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Xyloglucan for Generating Tensile Stress to Bend Tree Stem

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Molecular Plant 2009年第5期2卷 893-903页

作者： Kei'ichi Baba Yong Woo Park Tomomi Kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji Kondo Ziv Shani Oded Shoseyov tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi Kyoto University RISH Gokasho Uji Kyoto 611-0011 Japan Graduate School of Bioagricultural-Sciences Nagoya University Nagoya 464-8601 Japan Forest Tree Breeding Center Hitachi Ibaraki 319-1301 Japan CBD Technologies Rehovot 76100 Israel Division of Forest and Biomaterials Science Kyoto University Kyoto 606-8502 Japan Graduate School of Frontier Biosciences Osaka University Suita Osaka 565-0871 Japan Institute of Sustainability Science Kyoto University Gokasho Uji Kyoto 611-0011 Japan

In response to environmental variation, angiosperm trees bend their stems by forming tension wood, which consists of a cellulose-rich G （gelatinous）-Iayer in the walls of fiber cells and generates abnormal tensile stress in the secondary xylem. We produced transgenic poplar plants overexpressing several endoglycanases to reduce each specific polysaccharide in the cell wall, as the secondary xylem consists of primary and secondary wall layers. When placed horizontally, the basal regions of stems of transgenic poplars overexpressing xyloglucanase alone could not bend upward due to low strain in the tension side of the xylem. In the wild-type plants, xyloglucan was found in the inner surface of G-layers during multiple layering. In situ xyloglucan endotransglucosylase （XET） activity showed that the incorporation of whole xyloglucan, potentially for wall tightening, began at the inner surface layers S1 and S2 and was retained throughout G-layer development, while the incorporation of xyloglucan heptasaccharide （XXXG） for wall loosening occurred in the primary wall of the expanding zone. We propose that the xyloglucan network is reinforced by XET to form a further connection between wall-bound and secreted xyloglucans in order to withstand the tensile stress created within the cellulose G-layer micro fibrils.

关键词： G-layer tensile stress xyloglucan xyloglucan endotransglucosylase

Quantitative detection of metastasis-associated 1 mRNA and protein expression in breast cancer

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中华内分泌外科杂志 2013年第3期7卷 199-205页

作者： Hiroko Yamashita tatsuya Toyama Hiroshi Sugiura Mei ZHANG Shunzo Kobayashi Yoshitaka Fujii Hirotaka Iwase Zhenhuan ZHANG Department of Oncology Immunology and Surgery Nagoya City University Graduate School of Medical Sciences 1 Kawasumi Mizuho-eho Mizuho-ku Nagoya 467-8601 Japan

Objective Understanding the mechanism of breast cancer metastasis will benefit those patients in need of aggressive treatment and avoid side effects caused by chemotherapy over ***,a potential metastasis-associated gene and its product,the metastasis-associated 1 (MTA1),were identified; this gene has been found to be overexpressed in a variety of *** In the present study,therefore,the level of expression of MTA1 mRNA has been assessed by LightCycler quantitative real-time RT-PCR in 160 cases of invasive carcinoma of the ***1 protein expression level was also detected by immunohistochemistry from available paired tissues of 154 *** between MTA1 mRNA and protein expression and clinicopathological factors were *** It was found that MTA1 mRNA was expressed at significantly higher levels in patients with negative lymph node status,with ER and PgR positive and HER2 negative *** difference was found between patient age,tumor size and histological grade *** with high levels of expression of MTA1 mRNA had a better prognosis than those with low ***,no difference was found between the protein level and clinicopathological *** and multivariate prognostic analysis did not demonstrate that MTA1 mRNA was an independent prognostic factor for breast *** In breast cancer,inconsistent with other tumor types,MTA1 gene expression is correlated with non-invasive clinicopathological factors and longer survival,which might suggest MTA1 gene is a tumor type specific metastasis associated gene.

关键词：摘要编辑部编辑工作读者

Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction

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World Journal of Gastroenterology 2012年第21期18卷 2735-2738页

作者： Toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada tatsuya Toyokawa Toshio Kuwai Masanori Ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta Eiji Masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi Division of Gastroenterology National Hospital Organization Tokyo Medical CenterTokyo 1528902 Japan Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of MedicineTokyo 1608582 Japan Division of Gastroenterology National Hospital Organization Kyoto Medical CenterKyoto 6128555 Japan Division of Gastroenterology National Kyushu Medical CenterFukuoka 8108563 Japan Division of Gastroenterology National Hospital Organization Fukuyama Medical CenterFukuyama 7208520 Japan Division of Gastroenterology National Hospital Organization Kure Medical CenterKure 7370023 Japan Division of Gastroenterology National Hospital Organization Hakodate Medical CenterHakodate 0418512 Japan Division of Gastroenterology National Hospital Organization Maizuru Medical CenterMaizuru 6258502 Japan Division of Gastroenterology National Hospital Organization Higashihiroshima Medical CenterHigashihiroshima 7390041 Japan Division of Gastroenterology National Hospital Organization Sendai Medical CenterSendai 9838520 Japan Division of Gastroenterology National Hospital Organization Osaka Medical CenterOsaka 5400006 Japan Division of Gastroenterology National Hospital Organization Ureshino Medical CenterUreshino 8430393 Japan Division of Gastroenterology National Hospital Organization Osaka Minami Medical CenterKawachinagano 5868521 Japan Division of Gastroenterology National Hospital Organization Fukuoka Higashi Medical CenterKoga 8113195 Japan Division of Gastroenterology National Hospital Organization Yonago Medical CenterYonago 6838518 Japan Division of Gastroenterology National Hospital Organization Disaster Medical CenterTachikawa 1900014 Japan Pharmaceutical Department National Center for Global Health and MedicineTokyo 1658655 Japan

We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT.

关键词： Helicobacter pylori Amoxicillin Dual therapy Eradication Urea breath test

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太阳热处理对小白菜根肿病防治效果的研究

浙江农业学报 2020年第1期32卷 98-107页

作者：沈璐李勤超田中贵稻村达也伊日布斯昆明理工大学生命科学与技术学院云南昆明650504 日本京都大学农学研究科日本京都606-8502

为探讨太阳热处理对小白菜根肿病的防治效果,以超级小黄白为供试材料,测定太阳热处理前后的土壤理化性质、根肿菌休眠孢子数量、土壤微生物多样性及发病率和病情指数,评价太阳热处理对小白菜根肿病的影响。研究表明:经太阳热处理后土壤0... 详细信息

为探讨太阳热处理对小白菜根肿病的防治效果,以超级小黄白为供试材料,测定太阳热处理前后的土壤理化性质、根肿菌休眠孢子数量、土壤微生物多样性及发病率和病情指数,评价太阳热处理对小白菜根肿病的影响。研究表明:经太阳热处理后土壤0~10 cm处pH由4.96提高至5.60,根肿菌休眠孢子的浓度由1.09×106 g-1减少至5.74×105 g-1。变性梯度凝胶电泳(DGGE)结果证明,太阳热处理提高了土壤细菌微生物多样性,其中0~10 cm处和10~20 cm处土壤细菌微生物群落的香浓维纳指数分别由1.51、0.91提高到1.98、1.53,0~10 cm处根肿病的发病率由87.10%降低到49.12%,病情指数由45.24降低到16.96,防治效果明显。本研究为太阳热处理在实际农业生产中的应用及对根肿病的防治提供了理论基础。

关键词：小白菜根肿病太阳热处理发病率细菌多样性

文化史学的形成与意义——日本战后关于文化史学的反思

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史学理论与史学史学刊 2022年第1期26卷 271-283页

作者： [日]奈良本辰也林翔(译) 不详北京师范大学历史学院北京100875

长期以来,实证主义史学在日本占据主导地位,文化史学未受到应有的重视。文化史并非从异于政治和经济领域的文化事象中汲取而来,它不只是一种特殊史。文化史学是一种相对于历史的观念。西田直二郎是现代日本文化史学最具代表性的人物。... 详细信息

长期以来,实证主义史学在日本占据主导地位,文化史学未受到应有的重视。文化史并非从异于政治和经济领域的文化事象中汲取而来,它不只是一种特殊史。文化史学是一种相对于历史的观念。西田直二郎是现代日本文化史学最具代表性的人物。西田提倡通过意义性来把握时间,从而消解了历史与历史哲学的对立,由此建立了历史事件与全体时代及全体人类之关联。通过这种方式,实现了世界史和国别史的统一,亦引起学界关于审视历史的立场的反省。虽然文化史学因具有精神史的构造,被追究战争责任,且存在淡化历史学自身的主体性、弱化历史的实践性等缺点,但是其优点亦十分显著。文化史学以哲学性的考察为本,呈现观念论史学的最高阶段,它强调现实关怀、倡导综合性,恰好可以弥补实证主义史学之不足。鉴于日本历史学界对文化事象研究薄弱的现状,回顾文化史学尤为必要。

关键词：文化史学西田直二郎《日本文化史序说》实证主义史学精神史

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日本引进西洋技术史中的文化对应

北京化工大学学报（社会科学版） 2006年第3期 63-67,46页

作者：小林达也张明国日本中京大学北京化工大学文法学院北京100029

本文将日本近代引进欧美技术、制度和方法,完成产业和社会变革的过程分为三个阶段:幕府锁国体制的崩溃和明治维新变革的实现、战后的民主改革和产业技术创新及TLO与“产—学”技术转移阶段,分析了各个阶段的特点并与中国进行了比较论述... 详细信息

本文将日本近代引进欧美技术、制度和方法,完成产业和社会变革的过程分为三个阶段:幕府锁国体制的崩溃和明治维新变革的实现、战后的民主改革和产业技术创新及TLO与“产—学”技术转移阶段,分析了各个阶段的特点并与中国进行了比较论述,提出了自己的见解。

关键词：日本技术引进文化

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纳米Pt膜的晶粒尺寸及其对热导率的影响

金属学报 2006年第11期42卷 1207-1211页

作者：曹炳阳张清光张兴高桥厚史声田龙也乔文明滕井丕夫清华大学工程力学系热科学与动力工程教育部重点实验室北京100084 Graduate School of Engineering Kyushu University 华东理工大学化学工程联合国家重点实验室上海200237 Institute for Materials Chemistry and Engineering Kyushu University

采用电子束-物理气相沉积法(EB-PVD)制备了6个厚度为15-62 nm的铂薄膜,研究了纳米薄膜的晶粒尺寸及其对热导率的影响规律．当薄膜厚度小于30 nm时,晶粒平均尺寸接近于薄膜的厚度;晶粒尺寸随着薄膜厚度的增加而增大并趋于定值;当薄膜厚... 详细信息

采用电子束-物理气相沉积法(EB-PVD)制备了6个厚度为15-62 nm的铂薄膜,研究了纳米薄膜的晶粒尺寸及其对热导率的影响规律．当薄膜厚度小于30 nm时,晶粒平均尺寸接近于薄膜的厚度;晶粒尺寸随着薄膜厚度的增加而增大并趋于定值;当薄膜厚度大于30 nm时,晶粒尺寸约为20 nm．受薄膜的表面和内部晶界的综合影响,铂纳米薄膜的热导率大大低于体材料的值,并且纳米薄膜的热导率随着薄膜厚度的增加而增大并趋于一个低于体材料热导率的值．

关键词： Pt纳米薄膜热导率晶粒尺寸晶界效应尺寸效应

GM3通过MMP-9调节B16细胞的运动性

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沈阳药科大学学报 2008年第3期25卷 229-235页

作者：王璞张景海山形贞子山形达也沈阳药科大学生命科学与生物制药学院辽宁沈阳110016

目的通过不同的方法来研究GM3对MMP-9的调节作用。并进一步验证了GM3对细胞运动性的调节。方法分别用RT-PCR,Zymography,HPTLC,western blotting和transwell的方法来检测MMP-9的mRNA表达水平,MMP-9的活性,GM3,Akt的磷酸化以及细胞的运... 详细信息

目的通过不同的方法来研究GM3对MMP-9的调节作用。并进一步验证了GM3对细胞运动性的调节。方法分别用RT-PCR,Zymography,HPTLC,western blotting和transwell的方法来检测MMP-9的mRNA表达水平,MMP-9的活性,GM3,Akt的磷酸化以及细胞的运动性。结果通过几种不同的方法来研究是否GM3参与MMP-9的调空:a.通过转染半乳糖转移酶的顺反序列来调节GM3的表达,从而初步证明GM3可以调节MMP-9的表达;b.通过外加GM3可以清楚的观察到MMP-9的表达量升高;c.神经节苷脂抑制剂D-PDMP的加入更进一步的证明了MMP-9的表达始终与GM3的表达相关;另外,通过PI3K抑制剂的试验进一步证明了GM3通过PI3K来调节MMP-9的表达。在此基础上,更进一步的证明了神经节苷脂可以调节细胞的运动性。结论GM3可以通过PI3K/Akt信号传导途径来正调控MMP-9的表达,并且调节细胞的运动性。

关键词：神经节苷脂GM3 小鼠黑色素瘤细胞B16 金属蛋白酶MMP-9 P13K/Akt信号转导途径细胞运动性

烷烃系清洗剂“NS-Clean”提高清洗工程生产性的作用

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中国洗涤用品工业 2016年第11期 58-62页

作者：山内辰也岳宵(译) JX日矿日石能源株式会社日本9990011 不详

本文分析了烷烃系清洗剂的要点,详细介绍了烷烃系清洗剂"NS-Clean M型"的构成、特长,确认了"NS-Clean M型"在金属清洗方面提高清洗工程生产性的作用。

关键词：烷烃系清洗剂 “NS-Clean M型” 金属清洗生产性