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Validation of genetic variants associated with metabolic dysfunctionassociated fatty liver disease in an ethnic Chinese population

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World Journal of Hepatology 2020年第12期12卷 1228-1238页

作者： Guan Huei Lee Wah Wah Phyo Wai Mun Loo Raymond Kwok Taufique Ahmed Asim Shabbir Jimmy So Calvin Jianyi Koh Juanda Leo Hartono Mark Muthiah Kieron Lim Poh seng Tan Yin Mei Lee seng geelim Yock Young Dan Division of Gastroenterology and Hepatology Department of MedicineNational University Health SystemSingapore 119228Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Medicine Khoo Teck Puat HospitalSingapore 768828Singapore Department of Surgery National University Health SystemSingapore 119228Singapore

BACKGROUND Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To study the association of single nucleotide polymorphisms(SNPs),previously identified in Western populations,with the risk of MAFLD in a Singapore Chinese population and their interactions with environmental and medical risk *** A retrospective case-control study was conducted with 72 MAFLD cases and 72 controls with no hepatic steatosis on computed tomography,magnetic resonance imaging,or controlled attenuation parameter *** were recruited from two tertiary *** alleles such as NCAN,GCKR,LYPLAL1,PNPLA3,PPP1R3B,FDFT1,COL13A1,EFCAB4B,PZP,and TM6SF2 were genotyped using the TaqMan®Predesigned SNP Genotyping *** Weight and body mass index(BMI)were 1.2-times higher in patients(70.6 kg,95%confidence interval[CI]:57.1-84.1 vs 60.8 kg,95%CI:48.5-73.1,P<0.001 and 26.9 kg,95%CI:23-40.8 vs 23.3 kg 95%CI:19-27.6,P<0.001 respectively).The prevalence of diabetes mellitus in patients was 40.3%and 20.8%in controls(P=0.011).Patients had higher mean triglycerides than controls(P<0.001).PNPLA3 GG was more likely to be associated with MAFLD(43.4%CC vs 69.7%GG,P=0.017,and 44.8%CG vs 69.7%GG,P=0.022).In multivariable analysis,hypertriglyceridemia(odds ratio[OR]:2.0495%CI:1.3-3.1,P=0.001),BMI(OR:1.295%CI:1.1-1.4,P<0.001)and PNPLA3 GG(OR:3.495%CI:1.3-9.2,P=0.014)were associated with MAFLD(area under the receiver operating characteristic curve of 0.823).CONCLUSION Among the Chinese population of Singapore,PNPLA3 homozygous GG allele is a strong predictor of MAFLD,whereas LYPLAL1,GCKR,FDFT1,COL13A1,PZP,and TM6SF2 are not significantly ***,high BMI,and PNPLA3 GG are independent predictors of MAFLD.

关键词： Single nucleotide polymorphism PNPLA3 Genotyping Metabolic dysfunction-associated fatty liver disease Non-alcoholic steatohepatitis Hypertriglyceridemia Body mass index Waist-hip ratio,Screening Hepatic steatosis

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YOLO-CRD:A Lightweight Model for the Detection of Rice Diseases in Natural Environments

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1275-1296页

作者： Rui Zhang Tonghai Liu Wenzheng Liu Chaungchuang Yuan Xiaoyue seng Tiantian Guo Xue Wang Tianjin Key Laboratory of Intelligent Breeding of Major Crops Tianjin Agricultural UniversityTianjin300392China College of Computer and Information Engineering Tianjin Agricultural UniversityTianjin300392China

Rice diseases can adversely affect both the yield and quality of rice crops,leading to the increased use of pesticides and environmental *** detection of rice diseases in natural environments is crucial for both operational efﬁciency and quality *** learning-based disease identiﬁcation technologies have shown promise in automatically discerning disease ***,effectively extracting early disease features in natural environments remains a challenging *** address this issue,this study proposes the YOLO-CRD *** research selected images of common rice diseases,primarily bakanae disease,bacterial brown spot,leaf rice fever,and dry tip nematode disease,from Tianjin *** proposed YOLO-CRD model enhanced the YOLOv5s network architecture with a Convolutional Channel Attention Module,Spatial Pyramid Pooling Cross-Stage Partial Channel module,and Ghost *** former module improves attention across image channels and spatial dimensions,the middle module enhances model generalization,and the latter module reduces model *** validate the feasibility and robustness of this method,the detection model achieved the following metrics on the test set:mean average precision of 90.2%,accuracy of 90.4%,F1-score of 88.0,and GFLOPS of *** the speciﬁc diseases,the mean average precision scores were 85.8%for bakanae disease,93.5%for bacterial brown spot,94%for leaf rice fever,and 87.4%for dry tip nematode *** studies and comparative analyses veriﬁed the effectiveness and superiority of the proposed *** researchﬁnd-ings can be applied to rice disease detection,laying the groundwork for the development of automated rice disease detection equipment.

关键词： Convolutional neural network one stage training rice disease deep learning

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Graphene quantum dots:preparations,properties,functionalizations and applications

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Materials Futures 2024年第2期3卷 36-84页

作者： Pin Tian Libin Tang Kar-seng Teng Shu-Ping Lau Kunming Institute of Physics 650223 KunmingYunnanPeople’s Republic of China Department of Electronic and Electrical Engineering Faculty of Science and EngineeringSwansea UniversityBay CampusFabian WaySwansea SA18ENUnited Kingdom Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongPeople’s Republic of China

Zero-dimensional graphene quantum dots(GQDs)exhibit many different properties,such as strong fluorescence,nonzero bandgap and solubility in solvents,compared to two-dimensional *** are biocompatible and have low toxicity;hence,they are widely used in the biomedical *** edge effect of GQDs is of particular interest because edge modification can regulate the performance of *** this review,various preparation methods for GQDs,which can be divided into three main categories,namely top-down,bottom-up and chemical methods,are *** unique optical,electrical,thermal and magnetic properties of GQDs are *** functionalization of GQDs by doping with heteroatoms and forming composites with other materials is studied,and the characteristics of these GQDs are also *** applications of these GQDs in the fields of optics,electricity,optoelectronics,biomedicine,energy,agriculture and other emerging interdisciplinary fields are reviewed to highlight the enormous potential of *** review reports on the recent advancement in GQD research and suggests future directions for the development of GQDs.

关键词： graphene quantum dots:preparations properties functionalizations and applications

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Precise mode control of laser-written waveguides for broadband,low-dispersion 3D integrated optics

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Light(Science & Applications) 2024年第6期13卷 1186-1195页

作者： Yuying Wang Lijing Zhong Kuen Yao Lau Xuhu Han Yi Yang Jiacheng Hu Sergei Firstov Zhi Chen Zhijun Ma Limin Tong Kin seng Chiang Dezhi Tan Jianrong Qiu College of Optical Science and Engineering Zhejiang University310027HangzhouChina Institute of Light+X Science and Technology College of Information Science and EngineeringNingbo University315211NingboChina School of Optoelectronic Science and Engineering&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University215006SuzhouChina Prokhorov General Physics Institute of the Russian Academy of Sciences Dianov Fiber Optics Research Center38 Vavilov str.Moscow119333Russia Zhejiang Lab 311121HangzhouChina College of Materials Science and Engineering Key Laboratory of Advanced Materials of Yunnan ProvinceKunming University of Science and Technology650093KunmingYunnanChina Department of Electrical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina School of Materials Science and Engineering Zhejiang University310027HangzhouChina

Three-dimensional(3D)glass chips are promising waveguide platforms for building hybrid 3D photonic circuits due to their 3D topological capabilities,large transparent windows,and low coupling *** present,the key challenge in scaling down a benchtop optical system to a glass chip is the lack of precise methods for controlling the mode field and optical coupling of 3D waveguide ***,we propose an overlap-controlled multi-scan(OCMS)method based on laser-direct lithography that allows customizing the refractive index profile of 3D waveguides with high spatial precision in a variety of *** the basis of this method,we achieve variable mode-field distribution,robust and broadband coupling,and thereby demonstrate dispersionless LP21-mode conversion of supercontinuum pulses with the largest deviation of<0.1 dB in coupling ratios on 210 nm *** approach provides a route to achieve ultra-broadband and low-dispersion coupling in 3D photonic circuits,with overwhelming advantages over conventional planar waveguide-optic platforms for on-chip transmission and manipulation of ultrashort laser pulses and broadband supercontinuum.

关键词： waveguide mode dispersion

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Characteristics of Biopellets Manufactured from Various Lignocellulosic Feedstocks as Alternative Renewable Energy Sources

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Journal of Renewable Materials 2024年第6期12卷 1103-1123页

作者： Anggara Ridho Putra Apri Heri Iswanto Arif Nuryawan Saptadi Darmawan ElvaraWindra Madyaratri Widya Fatriasari Lee seng Hua Petar Antov Harisyah Manurung Ade Pera Amydha Sudrajat Herawati Pendi Department of Forest Products Faculty of ForestryUniversitas Sumatera Utara.Kampus USU Padang BulanMedan20155Indonesia Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Jl Raya Bogor KM 46 CibinongBogor16911Indonesia Department of Wood Industry Faculty of Applied SciencesUniversiti Teknologi MARA(UiTM)Cawangan Pahang Kampus JengkaShah Alam26400Malaysia Faculty of Forest Industry University of ForestrySofia1797Bulgaria

The increased valorization of renewable and cost-effective lignocellulosic feedstocks represents a viable,sustainable,and eco-friendly approach toward the production of biopellets as alternative energy *** aim of this research work was to investigate and evaluate the feasibility of using various lignocellulosic raw materials,i.e.,raru(Cotylelobium melanoxylon),mangrove(Rhizophora spp.),sengon(Paraserianthes falcataria),kemenyan toba(Styrax sumatrana),oil palm(Elaeis guineensis),manau rattan(Calamus manan),and belangke bamboo(Gigantochloa pruriens)for manufacturing biopellets with different particle *** raw materials used were tested for their moisture content,specific gravity,ash,cellulose,and lignin *** addition,thermal analyses,i.e.,calorific values,thermogravimetric analysis(TGA),and differential scanning calorimetry(DSC),were *** following properties of the biopellets produced were investigated:moisture content,volatile matter,ash content,fixed carbon,density,and thermal *** on an analysis of the raw materials,raru had the lowest moisture content(12%)and ash content(1.5%)and the highest specific gravity(1.2).Markedly,palm oil stem had the highestα-cellulose(55%)and lignin(37%)*** accordance with the SNI 8675:2018 standard requirements,biopellets with optimal properties(moisture content of 1.4%,ash content of 0.79%,density of 1.09 g/m^(3),calorific value of 4672 cal/g,and TGA residue of 13.9%),were manufactured from raru wood.

关键词： Biomass biopellet renewable energy particle size

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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神话演变与民族文化交融研究——以西王母神话为例

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西北民族大学学报（哲学社会科学版） 2024年第4期 92-101页

作者：僧格路转红西北民族大学中国语言文学学部甘肃兰州730030

神话是上古时期的人们用幻想形式观照和反映客观世界的产物,神话的演变往往与民族之间交往交流交融有关。发轫于昆仑山脉的西王母神话起初代表的是羌戎部族的文化记忆,随着羌戎与中原民族交往的加深,其主人公西王母的形象发生改变。西... 详细信息

神话是上古时期的人们用幻想形式观照和反映客观世界的产物,神话的演变往往与民族之间交往交流交融有关。发轫于昆仑山脉的西王母神话起初代表的是羌戎部族的文化记忆,随着羌戎与中原民族交往的加深,其主人公西王母的形象发生改变。西王母神话的演变过程中渗透着羌戎文化与中原文化的交融,其和谐的精神内核对民族文化的和谐共生具有重要意义。

关键词：西王母神话民族文化交融和谐共生

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Thermo-Mechanical, Physico-Chemical, Morphological, and Fire Characteristics of Eco-Friendly Particleboard Manufactured with Phosphorylated Lignin Addition

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Journal of Renewable Materials 2024年第7期12卷 1311-1341页

作者： Apri Heri Iswanto Harisyah Manurung Asma Sohail Lee seng Hua Petar Antov Deded Sarip Nawawi Sarah Latifah Dewi Shafa Kayla Sukma Surya Kusumah Muhammad Adly Rahandi Lubis Linda MakovickáOsvaldová MohdHazwan Hussin Rangabhashiyam Selvasembian Lum Wei Chen Puji Rahmawati Nurcahyani Nam Hun Kim Widya Fatriasari Department of Forest Products Faculty of ForestryUniversitas Sumatera UtaraKampus USU Padang BulanMedanNorth Sumatra20155Indonesia Department of Chemistry Lahore College for Women UniversityLahore4444Pakistan Department of Wood Industry Faculty of Applied SciencesUniversiti Teknologi MARA(UiTM)Cawangan Pahang Kampus JengkaShah Alam26400Malaysia Faculty of Forest Industry University of ForestrySofia1797Bulgaria Department of Forest Product Faculty of Forestry and EnvironmentIPB UniversityBogor16680Indonesia Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Cibinong16911Indonesia Department of Forest Engineering Faculty of Security EngineeringUniversity of ZilinaZilina01001Slovakia Materials Technology Research Group(MaTReC) School of Chemical SciencesUniversiti SainsMalaysiaMindenPenang11800Malaysia Department of Environmental Science and Engineering School of Engineering and SciencesSRM University-APAmaravatiAndhra Pradesh522240India Department of Bio and Natural Resources Faculty of Bioengineering and TechnologyUniversitiMalaysia KelantanJeliKelantan17600Malaysia Department of Forest Biomaterials Engineering College of Forest and Environmental SciencesKangwon National UniversityChuncheon24341Republic of Korea

Lignin,lignosulfonate,and synthesized phosphorylated lignosulfonate were introduced as greenﬁllers in citric acid-sucrose adhesives for bonding particleboard fabricated from areca leaf sheath(ALS).The characteristics of particleboards were compared to that of ultralow emitting formaldehyde(ULEF-UF).Theﬁllers derived from Eucalyptus ***-lignin were added forﬂame retardancy enhancement.10%of each lignin and modiﬁed lig-nin was added into the ULEF-UF and citric acid-sucrose bonded *** applied to particle-boards included thermal characteristics,X-ray diffraction analysis(XRD),morphological properties,Fourier transform infrared spectroscopy(FTIR),as well as physical,mechanical,andﬁre resistance characteristics of the laboratory-fabricated *** and modiﬁed lignin resulted in improved thermal stability of the composites bonded with ULEF-UF while the improvement in the particleboard bonded with citric acid-sucrose was not signiﬁ*** introduction ofﬁller exerted a higher inﬂuence on the UF-bonded particleboards compared to composites fabricated with citric ***,the presence of lignin,lignosulfonate,and phosphorylated lignosulfonate enhanced the mechanical strength of the ULEF-bonded particleboards,although their dimensional stability has ***,the use of lignin and lignosulfonate enhanced theﬁre resis-tance of the particleboards produced with lower observed weight *** laboratory particleboards exhibited satisfactoryﬁre resistance,attaining a V-0 rating in according to the UL-94 standard.

关键词： Modiﬁed lignin eco-friendly particleboard ﬁre and thermal properties citric acid-sucrose ultralow-emitting urea-formaldehyde resin

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ESG评级分歧对企业风险承担能力影响研究——基于资本市场投资视角

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金融理论与实践 2024年第5期 83-95页

作者：僧建芬张立杰新疆大学经济与管理学院新疆乌鲁木齐830000

当下国内外各ESG评级机构的评级结果存在分歧,其释放的信号可能影响资本市场投资者行为和企业风险承担能力。基于此,运用中国A股上市公司2009—2022年的数据样本,结合信息不对称理论考察ESG评级分歧与企业风险承担能力的关系。研究发现,... 详细信息

当下国内外各ESG评级机构的评级结果存在分歧,其释放的信号可能影响资本市场投资者行为和企业风险承担能力。基于此,运用中国A股上市公司2009—2022年的数据样本,结合信息不对称理论考察ESG评级分歧与企业风险承担能力的关系。研究发现,ESG评级分歧显著降低了企业风险承担水平,且在经过一系列内生性与稳健性检验后,基准回归结果依然成立。机制分析表明,ESG评级分歧将通过降低企业市场获利能力、加剧股价崩盘风险及投资者异质信念等三重机制降低企业风险承担能力。异质性分析表明,在市场化程度高、要素市场发育程度高的地区以及非国有企业、非重污染行业企业中,ESG评级分歧对企业风险承担能力的削弱作用更为显著。研究结论拓展了ESG评级分歧与企业行为关系研究的边界,为ESG评级体系构建提供参考意见。

关键词： ESG评级分歧企业风险承担市场收益股价崩盘风险投资者异质信念

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含V型缺口分数阶黏弹性复合材料反平面界面断裂的辛方法

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计算力学学报 2024年第4期41卷 689-695页

作者：徐成辉孙义国冷森邓子辰西北工业大学力学与土木建筑学院西安710129 西北工业大学复杂系统动力学与控制工信部重点实验室西安710129

本文提出求解含V型缺口的分数阶黏弹性复合材料反平面界面断裂问题的辛方法.分数阶Kelvin-Zener模型用于描述材料的黏弹性特征;借助Laplace变换,将时域内黏弹性反平面断裂问题的基本方程转换到频域空间;通过引入位移的对偶变量广义应力... 详细信息

本文提出求解含V型缺口的分数阶黏弹性复合材料反平面界面断裂问题的辛方法.分数阶Kelvin-Zener模型用于描述材料的黏弹性特征;借助Laplace变换,将时域内黏弹性反平面断裂问题的基本方程转换到频域空间;通过引入位移的对偶变量广义应力,建立问题的哈密顿求解体系.在该体系下,对偶方程的本征值和本征解可以利用分离变量法求解,本征解级数展开的系数通过本征解的辛共轭正交关系和外边界条件确定.这样将得到含缺口黏弹性复合材料反平面应力/应变强度因子的解析表达式.最后通过Laplace逆变换,得到时域空间内的应力/应变强度因子.数值算例验证本文方法的准确性,并揭示了分数阶参数、缺口角度和外载荷对应力/应变强度因子的影响.

关键词：辛方法分数阶黏弹性界面断裂反平面应力强度因子

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