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Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model

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Journal of Traditional Chinese Medicine 2019年第6期39卷 833-841页

作者： Young-Wook Park Gi yoon Heo Min Jae Kim seo-Yeon Lee Byung Tae Choi Hwa Kyoung Shin Division of Meridian and Structural Medicine School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea Korean Medical Science Research Center for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea

OBJECTIVE:To investigate the optimal timing and underlying mechanism of electroacupuncture(EA)at Baihui(GV 20)and Dazhui(GV 14)for improved long-term functional recovery after focal cerebral ischemia in a photothrombotic stroke mouse ***:Totally 50 adult male C57 BL/6 J mice were assigned into 5 groups:(a)the control group,sham-operated mice(n=10);(b)the vehicle group,focal cerebral ischemia induction without EA(n=10);(c)the acute EA group,mice received EA immediately post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(d)the subacute EA group,mice received EA 4 days post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(e)the delayed EA *** stimulation(2 Hz,2 V for 20 min)was applied to acupuncture points(acupoints),Baihui(GV 20)and Dazhui(GV 14),once a day for 7 consecutive days beginning immediately(acute treatment),4 d(subacute treatment)and 10 d(delayed treatment)after focal cerebral ischemia in C57 BL/6 J *** assessments were conducted 21 and 28 d post-ischemia and histopathological analyses were performed 28 days ***:The subacute EA treatment at Baihui(GV20)and Dazhui(GV 14)significantly improved functional recovery compared to the vehicle group 28 d after ischemic brain injury,although brain atrophy was not *** number of Neu N+and Neu N+/Brd U+cells as well as GFAP intensity in the ipsilateral cortex were significantly increased in the subacute group compared to the vehicle group 28 d *** concluded that EA stimulation 4 d post-ischemia(subacute treatment)enhanced neurogenesis and astrogliosis,likely contributing to long-term functional recovery following focal cerebral ***:Our findings suggest that the timing of the EA therapy at Baihui(GV 20)and Dazhui(GV 14)determines the therapeutic effects in mice with focal cerebral ischemia induced by photothrombotic occlusion.

关键词： Electroacupuncture Stroke Astrocytes Neurogenesis Post-stroke remodeling

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Vomiting-induced pharyngeal perforation during bowel preparation for colonoscopy:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3615-3621页

作者： Geonhee Kim Won Hyuk Lee seokin Kang Jung Rock Moon yoon Suk Lee Jun Hyuk Son Nam-Hoon Kim Jong Wook Kim Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea

BACKGROUND Effective bowel cleansing is essential for a successful ***,such as polyethylene glycol,are commonly used for bowel *** is a frequent complication during bowel preparation,and forceful vomiting can potentially lead to esophageal perforation,as reported in several previous ***,pharyngeal perforation during bowel preparation has not been previously ***,we present a case of pharyngeal perforation induced by forceful vomiting during bowel *** SUMMARY A 38-year-old man with a history of hypertension,dyslipidemia,diabetes mellitus,and end-stage renal disease on hemodialysis was admitted for evaluation of recurrent abdominal *** patient complained of sudden pain in the neck,throat,and anterior chest following forceful vomiting during bowel *** examination revealed crepitus under the skin of the neck and anterior chest on palpation,and upper gastrointestinal endoscopy revealed pharyngeal *** perforation site was located above the upper esophageal sphincter,which distinguished it from Boerhaave’s *** medical management was chosen after consultation with a thoracic surgeon and an otolaryngologist,considering the patient's mild symptoms,stable vital signs,and the small size of the lesion;the perforation resolved without endoscopic or surgical *** patient was discharged from hospital two weeks after the *** Despite its rarity,pharyngeal perforation should be considered a potential complication of bowel preparation for colonoscopy.

关键词： Colonoscopy Pharynx Polyethylene glycols Spontaneous perforation Case report

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Malignant mesothelioma of the greater omentum mimicking omental infarction:A case report

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World Journal of Gastroenterology 2009年第38期15卷 4856-4859页

作者： Min-Kee Shin Ok-Jae Lee Chang-yoon Ha hyun-Joo Min Tae-Hyo Kim Department of Internal Medicine & Institute of Health Science Gyeongsang National University School of Medicine

Mesothelioma develops most commonly in the pleura, and less frequently in the peritoneum. Usually, it manifests as diffuse peritoneal thickening and multiple nodules, and rarely as a solitary mass. We report a rare case of primary malignant mesothelioma of the greater omentum, which mimicked omental infarct. A 54-year-old Korean man was admitted because of severe abdominal pain of sudden onset. A tender mass with indistinct margins was palpated in the upper abdomen. Abdominal ultrasound and computed tomography showed an ill- def ined mass in the greater omentum and little ascites in the peri-hepatic space, and neutrophil-dominant exudates were documented on paracentesis. Intravenous antibiotics and analgesics were given for omental infarction with superimposed infection, which resulted in symptomatic improvement. The imaging studies after a week revealed a growing mass and ascites. Laparoscopic surgery was performed and an 8 cm×3.3 cm greater omental mass was found, with multiple small nodules on the peritoneum, diaphragm, and pelvic cavity wall. Histological examination showed proliferating malignant epithelioid cells that stained strongly for calretinin, which was compatible with malignant mesothelioma. We recommend that primary omental mesothelioma should be included in the differential diagnosis of patients with omental infarction, despite its rarity.

关键词： Infarction Mesothelioma, Omentum

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Endoscopic repair of delayed stomach perforation caused by penetrating trauma:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1228-1236页

作者： Jae hyun yoon Chung Hwan Jun Jae Pil Han Ji-Woong Yeom Seung-Ku Kang hyun Yi Kook Sung KyuChoi Department of Gastroenterology and Hepatology Chonnam National University Hospital and College of MedicineGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea Department of Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Cardiothoracic Surgery Mokpo Hankook HospitalMokpo 58643South Korea Department of Nursing Chonnam National University Hospitaland College of NursingGwangju 61469South Korea

BACKGROUND Primary endoscopic closure of a perforated gastric wall during endoscopic procedures is mostly effective and well-tolerated;however,there are very few studies on the efficacy of endoscopic management of delayed traumatic gastric ***,we report a novel case of a patient who was successfully treated for delayed traumatic stomach perforation using an alternative endoscopic *** SUMMARY A 39-year-old woman presented with multiple penetrating traumas in the back and left abdominal *** imaging studies revealed left diaphragmatic disruption and peri-splenic hemorrhage without gastric *** emergency primary repair of the disrupted diaphragm with omental reduction and suturing of the lacerated lung was performed;however,delayed free perforation of the gastric wall was noted on computed tomography after 3 *** an emergency abdominal surgery for the primary repair of the gastric wall,re-perforation was noted 15 d *** high risk associated with re-surgery prompted an endoscopic intervention using 2 endoloops and 11 endoscopic clips using a novel modified purse-string suture *** free perforated gastric wall was successfully repaired without additional surgery or *** patient was discharged after 46 d without any *** Endoscopic closure with endoloops and clips can be a useful therapeutic alternative to re-surgery for delayed traumatic gastric perforation.

关键词： Surgical endoscopy Trauma Stomach Re-perforation Endoloop Case report

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KoNA:Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 161-167页

作者： Gunhwan Ko Jae Ho Lee Young Mi Sim Wangho Song Byung-Ha yoon Iksu Byeon Bang Hyuck Lee Sang-Ok Kim Jinhyuk Choi Insoo Jang Hyerin Kim Jin Ok Yang Kiwon Jang Sora Kim Jong-Hwan Kim Jongbum Jeon Jaeeun Jung Seungwoo Hwang Ji-Hwan Park Pan-Gyu Kim seon-Young Kim Byungwook Lee Korea Bioinformation Center Korea Research Institute of Bioscience&BiotechnologyDaejeon 34141Republic of Korea

During the last decade,the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges,including access to human data,as well as transfer,storage,and sharing of enormous amounts of *** promote data-driven biological research,the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station(K-BDS),which consists of multiple databases for individual data ***,we introduce the Korean Nucleotide Archive(KoNA),a repository of nucleotide sequence *** of July 2022,the Korean Read Archive in KoNA has collected over 477 TB of raw next-generation sequencing data from national genome *** ensure data quality and prepare for international alignment,a standard operating procedure was adopted,which is similar to that of the International Nucleotide Sequence Database *** standard operating procedure includes quality control processes for submitted data and metadata using an automated pipeline,followed by manual *** ensure fast and stable data transfer,a high-speed transmission system called GBox is used in ***,the data uploaded to or downloaded from KoNA through GBox can be readily processed using a cloud computing service called *** seamless coupling of KoNA,GBox,and Bio-Express enhances the data experience,including submission,access,and analysis of raw nucleotide *** not only satisfies the unmet needs for a national sequence repository in Korea but also provides datasets to researchers globally and contributes to advances in *** KoNA is available at https://***/kona/.

关键词： Korea BioData Station Nucleotide sequence Next-generation sequencing repository Genomics Deposition and access of big data

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Acute myopathy associated with liver cirrhosis

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World Journal of Gastroenterology 2006年第14期12卷 2254-2258页

作者： Ok-Jae Lee Jee-Hyang yoon Eun-Jeong Lee hyun-Jin Kim Tae-Hyo Kim Department of Internal Medicine and Gyeongsang Institute of Health Science Gyeongsang National University College of Medicine JinjuRepublic of Korea

AIM： Many cirrhotic patients have muscular symptoms and rhabdomyolysis. However, myopathy associated with liver cirrhosis has not been established as a disease entity. We evaluated the clinical significance of acute myopathy associated with liver cirrhosis. METHODS： We retrospectively reviewed the medical records of 5440 cirrhotic patients who had been admitted to Gyeongsang National University Hospital from August 1997 to January 2003. Among these, 99 developed acute myopathies, and they were analyzed with respect to clinical and laboratory parameters, and outcomes. RESULTS： The Child-Pugh classification at the time of myopathy onset was A in 3（3.1%） cases, B in 33（33.3%）, and C in 63 （63.6%）. Infection was identified as the most predisposing factor to myopathy. Fifty percent of 18 idiopathic cases who were tested for influenza antibody were positive. Forty-two of the 99 cases were complicated by acute renal failure, and 25 （59.5%） of these expired. Apart from 6 cases lost to follow-up, 64 of 93 recovered, giving a mortality rate of 31.2%. Mortality was higher in Child-Pugh class C than in B or A. CONCLUSION： Acute myopathy can develop as a serious complication in liver cirrhosis. Its frequency, severity and mortality depend on underlying liver function, and are higher in decompensated liver cirrhosis. Influenza should be considered as an etiologic factor in idiopathic cases. It is proposed that acute myopathy associated with liver cirrhosis be called ＇hepatic myopathy; and that careful monitoring for hepatic myopathy is necessary in the patients with advanced liver cirrhosis.

关键词： Myopathy Rhabdomyolysis Liver cirrhosis

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Randomized clinical trial comparing fixed-time split dosing and split dosing of oral Picosulfate regimen for bowel preparation

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World Journal of Gastroenterology 2017年第32期23卷 5986-5993页

作者： Jae Hyuck Jun Koon Hee Han Jong Kyu Park hyun Il seo Young Don Kim Sang Jin Lee Baek Gyu Jun Min Sik Hwang yoon Kyoo Park Myeong Jong Kim Gab Jin Cheon Department of Internal Medicine Gangneung Asan Hospital University of Ulsan College of Medicine Catholic Kwandong University

AIM To compare the efficacy of fixed-time split dose and split dose of an oral sodium picosulfate for bowel *** This is study was prospective, randomized controlled study performed at a single Institution(2013-058). A total of 204 subjects were assigned to receive one of two sodium picosulfate regimens(i.e., fixed-time split or split) prior to colonoscopy. Main outcome measurements were bowel preparation quality and subject *** There was no statistical difference between the fixedtime split dose regimen group and the split dose regimen group(Ottawa score mean 2.57 ± 1.91 vs 2.80 ± 2.51, P = 0.457). Cecal intubation time and physician's satisfaction of inspection were not significantly different between the two groups(P = 0.428, P = 0.489). On subgroup analysis, for afternoon procedures, the fixed-time split dose regimen was equally effective as compared with the split dose regimen(Ottawa score mean 2.56 ± 1.78 vs 2.59 ± 2.27, P = 0.932). There was no difference in tolerability or compliance between the two groups. Nausea was 21.2% in the fixed-time split dose group and 14.3% in the split dose group(P = 0.136). Vomiting was 7.1% and 2.9%(P = 0.164), abdominal discomfort 7.1% and 4.8%(P = 0.484), dizziness 1% and 4.8%(P = 0.113), cold sweating 1% and 0%(P = 0.302) and palpitation 0% and 1%(P = 0.330), respectively. Sleep disturbance was two(2%) patients in the fixed-time split dose group and zero(0%) patient in the split dose preparation(P = 0.143) *** A fixed-time split dose regimen with sodium picosulfate is not inferior to a split dose regimen for bowel preparation and equally effective for afternoon colonoscopy.

关键词： Colonoscopy Bowel preparation Split dose preparation Sodium picosulfate Ottawa Bowel Preparation Scale

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Congenital retinal macrovessel with intracranial venous malformation in a pediatric patient: a case report

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1214-1216页

作者： Hyeon Jin Park Sook hyun yoon Sook Young Kim Donghun Lee Department of Ophthalmology Daegu Catholic University School of MedicineDaegu 42472Republic of Korea

Dear Editor,Congenital retinal macrovessel (CRM) is defined as an abnormal large retinal vessel that encircles the foveal avascular zone (FAZ).Since the first description of a large aberrant vessel crossing the macula by Mauthnerin 1868,there have been several case reports about *** recently,Pichi et alreported clinical manifestations and multimodal retinal imaging of 49 eyes with *** their study,they had identified an association between macrovessel in the retina and venous anomalies of the brain and they emphasized the importance of systemic workups including brain magnetic resonance imaging (MRI).

关键词： venous Congenital malformation

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Efficiency enhancement of fluorescent blue organic light-emitting diodes using doped hole transport and emissive layers

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Chinese Optics Letters 2016年第4期14卷 86-90页

作者： Nam Ho Kim You-hyun Kim Ju-An yoon Seung Ⅱ Yoo Kok Wai Cheah Furong Zhu Woo Young Kim Department of Green Energy & Semiconductor Engineering Hoseo University 513-3 2nd Engineering Building 20 Hoeo-ro beon-gil baebang-eup Asan-si Chungcheongnam-do 31499 South Korea Department of Engineering Physics McMaster University 1280 Main St W Hamilton L8S 4L8 Canada Department of Physics Hong Kong Baptist University Hong Kong Kowloon Tong Waterloo Road 224 China

The electroluminescent characteristics of blue organic light-emitting diodes （BOLEDs） fabricated with doped charge carrier transport layers are analyzed. The fluorescent blue dopant BCzVBi is doped in an emissive layer, hole transport layer （HTL） and electron transport layer （ETL）, respectively, to optimize the probability of ex- citon generation in the BOLEDs. The luminance and luminous efficiency of BOLEDs made with BCzVBi-doped HTL and ETL increase by 22% and 17% from 11,683 cd/m2 at 8.5 V and 6.08 cd/A at 4.0 V to 14,264 cd/m2 at 8.5 V and 7.13 cd/A at 4.0 V while CIE coordinates of （0.15, 0.15） of both types of BOLEDs remained unchanged. The electron mobility of BCzVBi is estimated to be 1.02 × 10-5 cm2/Vs by TOF.

关键词： Carrier transport Doping (additives) Efficiency Electron transport properties Fluorescence Hole mobility Light emission Light emitting diodes

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Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression

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Cellular & Molecular Immunology 2016年第6期13卷 862-870页

作者： Jeong-Min Lee Young-Saeng Jang Bo-Ra Jin Sun-Jin Kim Hyeon-Jin Kim Bo-Eun Kwon hyun-Jeong Ko Sung-il yoon Geun-Shik Lee Woan-Sub Kim Goo-Young seo Pyeung-Hyeun Kim Department of Molecular Bioscience School of Biomedical Science Kangwon National University Chuncheon Republic of Korea Laboratory of Microbiology and Immunology College of Pharmacy Kangwon National University Chuncheon Republic of Korea Department of Systems Immunology College of Biomedical Science Kangwon National University Chuncheon 200-701 Republic of Korea College of Veterinary Medicine Kangwon National University Chuncheon Gangwon 200-701 Republic of Korea Department of Animal Life and Environmental Science College of Agriculture and Life Science Hankyong National University Anseong-si 456-749 Republic of Korea

Lactoferrin （LF） and retinoic acid （RA） are enriched in colostrum, milk, and mucosal tissues. We recently showed that LF-induced IgA class switching through binding to betaglycan （transforming growth factor-beta receptor III, TpRIII） and activation of canonical TGF-p signaling. We investigated the combined effect of LF and RA on the overall IgA response. An increase in IgA production by LF was further augmented by RA. This combination effect was also evident in Ig germ-line α （GLa） transcription and GLa promoter activity, indicating that LF in cooperation with RA increased IgA isotype switching. We subsequently found that RA enhanced TβRIII expression and that this increase contributed to LF-stimulated IgA production. In addition to the IgA response, LF and RA in combination also enhanced the expression of the gut-homing molecules C-C chemokine receptor 9 （CCR9） and a4β7 on B cells. Finally, peroral administration of LF and RA enhanced the frequency of CCR9＋ IgA＋ plasma cells in the lamina propria. Taken together, these results suggest that LF in cooperation with RA can contribute to the establishment of gut IgA responses.

关键词： gut homing molecule IgA lactoferrin retinoic acid TGF-β receptor

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