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Epidemiological profiles of human immunodeficiency virus and hepatitis C virus infections in Malian women:Risk factors and relevance of disparities

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World Journal of Hepatology 2013年第4期5卷 196-205页

作者： Nouhoum Bouare Andre Gothot Jean Delwaide sebastien Bontems Dolores Vaira Laurence Seidel Paul Gerard Christiane Gerard Department of Clinical Biology Laboratory HematologyImmuno-Hematology and AIDS Reference Laboratory B35Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Hepatology and Gastroenterology Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Department of Public Health(Biostatistics) Centre Hospitalier UniversitaireUniversité de Liège4000 LiègeBelgium Institute of Mathematics Université de Liège4000 LiègeBelgium

AIM:To document the epidemiologic patterns and risk factors of human immunodeficiency virus(HIV)and hepatitis C virus(HCV)infections in Mali in order to develop prevention means for both ***:Two prospective studies were conducted in Bamako in 2009 among 1000 pregnant women(i.e.,young women)who consulted six reference health centers,and in 2010,among 231 older women who attended general practice in two *** tests and molecular analysis(performed only for HCV)were used to quantify the frequencies of both *** data were collected from patients recruited through a *** risk factors of both diseases were identified by univariate and multivariate ***:HCV seroprevalence was 0.2% for young and 6.5% for older *** prevalence was similar in both populations(4.1% vs 6.1%).In older women,the analysis of risk factors highlighted an association between HCV infection and episodes of hospitalization(P < 0.01).The study did not show an association between HIV infection and the variables such as hospitalization,transfusion,tattoo,dental care,and endoscopy.A significant decrease of HIV seroprevalence was detected in young women who used condoms for contraception more than for other purposes(P < 0.01).By contrast,HIV seroprevalence was significantly increased in young women using condoms mainly to prevent sexual infections rather than for contraception(P < 0.01).No HCV/HIV coinfection was detected in our ***:Risk factors and epidemiologic data of HIV and HCV as well as the absence of co-infection strongly suggest epidemiological disparities between these diseases.

关键词： Hepatitis C virus Human immunodeficiency virus Epidemiology Risk factors Women Mali Bamako

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爸爸

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疯狂英语（初中天地） 2005年第10期 28-29页

作者： sebastien L. 芥子

说起法国人,很多人马上就会联想到浪漫。其实,他们还有一个特点——就是十分热爱自己的文化,并以此为荣,有时还会给人高傲的感觉。我们可以从作者对他的法国爸爸幽默的描写中体会到这种文化差异;另外,文中还出现了很多法国美食,不要错过!

关键词：薄煎饼

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何种补贴策略最利于激励企业创新?--单项补贴工具vs.补贴工具组合

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软科学 2023年第5期37卷 54-61,70页

作者：赵凯陈泽平 MENARD sebastien 华侨大学数量经济研究院福建厦门361021 华侨大学统计学院福建厦门361021 法国曼恩大学经济学院法国勒芒72000

基于中国A股上市企业数据,深入考察R&D补贴、非R&D补贴这两种单项补贴工具及其工具组合对企业创新的真实影响。研究发现:在激励企业提高创新数量方面,补贴工具组合优于R&D补贴;而在激励企业提升创新质量方面,R&D补贴优于补贴工具组合。... 详细信息

基于中国A股上市企业数据,深入考察R&D补贴、非R&D补贴这两种单项补贴工具及其工具组合对企业创新的真实影响。研究发现:在激励企业提高创新数量方面,补贴工具组合优于R&D补贴;而在激励企业提升创新质量方面,R&D补贴优于补贴工具组合。“大龄”且处于“成熟期”的国有企业往往更易得到政府R&D补贴的垂青,而董监高研发背景以及低杠杆率也会提高企业获得R&D补贴支持的概率。政府倾向于为高新技术企业及获得风险投资的企业提供补贴组合支持。此外,企业在产权性质、生命周期、行业类别、地域区位等方面的差异会对不同补贴策略的实施效果起到显著调节作用。

关键词：补贴工具组合实质性创新 R&D补贴多水平处理效应模型

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Prevalence of HIV and HCV infections in two populations of Malian women and serological assays performances

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World Journal of Hepatology 2012年第12期4卷 365-373页

作者： Nouhoum Bouare Dolores Vaira Andre Gothot Jean Delwaide sebastien Bontems Laurence Seidel Paul Gerard Christiane Gerard Department of Hematobiology Immuno-Hematology and AIDS Reference Laboratory B35CHU-ULg4000 LiegeBelgium Department of Hepatology and Gastroenterology CHU-ULg4000 LiegeBelgium Department of Public Health(Biostatistics) CHU-ULg4000 LiegeBelgium Institute of Mathematics ULg4000 LiegeBelgium

AIM: To estimate the prevalence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections in women in Mali and to evaluate the performance of serological assays.

关键词： Human immunodeficiency virus Hepatitis C virus Serology Molecular diagnostics Women West Africa Bamako

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Quality control,validation and user feedback of the European Flood Alert System(EFAS)

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International Journal of Digital Earth 2011年第S1期4卷 77-90页

作者： Ad De Roo Jutta Thielen Peter Salamon Konrad Bogner sebastien Nobert Hannah Cloke David Demeritt Jalal Younis Milan Kalas Katalin Bodis Davide Muraro Florian Pappenberger European Commission Joint Research Centre(JRC)IspraItaly European Centre for Medium Range Weather Forecast(ECMWF) ReadingUK Department of Geography King’s College LondonLondonUK Czech Hydrometeorological Institute PragueCzech Republic

The quality control,validation and verification of the European Flood Alert System(EFAS)are *** is designed as a flood early warning system at pan-European scale,to complement national systems and provide flood warnings more than 2 days before a *** average 2030 alerts per year are sent out to the EFAS partner network which consists of 24 National hydrological authorities responsible for transnational river *** control of the system includes the evaluation of the hits,misses and false alarms,showing that EFAS has more than 50%of the time ***,the skills of both the meteorological as well as the hydrological forecasts are evaluated,and are included here for a 10-year ***,end-user needs and feedback are systematically *** improvements,such as real-time river discharge updating,are currently implemented.

关键词： flood warning forecasting EFAS probabilistic skill

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Techno-functionality of fisetin-enriched yoghurt fermented with Lactobacillus acidophilus bio-capsules produced via osmoporation

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 743-749页

作者： Eduardo Wagner Vasconcelos de Andrade sebastien Dupont Laurent Beney Edilene Souza da Silva Roberta Targino Hoskin Márcia Regina da Silva Pedrini Bioprocess Laboratory Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil Laboratory of Bioactive Compounds Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil UMR Procédés Alimentaires et Microbiologiques(PAM UMR A 02.102)Univ.Bourgogne Franche-ComtéAgroSup Dijon21000 DijonFrance

Osmoporation is a novel encapsulation approach for bioactive compounds based on the osmoresistance mechanisms of microbial *** the best of our knowledge,this is the first study investigating the production of fisetin-enriched yoghurt using Lactobacillus acidophilus-based bio-capsules via osmoporation as the starter *** showed that the milk acidification with fisetin-loaded *** progressed at a slower pace due to complex mechanisms induced by osmopo-ration and internalized *** fermentation using fisetin bio-capsules reached a maximum acidification rate of 0.18 pH units/h after 23 h and pH 4.6 was achieved after 32 ***,the antioxidant activity of yoghurts produced with fisetin bio-capsules did not change during cold storage,while the antioxidant activity of yoghurt produced with non-encapsulated fisetin was reduced by 2.5-fold after 28 ***,this study shows that fisetin osmoporation using *** is a versatile encapsulation bioprocess that enables the delivery of preserved phytoactives into fermented foods like *** strategy has the potential to be extended to other applications in the dairy industry using lactic acid bacteria as both the encapsulation matrix and fermentation agent.

关键词： Cell-based carriers Probiotic bacteria Dairy fermented products Food biotechnology Functional foods

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Spatial analysis of bacteria in brackish lake sediment

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International Journal of Sediment Research 2020年第3期35卷 227-236页

作者： Jean-sebastien Beaulne Samir R.Mishra Mrutyunjay Suar Ananta Narayan Panda Gurdeep Rastogi Ajit Kumar Pattnaik Vishakha Raina Timothy M.Vogel Environmental Microbial Genomics Ecole Centrale de LyonUniversite de Lyon ISARA Department of Agroecology and Environment Environmental Biotechnology Laboratory School of BiotechnologyKIIT University Wetland Research and Training Center Chilika Development AuthorityDepartment of Forest and EnvironmentGovernment of Odisha

The spatial distribution of bacterial communities inhabiting sediment is heterogeneous at different spatial scales,but mostly ***,it is postulated that the heterogeneity of the bacterial community composition varies at the same scale of the heterogeneity of sediment chemical *** large spatial scale(km) diversity in sediment from a brackish water lagoon(Chilika Lake,India) is studied,considering the large scale physical and chemical characteristics of land cover,climate,pH,and ***-two samples(24 stations,3 seasons:winter,rainy,and summer) of sediment from Chilika Lake were analyzed by 16 S ribosomal ribonucleic acid(rRNA) gene sequencing,and the relations with land cover and other physico-chemical paramete rs are *** re samples were collected after a severe cyclonic storm(Phailin) passed near the lagoon in 2013,to see the impact of the tropical storm on the spatial and tempo ral distribution of bacteria in the *** results demonstrate clear spatial relations between physico-chemical parameters(e.g.,salinity),land surfaces(e.g.,drainage area),and the distribution of sediment microbial communities.

关键词： Salinity 16S rRNA Macro-scale Sediment GIS

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Culture impacts on extrafoveal information use for faces but not for visual scenes

Culture impacts on extrafoveal information use for faces but...

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第四届中国国际眼动大会

作者： sebastien Miellet Roberto Caldara Department of Psychology and Centre for Cognitive Neuroimaging（CCNi） University of Glasgow

＜正＞Culture shapes how people gather information from the visual *** recently showed that Eastern observers deploy central fixations during face recognition despite using information from the eye *** observation ind...

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TREM-1 multimerization is essential for its activation on monocytes and neutrophils

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Cellular & Molecular Immunology 2019年第5期16卷 460-472页

作者： Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay sebastien Gibot Marc Derive INOTREM Vandœuvre-les-NancyFrance UMR-S 1116 Defaillance cardiovasculaire aigue et chroniqueVandœuvre-les-NancyFrance UMR7365 Ingénierie Moléculaire et Physiopathologie Articulaire(IMoPA)CNRS-Universitéde LorraineVandœuvre-les-NancyFrance Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics CenterUtrecht UniversityUtrechtThe Netherlands Innate Immunity German Cancer Research Center(DKFZ)HeidelbergGermany CovalX ZurichSwitzerland Service Commun de Biophysique Interactions Moléculaires(SCBIM) FR3209Biopole de l’Universitede LorraineVandœuvre-les-NancyFrance Inatherys Evry CedexFrance

The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune *** promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel ***,the molecular events leading to the activation of TREM-1 in innate immune cells remain ***,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 ***-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and *** addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its *** further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and ***-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 *** results provide evidence for ligand-induced,receptor-mediated dimerization of ***,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils.

关键词： TREM-1 multimerization activation monocytes neutrophils

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Preparation of highly dispersed supported Ni-Based catalysts and their catalytic performance in low temperature for CO methanation

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Carbon Resources Conversion 2020年第1期3卷 164-172页

作者： Yongbin Yao Jing Xu Xuhong Guo Jiangwei Li Qixia Zhang Jiangbing Li Chao Wang Mengjuan Zhang Bin Dai Feng Yu sebastien Thomas Anne-Cecile Roger Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003PR China State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237PR China Key Laboratory on Resources Chemicals and Materials of Ministry of Education Shenyang University of Chemical TechnologyShenyang 110142PR China Graduate School of Science and Technology Hirosaki University3 Bunkyo-choHirosakiAomori 036-8560Japan Institut de Chimie et Procedes pour l’Energie l’Environnement et la Sante(ICPEESUMR CNRS 7515)25 rue Becquerel67087 StrasbourgFrance

The use of non-noble nickel-based catalysts for low temperature CO methanation has been a challenge in recent ***,MgAl layered double oxides sample with high dispersion synthesized by a facile N-(2-Hydroxyethyl)ethylenediaminetriacetic acid assisted wetness impregnation approach,demonstrates much superior catalytic activity and exceptional stability for CO methanation in comparison with the classical Ni/MgAl-LDO catalyst prepared by the ordinary wetness impregnation *** results showed that N-(2-Hydroxyethyl)ethylenediaminetriacetic acid played a positive role in the dispersion of Ni,as well as Ni-support ***-dispersed Ni particles with a size of about 5 nm were formed in the presence of N-(2-Hydroxyethyl)ethylenediaminetriacetic *** to the Ni/MgAl-LDO prepared by conventional impregnation method,the NH-Ni/MgAl-LDO exhibited superior catalytic performance,especially excellent thermal *** NH-Ni30/MgAl-LDO catalyst was found to keep a 70%CO conversion even at 160◦C which demonstrates its good low temperature *** the in situ FTIR observations,this good performance at low temperatures may be linked to the delocalization of electrons around CO caused by surface hydroxyl groups.

关键词： Complexed-impregnation Layered double oxide CO methanation Low temperature catalyst

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