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Large animal models for Huntington's disease research

Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien Liang Xiao-Jiang Li Shihua Li sen yan Zhuchi Tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan University Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no ***,the development of appropriate disease models is critical to thoroughly investigate disease *** genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT *** HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain *** models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic *** to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD *** models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment *** have explored the advantages of utilizing large animal models,particularly pigs,in previous *** then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of *** the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic *** also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and *** objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

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Pre-mating nitenpyram exposure in male mice leads to depression-like behavior in offspring by affecting tryptophan metabolism in gut microbiota

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Journal of Environmental Sciences 2024年第3期137卷 120-130页

作者： sen yan Wei Sun Sinuo Tian Zhiyuan Meng Jinling Diao Zhiqiang Zhou Li Li Wentao Zhu Innovation Center of Pesticide Research Department of Applied ChemistryCollege of ScienceChina Agricultural UniversityBeijing 100193China College of Plant Protection/Joint International Research Laboratory of Agriculture&Agri-Product Safety Yangzhou UniversityYangzhou 225009China College of Plant Protection Shanxi Agricultural UniversityTaiyuan 030031China

Several studies have confirmed that the health status of the paternal affects the health of the offspring,however,it remains unknown whether paternal exposure to pesticides affect the offspring ***,we used untargeted metabolomics and 16S rRNA sequencing technology,combined with tail suspension test and RT-qPCR to explore the effects of paternal exposure to nitenpyram on the neurotoxicity of *** results found that the paternal exposure to nitenpyram led to the offspring’s depressive-like behaviors,accompanied by the reduction of tryptophan content and the disorder of microbial abundance in the gut of the ***,we determined the expression of tryptophan metabolism-related genes tryptophanase(tnaA)and tryptophan hydroxylase 1(TpH1)in gut bacteria and colonic *** found that tryptophan is metabolized to indoles rather than being absorbed into colonocytes,which coursed the reduce of tryptophan availability after nitenpyram *** conclusion,our study deepens our understanding of the intergenerational toxic effects of pesticides.

关键词： Nitenpyram Depressive-like behaviors Gut microbiota Tryptophan metabolism

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Optical responses of metallic plasmonic arrays under the localized excitation

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Nano Research 2024年第3期17卷 1571-1577页

作者： sen yan Hao Ma Yi-Fan Bao Maofeng Cao Chuan Liu Kaifeng Zhang Xiaowei Wu Jianbo He Xiang Wang Bin Ren State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Research&Development Group HitachiLtd.Yokohama 244-0817KanagawaJapan Department of Electronic Science and Engineering Kyoto UniversityKyoto 615-8510Japan

The metallic plasmonic array that can support both propagating surface plasmon polaritons(PSPPs)and localized surface plasmon resonance(LSPR)possesses rich optical properties and remarkable optical performance,making it a powerful platform for applications in photonics,chemistry,and *** practical applications,the excitation spot is usually smaller than the area of metal *** is thus imperative to address“how many array units are enough?”towards a rational design of plasmonic ***,we employed focused ion beam(FIB)to precisely fabricate a series of plasmonic array structures with increased unit *** utilizing photoluminescence(PL)and surface-enhanced Raman spectroscopy(SERS),we found that the array units outside the excitation spot still have a significant impact on the optical response within the *** with the numerical simulation,we found that the boundary of the finite array leads to the loss of PSPP outside the excitation point,which subsequently affects the coupling of PSPP and LSPR in the excitation spot,leading to variations in PL and SERS *** on the findings,we further tuned the LSPR mode of the metal arrays by electrodeposition to obtain strong near-field enhancement without any influence on the PSPP *** work advances the understanding of near-field and far-field optical behavior in finite-size array structures and provides guidance for designing highly-efficient photonic devices.

关键词： plasmonic periodic array finite-size effects dark field scattering surface-enhanced Raman spectroscopy(SERS)

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Effect of manganese on the formation of hybrid zirconiumbased conversion coating on low carbon steel surface

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China Welding 2024年第1期33卷 13-19页

作者：严森李建中 Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

This study revealed the effect of Mn on the formation of hybrid zirconium-based conversion coatings(HZCC)on low carbon *** XPS results indicated that the Mn compounds on the surface of low carbon steel were mainly MnO and Mn_(2)SiO_(4).Combined with the electrochemical measurements,the corrosion resistance of HZCC showed an increase followed by a decrease with increasing Mn concentration,which was related to the Mn_(2)SiO_(4) and SiO_(2) on the surface of low carbon *** excessive Mn concentration resulted in the loss of SiO_(2) and aggregation of Mn_(2)SiO_(4) on the low carbon steel surface,which caused the aggregation of Zr compounds on the surface and reduced the uniformity of the ***,a moderate amount of Mn addition would be beneficial to increase the adhesion of organic coatings.

关键词： Mn concentration hybrid Zr-based conversion coating corrosion resistance adhesion

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A MOF/poly(thioctic acid)composite for enhanced gold extraction from water matrices

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Nano Research 2024年第1期17卷 382-389页

作者： Ruiqing Li sen yan Tianwei Xue Rongxing Qiu Yin Li Wenli Hao Guangkuo Xu yanliang Wang yanzhen Hong Yuzhong Su Hongtao Wang Shuliang yang Li Peng Jun Li College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China College of Energy Xiamen UniversityXiamen 361005China National Engineering Laboratory for Green Chemical Productions of Alcohols Ethers and EstersXiamen UniversityXiamen 361005China Collaborative Innovation Center of Chemistry for Energy Materials Xiamen UniversityXiamen 361005China

With the fast generation of electronic waste(e-waste)and the increasing depletion of metal resources,“urban mining”that can selectively recover gold from secondary resources has attracted great *** of materials with high extraction capacity and satisfying selectivity in complex aqueous-based matrices still remains ***,a novel metal-organic framework/polymer composite(Fe-BTC/poly(thioctic acid),denoted as Fe-BTC/pTA)has been newly synthesized and applied for selective gold recovery in different matrices(river water,seawater,and leaching solution of e-waste).Benefiting from the high specific surface area and suitable pore sizes as well as the rational design of active sites,the composite exhibits high adsorption capacity(920 mg/g),high removal efficiency(>99%),fast kinetics(below 0.1 ppb within 10 min),and good applicability in complex matrices,which are better than those of most reported sulfur-containing ***-state metallic gold with high purity can be effectively enriched due to the high recyclability and long-term stability of the *** material after adsorption can be further applied as a heterogeneous catalyst for water remediation due to the in situ generated gold nanoparticles by the redox reaction between Au(III)ions and the S-containing groups in the composites.

关键词： metal-organic frameworks(MOFs) poly(thioctic acid)(pTA) polymer composites gold recovery urban mining

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37例颞下颌关节盘不可复性前移位患者自然转归的临床及磁共振成像特征分析

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华西口腔医学杂志 2024年第1期42卷 82-88页

作者：闫森乔永明段亮伟郑州大学第一附属医院口腔正畸科郑州450052 郑州大学第一附属医院口腔颌面外科郑州450052 郑州大学第一附属医院口腔修复科郑州450052

目的了解颞下颌关节盘不可复性前移位患者自然病程的临床、影像学变化及不同年龄段的差异性。方法选择2016年1月—2023年6月在郑州大学第一附属医院口腔颌面外科就诊的颞下颌关节盘不可复性前移位患者37例(45侧),男性4例,女性33例,平... 详细信息

目的了解颞下颌关节盘不可复性前移位患者自然病程的临床、影像学变化及不同年龄段的差异性。方法选择2016年1月—2023年6月在郑州大学第一附属医院口腔颌面外科就诊的颞下颌关节盘不可复性前移位患者37例(45侧),男性4例,女性33例,平均年龄23.5岁,平均病程14.4个月。收集初诊及复诊时临床及磁共振成像(MRI)资料,测量关节盘的长度和厚度、关节盘前移角度、髁突高度,使用SPSS 25.0进行统计分析,比较临床及影像学的变化。结果 37例(45侧)患者复诊与初诊相比较:3例3侧自愈为可复性盘前移位;48.4%患者自觉张口受限未缓解或加重;58.3%患者张口疼痛无改善;54.5%咀嚼疼痛无改善;33.3%患者面部偏斜呈现加重趋势,仅1例缓解。关节盘前移角度从初诊时61.63°增长至67.81°,关节盘长度从8.20 mm缩短至7.27 mm,髁突高度从23.17 mm降为22.76 mm,以上差异有统计学意义(P0.05)。结论在颞下颌关节盘不可复性前移位自然病程中,部分患者的临床症状不能完全缓解;不同年龄段患者都会出现关节盘前移程度逐渐增大,关节盘长度逐渐缩短,发生折叠变形,髁突出现吸收,继发面部偏斜、下颌后缩等继发畸形。

关键词：颞下颌关节不可复性盘前移位磁共振成像

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长链非编码RNA HOXA远端转录本在口腔鳞状细胞癌中的表达及生物学意义

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中国肿瘤临床 2024年第7期51卷 325-330页

作者：段亮伟闫森王晶晶孙强郑州大学第一附属医院口腔科郑州市450000

目的:探讨长链非编码RNA HOXA远端转录本(HOXA transcript at the distal tip,HOTTIP)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的表达及对OSCC细胞生物学功能的影响。方法:收集2020年1月至2021年6月在郑州大学第一附属... 详细信息

目的:探讨长链非编码RNA HOXA远端转录本(HOXA transcript at the distal tip,HOTTIP)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的表达及对OSCC细胞生物学功能的影响。方法:收集2020年1月至2021年6月在郑州大学第一附属医院接受手术治疗的52例OSCC患者,采用RT-qPCR检测HOTTIP在OSCC组织和癌旁组织以及人OSCC细胞株HSC-4、SCC-9和CAL-27和人正常口腔角质细胞株HOK中的表达水平,并分析其与OSCC患者临床病理资料及总生存期(overall survival,OS)的关系。采用CCK-8、流式细胞术、Transwell和Western blot分析下调HOTTIP或共下调HOTTIP和miR-637对CAL-27细胞增殖、凋亡、迁移、侵袭和上皮间质转化(epithelial-mesenchymal transition,EMT)能力的影响。采用双荧光素酶报告基因实验分析HOTTIP和miR-637的靶向关系。结果:与癌旁组织相比,OSCC组织中HOTTIP的表达水平明显升高(P<0.05),且与肿瘤大小、TNM分期、分化程度、淋巴结转移及OS相关(P<0.05)。与人正常口腔角质HOK细胞相比,HSC-4、SCC-9和CAL-27细胞中HOTTIP的表达明显升高(P<0.05)。下调HOTTIP后,CAL-27细胞的增殖、迁移、侵袭及EMT能力明显减弱,细胞凋亡率明显升高(P<0.05)。HOTTIP与miR-637具有靶向关系,且下调HOTTIP后,CAL-27细胞中miR-637表达明显升高(P<0.05)。同时下调HOTTIP和miR-637后,CAL-27细胞的增殖、迁移、侵袭与EMT能力明显增强,细胞凋亡率明显降低(P<0.05)。结论:HOTTIP在OSCC组织和细胞中高表达,可靶向miR-637调控OSCC细胞的增殖、凋亡、迁移、侵袭和EMT能力。

关键词：长链非编码RNA HOXA远端转录本口腔鳞状细胞癌增殖侵袭

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Study of bias voltage effect on the performance of ta-C coating prepared by high power impulse magnetron sputtering

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China Welding 2024年第1期33卷 7-12页

作者：冯利民何哲秋严森李建中石俊杰 Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

The mechanical and frictional properties of ta-C coatings deposited on the substrate surface affect applications in the field of cutting tools and wear-resistant *** this paper,the effect of bias parameters on the performance of ta-C coatings was investigated based on high power impulse magnetron sputtering(HiPIMS)*** results show that bias voltage has a significant effect on the deposition rate,structure,and wear resistance of the *** the range of bias voltage−50 V to−200 V,the ta-C coating performance was the best under bias voltage−150 *** thickness reached 530.4 nm,the hardness value reached 35.996 GPa,and the bonding force in-creased to 14.2 *** maximum sp3 bond content was 59.53% at this condition.

关键词： bias voltage magnetron sputtering deposition rate wear resistance

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基于改进SVT的电力负荷数据恢复算法

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湖南大学学报（自然科学版） 2024年第10期51卷 174-180页

作者：成达熊素琴马力唐求闫森中国电力科学研究院有限公司北京100192 湖南大学电气与信息工程学院湖南长沙410082

针对传统奇异值阈值(Singular Value Thresholding,SVT)数据恢复算法在对电力负荷数据恢复中忽视数据先验信息以及大规模数据计算效率低等问题,提出一种基于相空间重构与自适应变步长的改进SVT的数据恢复算法.为解决传统SVT容易忽视数... 详细信息

针对传统奇异值阈值(Singular Value Thresholding,SVT)数据恢复算法在对电力负荷数据恢复中忽视数据先验信息以及大规模数据计算效率低等问题,提出一种基于相空间重构与自适应变步长的改进SVT的数据恢复算法.为解决传统SVT容易忽视数据先验信息的问题,引入相空间重构算法将原始缺失数据映射到高维空间,利用数据间的关联性和结构特征,为后续数据恢复算法提供先验知识;结合对数与Sigmoid函数构建变步长基础函数,并利用等比项提高前期步长,构建自适应变步长SVT算法,克服传统SVT在大规模数据情况下计算效率低的问题.结合多项公用电力负荷数据集及多种常用电力负荷数据恢复算法进行对比实验分析,结果表明,改进SVT算法可获得更好的数据恢复效果,收敛速度、精度以及稳定性得到提升,具有较强的工程实用性.

关键词：电力负荷数据数据处理奇异值阈值相空间方法自适应变步长

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高铁开通带动中国制造业供应链效率提升——来自上市公司库存周转率的微观证据

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产业经济研究 2024年第4期 85-99页

作者：阎森孙新宇王嘉寅西安交通大学管理学院陕西西安710049 陕西省发展和改革委员会-西安交通大学丝路信用研究院陕西西安710049 西安交通大学计算机科学与技术学院陕西西安710049

供给侧结构性改革背景下,加快商品市场的库存流转是提升供应链效率的关键抓手。高速铁路如何通过提升旅客的出行效率从而促进存货流转?鲜有文献对此进行讨论。利用2003-2021年中国制造业上市公司数据,从区位可达性的视角,实证考察了高... 详细信息

供给侧结构性改革背景下,加快商品市场的库存流转是提升供应链效率的关键抓手。高速铁路如何通过提升旅客的出行效率从而促进存货流转?鲜有文献对此进行讨论。利用2003-2021年中国制造业上市公司数据,从区位可达性的视角,实证考察了高铁开通对沿线制造企业库存周转率的影响效果与动力机制。研究发现,高铁开通后制造企业库存周转率平均提升约4.24%。该影响经过遗漏变量偏差检验、熵平衡匹配以及采用“最小生成树”工具变量法缓解内生性后依旧稳健。机制分析表明,高铁带来的区位可达性进步通过生产效能提升效应、销货市场扩张效应和信息开放共享效应三种路径综合改善企业库存周转率。此外,异质性分析表明,高铁对库存周转率的改善作用在国有企业、成长期企业以及供应链下游企业中更加明显。研究强调了客运交通基础设施对中国制造业高质量发展的重要贡献,为制造企业运营能力提升和供应链效率优化提供了经验指导。

关键词：高速铁路区位可达性制造业企业库存周转率供应链效率企业运营能力

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