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MRI R2^(*)值鉴别肝细胞癌与肝内肿块型胆管癌

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中国介入影像与治疗学 2024年第4期21卷 224-228页

作者：罗森黄洪磊江卫民严川李跃明福建医科大学附属南平第一医院影像科福建南平353000 福建医科大学附属第一医院影像科福建福州350005

目的观察MRI定量R2^(*)值鉴别肝细胞癌(HCC)与肝内肿块型胆管癌(IMCC)的价值。方法回顾性分析106例HCC(HCC组)及49例IMCC(IMCC组)患者临床和上腹部MRI(包括2D多回波快速梯度回波序列R2^(*)Map图像)资料,比较2组肿瘤R2^(*)值、T2^(*)值... 详细信息

目的观察MRI定量R2^(*)值鉴别肝细胞癌(HCC)与肝内肿块型胆管癌(IMCC)的价值。方法回顾性分析106例HCC(HCC组)及49例IMCC(IMCC组)患者临床和上腹部MRI(包括2D多回波快速梯度回波序列R2^(*)Map图像)资料,比较2组肿瘤R2^(*)值、T2^(*)值、表观弥散系数(ADC)值、肿瘤近旁及远旁肝实质R2^(*)值、竖脊肌R2^(*)值,以及肿瘤与肝实质R2^(*)比值(T/L-R2^(*))和肿瘤与竖脊肌R2^(*)比值(T/M-R2^(*));绘制受试者工作特征曲线,计算曲线下面积(AUC),比较各参数鉴别HCC与IMCC的效能。结果相比IMCC组,HCC组男性、甲胎蛋白≥9 ng/ml、伴肝硬化、有假包膜、瘤内出血、动脉晚期非环形强化及门静脉期非环形廓清者占比均较高,而淋巴结转移者占比较低(P均0.05)而均高于ADC值(P均<0.05)。肿瘤R2^(*)值的AUC为0.848;以25.79 Hz为最佳截断值,其鉴别HCC与IMCC的敏感度为77.36%、特异度为85.71%。结论MRI定量R2^(*)值可用于鉴别HCC与IMCC。

关键词：肝肿瘤铁磁共振成像

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基于微分方程曲面求交跟踪法的包容式节点相贯区域建模研究

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中国工程机械学报 2024年第2期22卷 141-145页

作者：孙远韬罗森胡修齐王斌贺张氢同济大学机械与能源工程学院上海201804

包容式节点是一种新型管状相贯式节点,其形态是一种典型的薄壁自由曲面结构。在进行曲面造型过程中会涉及曲面求交的问题,而曲面求交是计算机辅助几何设计(CAGD)领域中的关键技术之一。本文构建了包容式节点非均匀有理B样条(NURBS)曲面... 详细信息

包容式节点是一种新型管状相贯式节点,其形态是一种典型的薄壁自由曲面结构。在进行曲面造型过程中会涉及曲面求交的问题,而曲面求交是计算机辅助几何设计(CAGD)领域中的关键技术之一。本文构建了包容式节点非均匀有理B样条(NURBS)曲面模型,将求包容式节点中的相贯线问题转化为NURBS曲面的求交问题。基于微分方程的跟踪算法原理,在分割法求得初始交点的基础上,采用微分方程追踪法求出所有交点,最后将所求得交点进行曲线拟合,交线包围区域即为包容式节点与腹杆相贯焊接区域。

关键词：包容式节点 NURBS模型曲面求交追踪法曲线拟合

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金果榄质量HPLC评价研究

中国新药杂志 2024年第4期33卷 400-406页

作者：陈帅袁崇均罗森汤依娜向缅周先建王笳杨玉霞四川省中医药科学院成都610041 中药材品质及创新中药研究四川省重点实验室成都610041

目的:建立同时测定金果榄药材中古伦宾、蜕皮激素和生物碱类成分的含量的方法,并寻找金果榄药材中的质量差异标志物。方法:采用HPLC法同时测定古伦宾、蜕皮激素、非洲防己碱、药根碱和巴马丁的含量,并以检测出的含量为指标,结合聚类分... 详细信息

目的:建立同时测定金果榄药材中古伦宾、蜕皮激素和生物碱类成分的含量的方法,并寻找金果榄药材中的质量差异标志物。方法:采用HPLC法同时测定古伦宾、蜕皮激素、非洲防己碱、药根碱和巴马丁的含量,并以检测出的含量为指标,结合聚类分析和偏最小二乘判别分析进一步确定金果榄药材中的质量差异标志物。结果:测定方法精密度、稳定性和重复性良好,聚类分析和偏最小二乘判别分析结果均显示20批样品可分为三大类,变量权重结果证实非洲防己碱、古伦宾、巴马汀为金果榄药材主要质量差异标志物。结论:所建方法利用DAD检测器特性,同时监测多个波长,方便快捷,能显著提高药材质量控制效率;聚类分析和偏最小二乘判别分析结果也可为金果榄药材种植、栽培提供依据。

关键词：金果榄古伦宾蜕皮激素非洲防己碱药根碱巴马丁聚类分析偏最小二乘判别分析

Numerical simulation of macrosegregation in continuously cast gear steel 20CrMnTi with final electromagnetic stirring

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Journal of Iron and Steel Research International 2021年第4期28卷 424-436页

作者： Sheng-kui Yin sen luo Wen-jie Zhang Wei-ling Wang Miao-yong Zhu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

A 3D/2D hybrid multi-physical-field mathematical model,which takes into consideration the thermosolutal buoyance,was developed to predict the macrosegregation of gear steel 20CrMnTi continuously cast by a curved billet caster with size of 160 mm×160 mm,and investigated the effect of final electromagnetic stirring(F-EMS)on the fluid flow,heat transfer and solute distribution in the liquid core of continuously cast *** results show that the application of F-EMS eliminates the effect of thermosolutal buoyancy on the asymmetric distribution of carbon concentration in the cross section of billet and accelerates the final solidification of resident molten steel in the liquid core of strand,but promotes the negative carbon segregation near the billet *** the gear steel 20CrMnTi is cast at the temperature of 1803 K and speed of 1.7 m/min,the solidification end advances forward from 9.84 to 9.72 m,and center carbon segregation ratio of billet decreases from 1.24 to 1.17 with the increase in current density of F-EMS from 0 to 350 A.

关键词： Gear steel Macrosegregation Final electromagnetic stirring Numerical simulation Continuous casting

基于数据挖掘探讨针灸治疗产后尿失禁选穴规律

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国际中医中药杂志 2024年第7期46卷 932-936页

作者：黄亮亮范郁山林睿罗森李湛广西中医药大学南宁530000 广西中医药大学针灸推拿学院南宁530000

目的运用数据挖掘技术探讨针灸治疗产后尿失禁的选穴规律。方法检索中国期刊全文数据库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)、中华医学期刊全文数据库、PubMed、Embase、... 详细信息

目的运用数据挖掘技术探讨针灸治疗产后尿失禁的选穴规律。方法检索中国期刊全文数据库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(重庆维普)、中国生物医学文献数据库(CBM)、中华医学期刊全文数据库、PubMed、Embase、Web of Science建库至2023年2月1日有关针灸治疗产后尿失禁的临床研究文献, 采用Excel 2016软件建立腧穴处方数据库并进行腧穴、归经和特定穴频次统计, 分别采用SPSS Statistics 25.0软件、SPSS Modeler 18.0软件对腧穴进行聚类分析与关联规则分析。结果共纳入文献70篇, 涉及针灸处方70首, 包含腧穴31个, 总频次384次。使用频次排名前5位的腧穴依次为三阴交(46次)、关元(45次)、足三里(43次)、中极(41次)和气海(38次), 常用经脉为任脉、足太阳膀胱经和足太阴脾经, 腧穴多位于下肢部和腹部, 特定穴以交会穴、募穴和五输穴居多。高频腧穴聚类分析得到5个有效聚类群。关联规则分析得到核心腧穴组合为三阴交-足三里-关元-气海-中极。结论产后尿失禁病机以气虚为主, 针灸治疗基于益气健脾、养肺补肾治法, 注重腹部和下肢部腧穴的使用, 并运用上下配穴、前后配穴等配穴方法。

关键词：尿失禁产后期针灸数据挖掘聚类分析关联规则选穴规律

Heat Transfer and Central Segregation of Continuously Cast High Carbon Steel Billet

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Journal of Iron and Steel Research International 2014年第6期21卷 565-574页

作者： Wang SU Wei-ling WANG sen luo Dong-bin JIANG Miao-yong ZHU School of Materials and Metallurgy Northeastern University

A numerical model of heat transfer was developed to investigate the heat transfer of continuously cast billet with the aid of surface temperature tests by ThermaCAMTM researcher and nail shooting experiments. The effects of secondary cooling practice and casting speed on the solidification process and central segregation of carbon were investigated as well with the actual central segregation tests. The results show that the surface center and billet center temperatures exhibit a different pattern during solidification, and the solidified shell thickness is presented as an ＂S＂ type. With the increase of secondary cooling intensity and the decrease of casting speed, the end points of the solidus line and the liquidus line move forward, and the central segregation level of carbon decreases. The optimal casting condition is suggested for continuously cast high carbon billet with F-EMS （final electromagnetic stirring）.

关键词： continuously cast billeti high carbon steel heat transfer central segregation

Ginsenosides from Stems and Leaves of Ginseng Prevent Ethanol-Induced Lipid Accumulation in Human L02 Hepatocytes

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Chinese Journal of Integrative Medicine 2017年第6期23卷 438-444页

作者： HU Chao-feng SUN Li-ping YANG Qin-he LU Da-xiang luo sen Department of Pathophysiology Key Laboratory of State Administration of Traditional Chinese Medicine of the People's Republic of ChinaMedical CollegeJinan UniversityGuangzhou 510632China Department of Nephrology Shenzhen People's HospitalSecond Clinical Medical College of Jinan UniversityShenzhenGuangdong Province 518020China Department of Traditional Chinese Medicine Medical CollegeJinan UniversityGuangzhou 510632China

Objective： To investigate the effect of ginsenosides from stems and leaves of ginseng on ethanolinduced lipid deposition in human LO2 hepatocytes. Methods： LO2 cells were exposed to ethanol for 36 h and treated with or without ginsenosides. The viability of LO2 cells was evaluated by methylthiazolyldiphenyl- tetrazolium bromide assay and the triglyceride （TG） content was detected. Lipid droplets were determined by oil red O staining. Intracellular reactive oxygen species （ROS） production and the mitochondrial membrane potential were tested by flow cytometry. The ATP level was measured by reverse phase high performance liquid chromatography. The expression of cytochrome p450 2E1 （CYP2E1） and peroxisome proliferator- activated receptor （PPAR α） was detected by reverse transcriptase-polymerase chain reaction and Western blotting, respectively. Results： Ethanol exposure resulted in the increase of TG level, lipid accumulation and ROS generation, and the decrease of mitochondrial membrane potential and ATP production in the cells. However, ginsenosides significantly reduced TG content （9.69 ± 0.22 μg/mg protein vs. 4.93 ± 0.49 μg/mg protein, P〈0.01）, and ROS formation （7254.8± 385.7 vs. 5825.2± 375.9, P〈0.01）. Meanwhile, improvements in mitochondrial membrane potential （10655.33± 331.34 vs. 11129.52 ± 262.35, P〈0.05） and ATP level （1.20±0.18 nmol/mg protein vs. 2.53±0.25 nmol/mg protein, P〈0.01） were observed by treatment with ginsenosides. Furthermore, ginsenosides could down-regulate CYP2E1 expression （P〈0.01） and upregulate PPAR α expression （P〈0.01） in ethanol-treated cells. Conclusions： Ginsenosides could prevent ethanol-induced hepatocyte steatosis in vitro related to the inhibition of oxidative stress and the improvement of mitochondrial function. In addition, the modulation of CYP2E1 and PPAR α expression may also play an important role in the protective effect of ginsenosides against lipid accumulation.

关键词： ginsenosides hepatocyte steatosis reactive oxygen species mitochondrial function cytochrome P450 2E1 peroxisome proliferator-activated receptor α

黄连乌梅提取物联合使用抑制脂多糖诱导的细胞炎症反应及机制研究

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中药药理与临床 2024年第3期40卷 42-48页

作者：潘海敏许洪玲陈晗袁崇均陈帅罗森杨薇袁明铭张磊陈梅周静四川省中医药科学院动物实验中心成都610041 江苏省中医院药学部南京210029 成都中医药大学药学院成都611137 国药控股四川医药股份有限公司成都611335

目的:探讨黄连乌梅提取物联合使用对脂多糖(Lipopolysaccharide,LPS)诱导小鼠单核巨噬细胞RAW264.7炎症反应的影响及作用机制。方法:采用LPS诱导RAW264.7细胞炎症模型,试验分为空白对照组、模型对照(LPS)组、二甲基亚砜(DMSO)组、黄连... 详细信息

目的:探讨黄连乌梅提取物联合使用对脂多糖(Lipopolysaccharide,LPS)诱导小鼠单核巨噬细胞RAW264.7炎症反应的影响及作用机制。方法:采用LPS诱导RAW264.7细胞炎症模型,试验分为空白对照组、模型对照(LPS)组、二甲基亚砜(DMSO)组、黄连乌梅提取物89、178、343μg/mL组。采用CCK-8法检测细胞增殖率;流式细胞术检测细胞凋亡率、活性氧(Reactive oxygen species,ROS)水平和细胞表面分子CD80、CD83、CD86的水平;ELISA法检测其对细胞分泌炎症因子的影响;Western blot法检测细胞中高迁移率族蛋白B1(HMGB1)、P65、Toll样受体4(TLR4)蛋白的表达。结果:与空白对照组比较,LPS模型组细胞HMGB1、TLR4蛋白表达明显上调(2.05±0.05、2.56±0.63,P<0.05或P<0.01),细胞表面分子CD80、CD83、CD86显著增多(19.81±1.85、3.81±0.40、3.23±0.40,P<0.01),细胞上清中TNF-α、IL-6和IL-1β含量显著升高(33.31±3.92、42.66±3.07、25.98±2.45,P<0.01);与模型对照组比较,黄连乌梅提取物343μg/mL组能下调HMGB1蛋白表达(1.50±0.08,P<0.01),降低细胞表面分子CD80、CD83和CD86的水平(8.73±2.92、1.04±0.15、1.35±0.15,P<0.01),明显减少细胞炎症因子TNF-α、IL-6和IL-1β的分泌(19.86±3.12、29.41±8.98、16.58±0.52,P<0.05或P<0.01)。结论:黄连乌梅提取物联合使用对LPS所致的RAW264.7细胞炎症模型具有较好的抗炎作用,其作用机制可能与抑制ROS/HMGB1/TLR4炎症信号通路的激活有关。

关键词：黄连乌梅提取物小鼠单核巨噬细胞炎症细胞凋亡活性氧高迁移率族蛋白 Toll样受体4

Numerical Simulation and Experimental Study of F-EMS for Continuously Cast Billet of High Carbon Steel

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Journal of Iron and Steel Research International 2014年第S1期21卷 51-55页

作者： sen luo Feng-yun PIAO Dong-bin JIANG Wei-ling WANG Miao-yong ZHU School of Materials and Metallurgy Northeastern University

A final electromagnetic stirring model was developed for billet continuous casting of high carbon steel using the commercial software ANSYS and CFX, and the numerical model was validated by the magnetic flux density measured under a Teslameter CT-3. The magnetic flux density and fluid flow in the liquid pool at the location of final electromagnetic stirring(F-EMS) were calculated by the present numerical model. Meanwhile, the plant trials were carried out to determine the optimum current intensity and frequency of F-EMS for the continuously cast billet of high carbon steel. The numerical results show that, through increasing the current intensity by 100 A, the corresponding increases of magnetic induction intensity, tangential electromagnetic force and flow velocity at the solid/liquid interface in the strand are 0.025 T, 1933 N/m3 and 6.9 cm/s, respectively. Moreover, the industrial trial results showed that for the continuously cast billet of 60 steel, the optimum current intensity and frequency of F-EMS, which is 8.2 m from the meniscus, are respectively 380 A and 6 Hz. With the optimum F-EMS parameters, the significant improvement of center segregation of billet is achieved, and the center carbon segregation index in billet reaches 1.04.

关键词： billet F-EMS center segregation numerical simulation industrial trial