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Large animal models of cardiac ischemia-reperfusion injury:Where are we now?

Zoological Research 2023年第3期44卷 591-603页

作者： Attaur Rahman Yuhao Li To-Kiu Chan Hui Zhao Yaozu Xiang Xing Chang Hao Zhou Dachun Xu sang-Bing Ong Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina Centre for Cardiovascular Genomics and Medicine(CCGM) Lui Che Woo Institute Innovative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina College of Veterinary Sciences and Animal Husbandry Abdul Wali Khan University MardanMardanKhyber Pakhtunkhwa 23200Pakistan School of Biomedical Sciences CUHK-GIBH CAS Joint Laboratory on Stem Cell and Regenerative MedicineThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina Institute for Tissue Engineering and Regenerative Medicine(iTERM) The Chinese University of Hong Kong(CUHK)Hong Kong SARChina SBS Core Laboratory CUHK Shenzhen Research InstituteShenzhenGuangdong 518172China Kunming Institute of Zoology–The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Shanghai East Hospital Key Laboratory of Arrhythmias of the Ministry of Education of ChinaSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Guang’anmen Hospital China Academy of Chinese Medical SciencesBeijing 100053China Department of Cardiology Chinese People’s Liberation Army General HospitalBeijing 100853China Center for Cardiovascular Research and Alternative Medicine University of Wyoming College of Health SciencesLaramieWY 82071USA Department of Cardiology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Hong Kong Hub of Paediatric Excellence(HK HOPE) Hong Kong Children’s Hospital(HKCH)Kowloon BayHong Kong SARChina CUHK Shenzhen Research Institute(SZRI) ShenzhenGuangdong 518172China Neural Vascularand Metabolic Biology Thematic Research ProgramSchool of Biomedical SciencesThe Chinese University of Hong Kong(CUHK)Hong Kong SARChina

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical ***,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models,which are not transferable or reproducible in large animal models due to different factors such as:(i)complex and varied features of human ischemic cardiac disease(ICD),which are challenging to mimic in animal models,(ii)significant differences in surgical techniques applied,and(iii)differences in cardiovascular anatomy and physiology between small versus large *** article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI),as well as the different methods used to induce and assess IRI,and the obstacles faced in using large animals for translational research in the settings of cardiac IR.

关键词： Cardiovascular disorder Ischemic cardiac disease Ischemic-reperfusion injury Large animal model Myocardial infarction Translational gap

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Modeling the impacts of temperature and precipitation changes on soil CO_2 fluxes from a Switchgrass stand recently converted from cropland

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Journal of Environmental Sciences 2016年第5期28卷 15-25页

作者： Liming Lai Sandeep Kumar Rajesh Chintala Vance N. Owens David Clay Joseph Schumacher Abdul-Sattar Nizami sang Soo Lee Rashad Rafique Department of Plant Science South Dakota State University Brookings South Dakota 57007 USA. North Central Sun Grant Center South Dakota State University Brookings South Dakota 57007 USA Center of Excellence in Environmental Studies (CEES) King Abdulaziz University Abdullah Sulayman Jeddah 22254 Saudi Arabia kangwon National University Chuncheon 200-701 South Korea Joint global Change Research Institute Pacific Northwest National Lab College Park Maryland 20740 USA

Switchgrass（Panicum virgatum L.） is a perennial C_4 grass native to North America and successfully adapted to diverse environmental conditions. It offers the potential to reduce soil surface carbon dioxide（CO_2） fluxes and mitigate climate change. However, information on how these CO_2 fluxes respond to changing climate is still lacking. In this study, CO_2 fluxes were monitored continuously from 2011 through 2014 using high frequency measurements from Switchgrass land seeded in 2008 on an experimental site that has been previously used for soybean（Glycine max L.） in South Dakota, USA. DAYCENT, a process-based model, was used to simulate CO_2 fluxes. An improved methodology CPTE[Combining Parameter estimation（PEST） with ＂Trial and Error＂ method] was used to calibrate DAYCENT. The calibrated DAYCENT model was used for simulating future CO_2 emissions based on different climate change scenarios. This study showed that：（i） the measured soil CO_2 fluxes from Switchgrass land were higher for 2012 which was a drought year, and these fluxes when simulated using DAYCENT for long-term（2015–2070） provided a pattern of polynomial curve;（ii） the simulated CO_2 fluxes provided different patterns with temperature and precipitation changes in a long-term,（iii） the future CO_2 fluxes from Switchgrass land under different changing climate scenarios were not significantly different, therefore, it can be concluded that Switchgrass grown for longer durations could reduce changes in CO_2 fluxes from soil as a result of temperature and precipitation changes to some extent.

关键词： Carbon dioxide Switchgrass DAYCENT Climate change

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淇河及支流水生态保护修复工程案例分析

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东北水利水电 2024年第8期42卷 28-30,72页

作者：柏义生桑成浩栗紫悦梁静孔德芳郑州大学环境技术咨询工程有限公司河南郑州450002 林州市淇淅河国家湿地公园管理处河南安阳456500 中国地质大学(武汉) 湖北武汉430078

本文构建了林州市淇河及支流水生态保护修复系统,该生态修复系统主要采用河流生态缓冲带、生态护坡、生态湿地、生境营造、水生植被恢复等修复技术措施。通过对效果分析可以看出,所采取的修复措施能够有效去除水体中的COD、氨氮、总磷... 详细信息

本文构建了林州市淇河及支流水生态保护修复系统,该生态修复系统主要采用河流生态缓冲带、生态护坡、生态湿地、生境营造、水生植被恢复等修复技术措施。通过对效果分析可以看出,所采取的修复措施能够有效去除水体中的COD、氨氮、总磷等污染物,主要水质指标由原来的地表水Ⅲ类转变为地表水Ⅱ类,水生生物多样性明显增加,运行费用低,生态环境效果稳定,具有良好的应用前景及环境、社会效益。

关键词：水生态修复水生植物生态缓冲带

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Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma

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Science China(Life Sciences) 2023年第7期66卷 1693-1696页

作者： Shen Wu Chen Xin Wei Zhu Yue Wan Qing sang Rong Du Jian Wu Jin Wang Ningli Wang Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing100730China Beijing Institute of Brain Disorders Collaborative Innovation Center for Brain DisordersCapital Medical UniversityBeijing100069China Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application Capital Medical UniversityBeijing100069China Department of Pharmacology School of PharmacyQingdao UniversityQingdao266021China

The blood circulatory system is the largest system of fluid flow in the human body,and it has been widely studied and well *** characterizes the blood circulatory system and results in three essentials,including(i)pressure fluctuations attributed to pumping of the heart,(ii)the self-regulatory,elastic cardiac muscle,which is sensitive to pressure variance and controls the output volume of the heart,and(iii)valves controlling the one-way flow.

关键词： glaucoma intraocular breakthrough

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Antagonistic interaction between male-killing and cytoplasmic incompatibility induced by Cardinium and Wolbachia in the whitefly,Bemisia tabaci

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Insect Science 2021年第2期28卷 330-346页

作者： Ning Lv Jing Peng Xin-Yi Chen Chang-Fei Guo Wen sang Xing-Min Wang Muhammad ZAhmed Yong-Yu Xu Bao-Li Qiu Key Laboratory of Bio-Pesticide Innovation and Application of Guangdong Province South China Agricultural UniversityGuangzhouChina Engineering Research Center of Biocontrol Ministry of EducationGuangzhouChina Maoming Branch Guangdong Laboratory of Lingnan Modern AgricultureMaomingGuangdong ProvinceChina Florida Department of Agriculture and Consumer Services 1911 SW 34th StreetGainesvilleUSA College of Plant Protection Shandong Agricultural UniversityTaianShandong ProvinceChina

Cardinium and Wolbachia are maternally inherited bacterial symbionts of arthropods that can manipulate host reproduction by increasing the fitness of infected ***,we report that Cardinium and Wolbachia coinfection induced male-killing and cytoplasmic incompatibility(CI)when they coexisted in a cryptic species of whitefly,Bemisia tabaci Asia *** and Wolbachia symbionts were either singly or simul-taneously localized in the bacteriocytes placed in the abdomen of *** nymphs and ***-Wolbachia coinfection induced male-killing and resulted in a higher female sex ratio in the intraspecific amphigenetic progeny of Asia ii7 IcwH and IcwL lines;interestingly,male-illing induction was enhanced with increased Cardinium ***,single infection of Wolbachia induced partial CI in the Asia ii7 Iw line and resulted in reduced fecundity,higher embryonic mortality,and lower female sex *** uninfected Asia ii7 Iu line had significantly higher fecundity,lower embryonic and nymphal mortalities,and a lower level of CI than both the Wolbachia infected Asia ii7 Iw line and the Cardinium--Wolbachia-coinfected Asia ii7 IcwH *** findings indicate that Cardinium-Wolbachia coinfection induced male-killing,which may have had antag-onistic effects on Wolbachia-induced CI in the Asia ii7 *** the first time,our study revealed that *** Asia ii7 reproduction is co-manipulated by Cardinium and Wolbachia endosymbionts.

关键词： antagonistic interaction Bemisia tabaci coinfection endosymbiont repro-ductive manipulation sex ratio

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Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy

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Bioactive Materials 2021年第8期6卷 2372-2389页

作者： Song Xue Xiaojun Zhou Weilin sang Cong Wang Haiming Lu Yiming Xu Yiming Zhong Libo Zhu Chuanglong He Jinzhong Ma Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China

Cartilage-targeting delivery of therapeutic agents is still an effective strategy for osteoarthritis(OA)***,scavenging for reactive oxygen species(ROS)and activating autophagy have been increasingly reported to treat OA *** this study,we designed,for the first time,a dual-drug delivery system based on metal organic framework(MOF)-decorated mesoporous polydopamine(MPDA)which composed of rapamycin(Rap)loaded into the mesopores and bilirubin(Br)loaded onto the shell of *** collagen ii-targeting peptide(WYRGRL)was then conjugated on the surface of above nanocarrier to develop a cartilage-targeting dual-drug delivery nanoplatform(RB@MPMW).Our results indicated the sequential release of two agents from RB@MPMW could be achieved via near-infrared(NIR)laser ***,the rapid release of Br from the MOF shell exhibited excellent ROS scavenging ability and anti-apoptosis effects,however responsively reduced autophagy activity,to a certain ***,following the NIR irradiation,Rap was rapidly released from MPDA core and further enhanced autophagy activation and chondrocyte ***@MPMW continuously phosphorylated AMPK and further rescued mitochondrial energy metabolism of chondrocytes following IL-1βstimulation via activating SIRT1-PGC-1αsignaling ***,the cartilage-targeting property of peptide-modified nanocarrier could be monitored via Magnetic Resonance(MR)and IVIS *** significantly,RB@MPMW effectively delayed cartilage degeneration in ACLT rat ***,our findings indicated that the as-prepared dual-drug delivery nanoplatform exerted potent anti-inflammation and anti-apoptotic effects,rescued energy metabolism of chondrocytes in vitro and prevented cartilage degeneration in vivo,which thereby showed positive performance for OA therapy.

关键词： Osteoarthritis Targeting therapy Autophagy Oxidative stress Energy metabolism

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Ephrin-A2 and-A3 are negative regulators of the regenerative potential of Müller cells

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Chinese Medical Journal 2014年第19期127卷 3438-3442页

作者： Zhu Ruilin Cho Kin-sang Chen Dong Feng Yang Liu Department of Ophthalmology Peking University First Hospital KeyLaboratory of Vision Loss and Restoration Ministry of EducationBeijing China Schepens Eye Research Institute Massachusetts Eye and EarHarvard Medical School Boston MA USA

Background In a previous study, we demonstrated that ephrin-A2 and -A3 negatively regulate the growth of neural progenitor cells in the central nervous system. Adult mice deficient in ephrin-A2 and -A3 （A2＋A3＋） displayed active ongoing neurogenesis throughout the brain, and mice deficient in ephrin-A3 alone showed increased proliferation of ciliary epithelium derived retinal stem cells. This study aimed to detect that the increase in proliferation and neurogenic potential of MOiler cells is influenced by the absence of ephrin-A2 and -A3. Methods We assessed the retinal and MOiler cell expression of ephrin-As and their receptor and neural progenitor cell markers by immunostaining and real-time PCR. We cultured purified primary MOiler cells derived from wild-type and A2＋A3＋ mice in a defined culture medium that enables trans-differentiation of Mu11er cells into retinal neurons. To evaluate proliferating MOiler cells in vivo, we injected 5＇-ethylnyl-2-deoxiuridine （EdU） intraperitoneally to adult mice. Results Expression of ephrin-A2/A3 and their receptor EphA4 were detected in the retinas of adult mice, with EphA4 expression particularly enriched in MOiler cells. MOiler cells of A2＋A3＋ mice exhibited significantly elevated expression of retinal progenitor cell markers, Pax6 and Chx10, when compared with those from wild-type mice. Moreover, a higher percentage of Mu11er cells of A2＋A3＋ mice trans-differentiated and became recoverin＋ and β-Ⅲ-tublin＋ in the culture than those from wild type mice. Strikingly, an increased number of EdU＋ retinal cells was detected in the retinas of adult A2＋A3＋ mice as compared with wild-type mice. Conclusions Ephrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Mu11er cells. Manipulating ephrin-A signaling may thus represent a novel strategy for stimulating neuroregeneration from endogenous progenitors to participate in retinal repair in case of disease or damage.

关键词： Muller cell stem cell retinal regeneration

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勃拉姆斯歌曲中的艺术手法选析(二)——纪念勃拉姆斯逝世110周年

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音乐艺术（上海音乐学院学报） 2007年第4期 6-16页

作者：桑桐上海音乐学院

本文选择勃拉姆斯的艺术歌曲,从歌词内容简介、歌曲的结构形式、艺术手法分析三方面,进行具体的介绍分析,从中了解勃拉姆斯歌曲中的艺术表现技巧、音乐形象创造与和声处理手法等方面的特色。

关键词：勃拉姆斯艺术歌曲艺术手法和声特色

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勃拉姆斯喜用的一种和声手法(二)——纪念勃拉姆斯逝世110周年

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音乐艺术（上海音乐学院学报） 2008年第2期 35-46页

作者：桑桐上海音乐学院

本文分析探讨德国作曲家勃拉姆斯所喜用的一种和声手法:小下属领域的降号音系统和声,亦即包含有降Ⅶ级、降Ⅵ级、降Ⅲ级、降Ⅱ级音和声的处理手法。他延续和发展了从巴赫时期开始的、作为降号音和声基础的"主小七度音和声"的处理方法,... 详细信息

本文分析探讨德国作曲家勃拉姆斯所喜用的一种和声手法:小下属领域的降号音系统和声,亦即包含有降Ⅶ级、降Ⅵ级、降Ⅲ级、降Ⅱ级音和声的处理手法。他延续和发展了从巴赫时期开始的、作为降号音和声基础的"主小七度音和声"的处理方法,继续了贝多芬音乐中降号系统和声语言的开发成果,再加以创新处理,形成了他自己富有特色的降号音系统的和声手法。本文分别从不同降号音的和声材料,分析它们在勃拉姆斯作品中的各种使用方法与音乐表现作用,使读者对这种和声手法有一个较全面的了解。

关键词：勃拉姆斯主小七度音和声小下属领域降号音系统混合利底亚调式弗里几亚调式

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Noble strain of Sparassis latifolia produces high content of β-glucan

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Asian Pacific Journal of Tropical Biomedicine 2015年第8期5卷 615-621页

作者： Dong Ju Lee Min Cheol Jang A Ra Jo Hyun Jun Choi Kwang-sang Kim Youn-Tae Chi School of Biological Sciences and Technology Chonnam National University Higher Education Center for Bioregulator Research Chonnam National University Jangheung Research Institute for Mushroom Industry 288 Woodland-gil Anyang-myun Jangheung-gun Jeollanam-do 529-851Republic of Korea

Objective: To classify four new Sparassis strains(CLM1, CKM1, CKM2, and KJM1) using the internal transcribed spacer sequence and to elucidate their β-glucan content and mycelial ***: Two different microbiological media were used to determine growth rate. The β-glucan contents were analyzed using the Megazyme Mushroom and Yeast Beta-Glucan kit. To determine the genetic relationships, phylogenetic trees were constructed using ClustalX. Multiple sequence alignments were printed and shaded with the BOXSHADE 3.21 program. Results: In this study, four new Sparassis strains were isolated from the southern region of the Korea Peninsula. They were all classified into the Sparassis latifolia clade as a monophyletic group based on the internal transcribed spacer sequence. Mycelial growth rate of the CLM1 strain was highest in potato dextrose agar and potato dextrose agar larch. The β-glucan content of the CLM1 strain was highest at 29.5%(w/w). A high degree of sequence divergence was detected in the RNA polymerase second largest subunit ii gene(RPB2) within Sparassis spp. tested. The putative amino acid sequences of the RPB2 had a distinct sequence. The nucleotide sequences of the RPB2's intron were also divergent among Sparassis spp., even though their nucleotide length was well conserved within Sparassis latifolia. Conclusions: These results indicate that the nucleotide sequences and the amino acid sequences of RPB2 can be used to identify individual Sparassis sp. The Sparassis strain CLM1 may be best for developing a remedy to prevent or treat cancer and other chronic diseases.

关键词： Divergence β-Glucan Intron RNA polymerase second largest subunit ii gene Sparassis

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