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Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents

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Food Science and Human Wellness 2023年第4期12卷 1008-1019页

作者： Weiyi Chu Chia Wei Phan seng Joe Lim Abdul Salam Babji Department of Pharmaceutical Life Sciences Faculty of PharmacyUniversiti MalayaKuala Lumpur 50603Malaysia Clinical Investigation Centre University Malaya Medical CentreLembah Pantai Kuala Lumpur 59100Malaysia Mushroom Research Centre Universiti MalayaKuala Lumpur 50603Malaysia Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor 43600Malaysia Innovation Centre for Confectionery Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor 43600Malaysia

Neurodegenerative diseases are often associated with the accumulation of oxidative stress and *** bird’s nest(EBN)is a glycoprotein(sialylated mucin glycopeptides)found to be beneficial against neurodegenerative ***,anti-inflammatory,and anti-apoptotic properties of EBN in preserving neuronal cells were widely researched using in vitro and in vivo *** effects of EBN are often linked to its great number of antioxidants and anti-inflammatory *** compounds in EBN,especially sialic acid,add value to neurotrophic potential of EBN and contribute to neuronal repair and *** studies reporting the neuroprotective effects of EBN,their molecular mechanisms,and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of EBN.

关键词： Antioxidant Composition Edible bird nest Neurodegenerative disease Neuroprotection Sialylated mucin glycopeptide

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单发性神经纤维瘤

临床皮肤科杂志 2024年第3期53卷 129-130页

作者：龙声志贾敏文昌晖曾维胡森陈晨毛微毕节市中医医院皮肤科贵州毕节551700 贵州中医药大学第一附属医院皮肤科贵州贵阳550000 毕节市中医医院病理科贵州毕节551700

患者女,25岁,主诉:胸部左侧结节25年。现病史:25年前患者出生时胸部左侧一丘疹样大肤色丘疹,随患者年龄增长逐渐增大,病程中无不适,未诊治。既往史及家族史:既往体健,家族中无类似疾病患者。体格检查:系统检查无异常,全身浅表淋巴结无... 详细信息

患者女,25岁,主诉:胸部左侧结节25年。现病史:25年前患者出生时胸部左侧一丘疹样大肤色丘疹,随患者年龄增长逐渐增大,病程中无不适,未诊治。既往史及家族史:既往体健,家族中无类似疾病患者。体格检查:系统检查无异常,全身浅表淋巴结无增大。皮肤科检查:胸部左侧腋前线与乳头平齐交界处见一2.2 cm×2.2 cm×0.3 cm圆形结节,蘑菇头状(图1),边界清楚,质地较硬,重压有疼痛感。

关键词：单发性神经纤维瘤肿瘤 S-100蛋白

Analysis of Corrugated Long-Period Gratings in Planar Waveguides and Their Polarization Dependence

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光学学报 2003年第S1期23卷 147-148页

作者： Kin seng Chiang Vipul Rastogi Optoelectronics Research Centre and Department of Electronic Engineering City University of Hong Kong Tat Chee Avenue Hong Kong P. R. ChinaOptoelectronics Research Centre and Department of Electronic Engineering City University of Hong Kong Tat Chee Avenue Hong Kong P. R. China

We present a theoretical analysis of corrugated long-period gratings in planar waveguides. In particular, we calculate the transmission spectra for both the TE and TM polarizations and highlight the polarization-indep... 详细信息

关键词： of TE TM mode in Analysis of Corrugated Long-Period Gratings in Planar Waveguides and Their Polarization Dependence Long

Extracting the low-energy constant L_(0)^(r)at three flavors from pion-kaon scattering

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Communications in Theoretical Physics 2022年第6期74卷 61-65页

作者： Chaitra Kalmahalli Guruswamy Ulf-G Meißner Chien-Yeah seng Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnD-53115 BonnGermany Institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron PhysicsForschungszentrum JülichD-52425 JülichGermany Tbilisi State University 0186 TbilisiGeorgia

based on our analysis of the contributions from the connected and disconnected contraction diagrams to the pion-kaon scattering amplitude,we provide the first determination of the only free low-energy constant at O(p^(4)),known as L_(0)^(r),in SU(4|1)Partially-Quenched Chiral Perturbation theory using the data from the Extended Twisted Mass collaboration,L_(0)^(r)(μ=M_(ρ))=0.77(20)(25)(7)(7)(2)·10^(-3).The theory uncertainties originate from the unphysical scattering length,the physical low-energy constants,the higher-order chiral corrections,the(lattice)meson masses and the pion decay constant,respectively.

关键词： lattice QCD partially quenched chiral perturbation theory pion-kaon scattering

新疆西昆仑—喀喇昆仑地区锂多金属成矿带地质特征及资源潜力

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西部探矿工程 2024年第7期36卷 78-81页

作者：蒋炜李伟杜斌裴森龙杜杰有色金属矿产地质调查中心北京100012

通过对新疆西昆仑—喀喇昆仑地区的地质背景、矿床类型及资源现状进行综合分析,揭示了其作为我国重要战略资源基地的潜力。该地区地质构造复杂,受特提斯构造域北缘的影响,历经多期构造活动,形成了丰富的锂多金属矿产资源。矿床类型主要... 详细信息

通过对新疆西昆仑—喀喇昆仑地区的地质背景、矿床类型及资源现状进行综合分析,揭示了其作为我国重要战略资源基地的潜力。该地区地质构造复杂,受特提斯构造域北缘的影响,历经多期构造活动,形成了丰富的锂多金属矿产资源。矿床类型主要为花岗伟晶岩型。目前,该区域的锂资源开发正处于起步阶段,大多数矿区仍未被充分开发。鉴于全球对清洁能源和新能源汽车的需求持续增长,该地区的锂多金属资源有望成为未来重要的供应基地。

关键词：新疆西昆仑—喀喇昆仑锂多金属地质特征矿床类型资源开发

Synthesis of a kind of geminal imidazolium ionic liquid with long aliphatic chains

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Chinese Chemical Letters 2007年第1期18卷 48-50页

作者： Yun Sheng Ding Min Zha Jun Zhang seng Shan Wang Department of Polymer Materials and Engineering School of Chemical Engineering Hefei University of Technology Hefei 230009 China CAS Key Laboratory of Engineering Plastics Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

A novel geminal imidazolium ionic liquid with long hydrocarbon group, 1,4-bis （3-tetradecylimidazolium- 1-yl） butane bromide was synthesized and an efficient synthesized method was introduced detailedly. Its structu... 详细信息

关键词： Geminai imidazolium ionic liquid Long aliphatic chain Physicochemicai properties

脉冲负载两级式DC-DC拓扑与控制策略研究

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电器与能效管理技术 2024年第5期 20-29页

作者：张森曹轩谭云飞赵志宏国网江苏省电力有限公司电力科学研究院江苏南京210000 南京理工大学江苏南京210096

为满足脉冲负载直流变换器高功率密度和高动态响应性能的要求,研究了一种应用于脉冲负载的两级式直流变换器。选用滤波电感更小、系统环路带宽更高的三电平同步整流Buck变换器作为前级变换器,选用DCX-LLC谐振变换器作为后级变换器,其相... 详细信息

为满足脉冲负载直流变换器高功率密度和高动态响应性能的要求,研究了一种应用于脉冲负载的两级式直流变换器。选用滤波电感更小、系统环路带宽更高的三电平同步整流Buck变换器作为前级变换器,选用DCX-LLC谐振变换器作为后级变换器,其相对闭环控制LLC在动态响应及效率方面更具优势。然后提出优化TL-Buck开关管电压应力的软起动策略,解决了软起动阶段飞跨电容电压在完成充电后降到很低的问题。最后,通过仿真和实验验证了所提两级式直流变换器闭环及软起动控制策略能优化前级TL-Buck起动时开关管电压应力。

关键词：脉冲负载直流变换器脉冲功率平衡两级式架构快速动态响应

Cloning, characterization and expression analysis of a microsomal glutathione S-transferase gene from the seagrass Zostera marina

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Acta Oceanologica Sinica 2019年第10期38卷 111-115页

作者： Wenjie Yan Jiao Liu Samphal seng Bin Zhou Kuke Ding Department of Marine Ecology College of Marine Life SciencesOcean University of ChinaQingdao 266003China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Faculty of Fisheries&Aquaculture Royal University of AgriculturePhnom Penh 12101Cambodia National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijing 100088China Key Laboratory of Radiological Protection and Nuclear Emergency Chinese Center for Disease Control and PreventionBeijing 100088China

The response of glutathione S-transferase(GST)in Zostera marina to temperature variation was analyzed at molecular level by cloning the microsomal GST gene and texting the microsomal GST expression regularity under different *** speaking,express ZmGST in Escherichia coli,then purify the recombinant protein and make the thermal stability ***,the experiments were carried out to provide a theoretical basis for the further elaboration to the population degradation mechanisms of *** conclusion,the thermostability and the response of ZmGST gene to temperature changes can determine its temperature tolerance range,and affect its resilience in turn.

关键词： Zostera marina antioxidant enzyme glutathione S-transferase (GST) temperature enzyme activity

Clinical relevance of cancer genome sequencing

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World Journal of Gastroenterology 2013年第13期19卷 2011-2018页

作者： Chee seng Ku David N Cooper Dimitrios H Roukos Department of Medical Epidemiology and Biostatistics Karolinska Institute Institute of Medical Genetics School of MedicineCardiff University Department of Surgery Ioannina University School of Medicine Centre for Biosystems and Synthetic Genomic Network Medicine Centre for BioSystems and Genomic Network MedicineIoannina University

The arrival of both high-throughput and bench-top next-generation sequencing technologies and sequence enrichment methods has revolutionized our approach to dissecting the genetic basis of cancer. These technologies have been almost invariably employed in wholegenome sequencing (WGS) and whole-exome sequencing (WES) studies. Both WGS and WES approaches have been widely applied to interrogate the somatic mutational landscape of sporadic cancers and identify novel germline mutations underlying familial cancer syndromes. The clinical implications of cancer genome sequencing have become increasingly clear, for example in diagnostics. In this editorial, we present these advances in the context of research discovery and discuss both the clinical relevance of cancer genome sequencing and the challenges associated with the adoption of these genomic technologies in a clinical setting.

关键词： Next-generation sequencing Exome Cancer Diagnostics Familial cancer syndrome Somatic mutation