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Genomics, Proteomics & Bioinformatics 2007年第1期5卷 45-52页

作者： Guillaume Brysbaert sebastian Noth Arndt Benecke Systems Epigenomics Group Institut des Hautes Etudes Scientifiques/Institut de Recherches InterdisciplinairesCNRS/INSERM 91440 Bures sur Yvette France

We have previously developed a combined signal/variance distribution model that accounts for the particular statistical properties of datasets generated on the Applied Biosystems AB1700 transcriptome system. Here we show that this model can be efficiently used to generate synthetic datasets with statistical properties virtually identical to those of the actual data by aid of the JAVA application *** creator 1.0 that we have developed. The fundamentally different structure of AB1700 transcriptome profiles requires re-evaluation, adaptation, or even redevelopment of many of the standard microarray analysis methods in order to avoid misinterpretation of the data on the one hand, and to draw full benefit from their increased specificity and sensitivity on the other hand. Our composite data model and the *** creator 1.0 application thereby not only present proof of the correctness of our parameter estimation, but also provide a tool for the generation of synthetic test data that will be useful for further development and testing of analysis methods.

关键词： transcriptome microarray analysis signal/variance distribution distribution modeling parameter approximation synthetic data generation

Finite Volume Evolution Galerkin Methods for the Shallow Water Equations with Dry Beds

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Communications in Computational Physics 2011年第7期10卷 371-404页

作者： Andreas Bollermann sebastian Noelle Maria Lukacova-Medvid’ova IGPM RWTH AachenTemplergraben 5552062 AachenGermany Institut fur Mathematik Universitat MainzStaudingerweg 955099 MainzGermany.

We present a new Finite Volume Evolution Galerkin(FVEG)scheme for the solution of the shallow water equations(SWE)with the bottom topography as a source *** new scheme will be based on the FVEG methods presented in(Noelle and Kraft,***.,221(2007)),but adds the possibility to handle dry *** most important aspect is to preserve the positivity of the water *** present a general approach to ensure this for arbitrary finite volume *** main idea is to limit the outgoing fluxes of a cell whenever they would create negative water ***,this corresponds to the absence of fluxes in the presence of *** is then re-established by splitting gravitational and gravity driven parts of the ***,a new entropy fix is introduced that improves the reproduction of sonic rarefaction waves.

关键词： Well-balanced schemes dry boundaries shallow water equations evolution Galerkin schemes source terms

Experimental proof of Joule heating-induced switched-back regions in OLEDs

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Light(Science & Applications) 2020年第1期9卷 1951-1960页

作者： Anton Kirch Axel Fischer Matthias Liero Jurgen Fuhrmann Annegret Glitzky sebastian Reineke Dresden Integrated Center for Applied Physics and Photonic Materials(IAPP)and Institute of Applied Physics Technische Universitat DresdenNothnitzer StraBe 6101187 DresdenGermany Weierstrass Institute Berlin MohrenstraBe 3910117 BerlinGermany

Organic light-emitting diodes(OLEDs)have become a major pixel technology in the display sector,with products spanning the entire range of current panel *** ability to freely scale the active area to large and random surfaces paired with flexible substrates provides additional application scenarios for OLEDs in the general lighting,automotive,and signage *** applications require higher brightness and,thus,current density operation compared to the specifications needed for general *** extended transparent electrodes pose a significant ohmic resistance,OLEDs suffering from Joule self-heating exhibit spatial inhomogeneities in electrical potential,current density,and hence *** this article,we provide experimental proof of the theoretical prediction that OLEDs will display regions of decreasing luminance with increasing driving *** a two-dimensional OLED model,we can conclude that these regions are switched back locally in voltage as well as current due to insufficient lateral thermal ***,we demonstrate this effect in lab-scale devices and derive that it becomes more severe with increasing pixel size,which implies its significance for large-area,high-brightness use cases of ***,these non-linear switching effects cannot be ignored with respect to the long-term operation and stability of OLEDs;in particular,they might be important for the understanding of sudden-death scenarios.

关键词： OLEDs switched proof

Strategic Partnership between the European Union and P.R. China in the 21st Century

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Strategic Partnership between the European Union and P.R. Ch...

作者： Demciuc sebastian 华中师范大学

学位级别：硕士

欧盟不是一个像联合国一样的国际组织,也不是一个为了取代国家政府的“政府”。欧盟对于“组织”更为强势而在“政府”面前却有无法弥补的劣势。它的作用体现在支撑欧盟成员国之间的共同行动比各自为战的单独行动更为高效。可以说欧盟... 详细信息

欧盟不是一个像联合国一样的国际组织,也不是一个为了取代国家政府的“政府”。欧盟对于“组织”更为强势而在“政府”面前却有无法弥补的劣势。它的作用体现在支撑欧盟成员国之间的共同行动比各自为战的单独行动更为高效。可以说欧盟是独一无二的。欧盟是一个由各国政府共同建立,在某些特定领域达成共识并共同行动的国际组织。在这些特定领域中,最好的政治理念是欧盟成员国之间合作共赢,而非单干。中国外交政策的原则是致力于促进世界和平与发展、国际合作。欧盟一直是中国在各领域良好的合作伙伴:如政治领域、经济领域、文化领域。中欧双方共同努力构建起来的联系与合作日益亲密,迅猛的发展势头令人无法想象。中国、欧盟两大经济体经济增长举世瞩目。中国正史无前例的在欧洲布局投资,同时欧洲各国也在紧密规划与中国的合作。本文论点是阐述欧盟中国之间合作潜力巨大。本文着力分析了 21世纪全球政治、经济格局之现状,并预测了未来战略合作伙伴关系。我们看到越来越多的项目如雨后春笋般在两个合作伙伴之间生根发芽,这种基于政治、经济、文化构建起的友谊牢不可破。对于中欧伙伴关系中出现的一般问题,处理方法是改变视角、审视范围与合作规模。中国与欧盟的战略伙伴关系的观点存在不同:中国强调的是综合、整体和长远的发展构架才能维持稳定和健康的双边关系,而欧盟则更看重的实质性的进展与具体的结果。其结论是:一种伙伴关系,两种处理方法。

关键词：战略伙伴关系欧盟中国

Pauli Radius of the Proton

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Chinese Physics Letters 2021年第12期38卷 1-6页

作者： Zhu-Fang Cui Daniele Binosi Craig D.Roberts sebastian M.Schmidt School of Physics Nanjing UniversityNanjing 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjing 210093China European Centre for Theoretical Studies in Nuclear Physics and Related Areas Villa TambosiStrada delle Tabarelle 286I-38123 Villazzano(TN)Italy Helmholtz-Zentrum Dresden-Rossendorf Dresden D-01314Germany RWTH Aachen University Ⅲ.Physikalisches Institut BAachen D-52074Germany

Using a procedure based on interpolation via continued fractions supplemented by statistical sampling,we analyze proton magnetic form factor data obtained via electron+proton scattering on Q^(2)∈[0.027,0.55]GeV^(2)with the goal of determining the proton magnetic *** approach avoids assumptions about the function form used for data interpolation and ensuing extrapolation onto Q^(2)■0 for extraction of the form factor *** this way,we find r_(M)=0.817(27)*** the difference between proton electric and magnetic radii calculated in this way,extant data are seen to be compatible with the possibility that the slopes of the proton Dirac and Pauli form factors,F1,2(Q^(2)),are not truly independent observables;to wit,the difference F_(1)’(0)-F_(2)’(0)/κp=[1+Kp]/[4 m_(p)^(2)],viz.,the proton Foldy term.

关键词： interpolation Pauli continued

The Effects of an Effective Customer Journey Design and Brand Experience on Flow and Customer Loyalty for Luxury Fashion Brands

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The Effects of an Effective Customer Journey Design and Bran...

作者： sebastian Badde 上海交通大学

学位级别：硕士

In recent years,business practitioners and the scientific community have started appraising customer experience as an emerging marketing *** business practice,corporations have begun focusing on developing a superb customer experience to differentiate themselves from competitors and gain a competitive edge in the *** contrast,scholars increasingly investigated the topic of customer experience,including its components and their respective implications on attitudinal and behavioral *** experience research up until now,however,indicates limitations in examining flow's potential mediating role,applying quantitative research methods with customer journey aspects,and analyzing the luxury fashion ***,this paper examines the impact of an effective customer journey design and brand experience on flow and customer loyalty for luxury fashion brands,helping to close these three research *** study builds on existing customer experience research and theories such as the information processing theory of consumer choice,theory of phenomenological perception,and flow theory to devise the conceptual *** quantitative assessment of the hypothesized interrelationships was completed with the computer program IBM AMOS 26,utilizing the structural equation modeling(SEM)*** data(n = 256)was gathered from consumers living in Germany with the help of an online survey created in Uni *** results demonstrate that an effective customer journey design and brand experience are separate but coherent value drivers,simultaneously influencing customer behavior *** that sense,both customer experience latent variables positively affect customer loyalty directly and indirectly via flow in the luxury fashion ***,the findings illustrate flow's partial mediating role between both customer experience components and customer *** paper offers new theoretical insights into the emerging customer experience resea

关键词： customer experience flow customer loyalty luxury fashion industry

Adhesion and cellsurface properties of wild species of spore formers against enteric pathogens

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Asian Pacific Journal of Tropical Medicine 2013年第2期6卷 110-114页

作者： Anu P sebastian Keerthi T.R Microbial Biotechnology Lab School of BiosciencesMahatma Gandhi UniversityKottayam-686560India

Objective:To investigate the adhesion potential and cell surface properties against enteric pathogens Salmonella *** para typhi A and Vibrio ***:Adhesion potentials of spore and vegetative phase were studied separately for the *** nature was measured on the basis of affinity towards the *** and coaggregation were studied on the basis of clumping of *** vitro adhesion studies were done on mucous which were prepared from infant child *** production of superior adhesive isolate was confirmed by SEM ***:Spore and vegetative phases of isolates possessed a different rate of adhesion potentials on intestinal mucous,which indicated that cell surface properties were involved in adhesion *** showed a higher hydrophobicity than their vegetative cells which remained less or non *** phases showed capabilities for autoaggregation and *** were found to be more adhesive on intestinal mucous than vegetative *** enteric pathogens Vibrio cholera registered higher adhesion potentials with supporting cell surface *** the five sporeforming isolates,isolate BM-3 possess superior adhesion than enteric pathogens and also exhibited biofilm formation which enhances colonization ***:Spore and vegetative cell phases shows differences in adhesion *** surface properties and adhesion studies reveals that isolate BM-3 can be selected as superior isolate which is capable for biofilm *** short,isolate BM-3 possesses an enhanced adhesion potential than enteric pathogens towards intestinal mucous which is a desirable probiotic character.

关键词： Spore formers Adhesion Aggregation Enteric pathogens

Normalization Using Weighted Negative Second Order Exponential Error Functions(NeONORM) Provides Robustness Against Asym-metries in Comparative Transcriptome Profiles and Avoids False Calls

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Genomics, Proteomics & Bioinformatics 2006年第2期4卷 90-109页

作者： sebastian Noth Guillaume Brysbaert Arndt Benecke Systems Epigenomics Group Institut des Hautes Etudes Scientifiques/Institut de Recherches InterdisciplinairesCNRS/INSERM 91440 Bures sur Yvette France.

Studies on high-throughput global gene expression using microarray technology have generated ever larger amounts of systematic transcriptome data. A major challenge in exploiting these heterogeneous datasets is how to normalize the expression profiles by inter-assay methods. Different non-linear and linear normalization methods have been developed, which essentially rely on the hypothesis that the true or perceived logarithmic fold-change distributions between two different assays are symmetric in nature. However, asymmetric gene expression changes are frequently observed, leading to suboptimal normalization results and in consequence potentially to thousands of false calls. Therefore, we have specifically investigated asymmetric comparative transcriptome profiles and developed the normalization using weighted negative second order exponential error functions （NeONORM） for robust and global inter-assay normalization. NeONORM efficiently damps true gene regulatory events in order to minimize their misleading impact on the norrealization process. We evaluated NeONORM＇s applicability using artificial and true experimental datasets, both of which demonstrated that NeONORM could be systematically applied to inter-assay and inter-condition comparisons.

关键词： microarray statistical analysis normalization asymmetry robustness

Development of Ag-Cu-Zn-Sn brazing filler metals with a 10 weight-% reduction of silver and same liquidus temperature

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China Welding 2014年第4期23卷 25-31页

作者： Daniel Schnee Gunther Wiehl sebastian Starck Chert Kevin Umicore AG & Co. KG Business Unit Technical MaterialsRodenbacher Chaussee 4 63457 Hanau-Wolfgang Germany.

With BrazeTec BlueBraze the manufacturers in HVACR industry have an alternative filler metal with 10 weight-% less silver but same brazing temperatures. The performance of these new alloys has been evaluated in several tests. The evaluation included wetting investigations, metallographic examinations, joint strength at different temperatures and pulsation and corrosion resistance. The results of these tests will be presented in this paper.

关键词： silver brazing filler metal shear strength corrosion

Patterning inconsistencies restrict the true potential of dopaminergic neurons derived from human induced pluripotent stem cells

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Neural Regeneration Research 2021年第4期16卷 692-693页

作者： Sameehan Mahajani Mathias Bähr sebastian Kügler Department of Neurology University Medical Center GöttingenGöttingenGermany Center for Nanoscale Microscopy and Molecular Physiology of the Brain at Department of Neurology University Medical Center GöttingenGöttingenGermany Department of Pathology Stanford University School of MedicineStanfordCAUSA

Human induced pluripotent stem cells(hiPSCs)are multipotent stem cells genetically reprogrammed using transcription factors,such as Sox2,c-Myc,Oct3/4 and Klf4(Takahashi and Yamanaka,2006)from fibroblasts,derived from either patient or control *** factors are highly expressed in embryonic stem cells,and their overexpression can induce pluripotency in human somatic cells such as *** the generation of hiPSCs after reprogramming,these cells can be further differentiated into multiple neuronal cell types by using a strictly designed *** process is known as *** use of these hiPSCs derived neurons holds immense potential for researchers to uncover the underpinnings of disease pathophysiology and therefore is considered as a powerful tool.

关键词： potential restrict holds