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Neoadjuvant Chemotherapy for Clinical Stage II and III Thoracic Esophageal Squamous Cell Carcinoma with Curative Esophagectomy

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Journal of Cancer Therapy 2015年第15期6卷 1207-1213页

作者： Masahide Ikeguchi Yusuke Kohno Kyoichi Kihara Kazunori Suzuki Kanenori Endo seiichi Nakamura Takashi Sawada Tetsu Shimizu Tomoyuki Matsunaga Yoji Fukumoto Hiroaki Saito Tottori Prefectural Central Hospital Tottori Japan Department of Surgery Division of Surgical Oncology Faculty of Medicine Tottori University Tottori Japan

Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal carcinoma with a poor prognosis. To improve the survival of patients with this disease, neoadjuvant chemotherapy (NAC) has been introduced. However, the survival benefits of NAC or the correlation between NAC and postoperative complications have not been well considered. In the present study, we retrospectively investigated the clinicopathological effectiveness of NAC in patients with clinical stage II and III thoracic ESCC. This retrospective study enrolled 63 patients with clinical stage II and III thoracic ESCC, who underwent resection of the thoracic esophagus and three-field lymph node dissection between January 2007 and December 2013. NAC with cisplatin plus 5-fluorouracil (5-FU) was introduced in 38 patients. NAC did not correlate with the occurrence of postoperative complications. The 5-year disease-free survival (DFS) rate of the 38 patients with NAC (41.6%) was similar to that for the 25 patients who did not receive NAC (38.1%;P = 0.784). However, we found that the DFS of 17 patients with histopathological Grade 2 and 3 tumors who received NAC (5-year DFS rate: 58.1%) was significantly higher than that of 21 patients with low histopathological grade tumors who received NAC (5-year DFS rate: 28.6%), or than that of the 25 patients who did not receive NAC (38.1%). Moreover, we found that the effectiveness of NAC assessed macroscopically did not correlate with the effectiveness of NAC assessed microscopically. These findings may indicate that preoperative estimation of NAC effectiveness is important in avoiding unnecessary adverse drug effects caused by NAC, and in prolonging the survival of patients with thoracic ESCC.

关键词： Esophageal Squamous Cell Carcinoma Histopathological Grade Neoadjuvant Chemotherapy Prognosis

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Enhancement of Photocatalytic Water Splitting Rate via Rayleigh Convection

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Green and Sustainable Chemistry 2014年第2期4卷 80-86页

作者： seiichi Deguchi Ben Kariya Norifumi Isu Shoji Shimasaki Haruna Banno Saeko Miwa Keisuke Sawada Junki Tsuge Shoichiro Imaizumi Hidenori Kato Kyota Tokutake Department of Energy Engineering and Science Nagoya University Nagoya Japan Kitchen and Bathroom Technology Research Institute LIXIL Corporation Tokoname Japan School of Chemical Engineering Purdue University West Lafayette USA

In order to enhance photocatalytic water splitting rates with Pt/TiO2 powder, sufficient agitation of the biphasic medium is required to switch surficial reactions to volumetric reactions. Additionally, agitation is conducive to higher diffusion rates of the generated hydrogen and co-produced oxygen, hindering their ability to re-couple to water on Pt loaded to TiO2 powder. In order to create agitation without consuming any electricity, a novel technique utilizing Rayleigh convection was applied, and its ability to enhance photocatalytic water splitting rates was evaluated. Higher Rayleigh convective flow rates resulted in higher photocatalytic water splitting rates. Utilization of Rayleigh convection approximately doubled the photocatalytic water splitting rates, despite relatively low convective flow velocities (obtained through simple thermo-hydrodynamic simulations). The rate enhancement achieved through Rayleigh convection is a result of its ability to disperse the ultrafine Pt/TiO2 particles throughout the whole medium, leading to volumetric reactions.

关键词： Photocatalytic Water Splitting Pt/TiO2 Powder Rate Enhancement Volumetric Reaction Thermal Treatment Rayleigh Convection Thermo-Hydrodynamic Simulation

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Piezoelectric Power Harvesting Process via Phase Changes of Low-Boiling-Point Medium Together with Water for Recovering Low-Temperature Heats

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Journal of Power and Energy Engineering 2018年第11期6卷 65-77页

作者： seiichi Deguchi Akinori Miyajima Hajime Arimura Haruna Banno Noriyuki Kobayashi Norifumi Isu Kentaro Takagi Tsuyoshi Inoue Takashi Nozoe Seigo Saito Takahiko Sano Department of Chemical Process Engineering Nagoya University Nagoya Japan Analysis & Assessment Center LIXIL Corporation Noda Japan Department of Mechanical Systems Engineering Nagoya University Nagoya Japan Fuji Ceramics Corporation Fujinomiya Japan

Low-temperature thermal energy conversions down to exergy zero to electric power must contribute energy sustainability. That is to say, reinforcements of power harvesting technologies from extremely low temperatures less than 373 K might be at least one of minimum roles for the current generations. Then, piezoelectric power harvesting process for recovering low-temperature heats was invented by using a unique biphasic operating medium of an underlying water-insoluble/low-boiling-point medium (i.e. NOVEC manufactured by 3M Japan Ltd.) in small quantity and upper-layered water in large quantity. The higher piezoelectric power harvesting densities were naturally revealed with an increase in heating temperatures. Excessive cooling of the operating medium deteriorated the power harvesting efficiency. The denser operating medium was surpassingly helpful to the higher piezoelectric power harvesting density. Concretely, only about 5% density increase of main operating medium (i.e. water with dissolving alum at 0.10 mol/dm3) came to the champion piezoelectric power harvesting density of 92.6 pW/dm2 in this study, which was about 1.4 times compared to that with the original biphasic medium of pure water together with a small quantity of NOVEC.

关键词： Piezoelectric Power Generation Low-Temperature Heat Recovery Biphasic Medium Phase Change Multiphase Flow Power Harvesting

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Effect of TiO2 Crystallite Diameter on Photocatalytic Water Splitting Rate

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Green and Sustainable Chemistry 2014年第2期4卷 87-94页

作者： Haruna Banno Ben Kariya Norifumi Isu Muneaki Ogawa Saeko Miwa Keisuke Sawada Junki Tsuge Shoichiro Imaizumi Hidenori Kato Kyota Tokutake seiichi Deguchi Department of Energy Engineering and Science Nagoya University Nagoya Japan Kitchen and Bathroom Technology Research Institute LIXIL Corporation Tokoname Japan School of Chemical Engineering Purdue University West Lafayette USA

The effect of (Pt-loaded)TiO2 crystallite diameter (i.e. Scherrer size) on the photocatalytic water splitting rate was investigated. (Pt-loaded)TiO2 powders with a wide range of crystallite diameters from about 16 to 45 nm with a blank region between about 23 and 41 nm were prepared by various annealing processes from an identical TiO2 powder. Water splitting experiments with these powders were carried out with methanol as an oxidizing sacrificial agent. It was found that the photocatalytic water splitting rate was sensitively affected by the crystallite diameter of the (Pt-loaded)TiO2 powder. More concretely, similar steep improvements of photocatalytic water splitting rates from around 15 and a little over 2 to about 30 μmol·m-2hr-1?were obtained in the two (Pt-loaded)TiO2 crystallite diameters ranging from 16 to 23 and from 41 to 45 nm, respectively.

关键词： Photocatalytic Water Splitting TiO2 Crystallite Diameter Scherrer Size X-Ray Diffraction Critical Water Anneal

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尿中二氯苯异构体的气相色谱/质谱法分析

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分析化学 2000年第4期28卷 443-445页

作者：刘俊亭原建二柏村征一 110001 中国医科大学基础医学院化学教研室!沈阳

应用项空固相微萃取法提取尿中邻、间、对位二氯苯。0．5mL检尿密封在12mL玻璃瓶中，30℃下用100μm聚二甲基硅氧烷萃取头萃取15min。用重氢对二甲苯作内标。选择离子监测m/z146（二氯苯异构体）和m／z116内标）两分子离子峰。以得到的... 详细信息

应用项空固相微萃取法提取尿中邻、间、对位二氯苯。0．5mL检尿密封在12mL玻璃瓶中，30℃下用100μm聚二甲基硅氧烷萃取头萃取15min。用重氢对二甲苯作内标。选择离子监测m/z146（二氯苯异构体）和m／z116内标）两分子离子峰。以得到的上述两峰面积之比为纵坐标，以二氯苯异构体的浓度为横坐标做校正曲线。尿中检测浓度可达0．01mg/L。用此方法快速准确地测定了二氯苯中毒患者尿中浓度的经时变化。

关键词：固相微萃取固相萃取色谱法

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21世纪半导体科学技术展望——纪念晶体管发明60周年

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微纳电子技术 2007年第1期44卷 1-5,22页

作者：彭英才 seiichi-Miyazaki 陈坤基徐骏河北大学电子信息工程学院广岛大学半导体电子学系与先端物质科学研究科集成科学研究室南京大学固体微结构物理实验室南京210093

半导体科学技术是20世纪最伟大的科技成就之一。主要从低维物理、纳米材料、有机半导体、量子点的自组织生长、量子器件以及光电子集成等几个方面,预测了半导体科学技术在21世纪的发展趋势,以纪念晶体管发明60周年。

关键词：晶体管发明半导体科学技术信息化社会

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Greater omentum gastrointestinal stromal tumor with PDGFRA-mutation and hemoperitoneum

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 119-124页

作者： Yoko Murayama Masayuki Yamamoto Ryuichiro Iwasaki Tamana Miyazaki Yukiko Saji Yoshinori Doi Haruki Fukuda seiichi Hirota Masahiro Hiratsuka Department of Gastroenterology and Hepatology Itami City HospitalItami 6648540Japan Department of Surgery Itami City HospitalItami 6648540Japan Department of Gastroenterology and Hepatology Otemae HospitalOsaka 5400008Japan Department of Pathology Itami City HospitalItami 6648540Japan Department of Surgical Pathology Hyogo College of MedicineNishinomiya 6638501Japan

Although gastrointestinal stromal tumor(GIST) occurs generally in the digestive tract,omental GIST is very *** report the first case of an adult greater omental GIST with a new platelet-derived growth factor receptor α gene(PDGFRA)-mutation with hemoperitoneum.A 43-year-old man was admitted to our hospital complaining of acute abdominal *** contrast-enhanced computed tomography revealed a huge mass in the right abdominal cavity,and a large accumulation of fluid in the pelvic cavity,suggesting *** diagnosed the rupture as an intra-abdominal tumor,and an emergency tumorectomy was performed with resection of the greater *** tumor was located in the distal right side ofthe greater omentum,and showed no continuity with the gastric *** tumor occurred primarily in the greater *** resected tumor was about 19 cm × 12 cm × 14 cm in diameter,and weighed 1529 ***,the tumor was composed of epithelioidshaped cells with high cellularity,and was positive for CD117 and CD34,and negative for S-100,α-smooth muscle *** mitosis was 6/50 under high power *** case showed exon 18 mutation of PDGFRA with 846(Asp to Glu) substitution,848(Asn to Lys) *** is the first report of this PDGFRA mutation in omental GIST,and this might play an important role in the tumorigenesis of this *** on these findings,the tumor was diagnosed as high risk GIST primarily occurring in the greater *** patient was treated with imatinib at a dose of 400 mg/d as adjuvant chemotherapy,and has been followed up for 24 mo with no evidence of recurrence.

关键词： Gastrointestinal stromal tumor Greater omentum Hemoperitoneum Platelet-derived growth factor receptor α gene KIT

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高碳铬轴承钢超长寿命疲劳破坏过程的研究

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金属学报 2005年第10期41卷 1066-1072页

作者：鲁连涛盐泽和章森井佑一西野精一西南交通大学牵引动力国家重点实验室成都610031 富山大学工学部

研究了高碳铬轴承钢超长寿命疲劳的破坏过程.结果表明,在超长寿命区,约在疲劳寿命的5%—10%时疲劳裂纹首先在内部夹杂物处萌生,由于夹杂物周围的球形碳化物开始从基体剥离,在夹杂物周围形成许多不连续的微小裂纹.然后,相邻的微小裂纹相... 详细信息

研究了高碳铬轴承钢超长寿命疲劳的破坏过程.结果表明,在超长寿命区,约在疲劳寿命的5%—10%时疲劳裂纹首先在内部夹杂物处萌生,由于夹杂物周围的球形碳化物开始从基体剥离,在夹杂物周围形成许多不连续的微小裂纹.然后,相邻的微小裂纹相互连接,直到疲劳寿命的90%以上,裂纹开始连续扩展.

关键词：轴承钢超长寿命疲劳内部疲劳裂纹裂纹的萌生与扩展断口分析

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从古代中国舶来日本的《王维集》版本初探——兼论《三体诗幻云抄》中的《题崔处士林亭》一诗

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运城学院学报 2014年第4期32卷 1-4页

作者：内田诚一安田女子大学

日本室町时代五山禅僧月舟寿桂(号幻云)曾编辑《三体诗幻云抄》,其中收录了王维诗的注释,这使得我们得以看到15世纪到16世纪日本五山禅林流传的王维集版本的情况。笔者认为在当时日本广为流传的《王维集》版本之中,应有现在中日两国都... 详细信息

日本室町时代五山禅僧月舟寿桂(号幻云)曾编辑《三体诗幻云抄》,其中收录了王维诗的注释,这使得我们得以看到15世纪到16世纪日本五山禅林流传的王维集版本的情况。笔者认为在当时日本广为流传的《王维集》版本之中,应有现在中日两国都没有见到的宋版《王维集》。这部版本与中国国家图书馆收藏的《王摩诘文集》和日本静嘉堂文库收藏的《王右丞文集》有所不同。此外,元刻本《须溪先生校本唐王右丞集》是目前的海内孤本,《中华再造善本·集部·金元编》存其影印版本,因无"帮手",无法确定其刊刻年代,但在《三体诗幻云抄》中明确记录了这部版本的刊刻时间、刊刻人信息。

关键词：《王维集》五山文学《三体诗幻云抄》《题崔处士林亭》宋元版

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蒸煮过程中稻米水分状态的质子核磁共振谱测定

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农业工程学报 2001年第2期17卷 126-131页

作者：侯彩云大下诚一濑尾康久川越义则中国农业大学北京100083 东京大学

对 3种稻米蒸煮过程中水分的状态进行了 1 H- NMR测定。结果表明 ,不同品种的原料稻米具有相近的弛豫特征。但在蒸煮过程中 ,纵弛豫时间会因品种的不同而呈现出显著的差异。分析结果认为 ,稻米中水分的存在状态有自由水、构造水和结合水... 详细信息

对 3种稻米蒸煮过程中水分的状态进行了 1 H- NMR测定。结果表明 ,不同品种的原料稻米具有相近的弛豫特征。但在蒸煮过程中 ,纵弛豫时间会因品种的不同而呈现出显著的差异。分析结果认为 ,稻米中水分的存在状态有自由水、构造水和结合水等 3种形式。蒸煮过程中各种稻米水分状态的差异与谷粒中有机物的理化特性密切相关 ,并可能是导致米饭具有不同食味特性的重要原因。

关键词：稻米纵驰豫时间水分状态蒸煮过程食米 NMR

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