P=0.04 and HR:2.27,95%CI:1.09–4.74,P=0.03,respectively].Furthermore,ypN stage was associated with RFS and OS(HR:4.74,95%CI:2.39–9.42,P<0.00 and HR:4.33,95%CI:2.20–8.53,P<0.00,respectively),but only in the radical resection *** Oncological outcomes of patients with ypT0–1 rectal cancer who received ACTx after PCRT showed no improvement,regardless of the radicality of *** trials are needed to evaluate the efficacy of ACTx in these group of patients.

关键词： Rectal neoplasm Adjuvant chemotherapy ypT0-1 Radical resection Local excision

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Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn's disease

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World Journal of Gastroenterology 2017年第38期23卷 7016-7024页

作者： Kwan Mo Yang Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park seok-byung lim Sang Hyoung Park Byong Duk Ye Suk-Kyun Yang Jin Cheon Kim Division of Colon and Rectal Surgery Department of Surgery University of Ulsan College of Medicine Asan Medical Center De-partment of Gastroenterology University of Ulsan College of Medicine Asan Medical Center

AIM To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn's disease(CD) *** This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000 and December 2010 at Asan Medical Center(Seoul, South Korea). The median follow-up period was 101 *** During the follow-up period, 66 patients(25.4%) underwent a second operation for disease *** 1, 5 and 10 years after the first operation, the cumulative rate of surgical recurrence was 1.1%, 8.3% and 35.9% and clinical recurrence occurred in 1.2%, 23.6% and 68.1%, respectively. In multivariate analysis, undergoing an emergency operation was a significant risk factor for surgical recurrence-free survival(SRFS) [HR = 2.431, 95%CI: 1.394-4.240, P = 0.002], as were the presence of perianal disease after the first operation(HR = 1.715, 95%CI: 1.005-2.926, P = 0.048) and history of smoking(HR = 1.798, 95%CI: 1.088-2.969, P = 0.022). The postoperative use of antitumor necrosis factor(TNF) agents reduced SRFS risk(HR = 0.521, 95%CI: 0.300-0.904, P = 0.02).CONCLUSION History of smoking, postoperative perianal disease and undergoing an emergency operation were independent risk factors for surgical recurrence. Using anti-TNF agents may reduce surgical recurrence.

关键词： Crohn’s disease Recurrence Risk factor

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Analysis of microsatellite instability in stool DNA of patients with colorectal cancer using denaturing high performance liquid chromatography

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World Journal of Gastroenterology 2006年第41期12卷 6689-6692页

作者： seok-byung lim Seung-Yong Jeong Il-Jin Kim Dae Yong Kim Kyung Hae Jung Hee Jin Chang Hyo Seong Choi Dae Kyung Sohn Hio Chung Kang Yong Shin Sang-Geun Jang Jae-Hyun Park Jae-Gahb Park Research Institute and Hospital National Cancer CenterGoyangKorea Cancer Research Institute and Cancer Research Center Seoul National UniversitySeoulKorea

AIM： To evaluate the usefulness of denaturing high performance liquid chromatography （DHPLC） for analyzing microsatellite instability （MSI） status in stool DNA of patients with colorectal cancer. METHODS： A total of 80 cancer tissues from patients with primary sporadic colorectal tumor （proximal cancer： 27, distal cancer： 53） and matched stool （which were employed for comparison with the tissues） were analyzed for MSI status in BAT 26. DNA samples extracted from stool were evaluated by nested polymerase chain reaction （PCR） and DHPLC for MSI analysis. RESULTS： Six cases （7.5%） of MSI were identified in BAT 26 from 80 cancer tissues. All the stool DNA samples from patients whose cancer tissue showed IVlSI also displayed MSI in BAT 26. CONCLUSION： As MSI is one of the established fecal DNA markers to screen colorectal cancer, we propose to use DHPLC for the IVlSI analysis in fecal DNA.

关键词： Colorectal cancer Denaturing high performance liquid chromatography Fecal DNA MicrosateUite instability Stool

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9-Hydroxy-6,7-dimethoxydalbergiquinol suppresses hydrogen peroxide-induced senescence in human dermal fibroblasts through induction of sirtuin-1 expression

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Asian Pacific Journal of Tropical Biomedicine 2021年第2期11卷 89-96页

作者： seok-Hee lim Bing Si Li Ri Zhe Zhu byung-Min Choi Department of Biochemistry School of MedicineInstitute of BiotechnologyWonkwang University460 Iksandae-roIksanJeonbuk 54538Republic of Korea

Objective:To investigate the potential anti-aging mechanism of9-hydroxy-6,7-dimethoxydalbergiquinol(HDDQ)on hydrogen peroxide(H2O2)-induced oxidative stress in human dermal fibroblasts(HDFs).Methods:The effect of HDDQ on cell viability was assessed by MTT assay,and the effects of HDDQ on senescence-like phenotypes were determined by senescence-associatedβ-galactosidase(SA-β-gal)staining,Western blotting analysis,and a cell proliferation *** expression level and activity of sirtuin-1(SIRT1)induced by HDDQ were also ***:HDDQ reversed senescence-like phenotypes in the oxidant-challenged model,through reducing SA-β-gal activity and promoting cell ***,decreases in ac-p53,p21Cip1/WAF1,and p16Ink4a and an increase in p Rb were *** induced the expression of SIRT1 in a concentration-and time-dependent ***,HDDQ inhibited H2O2-induced phosphorylation of Akt by SIRT1 up-regulation and reduced SA-β-gal ***:HDDQ inhibits H2O2-induced premature senescence and upregulation of SIRT1 expression plays a vital role in the inhibition of the senescence phenotype in HDFs.

关键词： 9-Hydroxy-6,7-dimethoxydalbergiquinol Hydrogen peroxide Senescence Sirtuin-1 Human dermal fibroblasts

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Nonampullary duodenal adenoma:Current understandingof its diagnosis,pathogenesis,and clinical management

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World Journal of Gastroenterology 2016年第2期22卷 853-861页

作者： Chul-Hyun lim Young-seok Cho Department of Internal Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Nonampullary duodenal adenomas are relatively common in familial adenomatous polyposis(FAP), but nonampullary sporadic duodenal adenomas(SDAs)are rare. Emerging evidence shows that duodenal adenomas, regardless of their anatomic location and whether they are sporadic or FAP-related, share morphologic and molecular features with colorectal adenomas. The available data suggest that duodenal adenomas develop to duodenal adenocarcinomas via similar mechanisms. The optimal approach for management of duodenal adenomas remains to be determined. The techniques for endoscopic resection of duodenal adenoma include snare polypectomy, endoscopic mucosal resection(EMR), endoscopic submucosal dissection(ESD), and argon plasma coagulation ablation. EMR may facilitate removal of large duodenal polyps. Although several studies have reported cases of successful ESD for duodenal adenomas, the procedure is technically difficult to perform safely because of the anatomical properties of the duodenum. Although current clinical practice recommends endoscopic resection of all large duodenal adenomas in patients with FAP, endoscopic treatment is usually insufficient to guarantee a polypfree duodenum. Surgery is indicated for FAP patients with severe polyposis or nonampullary SDAs or FAPrelated polyps not amenable to endoscopic resection. Further studies are needed to develop newer endoscopic techniques to guide diagnostic and therapeutic decisions for future management of nonampullary duodenal adenomas.

关键词： Duodenal adenoma Endoscopy Familialadenomatous polyposis Endoscopic mucosal resection Endoscopic submucosal dissection

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MAINTENANCE OF MULTI-STATE PRODUCTION SYSTEMS DETERIORATED BY RANDOM SHOCKS AND PRODUCTION

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Journal of Systems Science and Systems Engineering 2011年第1期20卷 110-118页

作者： Won seok YANG Dae E.lim Kyung C.CHAE Department of Business Administration Hannam University Department of Industrial and Systems Engineering

We consider the preventive maintenance of a production system that is deteriorated by random shocks and the production process itself. The degree of deterioration is modeled by discrete and finite states. Shocks arrive according to a Poisson process and deteriorate the system by random amounts. The system may deteriorate whenever it produces an item. The system is continuously monitored and repaired if the system state is at or above a predetermined level for maintenance. We analyze the lifetime, product quantity, average cost, and average profit considering revenue from the product and cost due to setup, operation, and repair. Assuming a structure of system parameters and costs, using numerical examples, we investigate the impact of production and shock arrivals on the average profit and the optimal maintenance level that maximizes the average profit. The proposed model is applicable to manufacturing tasks in which machines wear due to production, for example, press processes, milling, turning, punching, and drilling.

关键词： Multi-state deterioration random shock maintenance cost-benefit analysis

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Early recovery process and restoration planning of burned pine forests in central eastern Korea

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Journal of Forestry Research 2019年第1期30卷 243-255页

作者： Ji Hong An Chi Hong lim Yong Chan Cho Chang seok Lee Department of Bio and Environmental Technology Seoul Women's University Division of Plant Conservation Korea National Arboretum

In central eastern Korea, there has been a continued effort to sustain pine forests because of their value for wood and mushroom production, as well as for other resources. Through the analysis of previously burned areas,we clarified the effects of fire on vegetation dynamics of pine forests by measuring changes in species composition,population structure, and the growth rates of major tree species. Vegetation analysis was conducted on a series of 100 m^2 plots established in Korean red pine(Pinus densiflora Siebold. & Zucc.) and Mongolian oak(Quercus mongolica Fisch. Ex Ledeb.) forests situated in three different topographic positions on slopes where fire severity varied. We confirmed that most pine trees will succumb to even a surface fire, whereas oak may be killed following high intensity or infrequent fires but will sprout and become dominant. Complete protection from fire favors other, more shade-tolerant deciduous hardwoods. Different restoration plans apply, based on observed vegetation responses for each topographic zone. Near the ridge top,where pine seed sources are most limited, it may be necessary to restore pine forests by planting and to control competing shrubs and herbs. At the mountain foot, where exotic species and species modified by hybridization have invaded aggressively, restoration that involves the introduction of natural vegetation is required. Mid-slope sites,where pine has been replaced by natural vegetation dominated by Mongolian oak, do not require any form of restorative treatment.

关键词： Vegetation succession Vegetation type Fire severity Fire disturbance Landscape structure

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Morphologic factors of biliary trees are associated with gallstone-related biliary events

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World Journal of Gastroenterology 2015年第1期21卷 276-282页

作者： Jin-seok Park Don Haeng Lee Jun Hyeok lim seok Jeong Young Sun Jeon Department of Internal Medicine Digestive Disease CenterInha University School of MedicineIncheon 400-711South Korea Department of Radiology Inha University School of MedicineIncheon 400-711South Korea

AIM: To determine the risk factors for gallstone-related biliary ***: This retrospective cohort study evaluated magnetic resonance cholangiopancreatography imagesfrom 141 symptomatic and 39 asymptomatic gallstone patients who presented at a single tertiary hospital between January 2005 and December ***: Logistic regression analysis showed significant differences between symptomatic and asymptomatic patients with gallstones in relation to the number of gallstones,the angle between the long axis of the gallbladder and the cystic duct,and the cystic duct *** analysis showed that the number of gallstones(OR = 1.27,95%CI: 1.03-1.57; P = 0.026),the angle between the long axis of the gallbladder and the cystic duct(OR = 1.02,95%CI: 1.00-1.03; P = 0.015),and the diameter of the cystic duct(OR = 0.819,95%CI: 0.69-0.97; P = 0.018) were significantly associated with biliary *** incidence of biliary events was significantly elevated in patients who had the presence of more than two gallstones,an angle of > 92° between the gallbladder and the cystic duct,and a cystic duct diameter < 6 ***: These findings will help guide the treatment of patients with asymptomatic *** should closely monitor patients with asymptomatic gallstones who exhibit these characteristics.

关键词： Cystic duct Gallbladder Gallstone disease Magnetic

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Deduction of a meteorological phenology indicator from reconstructed MODIS LST imagery

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Journal of Forestry Research 2020年第6期31卷 2205-2216页

作者： Chi Hong lim Song Hie Jung Nam Shin Kim Chang seok Lee Department of Bio and Environmnetal Technology Graduate SchoolSeoul Women’s UniversitySeoul Republic of Korea Research Team on Ecological and Natural Map National Institute of EcologySeocheon Choongnam Republic of Korea Department of Bio and Environmnetal Technology Seoul Women’s UniversitySeoul Republic of Korea

Phenology is a valuable attribute of vegetation to assess the biological impacts from climate change.A challenge of phenological research is to obtain information on both high temporal resolution and fine spatial scale ***,we constructed an air temperature map based on temporal merging and spatial interpolation algorithms to overcome the cloud-related problem from the MODIS LST ***,we derived the accumulated growing degree days(AGDD)from the constructed mean air temperature map to use as a meteorological ***,we verified the indicator with the seasonal mean air temperature and the green-up date of a Quercus mongolica forest determined from the field-based *** AGDD threshold for each *** forest when the first leaf has unfolded was detected from the EXG trajectory extracted from digital camera images.A comparison between meteorological and MODIS-derived AGDD showed good agreement between *** was also high consistency between DoYs extracted from AGDD and EVI based on curvature K for *** forests of 30 sampling sites throughout South *** results prove that microclimatic factors such as elevation,waterbody,and land-use intensity were faithfully reflected in the reconstructed ***,the results of this study could be applied effectively in areas where microclimatic variation is very severe and for monitoring phenology of undergrowth,which is difficult to detect from reflectance imaging.

关键词： Climate change Digital camera Growing degree days MODIS Phenology Quercus mongolica

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Polydopamine-derived N-doped carbon-wrapped Na3V2(PO4)3 cathode H with superior rate capability and cycling stability for sodium-ion I batteries

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Nano Research 2019年第2期12卷 397-404页

作者： Hyeongwoo Kim Hyojun lim Hyung-seok Kim Ki Jae Kim Dongjin Byun Wonchang Choi Center for Energy Storage Research Korea Institute of Science and Technology 5 Hwarang-ro 14-gil Seongbuk-gu Seoul 02792 Republic of Korea Department of Material Science and Engineering Korea University 145 Anam-ro Seongbuk-gu Seoul 02841 Republic of Korea Division of Energy & Environment Technology KIST School Korea University of Science and Technology 5 Hwarang-ro 14-gik Seongbuk-gu Seoul 02792 Republic of Korea Department of Energy Engineering Konkuk University 120 Neungdong-ro Gwangin-gu Seoul 05029 Republic of Korea

Na superionic conductor (NASICON)-type Na3V2(PO4)3 (NVP) has been regarded as a promising cathode material for sodium-ion batteries (SIBs). However, NVP suffers from poor cyclability and rate capability because of its intrinsically low electronic conductivity. Herein, we successfully syn thesized N-doped carb on-wrapped Na3V2(PO4)3 (NC@NVP) through the carb on izati on of polydopami ne, which is rich in nitrogen species. The strong adhesion properties of the polydopamine lead to effective and homogeneous wrapping of NVP particles, and it I is further turned into a con ductive N-doped carb on n etwork itself, providi ng facile diffusi on of electr ons and Na+ i ons duri ng battery operation. NC@NVP displays remarkable electrochemical performanee, even under harsh operating conditions, such as a high rate capability (discharge capacity of 70.88, 49.21 mA·h·g^-1 at 50 and 100 C), long-term cycling stability (capacity retention of 94.77% over 1,000 cycles at 20 C), and high-temperature cycling (capacity retention of 92.0% after 500 cycles at 60 ℃).

关键词： polydopamine N-doped carbon Na3V2(PO4)3 cathode sodium-ion batteries

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