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CoFe_(2)O_(4) decorated graphene/C_(18)-functionalized mesoporous silica nanocomposites prepared for magnetic enrichment and electrochemical detection of promethazine in beef

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Chinese Chemical Letters 2024年第3期35卷 208-213页

作者： Xingdong Yang Shi-Ming Ying sen Zhang Jinxia Dai Wei Gao Tian-Qi Wang Jun-Qin Qiao Hong-Zhen Lian Li Mao State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry&Chemical Engineering and Centre of Materials AnalysisNanjing UniversityNanjing 210023China Ministry of Education(MOE)Key Laboratory of Modern Toxicology School of Public HealthNanjing Medical UniversityNanjing 211166China

Promethazine(PHZ)is used as a sedative in veterinary medicine,and its residue can threaten the health of *** electrochemical detection of PHZ is suitable method for application in the ***,the traditional electroanalysis is difficult to perform directly in meat samples due to matrix *** work integrates magnetic solid-phase extraction and differential pulse voltammetry for highly sensitive and selective determination of PHZ in beef and beef liver for the first ***_(2)O_(4)/graphene coated with C_(18)-functionalized mesoporous silica(MG@mSiO_(2)-C_(18))is synthesized as dispersed magnetic adsorbent to extract *** glassy carbon electrode modified with nitrogen-doped hollow carbon microspheres(HCM)attracts the MG@mSiO_(2)-C_(18)with PHZ,and directly detects the PHZ without elution ***@mSiO_(2)-C_(18)can separate PHZ to avoid the interference of impurities on following detection,and also concentrate PHZ on magnetic ***,the electrode modification with HCM can amplify the electrochemical signal of ***,the integrated PHZ determination method exhibits a wide linear range from 0.08μmol/L to 300μmol/L with a low limit of detection of 9.8 nmol/*** beef sample analysis presents excellent recovery,demonstrating that this protocol is promising for the rapid and onsite detection of PHZ in real meat samples。

关键词： Promethazine(PHZ) Drug residue Magnetic solid phase extraction Electrochemical detection Beef

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3D printed modular Bouligand dissipative structures with adjustable mechanical properties for gradient energy absorbing

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Materials Futures 2024年第2期3卷 104-116页

作者： Junfeng Xiao Mengxing Zhang Fei Zhai Hongrui Wei sen Liu Peng Wang Zhiyang Liu Zhongying Ji Xiaolong Wang Shenzhen Institute of Information Technology Shenzhen 518172People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai 264006People’s Republic of China School of Chemistry and Chemical Engineering Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous RegionShihezi UniversityShihezi 832003People’s Republic of China School of Transportation Engineering Shandong Jianzhu UniversityJinan 250101People’s Republic of China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518061People’s Republic of China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesGansu Lanzhou 730000People’s Republic of China

Three-dimensional(3D)printing allows for the creation of complex,layered structures with precise micro and macro architectures that are not achievable through traditional *** designing 3D structures with geometric precision,it is possible to achieve selective regulation of mechanical properties,enabling efficient dissipation of mechanical *** this study,a series of modular samples inspired by the Bouligand structure were designed and produced using a direct ink writing system,along with a classical printable polydimethylsiloxane *** altering the angles of filaments in adjacent layers(from 30◦to 90◦)and the filament spacing during printing(from 0.8 mm to 2.4 mm),the mechanical properties of these modular samples can be *** mechanical testing revealed that the 3D printed modular Bouligand structures exhibit stress-strain responses that enable multiple adjustments of the elastic modulus from 0.06 MPa to over 0.8 *** mechanical properties were adjusted more than 10 times in printed samples prepared using uniform *** gradient control mechanism of mechanical properties during this process was analyzed using finite element ***,3D printed customized modular Bouligand structures can be assembled to create an array with Bouligand structures displaying various orientations and interlayer details tailored to specific *** decomposing the original Bouligand structure and then assembling the modular samples into a specialized array,this research aims to provide parameters for achieving gradient energy absorption structures through modular 3D printing.

关键词： 3D printing additive manufacturing Bouligand structure energy absorbing structures

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A rare missense PAX6 mutation causes atypical aniridia in a three-generation Chinese family

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 466-472页

作者： Zhi-Bo Lin Chun-Yun Feng Jin Li An-Peng Pan Hai-sen Sun A-Yong Yu Shi-Hao Chen National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology the Quzhou Affiliated Hospital of Wenzhou Medical UniversityQuzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina

●AIM:To investigate the molecular diagnosis of a threegeneration Chinese family affected with aniridia,and further to identify clinically a PAX6 missense mutation in members with atypical aniridia.●METHODS:Eleven family members with and without atypical aniridia were *** family members underwent comprehensive ophthalmic examinations.A combination of whole exome sequencing(WES)and direct Sanger sequencing were performed to uncover the causative mutation.●RESULTS:Among the 11 family members,8 were clinically diagnosed with congenital aniridia(atypical aniridia phenotype).A rare heterozygous mutation c.622C>T(***208Trp)in exon 8 of PAX6 was identified in all affected family members but not in the unaffected members or in healthy control subjects.●CONCLUSION:A rare missense mutation in the PAX6 gene is found in members of a three-generation Chinese family with congenital atypical *** result contributes to an increase in the phenotypic spectrum caused by PAX6 missense heterozygous variants and provides useful information for the clinical diagnosis of atypical aniridia,which may also contribute to genetic counselling and family planning.

关键词： PAX6 gene atypical aniridia missense mutation mutation

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Oxygen tension modulates cell function in an in vitro three-dimensional glioblastoma tumor model

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Bio-Design and Manufacturing 2024年第3期7卷 307-319页

作者： sen Wang Siqi Yao Na Pei Luge Bai Zhiyan Hao Dichen Li Jiankang He J.Miguel Oliveira Xiaoyan Xue Ling Wang Xinggang Mao State Key Laboratory for Manufacturing System Engineering Xi’an Jiaotong UniversityXi’an 710054China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710054China NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices Xi’an Jiaotong UniversityXi’an 710054China 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/Guimar˜aesPortugal Department of Pharmacology School of PharmacyFourth Military Medical UniversityXi’an 710032China Department of Neurosurgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Hypoxia is a typical feature of the tumor microenvironment,one of the most critical factors affecting cell behavior and tumor ***,the lack of tumor models able to precisely emulate natural brain tumor tissue has impeded the study of the effects of hypoxia on the progression and growth of tumor *** study reports a three-dimensional(3D)brain tumor model obtained by encapsulating U87MG(U87)cells in a hydrogel containing type I *** also documents the effect of various oxygen concentrations(1%,7%,and 21%)in the culture environment on U87 cell morphology,proliferation,viability,cell cycle,apoptosis rate,and ***,it compares two-dimensional(2D)and 3D *** comparison purposes,cells cultured in flat culture dishes were used as the control(2D model).Cells cultured in the 3D model proliferated more slowly but had a higher apoptosis rate and proportion of cells in the resting phase(G0 phase)/gap I phase(G1 phase)than those cultured in the 2D ***,the two models yielded significantly different cell ***,hypoxia(e.g.,1%O2)affected cell morphology,slowed cell growth,reduced cell viability,and increased the apoptosis rate in the 3D *** results indicate that the constructed 3D model is effective for investigating the effects of biological and chemical factors on cell morphology and function,and can be more representative of the tumor microenvironment than 2D culture *** developed 3D glioblastoma tumor model is equally applicable to other studies in pharmacology and pathology.

关键词： Hypoxia Glioma Three-dimensional glioma model In vitro

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Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression

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Genes & Diseases 2024年第5期11卷 456-469页

作者： Lixin Liang Tian Cai Xiaojia Li Jianhong An sen Yu Yang Zhang Fengjie Guo Fang Wei Jie He Keping Xie Tingting Jiang Center for Pancreatic Cancer Research South China University of Technology School of MedicineGuangzhouGuangdong 510006China Department of Laboratory Medicine The Sixth Affiliated Hospital and Nanhai People’s HospitalSouth China University of Technology School of MedicineFoshanGuangdong 528200China The Second Affiliated Hospital and Guangzhou First People’s Hospital South China University of Technology School of MedicineGuangzhouGuangdong 510006China

Transcriptional factor Forkhead box M1(FOXM1)plays an important role in pancreatic ductal adenocarcinoma(PDAC)development and *** molecular mechanisms underlying its dysregulation remain *** identified and functionally validated the microRNAs(miRNAs)that critically regulate FOXM1 expression in *** expression levels of miRNA-23a(miR-23a-3p and-5p)were altered in PDAC cell lines and their effects on FOXM1 signaling and cell proliferation and migration and tumorigenesis were examined in vitro and in vivo using mouse PDAC *** with non-tumor pancreatic tissues,PDAC tissues and cell lines exhibited significantly reduced levels of miR-23a *** miR-23a expression and concomitant increase in FOXM1 expression were also observed in acinar-toductal metaplasia and pancreatic intraepithelial neoplasia,the major premalignant lesions of *** expression of miR-23a reduced the expression of FOXM1 and suppressed cell proliferation and migration in PDAC cells,whereas the inhibitors of miR-23a did the *** or reduced levels of miR-23a increased the levels of FOXM1 expression,while increased expression of FOXM1 down-regulated miR-23a expression,suggesting that miR-23a and FOXM1 were mutual negative regulators of their expression in PDAC ***,the miR-23a/FOXM1 signaling axis is important in PDAC initiation and progression and could serve as an interventional or therapeutic target for patients with early or late stages of PDAC.

关键词： FOXM1 Gene expression Gene regulation MicroRNA Pancreatic cancer Targeted therapy

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Covalent triazine frameworks modified by ultrafine Pt nanoparticles for efficient photocatalytic hydrogen production

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Nano Research 2024年第6期17卷 4908-4915页

作者： Xu Han Xueying Ge Wen-Wen He Wangwang Shen Tao Zhou Jian-sen Wang Rong-Lin Zhong Abdullah MAl-Enizi Ayman Nafady Shengqian Ma School of Chemistry and Life Science Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012China Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China Department of Chemistry University of North Texas1508 W.Mulberry St.DentonTX 76201USA Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia

Pt nanoparticles(PtNPs)as active species have always been considered as one of the best semiconductor materials for photocatalytic hydrogen *** this study,a Schottky heterojunction has been successfully constructed by evenly loading ultrafine PtNPs onto a triazine-based covalent organic frameworks(COFs).This strategy maintained the high activity of these ultra-small PtNPs while maximizing the utilization of the Pt active *** fabricated PtNPs@covalent triazine-based framework-1(CTF-1)composite accomplished a significantly high rate of hydrogen evolution(20.0 mmol·g^(−1)·h^(−1),apparent quantum efficiency(AQE)=7.6%,atλ=450 nm)with 0.40 wt.%Pt loading,giving rise to a 44-fold-increase in the efficiency of the photocatalytic hydrogen production compared to the pristine *** calculations revealed that the strong electron transfer(Q(Pt)=−0.726 qe,in the analysis of Bader charge,Q(Pt)is the charge quantity transferred from Pt cluster to CTF-1,and qe is the unit of charge transfer quantity)between PtNPs and CTF-1 triggers a strong interaction,which makes PtNPs being firmly attached to the structure of CTF-1,thereby enabling high stability and excellent hydrogen production ***,the hydrogen binding free energy(ΔGH*)of PtNPs@CTF-1 is much lower than that of the unmodified CTF-1,leading to a much lower intermediate state and hence a significant improvement in photocatalytic *** overall findings of this work provide a new platform to incorporate metallic NPs into COFs for the design and fabrication of highly efficient photocatalysts.

关键词： Pt nanoparticles covalent triazine-based framework-1(CTF-1) photocatalysts hydrogen evolution reaction

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Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus ***-2

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Chinese Chemical Letters 2024年第9期35卷 206-209页

作者： Hong Zhang Cui-Ping Li Li-Li Wang Zhuo-Da Zhou Wen-sen Li Ling-Yi Kong Ming-Hua Yang Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus *** structures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution electrospray ionization mass spectroscopy(HRESIMS),and single-crystal X-ray diffraction *** A possesses an intriguing skeleton bearing 5/6/6/6/7/5/5/5 octacyclic ring system,and asperochone B also exhibits an unusual carbon skeleton with five stereochiral *** structures were proposed as heterotrimeric and heterodimeric products of aromatic *** addition,asperochone A exhibited a potential anti-tuberculosis effect since it showed a moderate potency against Mycobacterium smegmatis.

关键词： Aspergillus sp. Asperochones A and B Aromatic polyketides Heterotrimeric compound Anti-tuberculosis effect Antifibrotic activity

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Asymmetric Synthesis of Dihydrospirotryprostatin B via a Silica Gel-Mediated Cyclization of Tryptamine-Ynamide

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Chinese Journal of Chemistry 2024年第12期42卷 1355-1359页

作者： Changhong Han Lu Yang Kaizong Yao sen Zhang Jiayue Fu Hanyang Sun Hongsheng Xu Bin Lin Maosheng Cheng Yongxiang Liu Key Laboratory of Structure:Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyangLiaoning 110016China Institute of Drug Research in Medicine Capital of China BenxiLiaoning 117000China Zhejiang Shapuaisi Pharmaceutical Co. LtdPinghuZhejiang 314299China

Comprehensive Summary An asymmetric synthesis of dihydrospirotryprostatin B was achieved in 15 steps(8 purifications)from *** main feature of our synthetic strategy is the efficient construction of spirocyclic oxindole intermediate containing a chiral quaternary carbon center,involving the silica gel-mediated cyclization of tryptamine-ynamide and oxidation under neat conditions.

关键词： Asymmetric synthesis Alkaloids Dihydrospirotryprostatin B Tryptamine-ynamide Cross-coupling Silica gel-mediated cyclization Oxidation

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Effects of Volcanic Activity on Organic Matter Sources and the Paleoenvironment:Geochemical Evidence from Upper Carboniferous Source Rocks(Batamayineishan Formation)in Eastern Junggar,NW China

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Journal of Earth Science 2024年第5期35卷 1482-1498页

作者： Ming Shao Tianzhu Lei Shuncun Zhang Shengyin Zhang Yu Pei sen Song Northwest Institute of Eco-Environment and Resources Chinese Academy of SciencesLanzhou 730000China Key Laboratory of Petroleum Resources Exploration and Evaluation Gansu ProvinceLanzhou 730000China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014060China

The mudstone,gray tuffite and carbonaceous shale in the Upper Carboniferous Batamayineishan Formation(Bashan Formation)are essential source rocks for the volcanic reservoir in eastern Junggar,northwestern *** kerogen components,vitrinite reflectance,Rock-Eval pyrolysis,lipid biomarkers and isotope compositions were measured to understand the provenance and depositional environment of Bashan Formation under the background of volcanic *** were 10 and 4 periods of volcanic eruptions identified in the wells CS and DZ,*** source rocks developed in the late or intermittent phase of volcanic *** original island arcs of the Early Carboniferous evolved into the Wucaiwan sag and the Dishuiquan sag in the Bashan *** Wucaiwan sag inherited the restricted,closed residual sea,which had a slightly anoxic and hypersaline *** Dishuiquan sag was generally an oxidizing lacustrine environment,influenced by a marine transgression that may have occurred at the end of the DZ_(Ⅲ)period during the Late *** the total organic matter decreased due to the volcanic eruption,ash could cause an increase of aquatic organisms,coinciding with increases in salinity and reducibility in the Dishuiquan sag.

关键词： organic geochemistry volcanic activity paleoenvironment upper carboniferous east-ern Junggar petroleumgeology

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生物化学与生物物理进展 2024年第8期51卷 1848-1859页

作者：张帅刘森湖北工业大学生命科学与健康工程学院工业发酵省部共建协同创新中心武汉430068 湖北工业大学生命科学与健康工程学院发酵工程教育部重点实验室武汉430068 湖北微生元生物科技有限公司鄂州436006

线粒体是细胞内能量代谢的中心,对于维持细胞稳态而言,其形态和功能的调控至关重要。小分子泛素相关修饰物蛋白(small ubiquitin-related modifier protein,SUMO)修饰和发动蛋白相关蛋白1(dynamin-related protein 1,DRP1)在细胞调控中... 详细信息

线粒体是细胞内能量代谢的中心,对于维持细胞稳态而言,其形态和功能的调控至关重要。小分子泛素相关修饰物蛋白(small ubiquitin-related modifier protein,SUMO)修饰和发动蛋白相关蛋白1(dynamin-related protein 1,DRP1)在细胞调控中扮演着重要角色,尤其与线粒体动力学密切相关。SUMO修饰是一种重要的蛋白质修饰形式,通过将靶蛋白与SUMO相连来调节这些蛋白质的功能。而DRP1是线粒体分裂蛋白,负责调节线粒体的形态和功能。近年来研究发现,SUMO修饰与DRP1之间存在复杂的相互作用网络,对于线粒体的分裂、融合、自噬等起着重要作用。在DRP1的可变结构域中,有8个赖氨酸残基可以在线粒体锚定蛋白连接酶(mitochondrial-anchored protein ligase,MAPL)的作用下完成SUMO修饰。并且不同亚型的SUMO蛋白对于DRP1功能的调节也不同。SUMO1修饰会使DRP1向线粒体富集,促进线粒体的分裂;SUMO2/3修饰会使DRP1向细胞质转移,减少线粒体的分裂。在实际的细胞程序中,不同亚型SUMO的修饰水平往往是由SUMO特异性蛋白酶(SUMO-specific proteases,senPs)的类型决定。线粒体作为细胞中重要的能量供应细胞器,其动力学的异常往往会导致诸多疾病的发生,例如:心肌缺血再灌注性损伤、阿尔茨海默病、脑血栓、视网膜病变等。本文综述了SUMO修饰与DRP1之间相互作用对于线粒体动力学调控的研究进展,为进一步揭示细胞调控机制和发展相关疾病的治疗策略提供一定的参考。

关键词：线粒体动力学蛋白质翻译后修饰小分子泛素相关修饰物蛋白修饰发动蛋白相关蛋白1 线粒体分裂

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