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Hydroxychavicol,a polyphenol from Piper betle leaf extract,induces cell cycle arrest and apoptosis in TP53-resistant HT-29 colon cancer cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第2期22卷 112-122页

作者： Aiysvariyah RAJEDADRAM Kar Yong PIN Sui Kiong LING see wan yan Mee Lee LOOI School of Biosciences Taylor’s UniversityLakeside Campus47500Subang JayaMalaysia Forest Research Institute Malaysia 52109KepongMalaysia Department of Biomedical Science Faculty of MedicineUniversity of Malaya50603Kuala LumpurMalaysia

This study aims to elucidate the antiproliferative mechanism of hydroxychavicol(HC).Its effects on cell cycle,apoptosis,and the expression of c-Jun N-terminal kinase(JNK)and P38 mitogen-activated protein kinase(MAPK)in HT-29 colon cancer cells were *** was isolated from Piper betle leaf(PBL)and verified by high-performance liquid chromatography(HPLC),nuclear magnetic resonance(NMR),and gas chromatography-mass spectrometry(GC-MS).The cytotoxic effects of the standard drug 5-fluorouracil(5-FU),PBL water extract,and HC on HT-29 cells were measured after 24,48,and 72 h of *** cycle and apoptosis modulation by 5-FU and HC treatments were investigated up to 30 *** in phosphorylated JNK(pJNK)and P38(pP38)MAPK expression were observed up to 18 *** half maximal inhibitory concentration(IC_(50))values of HC(30μg/mL)and PBL water extract(380μg/mL)were achieved at 24 h,whereas the IC_(50)of 5-FU(50μmol/L)was obtained at 72 *** cycle arrest at the G0/G1 phase in HC-treated cells was observed from12 h *** apoptotic cell death in HC-treated cells compared to 5-FU-treated cells(P<0.05)was *** expression of pJNK and pP38 MAPK was observed at 12 h in HC-treated cells,but not in 5-FU-treated HT-29 cells(P<0.05).It is concluded that HC induces cell cycle arrest and apoptosis of HT-29 cells,with these actions possibly mediated by JNK and P38 MAPK.

关键词： Piper betle Hydroxychavicol(HC) Cell cycle Apoptosis c-Jun N-terminal kinase(JNK) P38 mitogen-activated protein kinase(MAPK)

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang Yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Improved EMD Based on Piecewise Cubic Hermite Interpolation and Mirror Extension

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Chinese Journal of Electronics 2020年第5期29卷 899-905页

作者： ZHANG Xuejun HUO yan wan Dongsheng College of Electronic and Optical Engineering Nanjing University of Posts and Telecommunications Nation-Local Joint Project Engineering Laboratory of RF Integration and Micropackage

This paper proposes an improved Empirical mode decomposition(EMD) method piecewise cubic hermite interpolation and mirror extension. Firstly, mirror expansion method is used to expand preliminary signal endpoint; then the piecewise cubic Hermite interpolation algorithm is applied to obtain the envelopes. Finally Intrinsic mode functions(IMFs) are obtained through improved EMD(MPC-HEMD). Through the analysis on simulation signals and Electroencephalogram(EEG)signals, we found that the new method was better than the traditional method.

关键词： Common spatial pattern EEG signal Empirical mode decomposition Feature extraction Mirror expansion Piecewise cubic Hermite interpolation

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Three-dimensional Construction and Omni-directional Rolling Analysis of a Novel Frame-like Lattice Modular Robot

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Chinese Journal of Mechanical Engineering 2015年第4期28卷 691-701页

作者： DING wan WU Jianxu YAO yan'an School of Mechanical Electronic and Control Engineering Beijing Jiaotong University

Lattice modular robots possess diversity actuation methods, such as electric telescopic rod, gear rack, magnet, robot arm, etc. The researches on lattice modular robots mainly focus on their hardware descriptions and reconfiguration algorithms. Meanwhile, their design architectures and actuation methods perform slow telescopic and moving speeds, relative low actuation force verse weight ratio, and without internal space to carry objects. To improve the mechanical performance and reveal the locomotion and reconfiguration binary essences of the lattice modular robots, a novel cube-shaped, frame-like, pneumatic-based reconfigurable robot module called pneumatic expandable cube（PE-Cube） is proposed. The three-dimensional（3D） expanding construction and omni-directional rolling analysis of the constructed robots are the main focuses. The PE-Cube with three degrees of freedom（Do Fs） is assembled by replacing the twelve edges of a cube with pneumatic cylinders. The proposed symmetric construction condition makes the constructed robots possess the same properties in each supporting state, and a binary control strategy cooperated with binary actuator（pneumatic cylinder） is directly adopted to control the PE-Cube. Taking an eight PE-Cube modules＇ construction as example, its dynamic rolling simulation, static rolling condition, and turning gait are illustrated and discussed. To testify telescopic synchronization, respond speed, locomotion feasibility, and repeatability and reliability of hardware system, an experimental pneumatic-based robotic system is built and the rolling and turning experiments of the eight PE-Cube modules＇ construction are carried out. As an extension, the locomotion feasibility of a thirty-two PE-Cube modules＇ construction is analyzed and proved, including dynamic rolling simulation, static rolling condition, and dynamic analysis in free tipping process. The proposed PE-Cube module, construction method, and locomotion analysis enrich the family of the la

关键词： modular robot pneumatic expandable cube pneumatic actuation omni-directional rolling binary control strategy

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IN SlTU TRUING/DRESSING OF DIAMOND WHEEL FOR PRECISION GRINDING

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Chinese Journal of Mechanical Engineering 2008年第3期21卷 46-51页

作者： wan Daping wanG yan HU Dejin The State Key Laboratory of Mechanical Transmission Chongqing University Chongqing 400030 China College of Engineering Science and Technology Shanghai Fisheries University Shanghai 200090 China School of Mechanical Engineenng Shanghai Jiaotong University Shangha 200240 China

An application for achieving on-machine truing/dressing and monitoring of diamond wheel is dealt with in dry grinding. A dry electrical discharge （ED） assisted truing and dressing method is adopted in preparation of diamond grinding wheels. Effective and precise truing/dressing of a diamond wheel is carried out on a CNC curve grinding machine by utilizing an ED assisted diamond dresser. The dressed wheel is monitored online by a CCD vision system. It detects the topography changes of a wheel surface. The wear condition is evaluated by analyzing the edge deviation of a wheel image. The benefits of the proposed methods are confirmed by the grinding experiments. The designed truing/dressing device has high material removal rate, low dresser wear, and hence guarantees a desired wheel surface. Real-time monitoring of the wheel profile facilitates determining the optimum dressing amount, dressing interval, and the compensation error.

关键词： Diamond wheel Truing/dressing Dry electrical discharge Vision measurement

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Rheological model of semisolid Mg_(2)Si/AM60 composites prepared by ultrasonic vibration treatment

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Rare Metals 2022年第8期41卷 2783-2788页

作者： Yuan-Sheng Rao Hong yan Jun wan Department of Materials Processing Engineering School of Mechanical and Electrical EngineeringNanchang UniversityNanchang330031China Key Laboratory of Light Alloy Preparation and Processing in Nanchang City Nanchang330031China

The rheological behavior of semisolid Mg_(2)Si/AM60 composites prepared by ultrasonic vibration treatment was *** effects of primaryα-Mg solid content,the ultrasonic power and the content of reinforcement phase Mg_(2)Si on the apparent viscosity of semisolid composites were *** results show that the apparent viscosity of the semis olid composites increases with the increase in a-Mg solid ***,the apparent viscosity decreases with the increase in ultrasonic power,and the reduction amplitude is higher when the solid content is *** addition,the apparent viscosity increases with the increase in Mg_(2)Si *** on experimental data fitting,the rheological model of semisolid Mg_(2)Si/AM60 composites prepared by ultrasonic vibration was established.

关键词： Semisolid Magnesium matrix composites Ultrasonic vibration Apparent viscosity

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Two-sample Testing for Mean Functions with Incompletely Observed Functional Data

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 374-389页

作者： yan-qiu ZHOU yan-ling wan Tao ZHANG School of Science Guangxi University of Science and TechnologyLiuzhou 545006China School of Social Science Guangxi University of Science and TechnologyLiuzhou 545006China

In functional data analysis,the collected data are often assumed to be fully observed on the ***,in dealing with real data(for example,environmental pollution data),we are often faced with the scenario that some functional data are fully observed on dense lattice while others are incompletely *** this paper,we propose a method for testing equivalence of mean functions of two samples under this *** asymptotic results of the proposed methods are *** proposed test is employed to analyze an environmental pollution study in Liuzhou City of *** show that the proposed test has a good control of the type-I error,and is more powerful than the complete case test in most cases.

关键词： functional data analysis significance test incompletely observed functional data mean function

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An Estimation Method for Multi-channel EEG Data Based on Canonical Correlation Analysis

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Chinese Journal of Electronics 2015年第3期24卷 569-572页

作者： yan Zheng wan Xiaojiao LING Chaodong Department of Information Science and Engineering Huaqiao University

Electroencephalogram(EEG) signal is often contaminated by electronic noise as well as movement artifacts. This paper presented an algorithm based on Canonical correlation analysis(CCA) to estimate multichannel EEG data. Different from previous studies, in which CCA was mainly used to detect the invariant features specific to each brain state, in this paper, the canonical variates computed by CCA were used to reconstruct the multi-channel EEG data. Firstly, two data sets, EEG signals and the reference signals based on prior knowledge were constructed. Next, canonical variates were computed by pro jecting the two data sets onto basis vectors. Finally,a least squares solution was used to estimate the multichannel EEG data. The experiment results suggested that the algorithm is capable of reconstructing the actual specific components with high quality. We also hint future possible application of the algorithm in the estimation of functional connectivity patterns at the end of the paper.

关键词： Electroencephalogram(EEG) Canonical correlation analysis(CCA) Canonical variates

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The Anhydride-Amic Acid-Imide Forms of Maleinized Soybean Oil

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Chinese Journal of Polymer Science 2023年第12期41卷 1829-1835,I0005页

作者： Yun Zhou yan-Bin Huang wan-Tai yang Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Vegetable oil is one of the most promising renewable feedstocks as an alternative to fossil resources,but there are few studies aiming to transform it into hydrophilic *** proposed a facile method to prepare water-soluble derivatives from soybean oil,which could become water resistant again after simple heat *** model vegetable oil,soybean oil(SO),was first reacted with maleic anhydride(MA)by the Alder ene reaction to obtain maleinized soybean oil(SOMA),and SOMA was further reacted with gaseous ammonia to obtain the maleamic acid form(SOMA-Amic acid),which was very soluble in water(solubility>100 mg/mL).The obtained water-soluble product was converted to the water-resistant maleimide form(SOMA-Imide)by a simple heat *** potential application of these vegetable oil derived materials was demonstrated in paper sizing as an ***-Amic acid was demonstrated to be a novel green material,which can be used in an aqueous process and then heat-treated to become water-resistant in the final product.

关键词： Soybean oil Anhydride-amic acid-imide forms Maleinization

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Whole-lifetime Coordinated Service Strategy for Battery Energy Storage System Considering Multi-stage Battery Aging Characteristics

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Journal of Modern Power Systems and Clean Energy 2022年第3期10卷 689-699页

作者： Feilong Fan yan Xu Rui Zhang Tong wan IEEE Energy Research Institute@NTU Nanyang Technological UniversitySingapore College of Smart Energy Shanghai Jiao Tong UniversityShanghaiChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore The University of New South Wales SydneyAustralia University of Sydney SydneyAustralia

One battery energy storage system(BESS)can be used to provide different services,such as energy arbitrage(EA)and frequency regulation(FR)support,etc.,which have different revenues and lead to different battery degradation *** paper proposes a whole-lifetime coordinated service strategy to maximize the total operation profit of BESS.A multi-stage battery aging model is developed to characterize the battery aging rates during the whole *** the uncertainty of electricity price in EA service and frequency deviation in FR service,the whole problem is formulated as a twostage stochastic programming *** the first stage,the optimal service switching scheme between the EA and FR services are formulated to maximize the expected value of the whole-lifetime operation *** the second stage,the output power of BESS in EA service is optimized according to the electricity price in the hourly timescale,whereas the output power of BESS in FR service is directly determined according to the frequency deviation in the second *** above optimization problem is then converted as a deterministic mixed-integer nonlinear programming(MINLP)model with bilinear *** Cormick envelopes and a bound tightening algorithm are used to solve *** simulation is carried out to validate the effectiveness and advantages of the proposed strategy.

关键词： Battery energy storage system(BESS) wholelifetime coordinated service multi-stage battery aging model two-stage stochastic programming mixed-integer nonlinear programming(MINLP)

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