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The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime(HADES) framework

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National Science Review 2024年第5期11卷 46-55页

作者： Jakub Vohryzek Joana Cabral Christopher Timmermann selen atasoy Leor Roseman David J.Nutt Robin L.Carhart-Harris Gustavo Deco Morten L.Kringelbach Centre for Eudaimonia and Human Flourishing Linacre CollegeDepartment of Psychiatry University of Oxford Department of Psychiatry University of Oxford Center for Music in the Brain Aarhus University Center for Brain and Cognition Computational Neuroscience GroupDepartment of Information and Communication TechnologiesUniversitat Pompeu Fabra Life and Health Sciences Research Institute School of MedicineUniversity of Minho ICVS/3B's-PT Government Associate Laboratory Centre for Psychedelic Research Department of Brain Sciences Imperial College London Departments of Neurology and Psychiatry University of California San Francisco Institució Catalana de la Recerca i Estudis Avan?ats (ICREA) Department of Neuropsychology Max Planck Institute for Human Cognitive and Brain Sciences School of Psychological Sciences Monash University

The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of whole-brain recordings into harmonic modes has revealed a repertoire of gradient-like activity patterns associated with distinct brain functions. However, the way these activity patterns are expressed over time with their changes in various brain states remains unclear. Here, we investigate healthy participants taking the serotonergic psychedelic N,N-dimethyltryptamine(DMT) with the Harmonic Decomposition of Spacetime(HADES) framework that can characterize how different harmonic modes defined in space are expressed over time. HADES demonstrates significant decreases in contributions across most low-frequency harmonic modes in the DMT-induced brain state. When normalizing the contributions by condition(DMT and non-DMT), we detect a decrease specifically in the second functional harmonic, which represents the uni-to transmodal functional hierarchy of the brain,supporting the leading hypothesis that functional hierarchy is changed in psychedelics. Moreover, HADES'dynamic spacetime measures of fractional occupancy, life time and latent space provide a precise description of the significant changes of the spacetime hierarchical organization of brain activity in the psychedelic state.

关键词： spatio-temporal brain dynamics DMT harmonic modes

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Modeling aggregate size distribution of eroded sediment resulting from rain-splash and raindrop impacted flow processes

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International Journal of Sediment Research 2019年第2期34卷 166-177页

作者： selen Deviren Saygin Gunay Erpul Department of Soil Science and Plant Nutrition Faculty of AgricultureUniversity of Ankara

Soil susceptibility to detachment and transport sub-processes of erosion is generally controled by the aggregate breakdown *** particle size and aggregation to the estimate erodibility potential of soils is important under erosive rainfall *** Aggregate Size Distribution（ASD）is one of the most important determinants of soil structure along with soil organic matter content for describing the efficiency of applied,sustainable management *** study aimed to compare the performances of three different aggregate size distribution models to predict the characteristic aggregate size parameter(median diameter,D50)for eroded sediment from interrill erosion processes of RainSplash Transport（RST）and Raindrop Impacted Flow Transport（RIFT）.The ASDs of 1143 collected sediment samples from the RST and RIFT processes were measured and modeled by the Log-normal,Fractal,and Weibull *** D50value,as a characteristic parameter for aggregate size distributions,derived from the cumulative ASD curve was compared for soils from different land use types and different slope and rainfall intensity *** performance of each model was evaluated using the Mean Square Error（MSE）and Coefficient of Determination（R2）.The Weibull approach was the most accurate model showing the best fit with the lowest MSE values（0.0002≤MSE≤0.0048）and having the greatest R2values（0.936≤R2≤0.998）when compared with the Log-normal and Fractal ***,for semi-arid land use and soil,specific shape and scale parameters for the Weibull distribution,the respective ASDs were successfully re-generated for modeling the eroded sediment of the simulated RST and RIFT interill processes.

关键词： Aggregate size distribution Eroded sediment Log-normal model Fractal model Weibull model

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Removal of astrazon golden yellow 7GL from colored wastewater using chemically modified clay

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Journal of Central South University 2017年第4期24卷 743-753页

作者： Meltem CAKMAK Seyda TASAR Veyis selen Dursun OZER Ahmet OZER Department of Chemical Engineering Firat University23279 ElazigTurkey

Chemically modified clay(CMC) was used as an adsorbent for the removal of Astrazon Golden Yellow 7GL(AGY-7GL), which is a basic dye from wastewater. For this purpose, the chemically modified clay was first characterized by determining zero point of charge(p Hzpc), and using BET, SEM and FTIR. Then effects of operational parameters on adsorption of AGY-7GL were studied in a batch system. The effect of various parameters such as contact time(0-180 min), pH(2-8), temperature(293-323 K), CMC concentration(0.075-0.5 mg/L) and initial AGY-7GL concentration(75-250 mg/L) were investigated on the adsorption efficiency and capacity adsorption of CMC for the removal of AGY-7GL. Thermodynamic and kinetic parameters were calculated from the results of the adsorption experiment. The evaluation of kinetic models shows that this data best fits the pseudo-second-order model. It is determined that the adsorption equilibrium data works very well with the nonlinear Freundlich isotherm model. Thermodynamic parameters such as ?H^0(19.0 k J/mol), ?G^0(-28.8 k J/mol) and ?S^0(0.148 k J/mol) were also determined. According to the experimental results, it is concluded that CMC could be used as an alternative low cost potential adsorbent for the removal of AGY-7GL from wastewater.

关键词： adsorption astrazon golden yellow 7GL(AGY-7GL) chemically modified clay(CMC) thermodynamic and kinetic parameters

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Efficacy of custom-made soft keratoconus lenses on corneal aberrations and photic phenomena in patients with keratoconus:a corneal topography imaging based study

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 67-74页

作者： Aysegul Penbe Hatice selen Kanar Aysu Karatay Arsan Sevda Aydın Kurna Department of Ophthalmology Kartal Dr.Lutfi Kirdar Training and Research HospitalHealth Science UniversitySemsi Denizer CaddesiE-5Kartal Istanbul 34890Turkey Department of Ophthalmology Fatih Sultan Mehmet Training and Research HospitalHealth Science UniversityE-5Icerenkoy 34752IstanbulTurkey

AIM:To evaluate the efficacy of custom-made soft keratoconus(KC)lenses on corneal aberrations and photic phenomena in two different optical zones in patients with ***:Sixty eyes of 42 patients with KC were examined at baseline and after fitting HydroCone(Toris K)soft silicone hydrogel *** spectacle-corrected visual acuity(BSCVA)and contact lens-corrected visual acuity(CLCVA)were ***-and higher-order corneal aberrations(LOAs and HOAs)were measured with and without Toris K lenses and compared in central 4.5 mm and 7 mm *** pupil diameter and subjective photic phenomena were also ***:Mean CLCVA was significantly improved compared to BSCVA(P6.00 mm(85.7%).CONCLUSION:Toris K lenses provide good visual results and a significant reduction in central corneal aberrations in patients with KC but could cause an increase in peripheral *** practical and nonsurgical approach appears to be an effective method for the visual management of KC.

关键词： corneal aberrations custom-made soft keratoconus lenses higher-order aberrations keratoconus lower-order aberrations pupillography

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Evaluation of dry eye disease in newly diagnosed anxiety and depression patients using anterior segment optical coherence tomography

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Eye and Vision 2019年第1期6卷 213-218页

作者： Mahmut Oğuz Ulusoy selen Işık-Ulusoy SertaçArgun Kıvanç Department of Ophthalmology Başkent University School of Medicine Konya Research Hospital42000 KonyaTurkey Department of Psychiatry Başkent University School of Medicine Konya Research HospitalKonyaTurkey Department of Ophthalmology UludağUniversity School of MedicineBursaTurkey

Background:We aimed to evaluate dry eye diseases(DED)in patients with newly diagnosed depression and anxiety ***:Forty newly diagnosed depression,35 anxiety patients,and 37 controls without any history of taking psychiatric drugs(or before the beginning of psychiatric medication)and topical ophthalmic drop use,were included in the *** depression and anxiety diagnoses were performed by an experienced *** depression and anxiety tests were used to measure disease *** film break up time(TBUT),Schirmer’s test,Oxford scores and ocular surface disease index(OSDI)were admiinistered to *** segment optical coherence tomography was used to measure tear meniscus heights(TMH),tear meniscus depths(TMD)and tear meniscus areas(TMA).Results:In anxiety and depression groups,Schirmer’s test(mm)(7.24±6.02,6.58±4.9 and 18.79±4.9 respectively,p<0.05)and TBUT(s)(5.62±3.1,5.6±3.5 and 13.37±1.7 respectively,p<0.05)were significantly lower than control *** addition,OSDI and Oxford scores were significantly higher than *** scores were 28.01±19,30.43±18.49,14.38±8.14 respectively(p=0.002)and Oxford scores were 1.9±0.7,2.1±0.6 and 0.7±0.4 respectively(p=0.001).TMD,TMH and TMA values were significantly lower in anxiety and depression groups compared with control *** between disease inventory scores and dry eye tests were ***:This study showed a relation between DED and newly diagnosed anxiety and depression patients with no history of psychiatric drug *** presence of correlation between dry eye tests and disease inventory scores strengthens this *** is an important knowledge that need to be evaluated in these patients before starting psychiatric medication.

关键词： Depression Anxiety Dry eye Tear meniscus Anterior segment optical coherence tomography

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Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis

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World Journal of Clinical Cases 2022年第14期10卷 4348-4356页

作者： Basri Satilmis Gizem selen Cicek Egemen Cicek Sami Akbulut Tevfik Tolga Sahin Sezai Yilmaz Hepatology Research Laboratory Liver Transplant InstituteInonu UniversityMalatya 44000BattalgaziTurkey Department of Biochemistry Faculty of PharmacyInonu UniversityMalatya 44000BattalgaziTurkey Department of Anesthesiology and Reanimation Malatya Training and Research HospitalMalatya 44000YesilyurtTurkey Liver Transplant Institute InonuUniversityMalatya 44000BattalgaziTurkey

Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have ***-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and ***-MSC are mesenchymal stem cells that have pluripotent lineage *** are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem *** is also HLA-DR negative and can be transplanted allogenically without the need for *** advantages have popularized its use in many fields including plastic reconstructive ***,in the field of hepatology and liver transplantation,the progress is ***-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract *** are very important for the treatment of various hepatobiliary ***,the anti-inflammatory potential of these cells has paramount importance in the treatment of *** need alternative therapeutic approaches to treat end-stage liver ***-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver *** we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis.

关键词： Adipose-derived stem cells Hepatobiliary diseases Sepsis Mesenchymal stem cells Theoretic application

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The apoptotic effect of ozone therapy on mitochondrial activity of highly metastatic breast cancer cell line MDA-MB-231 using in vitro approaches

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Journal of Interventional Medicine 2022年第2期5卷 64-71页

作者： Merve Yildirim selen Erkisi Hazal Yilmaz Naz Unsal Elif inac Yldray Tanrnver Polen Kocak Departnent of Genetics and Bioenginering Facaly of Engineering and Architecture Yeditepe University26 Agustos CampusKaqrisdagt CadKaytsdag34755IstanbulTurkey Infirity Regnerative Clini Thy Sites YoluUlus34347IstanbulTurkey Department of Biomedical Engineering Faculy of Enginering Itirve Universit Vadi CampusAzerbaycan CadSariyer34396IstanbulTurkey

Ozone(O) gas is the triatomic state of oxygen and it is used as a disinfection agent due to its strong oxidizing effect, since its discovery in the mid-nineteenth century. Ozone therapy is also an alternative therapeutic approach for some diseases like circulatory disorders, AIDS, asthma, cardiovascular diseases, and certain types of cancer by increasing the oxygen levels in the blood by external addition of ozone to the body. In this study, the therapeutic potential of ozone therapy was examined by inhibiting the growth of breast cancer cells in a dose-dependent procedure. Ozone concentrations varying from 5 to 20 μg/ml were applied to the MDA-MB-231, human breast adenocarcinoma and HUVEC, human umbilical vein endothelium, cell lines, and MDA cells demonstrated an increased rate of death while its migration potential decreases. RT-PCR analysis showed mRNA expression levels of pro-apoptotic genes demonstrated higher folds in MDA cells after 10 μg/ml treatment. In the same context,Annexin V/PI and cell cycle analysis also concluded that ozone therapy causes apoptotic cell death on breast tumor cells. The use of ozone therapy for cancer treatment requires further and extensive research. However, this research has shown that ozone therapy is a promising source for cancer treatment in a way by inhibiting the proliferation of breast tumor cells.

关键词： Ozone therapy Antioxidants Apoptosis Breast cancer

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Impact structures and events - a Nordic perspective

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Episodes 2008年第1期31卷 107-114页

作者： Henning Dypvik Jueri Plado Claus Heinberg Eckart Hakansson Lauri J. Pesonen Birger Schmitz selen Raiskila Department of Geosciences University of Oslo P.O. Box 1047 Blindern NO 0316 Oslo Norway. Department of Geology University of Tartu Vanemuise 46 51014 Tartu Estonia. Department of Environmental Social and Spatial Change Roskilde University P.O. Box 260 DK-4000 Roskilde Denmark. Department of Geography and Geology University of Copenhagen Dster Voldgade 10 DK-1350 Copenhagen Denmark. Division of Geophysics University of Helsinki P.O. Box 64 FIN-00014 Helsinki Finland. Department of Geology University of Lund S61vegatan 12 SE-22362 Lund Sweden.

Impact cratering is one of the fundamental processes in the formation of the Earth and our planetary system, as reflected, for example in the surfaces of Mars and the Moon. The Earth has been covered by a comparable number of impact scars, but due to active geological processes, weathering, sea floor spreading etc, the number of preserved and recognized impact craters on the Earth are limited. The study of impact structures is consequently of great importance in our understanding of the formation of the Earth and the planets, and one way we directly, on the Earth, can study planetary geology. The Nordic-Baltic area have about thirty confirmed impact structures which makes it one of the most densely crater-populated terrains on Earth. The high density of identified craters is due to the level of research activity, coupled with a deterministic view of what we look for. In spite of these results, many Nordic structures are poorly understood due to the lack of 3D-geophysical interpretations, isotopeor other dating efforts and better knowledge of the amount of erosion and subsequent tectonic modifications. The Nordic and Baltic impact community is closely collaborating in several impact-related projects and the many researchers （about forty） and PhD students （some seventeen） promise that this level will continue for many more years. The main topics of research include geological, geophysical and geochemical studies in combination with modeling and impact experiments. Moreover, the Nordic and Baltic crust contains some hundred suspect structures which call for detailed analysis to define their origin. New advanced methods of analyzing geophysical information in combination with detailed geochemical analyses and numerical modeling will be the future basic occupation of the impact scientists of the region. The unique Cretaceous/Tertiary boundary （K-T） occurrences in Denmark form an important source of information in explaining one of the major mass extinctions on E

关键词：北欧冲击作用透视方法地质研究

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HDL DECREASED ESTROGEN-INDUCED RELAXATION IN RAT AORTA

HDL DECREASED ESTROGEN-INDUCED RELAXATION IN RAT AORTA

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第十五届国际药理学大会

作者： AKAR FATMA ISBIR-SOYLEMEZ selen Gazi University Faculty of Pharmacy Department of Pharmacology 06330 Etiler Ankara/TURKEY Gazi University Faculty of Pharmacy Department of Pharmacology 06330 Etiler Ankara/TURKEY

＜正＞ Estrogen and HDL （High-Density Lipoprotein） have previously been reported to exert both endotheliumdependent and independent relaxations in various animal arteries. The present study examined the effect of HDL preincubation on the en-dothelial relaxation to 17beta-estradiol in aorta from male rats. Isometric tension was recorded in isolated aortic rings. Superoxide production was measured by lu-cigenin-enhanced chemiluminescence. 17beta-estradiol produced marked relaxation starting physiologically relevant concentrations （1 nM） in aortic rings with endothelium. HDL （0.001-0.3 ug/ml） also induced concentrationdependent relaxations in aortic rings. Preincubation with HDL （0.01,0.03 ug/ml） selectively inhibited endothelium-dependent relaxation to 17beta-estradiol because endotheli-um-independent relaxations to 17betaestradiol and sodium nitroprusside were not decreased in the presence of HDL. Parallelly,HDL preincubation provoked vascular superoxide production in the presence of 17beta-estradiol in aortic rings with endothelium. HDL can inhibit endothelium-dependent relaxation to 17beta-estradiol by increasing endothelial superoxide production in rat aorta.

关键词： Estrogen HDL relaxation superoxide

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COVID-19 infection in a kidney transplant recipient—special emphasis on pharmacokinetic interactions:A case report

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World Journal of Transplantation 2020年第11期10卷 365-371页

作者： Ebru Gok Oguz Kadir Gokhan Atilgan Sanem Guler Cimen Hatice Sahin Tamer selen Fatma AyerdenEbinc Sertac Cimen Mehmet Deniz Ayli Department of Nephrology Diskapi Yildirim Beyazit Training and Res HospAnkara 6500Turkey Department of Nephrology Health Sciences UniversityAnkara 6500Turkey Department of General Surgery Diskapi Research and Training HospitalHealth Sciences UniversityAnkara 65000Select OneTurkey Department of Urology and Transplantation Health Sciences UniversityAnkara 65000Select OneTurkey Department of Nephrology and Transplantation Diskapi Yildirim Beyazit Teaching and Research HospitalAnkara 6500Turkey

BACKGROUND Solid organ transplant recipients are considered to be at high-risk of developing coronavirus disease 2019(COVID-19)-related *** optimal treatment for this patient group is ***,the treatment of COVID-19 in kidney transplant recipients should be determined individually,considering patient age and comorbidities,as well as graft function,time of transplant,and immunosuppressive *** treatments may give rise to severe *** the contrary,they may also lead to a milder and atypical presentation by diminishing the immune system *** SUMMARY A 50-year old female kidney transplant recipient presented to the transplant clinic with a progressive dry cough and fever that started three days *** the COVID-19 test was found to be negative,chest computed tomography images showed consolidation typical of the disease;thus,following hospital admission,anti-bacterial and COVID-19 treatments were ***,despite clinical improvement of the lung consolidation,her creatinine levels continued to *** of the graft showed no *** tacrolimus blood level was determined and the elevation in creatinine was found to be related to an interaction between tacrolimus and *** During the COVID-19 pandemic,various single or combination drugs have been utilized to find an effective treatment *** has increased the possibility of drug interactions.A limited number of studies published in the literature have highlighted some of these pharmacokinetic *** used for COVID-19 therapy;azithromycin,atazanavir,lopinavir/ritonavir,remdesivir,favipiravir,chloroquine,hydroxychloroquine,nitazoxanide,ribavirin,and tocilizumab,interact with immunosuppressive treatments,most importantly with calcineurin ***,their levels should be frequently monitored to prevent toxicity.

关键词： COVID-19 Kidney transplantation Drug interaction Pharmacokinetics Azithromycin Case report Calcineurin inhibitor

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