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Moving computational multi-domain method for modelling the flow interaction of multiple moving objects

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Advances in Aerodynamics 2022年第1期4卷 78-95页

作者： Momoha Nishimura Masashi Yamakawa Shinichi Asao seiichi Takeuchi Mehdi Badri Ghomizad Department of Mechanical and System Engineering Kyoto Institute of TechnologyKyotoJapan Department of Mechanical Engineering College of Industrial TechnologyHyogoJapan

This study proposes a method for modelling the flow interaction of multiple moving objects where the flow field variables are communicated between multiple separate moving computational *** of using the conventional approach with a single fixed computational domain covering the whole flow field,this method advances the moving computational domain(MCD)method in which the computational domain itself moves in line with the motions of an object *** computational domains created around each object move independently,and the flow fields of each domain interact where the flows *** eliminates the spatial restriction for simulating multiple moving ***,a shock tube test verifies that the overset implementation and grid movement do not adversely affect the results and that there is communication between the grids.A second test case is conducted in which two spheres are crossed,and the forces exerted on one object due to the other’s crossing at a short distance are *** results verify the reliability of this method and show that it is applicable to the flow interaction of multiple moving objects.

关键词： Crossing Moving boundary problems Compressible flow Moving mesh method

Characterization of CD133^+ parenchymal cells in the liver:Histology and culture

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World Journal of Gastroenterology 2009年第39期15卷 4896-4906页

作者： seiichi Yoshikawa Yoh Zen Takahiko Fujii Yasunori Sato Tetsuo Ohta Yutaka Aoyagi Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of Medicine Division of Gastro-enterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences Division of Pathology Kanazawa University Hospital Department of Gastrointestinal Surgery Kanazawa University Graduate School of Medicine

AIM： To reveal the characteristics of CD133^＋ cells in the liver, METHODS： This study examined the histological characteristics of CD133^＋ cells in non-neoplastic and neoplastic liver tissues by immunostaining, and also analyzed the biological characteristics of CD133^＋ cells derived from human hepatocellular carcinoma （HCC） or cholangiocarcinoma cell lines. RESULTS： Immunostaining reveated constant expression of CD133 in non-neoplastic and neoplastic biliary epithelium, and these cells had the immunophenotype CD133^＋/CK19^＋/HepPar-1. A small number of CD133^＋/CK19/HepPar-1^＋ cells were also identified in HCC and combined hepatocellular and cholangiocarcinoma. In addition, small ductal structures, resembling the canal of Hering, partly surrounded by hepatocytes were positive for CD133. CD133 expression was observed in three HCC （HUH7, PLC5 and HepG2） and two cholangiocarcinoma cell lines （HuCCT1 and CCKS1）. Fluorescence-activated cell sorting （FACS） revealed that CD133^＋ and CD133 cells derived from HuH7 and HuCCT1 cells similarly produced CD133^＋ and CD133 cells during subculture. To examine the relationship between CD133^＋ cells and the side population （SP） phenotype, FACS was performed using Hoechst 33342 and a monoclonal antibody against CD133. The ratios of CD133^＋/CD133 cells were almost identical in the SP and non-SP in HUH7. In addition, four different cellular populations （SP/CD133^＋, SP/CD133, nonP/CD133^＋, and non- SP/CD133） could similarly produce CD133^＋ and CD133- cells during subculture. CONCLUSION： This study revealed that CD133 could be a biliary and progenitor cell marker in vivo. However, CD133 alone is not sufficient to detect tumor-initiating cells in cell lines.

关键词： Cholangiocarcinoma Hepatocellular carcinoma Keratins Stem cells

Flight simulation from takeoff to yawing of eVTOL airplane with coaxial propellers by fluid-rigid body interaction

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Advances in Aerodynamics 2023年第1期5卷 29-43页

作者： Ritsuka Gomi Ayato Takii Masashi Yamakawa Shinichi Asao seiichi Takeuchi Momoha Nishimura Department of Mechanical Engineering Kyoto Institute of TechnologyKyotoJapan Department of Mechanical Engineering College of Industrial TechnologyHyogoJapan

In this study,we adopt a coupled fluid-rigid body simulation using the moving computational domain method and multi-axis sliding mesh method for the takeoff,hovering,and yawing flight of an electric vertical takeoff and landing aircraft(eVTOL).The aircraft model has four pairs of coaxial propellers,and the computational domain is divided into three domains to move the aircraft and eight propeller domains to rotate the *** a result,we clarify the behavior and aerodynamic force of the aircraft when the input values are determined by the automatic *** results in the flow field also show that the downwash spreads in a crisscross pattern on the ground,the wind reaches different ranges on the ground depending on the flight altitude,and that the coaxial propeller causes an asymmetry in the velocity field during ***-quently,we conclude that this method is effective for the flight simulation of an eVTOL.

关键词： Computational fluid dynamics Moving grid Coupled simulation Flying car eVTOL

Short and long-term outcomes of endoscopic balloon dilatation for Crohn's disease strictures

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World Journal of Gastroenterology 2013年第1期19卷 86-91页

作者： Katsuya Endo seiichi Takahashi Hisashi Shiga Yoichi Kakuta Yoshitaka Kinouchi Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of MedicineSendai 980-8574Japan

AIM:To investigate the short and long-term outcomes of endoscopic balloon dilatation(EBD) for Crohn's disease(CD) ***:Between January 1995 and December 2011,47 EBD procedures were performed in 30 patients(8 females and 22 males) with *** patients had strictures through which an endoscope could not pass,and symptoms of these strictures included abdominal pain,abdominal fullness,nausea,and/or *** 47 strictures included 17 anastomotic and 30 de novo *** and dilatation were performed under conscious sedation with intravenous diazepam or *** dilatations were all performed using through-the-scope balloons with diameters from 8 mm to 20 mm on inflation and lengths of 30-80 *** dilatation session consisted of two to four,3-min multistep inflations of the balloon,repeated at intervals of 1 wk until adequate dilatation(up to 15-20 mm in diameter) was *** follow-up data were collected from medical records and analyzed *** success was defined as passage of the scope through the stricture after *** outcomes were analyzed focusing on interventionfree survival and surgery-free survival demonstrated by the Kaplan-Meier method.(Intervention-free meant cases in which neither endoscopic balloon re-dilatation nor surgery was needed after the first dilatation during the observation period).The log rank test was used to evaluate the difference in long-term outcomes between anastomotic and de novo stricture ***:Primary success was achieved in 44 of the 47 strictures(93.6%).Balloon dilatations failed in 3 cases(6.4%).In 1 case,EBD was a technical failure because the guide-wire could not be passed through the stricture which showed severe adhesion and was a flexural lesion of the *** 2 cases,unexpected perforations occurred immediately after balloon *** the 47 treatments,complications occurred in 5(10.6%).All 5 patients had de novo *** suffered bleeding

关键词： Crohn’s disease Endoscopic balloon dilatation Stricture Anastomotic De novo Outcome

Effect of Catch Cup Geometry on 3D Boundary Layer Flow over the Wafer Surface in a Spin Coating

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Journal of Thermal Science 2008年第1期17卷 56-60页

作者： Mizue MUNEKATA seiichi KIMURA Hiroaki KURISHIMA Jinsuke TANAKA Sohei YAMAMOTO Hiroyuki YOSHIKAWA Kazuyoshi MATSUZAKI Hideki OHBA Department of Mechanical System Engineering 2-39-1 KurokamiKumamoto860-8555 Japan Assistant Professor Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiKumamoto860-8555 Japan Tokyo Electron Kyushu LTD. 1-1 FukuharaKoushi-shiKumamoto861-1116 Japan Department of Mechanical System Engineering 2-39-1 KurokamiKumamoto860-8555 Japan Tokyo Electron LTD. 650 MitsuzawaHosaka-choNirasaki-shiYamanashi407-0192 Japan

Recently, development of high technology has been required for the formation of thin uniform film in manufacturing processes of semiconductor as the semiconductor instruments become more sophisticated. Spin coating is usually used for spreading photoresist on a wafer surface. However, since rotating speed of the disk is very high in spin coating, the dropped photoresist scarers outward and reattaches on the film surface. A catch cup is set up outside the wafer in spin coating, and scattered photoresist mist is removed from the wafer edge by the exhaust flow generated at the gap between the wafer edge and the catch cup. In the dry process of a spin coating, it is a serious concern that the film thickness increases near the wafer edge in the case of low rotating speed. The purpose of this study is to make clear the effect of the catch cup geometry on the 3D boundary layer flow over the wafer surface and the drying rate of liquid film.

关键词： Rotating disk Spin coating Boundary layer flow Laser Doppler velocimeter Infrared camera

Electric Field Enhancement of Nano Gap of Silver Prisms

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Chinese Physics Letters 2007年第10期24卷 2934-2937页

作者： KENZO Yamaguchi TOMOHIRO Inoue MASAMITSU Fujii MASANOBU Haraguchi TOSHIHIRO Okamoto MASUO Fukui SHU Seki seiichi Tagawa Department of Optical Science and Engineering Faculty and School of Engineering The University of Tokushima 2-1 Minamijosanjima-cho Tokushima-city Tokushima 770-8506 Japan Department of Electronics and Mechanics Toba National College of Maritime Technology 1-1 Ikegami-cho Toba-city Mie 517-8501 Japan Institute of Scientific and Industrial Research Osaka University 8-1 Mihogaoka Ibaraki Osaka 567-0047 Japan

Using numerical calculation, we examine the effects of gap distance of a pair of nano gap silver prisms with rounded corners on the local light intensity enhancement. Two peaks due to localized surface plasmon （LSP） excitation are observed in a wavelength range from 900nm to 300nm. The results demonstrate that peaks at a longer and a shorter wavelength corresponded to dipole-like and quadrupole-like LSP resonances, respectively. It is found that a gap distance up to 20 nm provides larger light intensity enhancement than that of a single silver nano prism with rounded corners. Furthermore, nano gap silver prisms are fabricated by direct focused ion beam processing, and we measure the scattering light spectrum of a pair of nano prisms by a confocal optical system. However, the two LSP peaks are not observed in visible range because the sizes of the nano gap and prisms are too large.

关键词： SURFACE-PLASMON RESONANCE AG NANOPARTICLES NEAR-FIELD NANOANTENNAS SCATTERING

Strategy to differentiate autoimmune pancreatitis from pancreas cancer

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World Journal of Gastroenterology 2012年第10期18卷 1015-1020页

作者： Kensuke Takuma Terumi Kamisawa Rajesh Gopalakrishna seiichi Hara Taku Tabata Yoshihiko Inaba Naoto Egawa Yoshinori Igarashi Department of Internal Medicine Tokyo Metropolitan Komagome Hospital Department of Gastroenterology and Hepatology Omori Medical Center Toho University School of Medicine

Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organs of AIP patients, AIP appears to be a pancreatic lesion reflecting a systemic "IgG4-related sclerosing disease". Clinically, AIP patients and patients with pancreatic cancer share many features, such as preponderance of elderly males, frequent initial symptom of painless jaundice, development of new-onset diabetes mellitus, and elevated levels of serum tumor markers. It is of uppermost importance not to misdiagnose AIP as pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, and approach to the pancreas for histological examination is generally difficult, AIP is diagnosed using a combination of clinical, serological, morphological, and histopathological features. Findings suggesting AIP rather than pancreatic cancer include:fluctuating obstructive jaundice; elevated serum IgG4 levels; diffuse enlargement of the pancreas; delayed en- hancement of the enlarged pancreas and presence of a capsule-like rim on dynamic computed tomography; low apparent diffusion coefficient values on diffusion-weighted magnetic resonance image; irregular narrowing of the main pancreatic duct on endoscopic retrograde cholangiopancreatography; less upstream dilatation of the main pancreatic duct on magnetic resonance cholangiopancreatography, presence of other organ involvement such as bilateral salivary gland swelling, retroperitoneal fibrosis and hilar or intrahepatic sclerosing cholangitis; negative work-up for malignancy including endoscopic ultrasound-guided fine needle aspiration; and steroid responsiveness. Since AIP responds dramatically to steroid therapy, accurate diagnosis of AIP can avoid unnecessary laparotomy or pancreatic resection.

关键词： Autoimmune pancreatitis Pancreatic cancer Endoscopic retrograde cholangiopancreatography Magnetic resonance cholangiopancreatography

TiO2纳米结构在染料敏化太阳电池中的应用

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真空科学与技术学报 2009年第4期29卷 411-418页

作者：彭英才 seiichi Miyazaki 徐骏河北大学电子信息工程学院保定071002 中国科学院半导体研究所半导体材料科学重点实验室北京100083 Department of Semiconductor Electronics and Integration Science Graduate Sehool of Advanced Science of Mater Hiroshima UniversityKagamiyama 1-3-1Higashi-Hiroshima 739-8530Japan 南京大学物理系与固体微结构国家重点实验室南京210093

利用纳米结构材料作为光阳极制备的染料敏化太阳电池被称为纳米结构染料敏化太阳电池(NDSSC)。一般而言,它由纳米结构金属氧化物半导体的光阳极、染料敏化剂,电解质和对电极等几个部分组成。目前,纳米结构光阳极的研究主要集中在如何优... 详细信息

利用纳米结构材料作为光阳极制备的染料敏化太阳电池被称为纳米结构染料敏化太阳电池(NDSSC)。一般而言,它由纳米结构金属氧化物半导体的光阳极、染料敏化剂,电解质和对电极等几个部分组成。目前,纳米结构光阳极的研究主要集中在如何优化设计和成功制备各种纳米结构的光阳极材料,以改善NDSSC的光电转换性能。本文着重介绍了各种TiO2纳米结构,例如TiO2晶粒薄膜、TiO2准一维纳米结构、TiO2纳米复合物膜层、TiO2核-壳纳米结构、TiO2量子点敏化结构以及串联电池结构等在NDSSC中的应用,并评论了它们最近的主要研究进展。

关键词： TiO2纳米结构材料光阳极 NDSSC 光伏特性

Design of RLS Wiener Smoother and Filter for Colored Observation Noise in Linear Discrete-Time Stochastic Systems

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Journal of Signal and Information Processing 2012年第3期3卷 316-329页

作者： seiichi Nakamori Kagoshima University

Almost estimators are designed for the white observation noise. In the estimation problems, rather than the white observation noise, there might be actual cases where the observation noise is modeled by the colored noise process. This paper examines to design a new estimation technique of recursive least-squares (RLS) Wiener fixed-point smoother and filter for colored observation noise in linear discrete-time wide-sense stationary stochastic systems. The observation y(k) is given as the sum of the signal z(k)=Hx(k) and the colored observation noise vc(k). The RLS Wiener estimators explicitly require the following information: 1) the system matrix for the state vector x(k);2) the observation matrix H;3) the variance of the state vector x(k);4) the system matrix for the colored observation noise vc(k);5) the variance of the colored observation noise;6) the input noise variance in the state equation for the colored observation noise.

关键词： Discrete-Time Stochastic System RLS Wiener Filte RLS Wiener Fixed-Point Smoother Colored Observation Noise Covariance Information