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Usefulness of liver infiltrating CD86-positive mononuclear cells for diagnosis of autoimmune hepatitis

World Journal of Gastroenterology 2006年第16期12卷 2523-2529页

作者： Kazutaka Kurokohchi Tsutomu Masaki Takashi Himoto Akihiro Deguchi seiji nakai Asahiro Morishita Hirohito Yoneyama Yasuhiko Kimura Seishiro Watanabe Shigeki Kuriyama Third Department of Internal Medicine Kagawa University School of Medicine1750-1 IkenobeMiki-choKita-gunKagawa 761-0793Japan

AIM： Although the pathogenic mechanism underlying autoimmune hepatitis （AIH） remains unclear, the immune system is thought to be critical for the progression of the disease. Cellular immune responses may be linked to the hepatocellular damage in AIH. Recently, much attention has been focused on the critical functions of costimulatory molecules expressed on mononuclear cells in the generation of effective T cell-mediated immune responses. Analysis of costimulatory molecule expressed on mononuclear cells from the patients with AIH may give us insight into the pathogenic mechanism of hepatocellular damage in AIH. METHODS： Peripheral blood mononuclear cells （PBMC） were taken from the patients with AIH （34 cases） and healthy controls （25 cases）. Uver infiltrating mononuclear cells （LIMCs） were taken from the patients with AIH （18 cases）, the patient with chronic hepatitis C （CH-C）（13 cases） and the patients with fatty liver （2 cases）. Using flow cytometry, the cells were analyzed for the expression of costimulatory molecules, such as CD80, CD86, and CD152 （CTLA-4）. The results were compared with clinical data such as the level of gammaglobulin, histological grade, presence or absence of corticosteroids administration and the response to corticosteroids. RESULTS： The levels of CD80＋, CD86＋ and CD152＋ PBMC were significantly reduced in the patients with AIH as compared with healthy controls. By contrast, those cells were significantly higher in LIMC than in PBMC of the patients with AIH. Especially, the level of CD86＋ LIMC showed a marked increase irrespective of the degree of disease activity in the patients with AIH,although CD86＋ cells were rarely present in PBMC. The levels of CD86＋ cells were present in significantly higher frequency in patients with AIH than in the patients with CH-C. Furthermore, the patients with AIH with high levels of CD86＋ LIMC showed good responses to corticosteroids, whereas 2 cases of AIH with low levels of CD86＋ LIMC did not respond well. C

关键词： Autoimmune hepatitis Costimulatory molecule CD86 molecule Peripheral blood mononuclear cells Liver infiltrating mononuclear cells Flow cytometry

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Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第10期11卷 1426-1432页

作者： Kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura seiji nakai Akihiro Deguchi Hirohito Yoneyama Shuhei Yoshida Shigeki Kuriyama Third Department of Internal Medicine

AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into ***: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF ***: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both *** PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into ***: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated ***, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC.

关键词： Combination therapy Percutaneous ethanol injection Radiofrequency ablation Energy requirement

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Simultaneous detection of the shuttling motion of liquid metal droplets in channels under alternating pressure and capacitive sensor signals

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Microsystems & Nanoengineering 2024年第2期10卷 83-90页

作者： Shinji Bono Ryotaro nakai Satoshi Konishi Research Organization of Science and Technology Ritsumeikan UniversityShigaJapan Ritsumeikan Advanced Research Academy KyotoJapan Ritsumeikan Global Innovation Research Organization Ritsumeikan UniversityShigaJapan Graduate School of Science and Engineering Ritsumeikan UniversityShigaJapan

Implementing a signal-switching mechanism for the selective use of integrated sensors and actuators plays a crucial role in streamlining the functionality of miniaturized ***,a liquid metal droplet(LMD)-based signal-switching mechanism is introduced to achieve such *** modulation with a 100-μm spatial resolution enabled precise control of the position of the LMDs within a *** integrating the channel with asymmetrically structured electrodes,the effect of the shuttle-like movement of LMD on the temporal changes in the overall capacitance was ***,analysis of the capacitive peaks revealed the directional movement of the LMDs,enabling estimation of the position of the LMDs without direct *** addition,we achieved successful signal extraction from the capacitive sensor that was linked to the activated electrodes,thereby enabling selective data *** proposed signal-switching mechanism method achieved a detection accuracy of~0.1 *** sensor’s ability to simultaneously detect the LMD position and generate a signal underscores its significant potential for multiplexing in multisensing systems,particularly in concealed environments,such as in vivo settings.

关键词： liquid thereby integrating

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Activation of c-Yes in hepatocellular carcinoma: A preliminary study

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World Journal of Gastroenterology 2006年第35期12卷 5743-5745页

作者： Han Feng Tsutomu Masaki Takako Nonomura Asahiro Morishita Gong Jian seiji nakai Akihiro Deguchi Naohito Uchida Takashi Himoto Hisakazu Iwama Hisashi Usuki Hisao Wakabayashi Kunihiko Izuishi Hitoshi Yoshiji Kazutaka Kurokohchi Shigeki Kuriyama Third Departmentof Internal Medicine Kagawa Medical University 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Information Technology Center Kagawa Medical University 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Department of Gastroenterological Surgery Kagawa Medical University 1750-1 Ikenobe Miki-cho Kita-gun Kagawa 761-0793 Japan Third Department of Internal Medicine Nara Medical University 840 Shijo-cho Kashihara Nara 634-8522 Japan Department of Gastroenterology KKR Takamatsu Hospital 4-18 Tenjinmae Takamatsu Kagawa 760-0018 Japan

Hepatocellular carcinoma （HCC） is thought to develop through a multistep process. A long history of viral hepatitis or prolonged exposure to environmental toxins predisposes liver cells to mutations of the genes critical in the control of hepatocyte growth. In fact, both activation of cellular oncogenes and inactivation of tumorsuppressor genes are involved in the development of HCC. Activation of oncogenes by hepatitis virus integration has been shown in the woodchuck animal model, although the significance of this finding in human hepatocarcinogenesis is still under investigation. Tyrosine kinases, though a minor class of cellular protein, represent a major class of oncogenes. These tyrosine kinases are classified into two major groups.

关键词： Hepatocellular carcinoma Tyrosine kinase c-Yes Oncogene

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Singular and fractional integral operators on preduals of Campanato spaces with variable growth condition

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Science China Mathematics 2017年第11期60卷 2219-2240页

作者： nakai Eiichi Department of Mathematics Ibaraki University

We investigate the boundedness of singular and fractional integral operators on generalized Hardy spaces defined on spaces of homogeneous type, which are preduals of Campanato spaces with variable growth condition. To... 详细信息

关键词： singular integral fractional integral Hardy space Campanato space variable exponent space of homogeneous type

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A Generalization of Hardy Spaces H^p by Using Atoms

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Acta Mathematica Sinica,English Series 2008年第8期24卷 1243-1268页

作者： Eiichi nakai Department of Mathematics Osaka Kyoiku UniversityKashiwaraOsaka 582 8582Japan

Let X = （X, d,μ） The purpose of this paper is to be a space of homogeneous type in the sense of Coifman and Weiss. generalize the definition of Hardy space H^P（X） and prove that the generalized Hardy spaces have the same property as H^P（X）. Our definition includes a kind of Hardy- Orlicz spaces and a kind of Hardy spaces with variable exponent. The results are new even for the R^n case. Let （X, δ, μ） be the normalized space of （X, d, μ） in the sense of Macias and Segovia. We also study the relations of our function spaces for （X, d, μ） and （X, δ,μ）.

关键词： Hardy space Hard-Orlicz space variable exponent Campanato space space of homogeneous type

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Biological Control of Tortricidae in Tea Fields in Japan Using Insect Viruses and Parasitoids

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Virologica Sinica 2009年第4期24卷 323-332页

作者： Madoka nakai Tokyo University of Agriculture and Technology

Tea is a perennial and evergreen plant. Cultivated tea trees provide a habitat for insect pests and their natural enemies. In Japan, granuloviruses (GVs) have successfully controlled two of the most important pests of tea, Adoxophyes honmai and Homona magnanima (Tortricidae: Lepidoptera). The GVs are produced in vivo and a single application sustains pesticidal efficacy throughout a year, which encompasses 4 to 5 discrete generations of both species. A. honmai and H. magnanima also have various natural enemies, especially hymenopteran parasitoids. Such resident natural enemies also play a role in reducing the pest density in virus-controlled fields, but the effect of virus infection on parasitoids sharing the same host larva has not been well studied. Survival of one of the major parasitoids of A. honmai, Ascogaster reticulata (Braconidae: Hymenoptera), is reduced by virus infection of the host. Viruses, including GV and entomopoxvirus (EPV), and certain koinobiont endoparasitoids, including A. reticulata, are both known to regulate host endocrinology. However, the GV and EPV have distinct host regulation mechanisms, and consequently have different impacts on the survival of A. retuculata, when A. reticulata parasitizes a host that is infected with either GV or EPV. These additional effects on host regulation displayed by both viruses and parasitoids affect the outcome of virus-parasitoid interactions.

关键词： Tea Biological control Tortricidae Insect viruses Parasitoids

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Orlicz-Hardy spaces and their duals

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Science China Mathematics 2014年第5期57卷 903-962页

作者： nakai Eiichi SAWANO Yoshihiro Department of Mathematics Ibaraki UniversityMitoIbaraki 310-8512Japan Department of Mathematics and Information Sciences Tokyo Metropolitan UniversityMinami-Ohsawa 1-1Hachioji-shiTokyo 192-0397Japan

We establish the theory of Orlicz-Hardy spaces generated by a wide class of *** class will be wider than the class of all the *** particular,we consider the non-smooth atomic *** relation between Orlicz-Hardy spaces and their duals is also *** an application,duality of Hardy spaces with variable exponents is *** work is different from earlier works about Orlicz-Hardy spaces H（Rn）in that the class of admissible functions is largely *** can deal with,for example,Ф（r）≡（rp1（log（e＋1/r））q1,0〈r≤1,r^p2 （log（e＋r））q2,r〉1,with p1,p2∈（0,∞）and q1,q2∈（.∞,∞）,where we shall establish the boundedness of the Riesz transforms on H（Rn）.In particular,is neither convex nor concave when 0〈p1〈1〈p2〈∞,0〈p21〈p1〈∞or p1=p2=1 and q1,***（r）≡r（log（e＋r））q,then H（Rn）=H（logH）q（Rn）.We shall also establish the boundedness of the fractional integral operators I of order∈（0,∞）.For example,I is shown to be bounded from H（logH）1^1-α/n（Rn）to Ln/（n-α）（log L）（Rn）for 0〈α〈n.

关键词： Hardy space Orlicz space atomic decomposition Campanato space bounded mean oscillation

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Comparison of imo and Humphrey field analyzer perimeters in glaucomatous eyes

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1882-1887页

作者： Yoshinori nakai Kyoko Bessho Yuko Shono Kaori Taoka Yoshihide nakai Tokai Eye Clinic 399-Hadokoro-choTsu 514-0009Japan

AIM:To compare the imo perimeter,a new portable head-mounted perimeter unit that enables both eyes to be examined quickly and simultaneously,with the Humphrey field analyzer(HFA)perimeter to investigate correlations and their diagnostic ability in glaucomatous ***:The performance of the equipment in 128 glaucomatous eyes and 40 normal eyes were *** investigated the correlations of mean deviation,pattern standard deviation,visual field index,and the ***:Measurements of mean deviation(r=0.886,P<0.001),pattern standard deviation(r=0.814,P<0.001),and visual field index(r=0.871,P<0.001)in both perimeters were strongly and positively *** sensitivities in the imo perimeter were 80.5%for mean deviation,81.2%for pattern standard deviation,and 80.5%in visual field index;those in the HFA were 63.3%for mean deviation,74.5%for pattern standard deviation,and 80.5%for visual field *** perimeters demonstrated high diagnostic ***:The parameters by the imo and HFA in glaucomatous eyes show strong positive correlations with favorable sensitivity,specificity,and diagnostic ***,the difference between imo and HFA results increases with the increase in visual field disturbance.

关键词： imo perimeter visual field diagnosis diagnostic validation

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Management of severe acute pancreatitis: all hands to the pump

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 903-905页

作者： Yousuke nakai Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyoJapan Department of Endoscopy and Endoscopic Surgery The University of Tokyo HospitalTokyoJapan

Acute pancreatitis is one of the most common diseases in gastrointestinal,liver and pancreatic diseases,with about 300,000 annual admissions in the United States(1).Acute pancreatitis is complicated by pancreatic necrosis in 20%,and the mortality rate is 20%to 30%once infection occurs in pancreatic necrosis(2).Severe acute pancreatitis(SAP)was purely a surgical disease in 19th century due to its poor prognosis(3),but the importance of multidisciplinary approach is increasingly recognized as shown in the recent publication of French guidelines(4)by the collaboration of multisociety of surgery,gastroenterology,digestive endoscopy,interventional radiology,intensive care and nutrition.

关键词： pancreatitis Acute acute

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