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Proteomic Differences between Azole-Susceptible and -Resistant <i>Aspergillus fumigatus</i>Strains

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Advances in Microbiology 2018年第1期8卷 77-99页

作者： Edith Vermeulen sebastien Carpentier Olaf Kniemeyer Machteld Sillen Johan Maertens Katrien Lagrou Department of Microbiology and Immunology University of Leuven Leuven Belgium Facility for Systems Biology Based Mass Spectrometry University of Leuven Leuven Belgium Leibniz Institute for Natural Product Research and Infection Biology—Hans Knoell Institute (HKI) Molecular and Applied Microbiology Jena Germany Department of Microbiology and Immunology and UZ Leuven Clinical Department of Hematology University of Leuven Leuven Belgium Department of Microbiology and Immunology and UZ Leuven Clinical Department of Laboratory Medicine and National Reference Center for Mycosis University of Leuven Leuven Belgium

Background: Azole-resistance is increasingly reported in Aspergillus fumigatus infections. It remains challenging to rapidly assess antifungal susceptibility to initiate the appropriate therapy. The aim of this study was to map the proteomic differences of azole-susceptible and -resistant strains. Methods: Proteomic studies were performed with ultra-performance liquid chromatography tandem mass-spectrometry (UPLC-MS/MS). Results: UPLC-MS/MS detected 7899 peptides, of which 1792 peptides had a significantly different abundance (p A. fumigatus resistance. Conclusions: UPLC-MS/MS provided proof-of-concept that the proteome of azole-resistant A. fumigatus is diverse enough to serve as a diagnostic tool.

关键词： Aspergillus fumigatus Triazole Resistance Proteomic Mass Spectrometry

钴掺杂Sr1.5La0.5MnO4的合成及高温电化学性能研究

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无机化学学报 2016年第10期32卷 1730-1738页

作者：范宇航孙丽萍霍丽华赵辉 Jean-Marc Bassat Aline Rougier sebastien Fourcade Jean-Claude Grenier 黑龙江大学化学化工与材料学院功能无机材料化学教育部重点实验室哈尔滨150080 CNRS Universite de Bordeaux ICMCB 87 avenue du Dr. A. Schweitzer F-33608 Pessac-Cedex France

采用EDTA-柠檬酸法合成了中温固体氧化物燃料电池阴极材料Sr_(1.5)La_(0.5)Mn_(1-x)Co_xO_4(SLMCOx),并利用粉末X射线衍射(XRD)、X射线光电子能谱(XPS)以及电化学交流阻抗谱(EIS)进行表征。结果表明,该材料与Ce0.9Gd0.1O1.95(CGO)在1 200℃烧结12 h不发生化学反应。随着Co掺入量的增加,氧化物中Mn^(3+)和Co^(2+)含量增多,晶格氧含量降低,晶格畸变率增大。交流阻抗谱(EIS)测试结果显示,钴的掺杂明显降低电极的极化电阻,其中Sr_(1.5)La_(0.5)Mn_(0.7)Co_(0.3)O_4阴极在700℃空气中的极化电阻为0.62Ω·cm^2,明显小于Sr_(1.5)La_(0.5)MnO_4阴极在750℃的极化电阻(1.5Ω·cm^2),表明钴掺杂的Sr_(1.5)La_(0.5)Mn_(1-x)CoxO_4是一种潜在的IT-SOFC阴极材料。

关键词：中温固体氧化物燃料电池阴极材料

On the applicability of Kirchoff's law and the principle of heat balance in thermal infrared remote sensing:A non-isothermal system

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Science China Earth Sciences 2005年第1期48卷 53-64页

作者： ZHANG Renhua, LI Zhaoliang, SUN Xiaomin, ZHU Zhilin & WANG Weimin Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China LSIIT (CNRS UMR7005), Bld sebastien Brant, BP.10413, 67412 Illkirch, France Chinese Academy of Sciences Institute of Geographical Sciences and Natural Resources Research Beijing China LSIIT (CNRS UMR7005) Bld Sebastien Brant Illkirch France

This paper proposes a basic equation of thermal radiation interaction between surface objects on the basis of the principle of heat balance in the interface. The solution of this equation takes account of the contribution of sensible heat flux and latent heat flux more completely, compared with traditional solution for surface cooling and heating processes. By the aid of the experimental data conducted in the Xiaotangshan experimental site, Beijing, both the non-applicability of Kirchoff's law and the measurability of surface emissivity in a non-isothermal system have been highlighted. Two methods called ventilation and time-delay compensations have been proposed to reduce the error induced by change of surface temperatures of non-isothermal objects during the measurement of emissivity. Based on the solution of the basic equation, this paper has analyzed and pointed out the misunderstanding in comprehension and application of Kirchoff's law published in literature.

关键词： applicability of Kirchoff's law, heat balance, non-isothermal system.

用PLA51平面变压器设计增强功率密度和效率

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磁性元件与电源 2018年第6期 139-142,151页

作者： sebastien Marchio 威世公司

1总体定义如今，随着电动汽车和可再生能源等新技术的出现，开发电力转换器的需求迅速增长。设计师正在寻求更高的功率密度和效率，以及更小的尺寸和更轻的重量。开关频率的提高适合于实现这一目标，但是会导致其他限制，需要在设计磁... 详细信息

1总体定义如今，随着电动汽车和可再生能源等新技术的出现，开发电力转换器的需求迅速增长。设计师正在寻求更高的功率密度和效率，以及更小的尺寸和更轻的重量。开关频率的提高适合于实现这一目标，但是会导致其他限制，需要在设计磁性元件时进行管理，例如接近和趋肤效应。磁性元件面临的主要挑战是尽量减少功率损耗并改善热管理。

关键词：变压器设计功率密度平面磁性元件可再生能源电动汽车开关频率趋肤效应

The Use of Positron Emission Tomography in the Diagnosis of Prosthetic Arteriovenous Hemodialysis Graft Infection: A Case Study

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Surgical Science 2014年第2期5卷 70-73页

作者： Bertrand Saint-Lebes Celine Dubuis sebastien Deglise Francois Saucy Jean-Marc Corpataux Department of Vascular Surgery University HospitalToulouseFrance Department of Vascular Surgery Centre Hospitalier Universitaire Vaudois(CHUV)University HospitalLausanneSwitzerland

Patients on chronic hemodialysis (HD) required efficient arterio-venous access. Different types of vascular access are commonly used, such as native arteriovenous (AV) fistula, prosthetic AV graft, central venous catheter, or temporary and tunnelled cuffed catheters. Vascular access—related morbidity remains the major issue for patients requiring long-term therapy. Vascular access infection constitutes the most challenging and life-threatening complication of vascular access and causes significant morbidity, loss of access and mortality. Vascular access infection is defined as local signs at the vascular access site or a positive blood culture with no know source other than the vascular access. The critical issue in the management of AV graft infection is the need to remove the infection and to maintain HD access with reduced morbidity. The diagnosis of infected AV graft is not always easy, especially with low-grade infection or atypical presentation. Fluorodeoxyglucose positron emission tomography (FDG-PET) is an imaging method that uses a radioactively labelled tracer (18 fluorodeoxy glucose) which is taken up by tissue with high metabolic activity, such as neoplastic and inflammatory lesions. FDG-PET has been proposed to visualise localisation of infection in patients with suspected prosthetic graft infection. We report a case of methicilin resistant staphylococcus aureus (MRSA) hemodialysis access infection without local inflammatory signs diagnosed on the PET-CT.

关键词： Hemodialysis Access Graft Infection PET-CT

Simultaneous ramp right heart catheterization and echocardiography in a Reliant Heart left ventricular assist device

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World Journal of Cardiology 2017年第1期9卷 55-59页

作者： Dipanjan Banerjee Debleena Dutt sebastien Duclos Karim Sallam Matthew Wheeler Richard Ha Divisions of Cardiovascular Medicine Stanford University School of MedicineStanfordCA 94305United States

Many clinicians caring for patients with continuous flow left ventricular assist devices(CF-LVAD) use ramp right heart catheterization(RHC) studies to optimize pump speed and also to troubleshoot CF-LVAD malfunction. An investigational device,the Reliant Heart Heart Assist 5(Houston,TX),provides the added benefit of an ultrasonic flow probe on the outflow graft that directly measures flow through the CF-LVAD. We performed a simultaneous ramp RHC and echocardiogram on a patient who received the above CF-LVAD to optimize pump parameters and investigate elevated flow through the CF-LVAD as measured by the flow probe. We found that the patient's hemodynamics were optimized at their baseline pump speed,and that the measured cardiac output via the Fick principle was lower than that measured by the flow probe. Right heart catheterization may be useful to investigate discrepancies between flow measured by a CF-LVAD and a patient's clinical presentation,particularly in investigational devices where little clinical experience exists. More data is needed to elucidate the correlation between the flow measured by an ultrasonic probe and cardiac output as measured by RHC.

关键词：留给室帮助设备正确的心 catheterization 斜面学习流动评价

The maximum likelihood identification method applied to insect morphometric data

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Zoological Systematics 2017年第1期42卷 46-58页

作者： Jean-Pierre Dujardin sebastien Dujardin Dramane Kaba Soledad Santillan-Guayasamin Anita G.Villacis Sitha Piyaselakul Suchacla Sumruayphol Yudthana Samung Ronald Morales Vargas IRD UMR 177 IRD-CIRAD INTERTRYP Campus international de Baillarguet Montpellier France Ecole des Technologies Numdriques Appliquees Paris France Institut Pierre Riehet Institut National de Sante Publique Abidjan Cote d'Ivoire Center for Research on Health in Latin America School of Biological Sciences Pontifical Catholic University of Ecuador Quito Ecuador Av. 12 de Oetubre 1076y Roca Department of Anatomy Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 10700 Thailand Department of Medical Entomology Faculty of Tropical Medicine Mahidol University Bangkok 10400 Thailand

To distinguish species or populations using morphometric data is generally processed through multivariate analyses, in particular the discriminant analysis. We explored another approach based on the maximum likelihood method. Simple statistics based on the assumption of normal distribution at a single variable allows to compute the chance of observing a particular data （or sample） in a given reference group. When data are described by more than one variable, the maximum likelihood （MLi） approach allows to combine these chances to find the best fit for the data. Such approach assumes independence between variables. The assumptions of normal distribution of variables and independence between them are frequently not met in morphometrics, but improvements may be obtained after some mathematical transformations. Provided there is strict anatomical correspondence of variables between unknown and reference data, the MLi classification produces consistent classification. We explored this approach using various input data, and compared validated classification scores with the ones obtained after the Mahalanobis distance-based classification. The simplicity of the method, its fast computation, performance and versatility, make it an interesting complement to other classification techniques.

关键词： Medical entomology morphometrics classification probability Mahalanobisdistance.

采用Spartan-6 FPGA加速纹理映射

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今日电子 2012年第1期 38-41页

作者： sebastien Bourdeauducq Milkymist组织

作为一种以FPGA为构建基础，而非采用专业多媒体片上系统的手持设备，MilkymistOne无须计算机的辅助即能为聚会和音乐会提供视频特效。

关键词：纹理映射 FPGA 手持设备片上系统视频特效多媒体音乐会计算机

Ionic Liquids Mediated Ionothermal Process for the One-Step Synthesis of High Surface Area Alumina Supported Noble Metals

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Modern Research in Catalysis 2013年第2期2卷 28-35页

作者： Magali Bonne Pierrick Gaudin Yanlong Gu Francois Jerome Yannick Pouilloux Daniel Duprez sebastien Royer Universite de Haute Alsace(UHA) CNRSEquipe Materiaux a Porosite Controlee(MPC)Institut de Science des Materiaux de Mulhouse(IS2M)MulhouseFrance Universite de Poitiers Institut de Chimie des Milieux et Materiaux de Poitiers(IC2MP)PoitiersFrance Institute of Physical Chemistry and Industrial Catalysis Department of Chemistry and Chemical EngineeringUniversity of Science and TechnologyWuhanChina

Aluminas supported noble metal nanoparticles have been synthesized by a new ionothermal process. The method used is easy to implement and allows obtaining catalysts in one step with high specific surface area. In addi... 详细信息

关键词： Mesostructuration Alumina Noble Metals Ionothermal Process EISA