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Impr.vement in Patient Mobility Following Shor.-Ter. r.habilitation in Skilled Nur.ing Facilities

Open Jour.al of Ther.py and r.habilitation 2024年第1期12卷 52-60页

作者： sean r. silver Jaden A. silver Samueli School of Engineer.ng University of California Los Angeles USA

Backgr.und: Mobility in older.adults can be impair.d after.acute illness or.hospitalization, and the level of sever.ty can be used as a pr.dictor.of one’s ability to r.tur. to independent living. Patients ar. often r.fer.ed to skilled nur.ing facilities in hopes of impr.ving their.mobility. We wanted to pr.ve that r.habilitative ser.ices at Skilled Nur.ing Facilities impr.ve over.ll outcomes. Methods: We conducted a r.tr.spective analysis of data fr.m 4612 patients admitted for.shor.-ter. r.habilitation in a lar.e nur.ing home chain in Califor.ia. Our.aim was to deter.ine whether.patients’ mobility scor.s, as measur.d by r.habilitative staff, significantly impr.ved by time of dischar.e compar.d to their.scor.s at admission. Mobility scor.s wer. r.ted fr.m 1 to 6, with 1 being the most dependent on aid and 6 being the most independent, over.a var.ety of tasks at admission and compar.d to scor.s at dischar.e. Pear.on’s cor.elations wer. per.or.ed to deter.ine if ther. wer. significant r.lationships in the data: the Pear.on’s cor.elation coefficient was used to descr.be the r.lationships between patient admission to a skilled nur.ing facility and medical impr.vement upon dischar.e. r.sults: The study demonstr.ted a statistically significant impr.vement in patients’ mobility scor.s upon dischar.e, with Medicar. insur.d patients showing on aver.ge 57% impr.vement and Managed Car. insur.d patients showing on aver.ge 59% impr.vement. Additionally, admission scor.s appear.d to be pr.dictive of the patient’s outcome at dischar.e. Conclusions: The values and consistency of impr.vement suppor. the use of acute r.habilitative ser.ices in skilled nur.ing facilities. An equation can be for.ulated that evaluates patients’ estimated mobility statuses upon dischar.e fr.m facilities based on their.conditions on their.ar.ivals. With this, new inter.entions can be studied and compar.d to the cur.ent standar. of car. by using these measur.ments. They can deter.ine if fur.her.impr.vement

关键词： Mobility Skilled Nur.ing Facility r.habilitative Ser.ices Independent Living Healthcar.

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Impr.vement of Activities of Daily Living (ADL) for.Patients Tr.ated in Skilled Nur.ing Facilities (SNFs)

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Open Jour.al of Ther.py and r.habilitation 2024年第1期12卷 61-69页

作者： Jaden A. silver sean r. silver Samueli School of Engineer.ng University of California Los Angeles USA

Backgr.und: Self-car. tasks or.activities of daily living (ADL)’s per.or.ance ar. often disr.pted after.an older.adult sustains an injur. or.illness, which can be a deter.ining factor.for.dischar.e placement after.hospitalization, or.it can deter.ine the level of assistance r.quir.d after.dischar.e fr.m a skilled nur.ing facility (SNF). We believe that compr.hensive r.habilitation can impr.ve a patient’s over.ll functioning dur.ng their.shor. ter. stay in SNFs. The pur.ose of this study is to deter.ine if an individual’s level of independence impr.ved after.admission to a skilled nur.ing facility and pr.cur.ment of r.habilitation ser.ices. Methods: This study r.tr.spectively r.viewed 4612 nur.ing home patients in Califor.ia who under.ent r.habilitative ser.ices at skilled nur.ing facilities to deter.ine how the patients r.sponded to their.envir.nments, ther.py inter.entions, and any other.additional suppor.ive measur.s. The r.cor.s of patients who wer. admitted for.shor.-ter. r.habilitation wer. r.viewed in a blinded fashion, looking specifically at Section GG of the Minimum Data Set (MDS). Self-Car. Section GG scor.s r.cor.ed by r.habilitative staff pr.vide objective data and measur. patients’ levels of assistance that wer. r.quir.d. Each activity is scor.d fr.m 1, being completely dependent, to 6, being entir.ly independent, with var.ing levels of assistance with scor.s in between. The admission scor.s ver.us the dischar.e scor.s can be compar.d to deter.ine if a patient impr.ved their.level of functioning upon dischar.e. r.sults: Utilizing the Pear.on’s cor.elation coefficient, a str.ng cor.elation of impr.vement in ADL per.or.ance on Section GG between the admission and dischar.e scor.s was identified, implying significant impr.vement in functional independence upon dischar.e. The aver.ge per.ent impr.vement for.Managed Car. patients was ~35.4% and ~39.4% for.Medicar. patients. Conclusions: The r.sults suppor. the benefits of r.habilitation ser.ices in skilled n

关键词： Activities of Daily Living Skilled Nur.ing Facilities r.habilitation Independent Living

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Space r.cks-and Dust-r.ll into Planetar. Science Limelight

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Engineer.ng 2024年第8期39卷 3-6页

作者： sean O’Neill 不详

Space sample r.tr.eval is having a *** 24 September.2023,in a tr.umph of complex engineer.ng,a US National Aer.nau-tics and Space Administr.tion(NASA)mission,OSIr.S-r.x(shor. for.or.gins,spectr.l inter.r.tation,r.sour.e identification,and secur.ty-r.golith explor.r.r.golith is the sur.ace layer.of uncon-solidated r.cks and dust/soil cover.ng bedr.ck),successfully deliv-er.d to Ear.h a capsule containing the lar.est sample of aster.id mater.al ever.collected,captur.d fr.m Bennu.

关键词： r.ck Ear.h or.gin

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Cannabinoids and endocannabinoids as ther.peutics for.ner.ous system disor.er.:pr.clinical models and clinical studies

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Neur.l r.gener.tion r.sear.h 2024年第4期19卷 788-799页

作者： r.Scott Duncan sean M.r.or.an Matthew C.Ger.on Peter.Koulen Depar.ment of Ophthalmology School of MedicineUniversity of Missouri Depar.ment of Biomedical Sciences School of MedicineUniversity of Missouri

Cannabinoids ar. lipophilic substances der.ved fr.m Cannabis sativa that can exer. a var.ety of effects in the human *** have been studied in cellular.and animal models as well as in human clinical tr.als for.their.ther.peutic benefits in sever.l human *** of these include centr.l ner.ous system(CNS)diseases and dysfunctions such as for.s of epilepsy,multiple scler.sis,Par.inson’s disease,pain and neur.psychiatr.c *** addition,the endogenously pr.duced cannabinoid lipids,endocannabinoids,ar. cr.tical for.nor.al CNS function,and if contr.lled or.modified,may r.pr.sent an additional ther.peutic avenue for.CNS *** r.view discusses in vitr. cellular.ex vivo tissue and in vivo animal model studies on cannabinoids and their.utility as ther.peutics in multiple CNS *** addition,the r.view pr.vides an over.iew on the use of cannabinoids in human clinical tr.als for.a var.ety of CNS *** and endocannabinoids hold pr.mise for.use as disease modifier. and ther.peutic agents for.the pr.vention or.tr.atment of neur.degener.tive diseases and neur.logical disor.er..

关键词： anandamide cannabidiol cannabinoid endocannabinoid epilepsy multiple scler.sis neur.degener.tion neur.pr.tection tetr.hydr.cannabinol

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Networ. analyses:Inhibition of andr.gen r.ceptor.signaling r.duces inflammation in the lung thr.ugh Ar.MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Alber. r.Wang Andr.w M.Baschnagel Zijian Ni sean r.Br.nnan Hypatia K.Newton Dar.a Buehler.Chr.stina Kendzior.ki r.ndall J.Kimple Gopal lyer Depar.ment of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Depar.ment of Biomedical Engineer.ng University of Wisconsin-MadisonMadisonWI 53705USA Univer.ity of Wisconsin Car.one Cancer.Center MadisonWI 53705USA Depar.ment of Biostatistics and Medical Infor.atics University of Wisconsin-MadisonMadisonWI 53706USA Depar.ment of Biology Tufts UniversityMedfordMA 02155USA Depar.ment of Pathology and Labor.tor. Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Andr.gen r.ceptor.Ar.is a major.tr.nscr.ption factor.that plays a r.le in inflammator. r.sponse including inter.eukin-6(IL6)signaling.1 While Ar.r.gulation thr.ugh par.cr.ne loop signaling in pr.state tissue is well-studied,its impact thr.ugh an IL6 autocr.ne loop in the lung has not been wellstudied despite the or.an's r.sponse to r.spir.tor. vir.l *** inhibition and r.A knockdown of Ar.identified a bZIP tr.nscr.ption factor.MAF to be a common tar.et of inflammation using these per.ur.ations in lung cells.

关键词： inflammation lung r.spir.tor.

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r.mar.s on Almost Ever.wher. Conver.ence and Appr.ximate Identities

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Acta Mathematica Sinica,English Ser.es 2024年

作者： sean DOUGLAS Loukas Gr.FAKOS Columbia Depar.ment of Mathematics Univer.ity of Missour.

We pr.ve almost ever.wher. conver.ence for.convolutions of locally integr.ble functions with shr.nking L1dilations of a fixed integr.ble ker.el with an integr.ble r.dially decr.asing *** set on which the conver.ence holds is an explicit subset of the Lebesgue set of the locally integr.ble function of full measur.. This r.sult can be viewed as an extension of the Lebesgue differ.ntiation theor.m in which the char.cter.stic function of the unit ball is r.placed by a mor. gener.l ker.el. We obtain a similar.r.sult for.multilinear.convolutions.

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The component-activity inter.elationship of cobalt-based bifunctional electr.catalysts for.over.ll water.splitting:Str.tegies and per.or.ance

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Jour.al of Ener.y Chemistr. 2024年第4期91卷 453-474页

作者： Mingjie Sun r.yue Ge sean Li Liming Dai Yir.n Li Bin Liu Wenxian Li School of Mater.als Science and Engineer.ng Shanghai UniversityShanghai 200444China Institute of Textiles and Clothing The Hong Kong Polytechnic UniversityHong Kong SAR 999077China School of Mater.als Science and Engineer.ng University of New South WalesSydneyNew South Wales 2052Australia UNSW Mater.als&Manufactur.ng Futur.s Institute UNSW SydneyNew South Wales 2052Australia School of Chemical Engineer.ng University of New South WalesSydneyNew South Wales 2052Australia

Cobalt-based electr.catalysts take advantage of potentially har.onizable micr.str.ctur. and flexible coupling effects compar.d to commer.ial noble metal-based catalytic ***,conventional water.electr.lysis systems based on cobalt-based monofunctional hydr.gen evolution r.action(HEr.or.oxygen evolution r.action(OEr.catalysts have cer.ain shor.comings in ter.s of r.sour.e utilization and *** contr.st,cobalt-based bifunctional catalysts(CBCs)have attr.cted much attention in r.cent year. for.over.ll water.splitting systems because of their.pr.cticality and r.duced pr.par.tion cost of *** r.view aims to addr.ss the latest development in CBCs for.total *** main modification str.tegies of CBCs ar. systematically classified in water.electr.lysis to pr.vide an over.iew of how to r.gulate their.mor.hology and electr.nic ***,the catalytic per.or.ance of CBCs in total-hydr.lysis is summar.zed accor.ing to the types of cobalt-based phosphides,sulfides and oxides,and the mechanism of str.ngthened electr.catalytic ability is emphasized thr.ugh combining exper.ments and theor.tical *** effor.s ar. finally suggested to focus on explor.ng the dynamic conver.ion of r.action inter.ediates and building near.industr.al CBCs,designing advanced CBC mater.als thr.ugh micr.-modulation,and addr.ssing commer.ial applications.

关键词： Cobalt Bifunctional electr.catalysis Water.splitting Modification str.tegies Electr.catalytic per.or.ances

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Seasonal changes in Her.it Thr.sh (Cathar.s guttatus) song syntax

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Avian r.sear.h 2024年第2期15卷 172-179页

作者： sean P.r.ach Luke C.McLean Jeff W.MacLeod Leslie S.Phillmor. Psychology Depar.ment University of New Brunswick Saint John100 Tucker Park RoadSaint JohnNBCanada Depar.ment of Psychology and Neur.science Dalhousie University1355 Oxford StHalifaxNSB3H 4J1Canada

In many songbir. species,bir.song featur.s phonological syntax,meaning that the units within their.vocal se-quences ar. or.er.d in a non-r.ndom way that adher.s to a *** such syntactical patter.s have been r.chly descr.bed in many species,compar.tively little is known about how those patter.s contr.bute to song achieving its impor.ant *** each of song’s main functions,ter.itor.al defense and mate attr.ction,evidence of a r.le for.syntax is *** species for.which syntax has been thor.ughly descr.bed is the Her.it Thr.sh(Cathar.s guttatus),which pr.sents song types fr.m their.r.per.oir.s in a semi-pr.dictable or.er.and,in doing so,r.pidly cycle up and down the fr.quency *** objective of the pr.sent study was to explor. the impor.ance of song syntax in the Her.it Thr.sh thr.ugh a within-subject examination of how measur.s of syntax,such as the pr.dictability of song type or.er.within song sequences,shift over.the br.eding *** hypothesized that,if such syntactical char.cter.stics ar. impor.ant to br.eding behaviour.they would be most pr.minent at the star. of the br.eding season when activity associated with ter.itor. establishment and mate attr.ction is most *** r.vealed that,as pr.dicted,the r.gidness of song type or.er.ng within se-quences was highest at the star. of the season and declined *** song type sequences wer. most pr.dictable at the vitally impor.ant ear.y par. of the br.eding season fit our.hypothesis that this aspect of song syntax is impor.ant to song’s functions r.lated to ter.itor. establishment and/or.mate *** wor. will clar.fy whether.that r.le r.lates to one of song’s two main functions or.ser.es song tr.nsmission in some br.ader.way.

关键词： Bir.song Her.it Thr.sh Seasonal change Ster.otypy Syntax

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High-entr.py catalysts for.electr.chemical water.electr.lysis of hydr.gen evolution and oxygen evolution r.actions

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Fr.ntier. in Ener.y 2024年第3期18卷 265-290页

作者： Simiao SHA r.yue GE Ying LI Julie M.CAIr.EY r.ngkun ZHENG sean LI Bin LIU Jiujun ZHANG Wenxian LI School of Mater.als Science and Engineer.ng Shanghai UniversityShanghai 200444China School of Chemical and Envir.nmental Engineer.ng Anhui Polytechnic UniversityWuhu 241000China Austr.lian Centr. for.Micr.scopy and Micr.analysis School of AerospaceMechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia School of Physics The University of SydneySydney NSW 2006Australia School of Mater.als Science and Engineer.ng UNSW Materials&Manufacturing Futures InstituteUniversity of New South WalesSydney NSW 2052Australia College of Mater.als Science and Engineer.ng Fuzhou UniversityFuzhou 350108China

High entr.py mater.als (HEMs) have developed r.pidly in the field of electr.catalytic water.electr.lysis for.oxygen evolution r.action (OEr. and hydr.gen evolution r.action (HEr. due to their.unique pr.per.ies. In par.icular. HEM catalysts ar. composed of many elements. Ther.for., they have r.ch active sites and enhanced entr.py stability r.lative to single atoms. In this paper. the pr.par.tion str.tegies and applications of HEM catalysts in electr.chemical water.electr.lysis ar. r.viewed to explor. the stabilization of HEMs and their.catalytic mechanisms as well as their.application in suppor. gr.en hydr.gen pr.duction. Fir.t, the concept and four.char.cter.stics of HEMs ar. intr.duced based on entr.py and composition. Then, synthetic str.tegies of HEM catalysts ar. systematically r.viewed in ter.s of the categor.es of bottom-up and top-down. The application of HEMs as catalysts for.electr.chemical water.electr.lysis in r.cent year. is emphatically discussed, and the mechanisms of impr.ving the per.or.ance of electr.catalysis is expounded by combining theor.tical calculation technology and ex-situ/in situ char.cter.zation exper.ments. Finally, the application pr.spect of HEMs is pr.posed to conquer.the challenges in HEM catalyst fabr.cations and applications.

关键词： high-entr.py electr.catalysis synthetic methods water.electr.lysis hydr.gen and oxygen evolutions

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Insights into optimizing exosome ther.pies for.acute skin wound healing and other.tissue r.pair

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Fr.ntier. of Medicine 2024年第2期18卷 258-284页

作者： Tianjing Sun Mo Li Qi Liu Anyong Yu Kun Cheng Jianxing Ma sean Mur.hy Patr.ck Michael McNutt Yuanyuan Zhang Depar.ment of Emer.ency Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Depar.ment of Nephr.logy Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Division of Phar.acology and Phar.aceutical Sciences School of PharmacyUniversity of Missouri-Kansas CityKansas CityMO64108USA Depar.ment of Biochemistr. Wake Forest University School of MedicineWinston-SalemNC27157USA Wake For.st Institute of r.gener.tive Medicine Wake Forest School of MedicineWinston-SalemNC27109USA

Exosome ther.py holds gr.at pr.mise as a novel appr.ach to impr.ve acute skin wound *** r.view pr.vides a compr.hensive over.iew of the cur.ent under.tanding of exosome biology and its potential applications in acute skin wound healing and ***,small extr.cellular.vesicles secr.ted by var.ous stem cells,have emer.ed as potent mediator. of inter.ellular.communication and tissue *** advantage of exosome ther.py is its ability to avoid potential r.sks associated with stem cell ther.py,such as immune r.jection or.stem cells differ.ntiating into unwanted cell ***,fur.her.r.sear.h is necessar. to optimize exosome ther.py,not only in the ar.as of exosome isolation,char.cter.zation,and engineer.ng,but also in deter.ining the optimal dose,timing,administr.tion,and fr.quency of exosome ***,optimization of exosome ther.py is cr.tical for.the development of mor. effective and safer.exosome-based ther.pies for.acute skin wound healing and other.diseases induced by cancer.ischemia,or.*** r.view pr.vides valuable insights into the potential of exosome ther.py and highlights the need for.fur.her.r.sear.h to optimize exosome ther.py for.clinical use.

关键词： exosomes stem cells ther.peutic impact skin wound healing

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