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聚乳酸羟基乙酸缝线在睑板外侧条形剥离术中的应用

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 15-16页

作者： Hsuan J. selva d. 陈立军

To evaluate the rate of recurrence of horizontal laxity or lid malposition and suture- related complications associated with the use of an absorbable suture in the lateral tarsal strip procedure. Prospective, interventional, consecutive case series. A prospective study. setting: Institutional. patient population: One hundred patients with horizontal lid laxity associated with ectropion or entropion. Patients with paralytic ectropion or ocular prostheses were excluded. intervention: One hundred and five lateral tarsal strip procedures were performed using a 6- 0 polyglactin suture. These were combined with full- thickness skin grafts (34), internal (55) or external (23) retractor plications, and inverting sutures (4) as required to correct the lid malposition. main outcome measures: Recurrence of horizontal laxity or lid malposition and suture related complications were the main outcome measures. Suture related wound infection was diagnosed clinically by the presence of pus associated with wound breakdown. One patient failed to reach 3- month follow- up and was excluded. There was one recurrence of horizontal laxity after a mean follow- up period of 9.1 months. Four patients developed lateral canthal wound infections, compared with none at the other operative sites. The 95% confidence intervals for infections in the tarsal strip procedure were 1.1% to 9.6% , which were significantly greater than zero (P dures. A 6- 0 absorbable suture may be used for the lateral tarsal strip and does not lead to a recurrence of horizontal laxity. It does not appear to reduce the wound infection rate associated with this procedure.

关键词：睑板聚乳酸羟基乙酸肌折叠术麻痹性睑外翻剥离术睑内翻复发率外眦部可吸收性缝线义眼

皮肤原位鳞状细胞癌(Bowen病):莫氏显微手术治疗

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 3-4页

作者： Leibovitch I Huilgol S.C selva d 焦婷 Oculoplastic and Orbital division Department of Ophthalmology and Visual Sciences Royal Adelaide Hospital N Terrace Adelaide SA 5000 Australia

Background:Bowen’s disease (Bd), also known as squamous intraepidermal carcinoma, is a malignant skin tumor with a potential to progress to invasive carcinoma. Objective:We sought to report a large series of patients with Bd treated with Mohs micrographic surgery (MMS). Methods:This prospective, multicenter, case series included all patients in Australia treated with MMS for Bd, who were monitored by the Skin and Cancer Foundation between 1993 and 2002. Results:There were 270 cases; the majority (93.4%) were located in the head and neck area. In 50.7%of cases it was a recurrent tumor. In 20%the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma. No cases with perineural invasion were diagnosed. There were 6 cases of recurrence (6.3%) of 95 patients who completed a 5-year follow-up period after MMS. Conclusion:The low 5-year recurrence rate of Bd with MMS emphasizes the importance of margin-controlled excision, especially in the head and neck area where tissue preservation is essential.

关键词： Bowen 原位鳞状细胞癌显微手术基底细胞癌年复发率侵袭性肿瘤皮损边缘前瞻性调查

在澳大利亚莫氏显微外科手术治疗基底细胞癌Ⅰ:10年经验

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 12-13页

作者： Leibovitch I. Huilgol S.C. selva d. 刘芯 dr. Wakefield Clinic 270 Wakefield St Adelaide SA 5000 Australia

Background: Only a few prospective studies have been published on surgical treatments for cutaneous basal cell carcinoma (BCC). Objective: Our purpose was to report the clinical findings of all patients with BCC treated with Mohs micrographic surgery (MMS) in Australia between 1993 and 2002. Method: This prospective,multicenter case series included all patients in Australia treated with MMS for BCC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002. The main outcome measures were patient demographics, reason for referral, duration of tumor, site, preoperative tumor size, recurrences before MMS, histologic classification of malignancy, and postoperative defect size. Results: The study included 11,127 patients (47% females and 53% males) with a mean age of 62 years (range, 15- 98 years). In 43.8% of cases BCC was a recurrent tumor. Most of the tumors (98.3% ) were on the head and neck area, most commonly on the nose (39% ), cheek and maxilla (16.5% ), periocular area (12.7% ), and auricular region (11.4% ). The most common histologic subtypes were infiltrating (30.7% ), nodulocystic (24.2% ), and superficial (13.6% ). Previously recurrent tumors were larger than primary tumors (P d a larger postexcision defect and more subclinical extension, and required more levels of excision (P data were missing for some outcome measures. Conclusion: This large prospective series of BCC managed by MMS is characterized by a high percentage of high- risk tumors. Most tumors were located in the mid- facial area and the histologic subtype was mainly infiltrating or nodulocystic. That previously recurrent tumors were larger and demonstrated a more extensive subclinical extension compared with primary tumors emphasizes the importance of initial tumor eradication with margin control.

关键词：基底细胞癌显微外科原发肿瘤组织学恶性程度复发性肿瘤囊肿型统计学数据亚临床面中部浸润型

莫氏显微手术治疗唇部皮肤癌:临床特征与手术结局

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 38-39页

作者： Leibovitch I. Huilgol S.C. selva d. 焦婷 department of Ophthalmology and Visual Sciences Royal Adelaide Hospital University of Adelaide Adelaide SA Australia

Background: The Australian Mohs micrographic surgery (MMS) database was initiated in 1993 by the Skin and Cancer Foundation Australia (SCFA) with the aim of collecting prospective data, and involved all Mohs surgeons in the country. Objectives: To present a large series of patients with cutaneous lip tumours treated with MMS in Australia between 1993 and 2002. Methods: This prospective multicentre case series included all patients with cutaneous lip tumours who were monitored by the SCFA. The main outcome measures were patient demographics, reason for referral, duration of tumour, site, preoperative tumour size and postoperative defect size, recurrences prior to MMS, histological subtypes, perineural invasion and 5-year recurrence after MMS. Results: There were 581 patients (66.1% women and 33.9% men, P d age of 58 ± 15 years. The upper lip was the most common site involved (81.1% ). Basal cell carcinoma (BCC) was diagnosed in 82.3% , squamous cell carcinoma (SCC) in 16.5% , Bowen s disease (Bd) in 0.7% and microcystic adnexal carcinoma (MAC) in 0.5% of cases. BCC was more common on the upper lip and in women, whereas SCC was more common on the lower lip and in men (P d in women (75.4% ), whereas most lower lip tumours occurred in men (73.6% ). SCC was associated with a larger tumour and postoperative defect size compared with the other tumours. The 5-year recurrence for BCC was 3.0% , and there were no cases of recurrence for SCC, Bd or MAC. Conclusions: BCC was the most common cutaneous lip tumour managed by MMS, and was significantly more common on the upper lip and in women. The low 5-year recurrence rate emphasizes the importance of margin-controlled excision.

关键词：显微手术治疗皮肤癌手术结局临床特征唇部澳大利亚肿瘤部位术后缺损年复发率人口统计学

在澳大利亚莫氏显微外科手术治疗基底细胞癌Ⅲ:嗜神经浸润

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 13-14页

作者： Leibovitch I. Huilgol S.C. selva d. 张莹 dr. Wakefield Clinic 270 Wakefield St Adelaide SA 5000 Australia3

Background: Perineural invasion (PNI) is an important factor may possibly influence the aggressiveness of basal cell carcinoma (BCC). Objective: Our purpose was to evaluate the incidence, features, and outcomes of BCC with PNI in patients treated with Mohs micrographic surgery (MMS). Method: This prospective, multicenter case series included all patients in Australia treated with MMS for BCC with PNI, who were monitored by the Skin and Cancer Foundation Australia between 1993 and 2002. The parameters recorded were patient demographics, reason for referral, duration of tumor, site, preoperative tumor size, recurrence before MMS, histologic subtypes, postoperative defect size, and recurrence at 5 years after MMS. Results: Two- hundred eighty- three patients were diagnosed with PNI. Most cases occurred in male patients (61% ; P=.006) and in previously recurrent tumors (60.4% ; P d basosquamous subtypes were more likely to be associated with PNI (P d postoperative defect sizes were significantly larger in cases with PNI compared with cases with no PNI (P d a 5- year follow- up period after MMS, and 6 of them (7.7% ) were diagnosed with ***: data were missing for some outcome measures. Conclusion: PNI is an uncommon feature of BCC. When present, PNI is associated with larger, more aggressive tumors, and the risk of 5- year recurrence is higher. This emphasizes the importance of tumor excision with margin control and long- term patient monitoring.

关键词：基底细胞癌显微外科神经浸润统计学数据硬斑侵袭性病例研究浸润型持续时间长期监测

俯卧位脊柱手术的并发症:缺血性眶间隔综合征

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 58-59页

作者： Leibovitch I Casson R Laforest C selva d 王永强(译 ) Oculoplastic and Orbital division Department of Ophthalmologyand Visual Sciences Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia 不详

Objectives: To report a patient with ischemic orbital compartment syndrome as a complication of spinal surgery in the prone position. design: Interventional case report. Methods: An 80-year-oldman underwent a prolonged lumbar decompression laminectomy for spinal stenosis, under general anesthesia in the prone position. Several hours later, the patient complained of left periocular pain and reduced vision. Examination revealed significant facial edema, left proptosis, and a tight orbit, as well as no light perception and elevated intraocular pressure in the left eye, with complete internal and external ophthalmoplegia. Main Outcome Measures: Clinical course, imaging findings, management, and final outcome. Results: Magnetic resonance imaging confirmed the clinical diagnosis of a compartment syndrome with elevated intraorbital tension. A lateral canthotomy and cantholysis were performed, and high-dose IV steroids were started. The proptosis and facial swelling subsided gradually, but no improvement was noted in left visual acuity or left ocular movements. Conclusion: It is important to be familiar with this rare complication after prolonged surgery in the prone position. Although the prognosis seems to be poor, it is essential to monitor these patients perioperatively and to intervene surgically and medically once the diagnosis of orbital compartment syndrome is established.

关键词：俯卧位脊柱手术间隔综合征缺血性并发症左眼球突出眼内压增高男性患者影像检查外眼肌麻痹磁共振检查

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游离眼睑移植的皮瓣供区并发症研究

世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 36-37页

作者： Leibovitch I. selva d. davis G. Ghabrial R. 张少娟

Purpose To determine if harvesting free tarsal grafts from the upper eyelids i s associated with significant morbidity. design Prospective case series. Methods Consecutive patients managed with free tarsal grafts by three of the authors (d .S., d.G., R.G.) over a 4 year period. Results Ninety one eyelids in 75 patien ts were operated on using the free tarsal graft for various eyelid pathologies. Mean follow up period was 14.83 ±8.45 months (range, 4 to 42 months). Contour peaking in donor upper eyelid appeared in two eyelids (2.2%), lash ptosis in fo ur eyelids (4.4%) of three patients, and donor site infection in one eyelid (1. 1%). Four patients (5.3%) complained of a transient ocular discomfort. There w ere no cases of postoperative changes on the eyelid height, entropion, or kerato pathy in the donor site eye. Most of the donor site complications were mild or t ransient and required no further surgery. In three patients who underwent subseq uent surgery to treat preexisting ptosis or retraction of the donor eyelid, the results were less predictable and further procedures were required. Conclusion F ree tarsal grafts harvested from the upper eyelids, with preservation of at leas t 4 mm of the tarsal plate inferiorly, do not lead to significant donor site mor bidity. However, subsequent procedures to alter the position of the donor eyelid may be less predictable.

关键词：并发症研究皮瓣供区睑内翻上睑角膜病变睑板移植术病例研究

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眼周基底细胞癌的眼眶浸润

世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 57-58页

作者： Leibovitch I. McNab A. Sullivan T. d. selva 宋虎平 Oculoplastic and Orbi tal division Dept. of Ophthalmol. and Vis. Sci. Royal Adelaide Hospital North Terrace Adelaide SA 5000 AustraliaDr.

Objectives: To present a large series of patients with orbital invasion by per iocular basal cell carcinoma (BCC). design: Retrospective, noncomparative, inter ventional case series. Patients: All cases diagnosed with orbital invasion by pe riocular BCC between January 1985 and July 2004 in 3 Orbital Units in Australia. Methods: The clinical records of all patients were reviewed. Main Outcome Measu res: Patients’demographics, clinical presentation, histologic subtypes, treatme ntmodalities, recurrence rate, and tumor-related death. Results: There were 64 patients (49 males) with a mean age of 70±13 years. Most tumors (84.4%) were r ecurrent or previously incompletely excised, and the medial canthus was most fre quently involved (56.2%). Signs suggestive of orbital involvement included a ma ss with bone fixation (35.7%), limitation of ocular motility (30.4%), and glob e displacement (17.6%). There were no signs suggestive of orbital invasion in 3 5.7%. Most patients (51.6%)-had infiltrative histologic findings, and perineu ral invasion was present in 19.3%. Treatment modalities were mainly exenteratio n alone or combined with radiotherapy. during a mean follow-up period of 3.6 ye ars, 3 cases of recurrence (4.7%)were diagnosed. Only 1 patient (1.6%) died fr om tumor-related causes. Conclusions: Orbital invasion by periocular BCC is an uncommon event that may be associated with significant ocular morbidity and, rar ely, death. Because orbital invasion may often be clinically silent, clinicians need to be alert to the possibility in high-risk tumors and consider appropriat e imaging. Surgical treatment with exenteration or excision, with or without rad iotherapy, results in a low recurrence and mortality rate.

关键词：基底细胞癌眼周眼眶病复发率眼球运动受限内眦肿瘤相关性眶内容剜出术眶骨干预性

Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： dongping Li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling Chen Ruofan Liu Yantong Wan Yinghao Hong Zhenhua Zeng Peng Gu Zhang Wang Kutty selva Nandakumar Yong Jiang Hongwei Zhou Peng Chen department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China Institute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China department of Environmental and Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Medicine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated with the disruption of gut ***,the modulatory mechanisms of gut microbiota operating during sepsis are still ***,we investigated how gut commensals impact sepsis development in a pre-clinical *** ligation and puncture(CLP)surgery was used to establish polymicrobial sepsis in *** depleted of gut microbiota by an antibiotic cocktail(ABX)exhibited a significantly higher level of mortality than *** determined by metabolomics analysis,ABX treatment has depleted many metabolites,and subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohydrate metabolite,exerted profound immunomodulatory properties with a significant enhancement in macrophage phagocytosis,which in turn improved organ damage and ***,rhamnose binds directly to and activates the solute carrier family 12(potassium-chloride symporter),member 4(SLC12A4)in macrophages and promotes phagocytosis by activating the small G-proteins,Ras-related C3 botulinum toxin substrate1(Rac1)and cell division control protein 42 homolog(Cdc42).Interestingly,rhamnose has enhanced the phagocytosis capacity of macrophages from sepsis *** conclusion,by identifying SLC12A4 as the host interacting protein,we disclosed that the gut commensal metabolite rhamnose is a functional molecular that could promote the phagocytosis capacity of macrophages and protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cdc42 Macrophage Phagocytosis