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Different oncological features of colorectal cancer codon-specific KRAS mutations:Not codon 13 but codon 12 have prognostic value

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World Journal of Gastroenterology 2023年第32期29卷 4883-4899页

作者： hong-Min Ahn Duck-woo Kim Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung wook Suh Heung-Kwon Oh Sung-Bum Kang Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University HospitalSeoul 03080South Korea

BACKGROUND Approximately 40%of colorectal cancer(CRC)cases are linked to Kirsten rat sarcoma viral oncogene homolog(KRAS)*** mutations are associated with poor CRC prognosis,especially KRAS codon 12 mutation,which is associated with metastasis and poorer ***,the clinicopathological characteristics and prognosis of KRAS codon 13 mutation in CRC remain *** To evaluate the clinicopathological characteristics and prognostic value of codonspecific KRAS mutations,especially in codon *** This retrospective,single-center,observational cohort study included patients who underwent surgery for stage I-III CRC between January 2009 and December *** with KRAS mutation status confirmed by molecular pathology reports were *** relationships between clinicopathological characteristics and individual codon-specific KRAS mutations were *** data were analyzed to identify codon-specific KRAS mutations as recurrence-related factors using the Cox proportional hazards regression *** Among the 2203 patients,the incidence of KRAS codons 12,13,and 61 mutations was 27.7%,9.1%,and 1.3%,*** KARS codons 12 and 13 mutations showed a tendency to be associated with clinical characteristics,but only codon 12 was associated with pathological features,such as stage of primary tumor(T stage),lymph node involvement(N stage),vascular invasion,perineural invasion,tumor size,and microsatellite *** codon 13 mutation showed no associations(77.2%vs 85.3%,P=0.159),whereas codon 12 was associated with a lower 5-year recurrence-free survival rate(78.9%vs 75.5%,P=0.025).In multivariable analysis,along with T and N stages and vascular and perineural invasion,only codon 12(hazard ratio:1.399;95%confidence interval:1.034-1.894;P=0.030)among KRAS mutations was an independent risk factor for *** This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biom

关键词： Genes Ras Codon Colonic neoplasms Rectal neoplasms

Low cross-talk, deep subwavelength plasmonic metal/insulator/metal waveguide intersections with broadband tunability

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Photonics Research 2016年第6期4卷 272-276页

作者： Tae-woo Lee Da Eun Lee Young Jin Lee Soon-hong Kwon Department of Physics Chung-Ang University

We suggest a low cross-talk plasmonic cross-connector based on a metal/insulator/metal cavity and *** separately investigate the isolated cavity mode, the waveguide mode, and the combination of cavity and waveguide modes using a finite-different time-domain method. Due to resonant tunneling and the cutoff frequency of the odd waveguide mode, our proposed structure achieves a high throughput transmission ratio and eliminates cross-talk. Furthermore, the proposed structure has a broadband tunability of 587 nm, which can be achieved by modulating the cavity air gap thickness. This structure enables the miniaturization of photonic integrated circuits and sensing applications.

关键词： mode Low cross-talk deep subwavelength plasmonic metal/insulator/metal waveguide intersections with broadband tunability

利用桑木人工栽培药用真菌灵芝(Phellinus linteus)的研究(英文)

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华中农业大学学报 2004年第1期23卷 72-77页

作者： hong In Pyo Sung Gyoo Byung Nam Hack woo Department of Sericulture and Entomology National Institute of Agricultural Science and TechnologyR.D.A.Suwon 441-707KoreaDepartment of Sericulture and EntomologyNational Institute of Agricultural Science and TechnologyR.D.A.Suwon 441-707KoreaDepartment of Sericulture and EntomologyNational Institute of Agricultural Science and TechnologyR.D.A.Suwon 441-707Korea

比较了利用无菌短木接种法、钻孔接种法和端木夹心接种法等接种方法接种桑树段木后Phellinus linteus的菌丝生长和定殖状况。研究表明利用灭菌的短木接种***,生长和定殖良好,传统的钻孔接种法和端木夹心接种法菌丝生长定殖不好。***在20... 详细信息

比较了利用无菌短木接种法、钻孔接种法和端木夹心接种法等接种方法接种桑树段木后Phellinus linteus的菌丝生长和定殖状况。研究表明利用灭菌的短木接种***,生长和定殖良好,传统的钻孔接种法和端木夹心接种法菌丝生长定殖不好。***在20 cm长的桑木上生长和定殖所需的最适的含水量为42%,接种后12 h,***立即进入快速生长期。接种后的桑木埋入土壤中需要5～6个月产生担子果,在培养室内温度为31～35℃,相对湿度大于96%时有利于子实体的形成。

关键词：药用真菌灵芝桑树人工栽培接种方法菌丝生长定殖培养条件

Modeling of hydrogen diffusion process at a blunt notch in zirconium

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Journal of University of Science and Technology Beijing 2005年第5期12卷 416-421页

作者： Xingqiao Ma Sanqiang Shi Senyang Hu Chungho woo Longqing Chen Department of Physics University of Science and Technology Beijing Beijing 100083 China Department of Mechanical Engineering The Hong Kong Polytechnic University Hong Kong China Department of Materials Science and Engineering The Pennsylvania State University University Park PA 16802 USA

The two-dimensional diffusion of interstitial hydrogen atoms in zirconium in a non-uniform stress field was simulated using the phase-field method. The interaction between hydrogen interstitials and the stress field was described by Khachaturyan＇s elastic theory. The Cahn-Hilliard diffusion equation was then solved by an explicit finite difference method. The result shows that hydrogen atoms diffuse to the high-tensile hydrostatic region near the tip of the notch. The content of hydrogen near the tip of the notch increases by 13%, while the stress distribution caused by hydrogen interstitials around the notch is modified by only 0.7%.

关键词： phase-field hydrogen diffusion non-uniform applied stress zirconium

From Infinite Horizon to Receding Horizon for Controls, Estimations and Optimizations

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2000年后中国Q热的临床表现及诊疗研究进展

第二十六届中国控制会议

作者： Kwon woo Hyun School of Electrical Engr.＆ Computer Science Seoul Nat’l Univ.Seoul151-742Korea

ISBN: (纸本)7900719229;9787900719225

This paper introduces some recent developments on the receding horizon *** deal with mathematical models such as state space models of continuous variable systems and controlled Markov chains （CMC） of discrete event systems （DES）.For given mathematical models,common design objectives and performance indices are *** advantages of the receding horizon scheme are *** this paper,receding horizon schemes are introduced for both minimization and minimaximization *** the case of state space models,we first start from a general nonlinear system and move to a linear ***,we introduce the state feedback and the output feedback receding horizon controls.A linear time delay and I/O systems are also discussed for applicability of the receding horizon *** an application to a discrete event system,we introduce receding horizon policies for the average reward criterion and the two person zero sum game of controlled Markov *** differences between the receding horizon performance criteria and the infinite horizon ones are represented in terms of the horizon size.

关键词： Infinite horizon Receding horizon Receding horizon control Receding horizon filter Receding horizon finite memory control Receding horizon policy.

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中国感染与化疗杂志 2024年第2期24卷 231-239页

作者：邓超文孙林琳叶海燕陈福和邢凡凡香港大学深圳医院感染性疾病医学部感染科广东深圳518000

Q热(Q fever)是贝纳柯克斯体(Coxiella burnetii)感染引起的一种世界性分布的人畜共患病,可累及颅脑、肺脏、肝脏、心脏瓣膜、血管、骨关节等部位。Q热侵入人体网状内皮系统可引起多系统发热性急性或持续性局灶感染,急性感染表现为发热... 详细信息

Q热(Q fever)是贝纳柯克斯体(Coxiella burnetii)感染引起的一种世界性分布的人畜共患病,可累及颅脑、肺脏、肝脏、心脏瓣膜、血管、骨关节等部位。Q热侵入人体网状内皮系统可引起多系统发热性急性或持续性局灶感染,急性感染表现为发热、头痛、肺炎、肝炎等,持续性局灶感染表现为心内膜炎、血管感染、骨髓炎等。由于Q热的临床表现多样、流行病学史资料无特异性、未纳入我国法定传染性疾病、医务工作者对其诊断和治疗方面存在认识不足以及实验室检查方法未被广泛应用等原因,导致误诊和延误诊断时有发生。另一方面,国内关于Q热的研究更多聚焦在畜牧业领域或病例报告,较少有临床或研究工作者对该病进行分析总结。

关键词： Q热贝纳柯克斯体诊断治疗

Preliminary results of pre-radiation neck dissection in head ＆ neck cancer patients undergoing organ preservation treatment

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Preliminary results of pre-radiation neck dissection in head...

Five-year major clinical outcomes between first-generation ana second- generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention

2005国际暨第八届全国头颈肿瘤大会

作者： Kwang Hyun Kim J.Hun Hah woo-Jin Jeong Young-Ho Jung Seong Keun Kwon Dae seog Heo hong-Gyun Wu Myung-Whun Sung Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Departments of Otolaryngology-Head ＆ Neck Surgery Internal Medicine and Radiation Oncology Seoul National University College of MedicineSeoulKorea Departments of Otolaryngology-Head ＆ Neck Surgery

＜正＞ Aim of study:Establish the role of pre-radiation neck dissection in undergoing organ preservation treatment for patients with head ＆ neck squamous cell *** ＆ methods:Thirty-two patients treated at two tertiary referral centersbetween July 1997 and March 2005 were *** had histologically confirmedadvanced head ＆ neck squamous cell carcinoma with proven regional *** treated with organ preservation intent with or without pre-radiation *** induction chemotherapy,15 patients with less than completeresponse in the neck underwent neck dissection prior to definitive radiotherapy,and 17 patients proceded in conventional *** medical record

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Journal of Geriatric Cardiology 2018年第8期15卷 523-533页

作者： Yong Hoon Kim Ae-Young Her Seung-woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Ju Yeol Baek woong Gil Choi Tae Soo Kang Ji Hoon Ahn Sang-Ho Park Ahmed Mashaly Jin Oh Na Cheol Ung Choi hong Euy Lim Eung Ju Kim Chang Gyu Park hong seog Seo Dong Joo Oh Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuneheon South Korea Cardiovascular Center Korea University Guro Hospital Seoul South Korea Department of Medicine Korea University Graduate School Seoul South Korea Cardiovascular Center Cheong Ju St. Mary hospital Cheong Ju Chung Buk South Korea SCardiology Department Konkuk University Chungju Hospital Chungju South Korea Department of Internal Medicine Cardiovascular Division Dankook University Hospital Cheonan South Korea Department of Cardiology Soonchunhyang University Gumi Hospital G-umi South Korea Cardiology Department Soonchunhyang University Cheonan Hospital Cheonan South Korea

Background There were limited data comparing the major clinical outcomes between first-generation （1G）-drug eluting stentts （DES） and second-generation （2G）-DES in patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI） during very long follow-up periods. We thought to investigate the comparative efficacy and safety of 2G-DES compared with 1G-DES in AMI patients during 5-year follow-up periods. Method A total of 1016 eligible AMI patients who underwent PCI with 1G-DES [paclitaxel-, sirolimus-, 1G-zotarolimus-eluting stent （endeavor~ or endeavor sprintS）, n = 554] or 2G-DES [2G-zotarolimus （endeavor resolute~）- or everolimus-eluting stent, n = 462] were enrolled. The primary endpoint was the occurrence of major adverse cardiac events （MACE） defined as total death, non-fatal myocardial infarction （MI）, target lesion revascularization （TLR）, target vessel revascularization （TVR）, non-target vessel revascularization （Non-TVR） and the secondary endpoint was stem thrombosis （ST） at 5 years. Results Two propensity score-ma- tched （PSM） groups （232 pairs, n = 464, C-statistic = 0.802） were generated. During the 5-year follow-up period, the cumulative incidence of TLR [hazard ratio （HR）： 3.133; 95% confidence interval （CI）： 1.539-6.376; P = 0.002], TVR （HR： 3.144; 95% CI： 1.59645.192; P = 0.001） and total revascularization rate （FIR： 1.874; 95% CI： 1.086-3.140; P = 0.023） were significantly higher in 1G-DES compared with 2G-DES after PSM. However, the incidence of total death, non-fatal MI and ST were similar between the two groups. Conclusion In this single-center and all-comers registry, 2G-DES＇s superiorities for TLR, TVP, and total revascularization in AMI patients suggested during 5-year clinical follow-up periods.

关键词： Acute myocardial infarction Clinical outcomes Drug-eluting stem

Segmented tomographic evaluation of structural degradation of carbon support in proton exchange membrane fuel cells

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Journal of Energy Chemistry 2022年第11期31卷 359-367,I0010页

作者： Jung A.hong Min-Hyoung Jung Sung Yong Cho Eun-Byeol Park Daehee Yang Young-Hoon Kim Sang-Hyeok Yang woo-Sung Jang Jae Hyuck Jang Hyo June Lee Sungchul Lee Hu Young Jeong Young-Min Kim Department of Energy Science Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Fuel Cell Core Parts Development Cell Hyundai Mobis Co.Ltd.Uiwang 16082Republic of Korea Electron Microscopy&Spectroscopy Team Korea Basic Science Institute(KBSI)Daejeon 34133Republic of Korea Graduate School of Semiconductor Materials and Devices Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

The variation of the three-dimensional(3D)structure of the membrane electrode of a fuel cell during proton exchange cycling involves the corrosion/compaction of the carbon *** increasing degradation of the carbon structure continuously reduces the electrocatalytic performance of proton exchange membrane fuel cells(PEM-FCs).This phenomenon can be explained by performing 3D tomographic analysis at the ***,conventional tomographic approaches which present limited experimental feasibility,cannot perform such evaluation and have not provided sufficient structural information with statistical significance thus ***,a reliable methodology is required for the 3D geometrical evaluation of the carbon ***,we propose a segmented tomographic approach which employs pore network analysis that enables the visualization of the geometrical parameters corresponding to the porous carbon structure at a high *** approach can be utilized to evaluate the 3D structural degradation of the porous carbon structure after cycling in terms of local surface area,pore size distribution,and their 3D *** geometrical parameters of the carbon body were demonstrated to be substantially reduced owing to the cycling-induced *** information enables a deeper understanding of the degradation phenomenon of carbon supports and can contribute to the development of stable PEM-FC electrodes.

关键词： Electron tomography Fuel cell Proton exchange membrane Membrane electrode assembly Carbon corrosion