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Doppler Effect: A Look from Biology Aging

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Advances in Aging Research 2024年第4期13卷 75-84页

作者： Jorge Barragán sebastián Sánchez Department of Histology Universidad del Gran Rosario Rosario Argentina

The Doppler effect can be defined as the frequency shift suffered by a wave phenomenon, when there is a difference in relative speed between the waves generated and their source. We know that it occurs in the case of mechanical and electromagnetic waves. We propose to generalize the Doppler effect to the case of frequency changes of certain oscillatory variables in biology before and after puberty, starting from the basis that a metabolically accelerated system is equivalent to a mechanically accelerated system. We then established the following objectives: To verify if there is an average difference in heart and respiratory rates, before and after puberty. To verify the association of these frequency differences with the metabolic activity estimated as basal metabolic rate or BMR. We studied heart and respiratory rate data from healthy people of both sexes, verifying the frequency distribution before and after puberty. We also study the relationship of the frequency distribution with the evolution of the basal metabolic rate throughout life. Analysis of the results shows that the highest heart and respiratory rates occur before puberty, while the lowest rates occur after puberty. A high correlation of the evolution of the variables studied with the evolution of the metabolic acceleration of the system throughout life is also evident. Taking into account that a mechanically accelerated system is equivalent to a metabolically accelerated system, we can conclude that the frequency distribution found is the expression of a generalization of the Doppler effect in the case of biological physical systems.

关键词： Oscillatory Variables Metabolic Acceleration Mechanical Acceleration Equivalence Principle non-Inertial System Rate of Change

About the Thermodynamics and Aging of Self-Organizing Systems

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Advances in Aging Research 2023年第4期12卷 56-66页

作者： Jorge Barragán sebastián Sánchez Department of Histology Universidad del Gran Rosario Rosario Argentina

We know that the total daily energy dissipation increases in complex organisms like the humans. It’s very probable that this increase in total energy dissipation is related to the progressive increase in mass. But we also know that day by day the dissipation of energy per unit mass decreases in these organisms. We intend to verify if this decrease is only an expression of the second law of thermodynamics, or if it is related to the increase in mass that occurs in these organisms. For this, we set ourselves the following objectives: verify the correlation between total energy dissipation and the evolution of body mass, and verify the correlation between the dissipation of energy per unit of mass and the evolution of body mass. As a result of the data analysis, we found a high degree of correlation between total energy dissipation and the evolution of body mass. And we also found a high correlation between the energy dissipated per unit of mass and the evolution of body mass. We can conclude that self-organization produces not only an increase in mass, but also a decline in energy dissipation per unit mass beyond what is expected by the second law of thermodynamics.

关键词： Body Mass Energy Dissipation neutral Operator Structural Geometry Information Density Inertial Systems non-Inertial Systems

Tumor necrosis family receptor superfamily member 9/tumor necrosis factor receptor-associated f

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World Journal of Hepatology 2020年第10期12卷 754-765页

作者： Julia peña-Asensio Eduardo Sanz-de-Villalobos Joaquín Miquel Juan Ramón Larrubia Department of Systems Biology Guadalajara University Hospital.University of AlcaláGuadalajara E-19002GuadalajaraSpain Translational Hepatology Unit Guadalajara University HospitalUniversity of AlcaláGuadalajara E-19002GuadalajaraSpain

Hepatitis C virus(HCV)infection is an excellent immunological model for understanding the mechanisms developed by non-cytopathic viruses and tumors to evade the adaptative immune *** antigen-specific cytotoxic T cell response is essential for keeping HCV under control,but during persistent infection,these cells become exhausted or even *** exhaustion process is progressive and depends on the infection duration and level of *** high antigenic load and long duration of infection,T cells become extremely exhausted and ultimately disappear due to *** development of exhaustion involves the impairment of positive co-stimulation induced by regulatory cytokines,such as transforming growth factor beta *** cytokine downregulates tumor necrosis factor receptor(TnFR)-associated factor 1(TRAF1),the signal transducer of the T cell co-stimulatory molecule TnFR superfamily member 9(known as 4-1BB).This impairment correlates with the low reactivity of T cells and an exhaustion *** with interleukin-7 in vitro restores TRAF1 expression and rescues T cell effector *** process of TRAF1 loss and its in vitro recovery is hierarchical,and more affected by severe disease *** conclusion,TRAF1 dynamics on T cells define a new pathogenic model that describes some aspects of the natural history of HCV,and sheds light on novel immunotherapy strategies for chronic viral infections and cancer.

关键词： Hepatitis C virus Tumor necrosis factor receptor-associated factor 1 CD8 Exhaustion Tumor necrosis family receptor superfamily member 9 Chronic hepatitis

Early Paleozoic accretionary orogens along the Western Gondwana margin

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Geoscience Frontiers 2021年第1期12卷 109-130页

作者： sebastián Oriolo Bernhard Schulz Silvana Geuna Pablo DGonzález Juan E.Otamendi JiíSláma Elena Druguet Siegfried Siegesmund COnICET-Universidad de Buenos Aires Instituto de Geociencias BasicasAplicadas y Ambientales de Buenos Aires(IGEBA)Intendente Güiraldes 2160C1428EHABuenos AiresArgentina Institute of Mineralogy Division of Economic Geology and PetrologyTU Bergakademie FreibergBrennhausgasse 14D-09596FreibergSaxonyGermany Instituto de Investigacion en Paleobiología y Geología(UnRn-COnICET) Avenida Julio A.Roca 1242R8332EXZGeneral RocaArgentina COnICET Departamento de GeologíaUniversidad Nacional de Río CuartoCampus UniversitarioX5804BYARío CuartoArgentina Institute of Geology The Czech Academy of SciencesRozvojova 269CZ-16500Prague 6Czech Republic Departament de Geologia Universitat Autonoma de Barcelona08193BellaterraBarcelonaSpain Geoscience Centre Georg-August-Universit€at G€ottingenGoldschmidtstraße 337077GottingenGermany

Early Paleozoic accretionary orogens dominated the Western Gondwana margin and were characterized by nearly continuous subduction associated with crustal extension and back-arc basin *** southwestern margin is represented by Famatinian and Pampean basement realms exposed in South America,both related to the protracted Paleozoic evolution of the Terra Australis Orogen,whereas the northwestern margin is mainly recorded in Cadomian domains of Europe and adjacent ***,no clear relationships between these regions were so far *** on a compilation and reevaluation of geological,paleomagnetic,petrological,geochronological and isotopic evidence,this contribution focuses on crustal-scale tectonic and geodynamic processes occurring in Western Gondwana accretionary orogens,aiming at disentangling their common Early Paleozoic *** show that accretionary orogens were dominated by high-temperature/lowpressure metamorphism and relatively high geothermal gradients,resulting from the development of extended/hyperextended margins and bulk transtensional *** this sense,retreating-mode accretionary orogens characterized the Early Paleozoic Gondwana margin,though short-lived pulses of compression/transpression also *** existence of retreating subduction zones favoured mantle-derived magmatism and mixing with relatively young(meta)sedimentary sources in a thin continental *** reworking of previous forearc sequences due to trenchward arc migration thus took place through assimilation and anatexis in the arc/back-arc ***,retreating-mode accretionary orogens were the locus of Early Paleozoic crustal growth in Western Gondwana,intimately associated with major flare-up events,such as those related to the Cadomian and Famatian *** roll back,probably resulting from decreasing convergence rates and plate velocities after Gondwana assembly,was a key factor for orogen-scale geodynamic ***

关键词： Retreating accretionary orogen Lower Paleozoic Crustal growth Hf isotopic array Famatinian Cadomian

Avian-power line interactions in the Gobi Desert of Mongolia:are mitigation actions effective?

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Avian Research 2021年第3期12卷 382-390页

作者： Adrian Orihuela-Torres Juan MPérez-García Zebensui Morales-Reyes Lara naves-Alegre JoséASánchez-Zapata Esther sebastián-González Área de Ecología Departamento de Biología AplicadaUniversidad Miguel Hernández de ElcheAvda.Universidad s/n03202 ElcheAlicanteSpain Departamento de Ecología Universidad de AlicanteCtra.San Vicente del Raspeig s/n03690 San Vicente del RaspeigAlicanteSpain

Background:Electrocution and collisions on power lines are among the leading causes of non-natural mortality for *** lines are exponentially increasing,particularly in developing countries,but mitigation strategies to prevent bird mortality are *** combines a recently increased power line network,an abundant raptor population,a dangerous crossarm configuration and a habitat with no natural perches,producing many bird-power line *** aim is to assess the bird mortality caused by power lines in the Gobi Desert of Mongolia,to determine the factors increasing the risk of bird electrocution,and to evaluate the effectiveness of used retrofitting ***:In July 2019 we covered 132.9 km of 15 kV power lines checking 1092 *** also conducted bird tran-sects to record raptor and corvid richness and abundance,to assess species vulnerability to ***:We recorded 76 electrocuted birds of 7 *** rate was 6.96 birds/100 *** most affected species were Common Raven(Corvus corax)and Upland Buzzard(Buteo hemilasius),highlighting the electro-cution of 5 endangered Saker Falcons(Falco cherrug).By contrast,we only recorded 8 individuals of 5 species collid-ing with wires,the most affected being Pallas’s Sandgrouse(Syrrhaptes paradoxus).About 76.1%of sampled poles had some mitigation *** these,96.6%were brush perch deflectors and 3.4%rotating-mirrors perch *** found differences in electrocution rates among crossarm configurations,with the strain insulator with one jumper being the most ***,we found no correlation between bird abundance and electrocution rates,suggesting that some species are more sensitive to *** no differences in total bird electrocu-tion rates were detected between poles with and without perch deterrents,when bird size is considered,deterrents reduced the mortality rate of small birds,while they were ineffective for medium-sized

关键词： Collision Crossarm configuration Electrocution Electric infrastructures perch deterrent Power line network Raptor

Probabilistic Seismic Risk Assessment in Manizales,Colombia: Quantifying Losses for Insurance Purposes

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International Journal of Disaster Risk Science 2017年第3期8卷 296-307页

作者： Mario A. Salgado-Gálvez Gabriel A. Bernal Daniela Zuloaga Mabel C. Marulanda Omar-Darío Cardona sebastián Henao Centre Internacional de Metodes numerics en Enginyeria(CIMnE) 08034 BarcelonaSpain InGEnIAR Ltda. BogotaD.C.110221Colombia Instituto de Estudios Ambientales(IDEA) Universidad Nacional de Colombia Sede ManizalesManizales 170004Colombia Universidad nacional de Colombia Sede Manizales Manizales 170004Colombia

A fully probabilistic seismic risk assessment was developed in Manizales, Colombia, considering assets of different types. The first type includes elements that are part of the water and sewage network, and the second type includes public and private buildings. This assessment required the development of a probabilistic seismic hazard analysis that accounts for the dynamic soil response,assembling high resolution exposure databases, and the development of damage models for different types of elements. The economic appraisal of the exposed assets was developed together with specialists of the water utilities company of Manizales and the city administration. The risk assessment was performed using several Comprehensive Approach to Probabilistic Risk Assessment modules as well as the R-System, obtaining results in terms of traditional metrics such as loss exceedance curve, average annual loss, and probable maximum loss. For the case of pipelines, repair rates were also estimated. The results for the water and sewage network were used in activities related to the expansion and maintenance strategies, as well as for the exploration of financial retention and transfer alternatives using insurance schemes based on technical,probabilistic, and prospective damage and loss *** the case of the buildings, the results were used in the update of the technical premium values of the existing collective insurance scheme.

关键词： CAPRA Earthquake insurance Manizales (Colombia) Probabilistic seismic risk assessment Risk retention and transfer

Work-family Interfase and Job performance: Job Satisfaction as Mediator

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Journal of Psychological Research 2019年第2期1卷 36-44页

作者： sebastián Gabini Solana Salessi Consejo nacional de Investigaciones Científicas y Técnicas Argentina Universidad Abierta Interamericana Facultad de Psicología y Relaciones HumanasArgentina Universidad Católica Argentina Facultad de Derecho y Ciencias Sociales del RosarioArgentina

The objective of the study was to examine the relationships between work-family interfase,job satisfaction and job performance in an Argentinian workers sample.A cross-sectional empirical study,based on explicative-associative strategy was *** availability sample of 383 workers(195 male)from different kinds of organizations was *** on past evidence,it was hypothesized the mediator role of job *** equation analysis showed that the indirect effects of work-family interfase dimensions(conflict and enrichment)on job performance through job satisfaction were statically significant,which indicated partial *** variables explained 72%of job performance *** study provides new evidence regarding the interrelations between job-family articulation and individual job performance,illuminating the crucial role played by *** findings and practical implications of the study are discussed.

关键词： Work-family enrichment Work-family conflict Job satisfaction Job performance Explicative model

Do biometric payment systems work during the COVID-19 pandemic?Insights from the Spanish users’viewpoint

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Financial Innovation 2022年第1期8卷 770-794页

作者： Francisco Liébana-Cabanillas Francisco Muñoz-Leiva sebastián Molinillo Elena Higueras-Castillo Department of Marketing and Market Research Faculty of Economics and Business AdministrationUniversity of Granada18011 GranadaSpain Faculty of Economics and Business Department of Business ManagementUniversity of MálagaCampus El Ejido29013 MálagaSpain

Technological developments are changing how users pay for goods and *** the context of the COVID-19(coronavirus disease 2019)pandemic,new payment systems have been established to reduce contact between buyer and *** addition to the pandemic,the future is payment processing is also uncertain due to the new EU security regulations of the Payment Services Directive(PSD2).Biometric payments one option that would guarantee the security of transactions and reduce the risk of *** research analyses the intention to recommend the use of the mobile phone as a tool for collecting payments in a shop using iris reading as a biometric measure of the *** moderating effect of the fear of contagion in the proposed relationships was also *** online survey was carried out,which yielded a sample of 368 *** results indicate that the main antecedents of intention to use,which precedes intention to recommend,are perceived trust,habit,personal innovativeness and comfort of ***,the moderating effect of COVID-19 was checked among users with a higher perception of *** results obtained have interesting implications for purchase management among manufacturers and retailers.

关键词： Biometric payment systems Intention to recommend COVID-19 Fear

Poor performance of anti-mitochondrial antibodies for the diagnosis of primary biliary cholangitis in female Colombian patients:A singlecenter study

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World Journal of Gastroenterology 2021年第29期27卷 4890-4899页

作者： Valentina Guatibonza-García Paula Valentina Gaete Agustín Pérez-Londoño Danna Kathalina Puerto-Baracaldo sebastián Antonio Gutiérrez-Romero Carlos O Mendivil Monica Tapias School of Medicine Universidad de los AndesBogotá110111Colombia Section of Endocrinology Department of Internal MedicineFundación Santa Fe de BogotáBogotá110111Colombia Department of Hepatology Fundación Santa Fe de BogotáBogotá110111Colombia

BACKGROUnD Primary biliary cholangitis(PBC)is a serious disease that causes significant *** is confirmed with liver biopsy but autoantibodies are frequently used as proxies for *** performance of autoantibodies for the diagnosis of PBC seems to vary widely across *** To assess the diagnostic performance of several autoantibodies for the diagnosis of PBC in Latin American *** We studied 85 female adult Colombians,43 cases with biopsy-confirmed PBC and 42 controls in whom a liver biopsy ruled out *** anti-mitochondrial antibodies(AMAs),anti-smooth muscle antibodies(ASMAs)and anti-nuclear antibodies(AnAs),as well as total immunoglobulin(Ig)M and IgG were determined using immunofluorescence or enzyme-linked immunosorbent assay in all study participants within 1 year of the *** all variables,values analyzed were those closest to the date of the *** with viral or alcoholic hepatitis were *** Mean age at diagnosis was 58.7 years for cases and 56.9 years for controls,and the body mass index was lower among *** cases received ursodeoxycholic acid,while most controls received vitamin ***ögren syndrome and Hashimoto’s thyroiditis were the most frequent autoimmune comorbidities of *** prevalence of AMA positivity among PBC cases was unexpectedly *** sensitivity and specificity values were respectively 44.2%and 76.2%for AMA,74.4%and 38.1%for AnA,14.0%and 73.8%for ASMA,26.7%and 80.0%for IgG,and 57.1%and 85.7%for *** combination of positive AMA plus positive IgM had 91%positive predictive value for *** AMA-negative cases,the most prevalent antibodies were AnA(87.5%).In all,62%of AMA-positive and 84.6%of IgM-positive individuals had fibrosis in their *** AMA positivity was very low among female Latin American patients with *** performance of all antibodies was quite *** results highlight the urgent need for better PBC biomarkers.

关键词： Primary biliary cholangitis Antibodies Anti-mitochondrial antibodies Latin America Anti-smooth muscle antibodies