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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang Daniel Fu Alison n.DeVore Marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

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Beyond Biological Aging: Table Analysis

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Advances in Aging Research 2022年第2期11卷 27-34页

作者： Jorge Barragán sebastián Sánchez Universidad del Gran Rosario Rosario Argentina

Keeping in mind the relationship between the basal metabolic rate and the change in weight in the aging process, we propose to verify the holographic description of the same. For this we set ourselves the following objectives: Verify the correlation between total energy dissipation and energy dissipation per unit body mass, and verify the correlation between the total energy dissipation and the body mass. As a result of the data analysis, we obtained a coherent representation of our proposal. A high degree of correlation between the total energy dissipation in an organism and the basal metabolic rate/dry kg was found. Such a condition implies that the stated biological system satisfies the Holographic Principle.

关键词： Basal Metabolic Rate Body Weight Energy Dissipation Geometric Phase Information Density Relative Surface Structural Geometry

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Work-family Interfase and Job Performance: Job Satisfaction as Mediator

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Journal of Psychological Research 2019年第2期1卷 36-44页

作者： sebastián Gabini Solana Salessi Consejo nacional de Investigaciones Científicas y Técnicas Argentina Universidad Abierta Interamericana Facultad de Psicología y Relaciones HumanasArgentina Universidad Católica Argentina Facultad de Derecho y Ciencias Sociales del RosarioArgentina

The objective of the study was to examine the relationships between work-family interfase,job satisfaction and job performance in an Argentinian workers sample.A cross-sectional empirical study,based on explicative-associative strategy was *** availability sample of 383 workers(195 male)from different kinds of organizations was *** on past evidence,it was hypothesized the mediator role of job *** equation analysis showed that the indirect effects of work-family interfase dimensions(conflict and enrichment)on job performance through job satisfaction were statically significant,which indicated partial *** variables explained 72%of job performance *** study provides new evidence regarding the interrelations between job-family articulation and individual job performance,illuminating the crucial role played by *** findings and practical implications of the study are discussed.

关键词： Work-family enrichment Work-family conflict Job satisfaction Job performance Explicative model

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Do biometric payment systems work during the COVID-19 pandemic?Insights from the Spanish users’viewpoint

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Financial Innovation 2022年第1期8卷 770-794页

作者： Francisco Liébana-Cabanillas Francisco Muñoz-Leiva sebastián Molinillo Elena Higueras-Castillo Department of Marketing and Market Research Faculty of Economics and Business AdministrationUniversity of Granada18011 GranadaSpain Faculty of Economics and Business Department of Business ManagementUniversity of MálagaCampus El Ejido29013 MálagaSpain

Technological developments are changing how users pay for goods and *** the context of the COVID-19(coronavirus disease 2019)pandemic,new payment systems have been established to reduce contact between buyer and *** addition to the pandemic,the future is payment processing is also uncertain due to the new EU security regulations of the Payment Services Directive(PSD2).Biometric payments one option that would guarantee the security of transactions and reduce the risk of *** research analyses the intention to recommend the use of the mobile phone as a tool for collecting payments in a shop using iris reading as a biometric measure of the *** moderating effect of the fear of contagion in the proposed relationships was also *** online survey was carried out,which yielded a sample of 368 *** results indicate that the main antecedents of intention to use,which precedes intention to recommend,are perceived trust,habit,personal innovativeness and comfort of ***,the moderating effect of COVID-19 was checked among users with a higher perception of *** results obtained have interesting implications for purchase management among manufacturers and retailers.

关键词： Biometric payment systems Intention to recommend COVID-19 Fear

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Aging and Biological Oscillation: A Question of Geometry

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Advances in Aging Research 2023年第1期12卷 1-9页

作者： Jorge Barragán sebastián Sánchez Histology Universidad del Gran Rosario Rosario Argentina

Previous studies in different ethnic groups show changes in heart rate, respiratory rate, cortisol cycle, and sleep-wake cycle throughout life. Our purpose is to verify such changes by comparing the values of each variable before and after puberty. Puberty is associated with the end of growth and is an important point in our theoretical framework: when growth ends, changes occur in the geometry of the biological system. At the same time, this causes phase changes in the oscillatory variables, which are seen as chronodisruption. The results confirm the changes found by other authors in the evolution of the variables throughout life. Then, we can conclude that the variables studied present phase changes when growth ends, in accordance with the proposed theoretical framework.

关键词： Chronodisruption Phase Changes Geometry Changes After Puberty Wave Function Order-Chaos Transition Information Density Limit

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Doppler Effect: A Look from Biology Aging

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Advances in Aging Research 2024年第4期13卷 75-84页

作者： Jorge Barragán sebastián Sánchez Department of Histology Universidad del Gran Rosario Rosario Argentina

The Doppler effect can be defined as the frequency shift suffered by a wave phenomenon, when there is a difference in relative speed between the waves generated and their source. We know that it occurs in the case of mechanical and electromagnetic waves. We propose to generalize the Doppler effect to the case of frequency changes of certain oscillatory variables in biology before and after puberty, starting from the basis that a metabolically accelerated system is equivalent to a mechanically accelerated system. We then established the following objectives: To verify if there is an average difference in heart and respiratory rates, before and after puberty. To verify the association of these frequency differences with the metabolic activity estimated as basal metabolic rate or BMR. We studied heart and respiratory rate data from healthy people of both sexes, verifying the frequency distribution before and after puberty. We also study the relationship of the frequency distribution with the evolution of the basal metabolic rate throughout life. Analysis of the results shows that the highest heart and respiratory rates occur before puberty, while the lowest rates occur after puberty. A high correlation of the evolution of the variables studied with the evolution of the metabolic acceleration of the system throughout life is also evident. Taking into account that a mechanically accelerated system is equivalent to a metabolically accelerated system, we can conclude that the frequency distribution found is the expression of a generalization of the Doppler effect in the case of biological physical systems.

关键词： Oscillatory Variables Metabolic Acceleration Mechanical Acceleration Equivalence Principle non-Inertial System Rate of Change

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About the Thermodynamics and Aging of Self-Organizing Systems

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Advances in Aging Research 2023年第4期12卷 56-66页

作者： Jorge Barragán sebastián Sánchez Department of Histology Universidad del Gran Rosario Rosario Argentina

We know that the total daily energy dissipation increases in complex organisms like the humans. It’s very probable that this increase in total energy dissipation is related to the progressive increase in mass. But we also know that day by day the dissipation of energy per unit mass decreases in these organisms. We intend to verify if this decrease is only an expression of the second law of thermodynamics, or if it is related to the increase in mass that occurs in these organisms. For this, we set ourselves the following objectives: verify the correlation between total energy dissipation and the evolution of body mass, and verify the correlation between the dissipation of energy per unit of mass and the evolution of body mass. As a result of the data analysis, we found a high degree of correlation between total energy dissipation and the evolution of body mass. And we also found a high correlation between the energy dissipated per unit of mass and the evolution of body mass. We can conclude that self-organization produces not only an increase in mass, but also a decline in energy dissipation per unit mass beyond what is expected by the second law of thermodynamics.

关键词： Body Mass Energy Dissipation neutral Operator Structural Geometry Information Density Inertial Systems non-Inertial Systems

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Sodium-glucose cotransporter-2 inhibitors protect tissues via cellular and mitochondrial pathways:Experimental and clinical evidence

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World Journal of Experimental Medicine 2024年第2期14卷 46-52页

作者： Raúl Lelio Sanz sebastián García Menéndez Felipe Inserra Leon Ferder Walter Manucha Department of Pathology Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendoza 5500Argentina Department of Pharmacology Instituto de Medicina y Biología Experimental de CuyoCentro Científico TecnológicoMendoza 5500Argentina Department of nephrology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina Department of Cardiology Universidad de MaimónidesCiudad Autónoma de Buenos Aires C1405Argentina

Mitochondrial dysfunction is a key driver of cardiovascular disease(CVD)in metabolic syndrome and *** dysfunction promotes the production of reactive oxygen species(ROS),which cause oxidative stress and *** II,the main mediator of the renin-angiotensin-aldosterone system,also contributes to CVD by promoting ROS *** activity of sirtuins(SIRTs),a family of proteins that regulate cellular metabolism,also worsens oxidative *** of energy production by mitochondria is a common feature of all metabolic *** SIRT levels and 5’adenosine monophosphate-activated protein kinase signaling stimulate hypoxia-inducible factor 1 beta,which promotes ***,in turn,increases autophagy and mitophagy,processes that clear cells of debris and protect against *** cotransporter-2 inhibitors(SGLT2i),a class of drugs used to treat type 2 diabetes,have a beneficial effect on these *** clinical trials have shown that SGLT2i improves cardiac function and reduces the rate of cardiovascular and renal ***2i also increase mitochondrial efficiency,reduce oxidative stress and inflammation,and strengthen *** findings suggest that SGLT2i hold great potential for the treatment of ***,they are proposed as anti-aging drugs;however,rigorous research is needed to validate these preliminary findings.

关键词： Sodium-glucose cotransporter-2 inhibitors Cardiovascular diseases Sirtuins Oxidative stress Inflammation Mitochondrial dysfunction

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Functional strategies and distribution of climbing plant communities in different vegetation patches in a subtropical dry forest, central Argentina

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Journal of Plant Ecology 2019年第1期12卷 23-33页

作者： María Cecilia Ferrero sebastián R.Zeballos Juan I.Whitworth-Hulse Melisa A.Giorgis Diego E.Gurvich Instituto Multidisciplinario de Biología Vegetal CONICET-Universidad Nacional de CórdobaAv.Vélez Sársfield 1611CP X5016ZAACórdobaArgentina Facultad de Ciencias Exactas Físicas y NaturalesUniversidad Nacional de CórdobaAv.Vélez Sársfield 299CP X5000JJCCórdobaArgentina

Aims In the context of global change,the impacts of forest structure alter-ation on climbing plants in extra-tropical ecosystems are poorly *** also remains little explored,the functional strategies among climbing plant species and its relationship with the local-scale distribution of climbing plant ***,we aimed at three goals:(i)we studied how climbing plant community com-position responds to the modification of the original forest structure in a subtropical dry forest;(ii)we characterized climbing plant spe-cies according to functional traits related to the acquisition and use of resources;and(iii)we examined whether functional strategies at the community level are also responding to vegetation structure change,a much less addressed topic in the ecology of climbing *** The study was carried out in the Chaco forest of Córdoba Mountains,central *** selected 18 patches of‘native forests’,‘shrublands’and‘Ligustrum lucidum forests’.We counted and identified climbing plant individuals in each patch,including woody and herbaceous *** each spe-cies,we measured 10 functional traits:leaf area,leaf area ratio,leaf dry matter content,leaf tensile strength,specific leaf area,stem density,wood saturated water content,inter-node length,petiole length and plant *** compared climbing plant composition,richness and abundance among the three vegeta-tion ***,we assessed trends of functional variation of climbing plant species by performing a principal component ***,we investigated whether simple mean,weighted mean and Functional Richness index of principal component analysis(PCA)axes differed among the climbing plant communi-ties of the three vegetation *** Findings Multivariate analysis revealed that climbing plant composition of native forests significantly differed from that of shrublands and *** ***,*** forests had the lowest climb-ing plant species *** var

关键词： vines functional traits Chaco Serrano climbing plant species richness community weighted means

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Study of polygalacturonase production by an Antarctic yeast and obtention of dragon fruit juice by maceration at mild temperature

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Food Bioscience 2022年第5期49卷 893-903页

作者： Brenda Bezus Juan Carlos Contreras Esquivel sebasti´an Cavalitto Ivana Cavello Centro de Investigaci´on y Desarrollo en Fermentaciones Industriales(CInDEFI UNLPCCT-La PlataCONICET)Calle 47 y 115B1900ASHLa PlataProvincia de Buenos AiresArgentina Laboratory of Applied Glycobiotechnology Academic Group of Food Science and TechnologySchool of ChemistryUniversidad Autonoma de CoahuilaUnidad SaltilloSaltillo2528CoahuilaMexico

The objectives of the present survey were to study the production and the biochemical characterization of an enzymatic cold-active extract with polygalacturonase activity,to perform a first insight into its possible application in fruit-juice obtention process,and to use this juice for food products *** enzymatic extract was produced by the Antarctic yeast Mrakia *** January 7,2016 in a bioreactor with citric pectin as *** polygalacturonase activity showed optimum conditions for reaction at 45◦C and pH *** activity was stable until 40◦C but deactivated at higher *** by Hg+2 suggested the presence of a thiol-dependent enzyme.A high-molecular polygalacturonase was detected in an SDS-PAGE and zymography ***-products were observed by thin-layer chromatography and suggested the endo-mode of *** enzymatic extract had some accessory enzymes,such as pectin methylesterase,β-glucosidase,cellulase and *** a first insight into the potential use of this enzymatic extract for fruit maceration at mild temperatures,red and white dragon fruits were selected as *** 23◦C,juice yields of 15%-23%higher than control were obtained after treatments,with a decrease of remanent solid of 25%-35%.The color of red dragon fruit juice increased with enzymatic *** balls that were prepared with the juices demonstrated a hardness of~10 *** compression force of low-calorie sugar gels was 3.8 *** work provided a complete study of the production,characterization,application and food product production using a new cold-active polygalacturonase extract of Antarctic origin.

关键词： Antarctic enzymes Cold active pectinases Mrakia sp Hylocereus monacanthus Hylocereus undatus

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