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Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Development of immature ovarian teratoma after mature teratoma in a girl with familial ovarian teratoma:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1442-1447页

作者： U Chul ju Woo Dae kang seok Mo Kim Department of Obstetrics and Gynecology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Immature ovarian teratoma is a rare and aggressive neoplasm that affects young *** report is the first to describe the development of immature teratoma after ovarian cystectomy for mature teratoma of the ovary in an adolescent female with a family history of ovarian *** SUMMARY A 16-year-old girl who had undergone bilateral ovarian cystectomy for mature teratomas 3 years ago showed bilateral adnexal tumors during her regular ultrasonography follow-up every 6 *** received laparoscopic bilateral ovarian cystectomy,and final histopathology showed grade-1 immature teratoma of the left ovary and mature teratoma of the right *** left salpingo-oophorectomy and staging procedures were performed *** mother,maternal aunt,and maternal grandmother had also received surgeries for mature ovarian *** It is important to have guidance on management of patient and family members with familial ovarian teratomas.

关键词： Familial ovarian teratomas Adolescent female Immature ovarian teratoma Management Case report

Optimization of roller shape for roller-type onion pot-seeding machine

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International Journal of Agricultural and Biological Engineering 2020年第1期13卷 111-119页

作者： seok-Joon Hwang ju-seok Nam Dept.of Biosystems Engineering Kangwon National University1 Kangwondaehak-gilChuncheonGangwon-do24341Republic of Korea

In this study,roller shape optimization was performed on a roller-type pot-seeding machine used for sowing onion *** parameters for optimization were derived by analyzing the operating characteristics of the pot-seeding *** on this,the roller shape was determined to minimize weight while satisfying the required *** the optimized roller shape was applied,it was possible to reduce the weight of the roller by 17.7%compared with the conventional one,while satisfying the safety factor of 2.0 or *** optimum bed soil compaction required for onion sowing was also ***,applying the roller shape derived from this study to an existing roller-type pot-seeding machine may increase the production efficiency of healthy seedling.

关键词： onion pot-seeding machine roller-type shape optimization

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

Solvent extraction and stripping of lithium ion from aqueous solution and its application to seawater

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Rare Metals 2016年第12期35卷 948-953页

作者： Gregorius Rionugroho Harvianto seok-Hyeon Kim Chang-Sik ju Department of Chemical Engineering Pukyong National University

For the development of lithium ion recovery process from seawater, a series of experimental researches were performed. Solvent extraction of lithium ion from aqueous solution using kerosene as solvent was proposed. Lithium ion is effectively extracted by thenoyltrifluoroace- tone-trioctylphosphine oxide （TTA-TOPO） in kerosene within 80 min. Extraction efficiency is severely influenced by stoichiometric parameters. Among the stoichiometric parameters, volume ratio of aqueous （A） to extraction （E） solution is the most influential parameter. After extrac- tion, lithium ion could be easily stripped from the extraction solution by acidic solutions. Stripping efficiency decreases with pH of acidic solutions, and the kind of acid does not affect the stripping efficiency. Extraction efficiency main- tains at more than 93 % even when the extraction solution is recycled three times. 65 % of lithium ion can be extracted from seawater by this solvent extraction process when magnesium ion is precipitated by NHaOH prior to solvent extraction process. Other metallic ions in seawater decrease the extraction efficiency of lithium ion.

关键词： Lithium Thenoyltrifluoroacetone Trioctylphosphine oxide Solvent extraction Stripping Recycling

Novel acoustic features for speech emotion recognition

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Science China(Technological Sciences) 2009年第7期52卷 1838-1848页

作者： ROH Yong-Wan KIM Dong-ju LEE Woo-seok HONG Kwang-seok School of Information and Communication Engineering Sungkyunkwan University300Chunchun-dongJangan-guSuwonKyungki-do440-746Korea Development Division / DSP Development Team Tamul Multimedia10th Fl.Anyang Trade Center1107Bisan-DongDongAn-GuAnyang-City431-050Korea

This paper focuses on acoustic features that effectively improve the recognition of emotion in human *** novel features in this paper are based on spectral-based entropy parameters such as fast Fourier transform(FFT) spectral entropy,delta FFT spectral entropy,Mel-frequency filter bank(MFB) spectral entropy,and Delta MFB spectral ***-based entropy features are *** reflect frequency characteristic and changing characteristic in frequency of *** implement an emotion rejection module using the probability distribution of recognized-scores and *** reduces the false recognition rate to improve overall ***-scores and rejected-scores refer to probabilities of recognized and rejected emotion recognition results,*** scores are first obtained from a pattern recognition *** pattern recognition phase uses the Gaussian mixture model(GMM).We classify the four emotional states as anger,sadness,happiness and *** proposed method is evaluated using 45 sentences in each emotion for 30 subjects,15 males and 15 *** results show that the proposed method is superior to the existing emotion recognition methods based on GMM using energy,Zero Crossing Rate(ZCR),linear prediction coefficient(LPC),and pitch *** demonstrate the effectiveness of the proposed *** of the proposed features,combined MFB and delta MFB spectral entropy improves performance approximately 10% compared to the existing feature parameters for speech emotion recognition *** demonstrate a 4% performance improvement in the applied emotion rejection with low confidence score.

关键词： speech emotion recognition MFB spectral entropy entropy emotion recognition rejection

Bayesian Estimation and Model Selection for the Spatiotemporal Autoregressive Model with Autoregressive Conditional Heteroscedasticity Errors

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Acta Mathematicae Applicatae Sinica 2023年第4期39卷 972-989页

作者： Bing SU Fu-kang ZHU ju HUANG Department of Statistics&Actuarial Science University of Hong KongHong Kong 999077China School of Mathematics Jilin UniversityChangchun 130012China National Energy Administration Information Center Beijing 100045China

The spatial and spatiotemporal autoregressive conditional heteroscedasticity(STARCH) models receive increasing attention. In this paper, we introduce a spatiotemporal autoregressive(STAR) model with STARCH errors, which can capture the spatiotemporal dependence in mean and variance simultaneously. The Bayesian estimation and model selection are considered for our model. By Monte Carlo simulations, it is shown that the Bayesian estimator performs better than the corresponding maximum-likelihood estimator, and the Bayesian model selection can select out the true model in most times. Finally, two empirical examples are given to illustrate the superiority of our models in fitting those data.

关键词： autoregressive conditional heteroscedasticity model Bayesian estimation model selection spatial ARCH model spatial panel model spatiotemporal model

Atypical onset of bicalutamide-induced liver injury

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World Journal of Gastroenterology 2016年第15期22卷 4062-4065页

作者： Gee Young Yun seok Hyun Kim seok Won Kim Jong seok Joo ju seok Kim Eaum seok Lee Byung seok Lee Sun Hyoung kang Hee seok Moon Jae Kyu Sung Heon Young Lee Kyung Hee Kim Department of Internal Medicine Chungnam National University School of Medicine Chungnam National University Hospital Departments of Pathology Chungnam National University School of Medicine Chungnam National University Hospital

Anti-androgen therapy is the leading treatment for advanced prostate cancer and is commonly used for neoadjuvant or adjuvant treatment. Bicalutamide is a non-steroidal anti-androgen, used during the initiation of androgen deprivation therapy along with a luteinizing hormone-releasing hormone agonist to reduce the symptoms of tumor-related flares in patients with advanced prostate cancer. As side effects, bicalutamide can cause fatigue, gynecomastia, and decreased libido through competitive androgen receptor blockade. Additionally, although not as common, drug-induced liver injury has also been reported. Herein, we report a case of hepatotoxicity secondary to bicalutamide use. Typically, bicalutamideinduced hepatotoxicity develops after a few days; however, in this case, hepatic injury occurred 5 mo after treatment initiation. Based on this rare case of delayed liver injury, we recommend careful monitoring of liver function throughout bicalutamide treatment for prostate cancer.

关键词： Bicalutamide Drug-induced liver injury Prostate neoplasm

Iron sulfides with dopamine-derived carbon coating as superior performance anodes for sodium-ion batteries

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Nano Research 2019年第10期12卷 2609-2613页

作者： Aihua Jin Seung-Ho Yu Jae-Hyuk Park seok Mun kang Mi-ju Kim Tae-Yeol Jeon junyoung Mun Yung-Eun Sung Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Chemical and Biological Engineering Korea University145 Anatn-roSeongbtik-guSeoul 02841Republic cf Korea Beamline Department Pohang Accelerator Laboratory(PAL)Pohang 37673Republic of Korea Department of Energy and Chemical Engineering Incheon National University12-1Songdo-dong Yeonsu-guIncheon 22012Republic of Korea

High energy ball-milled iron sulfides with thin carb on layer coati ng(BM-FeS/C composites)were prepared by the simple and econo mical ***-milled process,followed by carb on coati ng,reduced the particle size and increased the electrical con *** n employed as sodium-ion battery ano des,BM?F eS/C composites showed extremely high electrochemical performa nee with reversible specific capacity of 589.8 mAh·g^-1 after 100 cycles at a current density of 100 mA·g^-*** also exhibited superior rate capabilities of 375.9 mAh·g^-1 even at 3.2 Ag^1 and 423.6 mAh·g^-1 at 1.5 Ag_1.X-ray absorptio n near edge structure an alysis con firmed the electrochemical pathway for con version reaction of BM-FeS/C composites.

关键词： sodium-ion batteries iron sulfides high energy ball-milling dopamine X-ray absorption near edge structure