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Expression of CD133 and Extracellular Matrix Molecules in Malignant Brain Tumors

Neuroscience & Medicine 2011年第4期2卷 392-396页

作者： seiichi yoshida Toshiro Koike 不详

Background: CD133 could be characterized as a “stem-like” cell subpopulation and an invasive tumor phenotype. The objectives of this study were to investigate the relationship of CD133 and other remodeling factors such as matrix metalloproteinases (MMP) in the brain tumors. Methods: Tumors from 13 patients with brain tumors (8 lung cancer metastasis, 3 breast cancer metastasis, 2 gliomas) were studied to investigate the expression-patterns of CD133, EGFR, MT1-MMP, and MMP7 using the immunostaining and RT-PCR analysis. Results: EGFR immunostaining was detected in 75% (6/8) and 67% (1/3) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. MT1-MMP immunostaining was also detected in 73% (8/11) of these brain metastasis. CD133 was not detected in these 13 patients. EGFR immunostaining was detected in 75% (6/8) and 67% (1/3) of brain metastasis from lung adenocarcinoma and breast cancer, respectively. MT1-MMP immunostaining was also detected in 73% (8/11) of these brain metastasis. CD133 was not detected in these 13 patients. Conclusions: The expression of CD133 indicates a marker for brain tumor initiating.

关键词： CD133 EGFR MT1-MMP MMP7 Brain Tumors

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Effects of Asian Sand Dust on Allergic Airway Inflammation in Mice

Effects of Asian Sand Dust on Allergic Airway Inflammation i...

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2012年环境污染与大众健康学术会议

作者： Takamichi Ichinose seiichi yoshida Rie Yanagisawa Hirohisa Takano Department of Health Sciences Oita University of Nursing and Health SciencesJapan Pathophysiology Research Team National Institute for Environmental StudiesJapan

There is no experimental study demonstrating the effects of airborne Asian sand dust （ASD） on allergic lung eosinophilia. The organic substances adsorbed onto ASD collected from the atmosphere of Iki-island in Japan were excluded by heat treatment at 360°C for 30 min. The effects of ASD or heated-ASD （H-ASD） towards allergic lung inflammation were compared in murine lungs to investigate the role of organic substances. ICR mice were administrated with the two kinds of ASD and/or ovalbumin （OVA） intratracheally four times at 2-week intervals. ASD and H-ASD enhanced eosinophil recruitment induced by OVA in the the airway. ASD and H-ASD synergistically increased Th2 cytokines-interleukin-13 （IL-13）, eosinophil-relevant cytokine and chemokine, such as IL-5, and monocyte chemotactic protein-3 （MCP-3） induced by OVA in whole lung lavage fluid. The enhancing effects were much greater in ASD than in H-ASD. These results suggest that the aggravated lung eosinophilia in ASD is due to activation of a Th2-associated immune response and microbial materials could be participating in this phenomenon.

关键词： Asian sand dust allergen lung eosinophilia murine

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Enhancement of Antigen-Induced Eosinophilic Inflammation in the Airways of Mice by Urban Particles in Beijing

Enhancement of Antigen-Induced Eosinophilic Inflammation in ...

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2012年环境污染与大众健康学术会议

It has been reported that ambient particulate matter （PM） in some large cities, such as Beijing, China, causes adverse respiratory health effects. However, there is currently no experimental report on the relationship between bronchial asthma and urban PM （UPM） in northeast Asia. In this study, the microbial and chemical substances adsorbed onto UPM collected in Beijing were excluded by heat-treatment at 360°C for 30 min. The effects of UPM or heated UPM （H-UPM） toward allergic lung inflammation were compared in murine lungs to investigate the role of organic substances. ICR mice were administrated intratracheally with the two kinds of UPM and/or ovalbumin （OVA） 4 times at 2-week intervals. UPM and H-UPM enhanced eosinophil recruitment induced by OVA in the alveoli and in the submucosa of the airway. UPM and H-UPM synergistically increased Th-2 cytokines-interleukin （IL）-4 and IL-13, eosinophil-relevant cytokines and chemokines, such as IL-5 and monocyte chemotactic protein-3 （MCP-3）, induced by OVA in bronchoalveolar lavage fluid （BALF）. The enhancing effects were much greater in UPM than in H-UPM. These results suggest that the aggravated lung eosinophilia in UPM was due to activation of a Th2-associated immune response. Chemical materials of air pollutant origin contained in UPM, and inorganic components （elemental carbon, mineral elements） in H-UPM, could also cause the aggravation.

关键词： Allergen Beijing lung eosinophilia murine particulate matter

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Polyamine-Polymeric Micelle Hybrid Hydrogel: Microscopic Properties of Crosslinkers Affecting Macroscopic Rheological Properties of Hydrogel

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Journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 36-44页

作者： Chikara yoshida Tomoki Ito Ryosuke Anzai Kengo Fukuda Keita Kinoshita seiichi Sonotaki Taku Takami Yoshihiko Murakami Department of Organic and Polymer Materials Chemistry Faculty of Engineering Tokyo University of Agriculture and Technology Tokyo Japan

We have developed a hybrid hydrogel that is formed from a crosslinkable polymeric micelle and a polyamine. Under optimal conditions, the hydrogel rapidly formed in one second after a crosslinkable polymeric micelle solution was mixed with a polyamine solution. We could change the hydrogel’s gelation properties, such as the storage modulus and gelation time by tuning the molecular weights of block copolymers and by tuning the pH of the dissolving-solvent of the hydrogel’s constituent components. Furthermore, we have clarified here that the structural difference among the micelles acting as crosslinkers can affect the gelation properties of the hydrogel. According to our findings, the hydrogel that was formed from the polymeric micelles possessing a highly packed (i.e., well-entangled or crosslinked) inner core exhibited a higher storage modulus than the hydrogel that was formed from the polymeric micelles possessing a lowly packed structure. Our results demonstrate that a microscopic structural difference among crosslinkers can induce a macroscopic change in the properties of the resulting hydrogels. For medical applications, the hydrogel proposed in the present paper can encapsulate the hydrophobic compounds in crosslinkers (polymeric micelles) so that the hydrogel can be available as the biomaterial for their sustained release.

关键词： Hydrogel Polymeric Micelle Self-Assembly Crosslinker Block Copolymer

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Recent evidence for subcutaneous drains to prevent surgical site infections after abdominal surgery:A systematic review and metaanalysis

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2879-2889页

作者： Tomohiro Ishinuki Hiroji Shinkawa Keita Kouzu seiichi Shinji Erika Goda Toshio Ohyanagi Masahiro Kobayashi Motomu Kobayashi Katsunori Suzuki Yuichi Kitagawa Chizuru Yamashita Yasuhiko Mohri Junzo Shimizu Motoi Uchino Seiji Haji Masahiro yoshida Hiroki Ohge Toshihiko Mayumi Toru Mizuguchi Department of Nursing Surgical SciencesSapporo Medical UniversitySapporo 060-8556HokkaidoJapan Department of Hepatobiliary-Pancreatic Surgery Osaka Metropolitan University Graduate School of MedicineAbeno-Ku 545-0051Japan Department of Surgery National Defense Medical CollegeTokorozawa 359-8513Japan Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery Nippon Medical SchoolTokyo 113-8602Japan Department of Nursing Japan Health Care UniversitySapporo 062-0053Japan Department of Liberal Arts and Sciences Center for Medical EducationSapporo Medical UniversitySapporo 060-8556Japan Department of Clinical Pharmacokinetics Research and Education Center for Clinical PharmacyKitasato UniversityTokyo 108-8641Japan Department of Anesthesiology Hokushinkai Megumino HospitalEniwa 061-1395Japan Department of Infectious Disease Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Gastrointestinal Surgery National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Anesthesiology and Critical Care Medicine Fujita Health UniversityToyoake 470-1192Japan Department of Gastrointestinal Surgery Mie Prefectural General Medical CenterYokkaich 510-8561Japan Department of Surgery Toyonaka Municipal HospitalToyonaka 560-8565Japan Department of Gastroenterological Surgery Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Surgery Soseikai General HospitalKyoto 612-8473Japan Department of Hepato-Biliary-Pancreatic&Gastrointestinal Surgery International University of Health and WelfareIchikawa 272-0827Japan Department of Infectious Disease Hiroshima University HospitalHiroshima 734-8551Japan Department of Intensive Care Unit Chukyo HospitalJapan Community Health Care OrganizationNagoya 457-8510Japan

BACKGROUND Surgical site infections(SSIs)increase mortality,hospital stays,additional medical treatment,and medical *** drains prevent SSIs in gynecological and breast surgeries;however,their clinical impact in abdominal surgery remains *** To investigate whether subcutaneous drains were beneficial in abdominal surgery using a systematic review and *** The database search used PubMed,MEDLINE,and the Cochrane *** following inclusion criteria were set for the systematic review:(1)Randomized controlled trial studies comparing SSIs after abdominal surgery with or without subcutaneous drains;and(2)Studies that described clinical outcomes,such as SSIs,seroma formation,the length of hospital stays,and *** Eight studies were included in this *** rate of total SSIs was significantly lower in the drained group(54/771,7.0%)than in the control group(89/759,11.7%),particularly in gastrointestinal ***,the rate of superficial SSIs was slightly lower in the drained group(31/517,6.0%)than in the control group(49/521,9.4%).No significant differences were observed in seroma formation between the *** stays were shorter in the drained group than in the control *** Subcutaneous drains after abdominal surgery prevented SSIs and reduced hospital stays but did not significantly affect seroma *** timing of drain removal needs to be reconsidered in future studies.

关键词： Abdominal surgery Mortality Seroma formation Subcutaneous drain Surgical site infections

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