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Advances in microbiology 2014年第8期4卷 484-492页

作者： sean m. Rollins Department of Biology and Chemistry Fitchburg State University Fitchburg USA

T box sequences have been identified upstream of a large number of uncharacterized genes such as transporters in bacterial genomes. Expression of each T box family gene is induced by limitation for a specific amino acid. T box family genes contain an untranslated leader region containing a factor-independent transcriptional terminator upstream of the structural genes. The anticodon of uncharged tRNA base-pairs with the leader mRNA at a codon referred to as the specifier sequence, inducing formation of an alternative antiterminator structure, allowing expression of the structural genes. There are several additional conserved primary sequence and secondary structural elements. Analysis of these elements can be used to predict the identity of the specifier codon and the amino acid signal.?Bacillus subtilis hypothetical amino acid permease, yvbW, was analyzed as an example of this type of transcriptional regulatory prediction suggesting expression in response to leucine limitation. Expression was induced up to 130-fold in response to leucine limitation, utilizing a yvbW-lacZ transcriptional fusion. These data suggest that hypothetical amino acid permease YvbW may participate in leucine metabolism. A yvbW knockout strain was generated, although the substrate specificity for the putative amino acid permease was not identified.

关键词： T Box Antitermination Riboswitch Amino Acid Permease YvbW

multilocus phylogeny suggests a distinct species status for the Nepal population of Assam macaques(macaca assamensis):implications for evolution and conservation

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Zoological Research 2021年第1期42卷 3-13页

作者： Laxman Khanal mukesh Kumar Chalise Peng-Fei Fan randall CKyes Xue-Long Jiang Central Department of Zoology Institute of Science and TechnologyTribhuvan UniversityKathmandu 44613Nepal State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650203China Nepal Biodiversity Research Society(NEBORS) Lalitpur 23513Nepal School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China Department of Psychology Global Healthand AnthropologyCenter for Global Field Studyand Washington National Primate Research CenterUniversity of WashingtonSeattle 98195USA

Phylogenetic relationships within the sinica-group of macaques based on morphological,behavioral,and molecular characteristics have remained *** Nepal population of Assam macaques(macaca assamensis)(NPAm),the westernmost population of the species,is morphologically distinct but has never been used in phylogenetic ***,the phylogenetic relationship of NPAm with other congeners was tested using multiple mitochondrial and Ychromosomal *** divergence times and evolutionary genetic distances among macaques were also *** revealed two major mitochondrial DNA clades of macaques under the sinica-group:the first clade included ***,***,and eastern subspecies of Assam macaque(*** assamensis);the second clade included *** together with species from the eastern and central Himalaya,namely,***,***,and *** the second-clade species,NPAm was the first to diverge from the other members of the clade around 1.9 million years *** results revealed that NPAm is phylogenetically distinct from the eastern Assam macaques and closer to other species and hence may represent a separate *** of its phylogenetic distinctiveness,isolated distribution,and small population size,the Nepal population of sinica-group macaques warrants detailed taxonomic revision and high conservation priority.

关键词： Himalaya macaques Paraphyletic sinica-group Taxonomy

Biochar granulation reduces substrate erosion on green roofs

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Biochar 2022年第1期4卷 164-176页

作者： Wenxi Liao melanie A.Sifton sean C.Thomas Institute of Forestry and Conservation John H Daniels Faculty of Architecture Landscape and DesignUniversity of Toronto33 Willcocks St.TorontoON M5S 3B3Canada

Green roofs are exposed to high winds and harsh environmental conditions that can degrade vegetation and erode substrate material,with negative consequences to ecosystem *** has been promoted as an effective substrate additive to enhance plant performance,but unprocessed biochars are susceptible to wind and water *** of granulated biochars or chemical dust suppressants are suggested as a means to mitigate biochar and substrate erosion;however,research on biochar type and chemical dust suppressant use on biochar and substrate erosion is *** is a crucial factor that influences substrate erosion,yet plant responses may vary with biochar type and chemical dust suppressant;thus,the effects of possible mitigation measures on biochar and substrate erosion are *** investigated the effects of surface-applied granulated and unprocessed biochars and an organic dust suppressant(Entac™)on biochar and substrate erosion on green roofs with Sedum album *** a native plant *** results show that 94%of unprocessed biochars were lost from green roofs after 2 years regardless of the Entac™amendment,likely due to the lightweight nature and fragmentation of biochar *** contrast,granulation of biochars reduced the biochar erosion and total substrate erosion by 74%and 39%,respec-tively,possibly due to enhanced biochar bulk density and particle size and improved moisture retention of biochar-amended ***,Sedum album better reduced biochar and substrate erosion than the native plant mix,likely due to rapid development of high vegetation cover that reduced wind exposure and enhanced substrate moisture *** conclude that applications of granulated biochars can substantially reduce biochar and sub-strate erosion on green roofs,improving green roof sustainability.

关键词： Charcoal Post-processing Dust suppressant Erosion control Vegetation Green infrastructure

Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients

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Stroke & Vascular Neurology 2022年第2期7卷 124-131页

作者： Deepthi Rajashekar matthias Wilms m Ethan macDonald Serena Schimert michael D Hill Andrew Demchuk mayank Goyal sean P Dukelow Nils Daniel Forkert Biomedical Engineering Graduate Program Hotchkiss Brain InstituteUniversity of CalgaryCalgaryAlbertaCanada Department of Radiology Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Hotchkiss Brain Institute University of CalgaryCalgaryAlbertaCanada Department of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada Department of Electrical and Computer Engineering University of CalgaryCalgaryAlbertaCanada Department of Community Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Department of medicine Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Alberta Children's Hospital Research Institute University of CalgaryCalgaryABCanada

Background Lesion-symptom mapping(LSm)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical *** clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to *** far,LSm studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS ***,the aim of this work was to investigate the feasibility to perform LSm analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not *** Employing a multivariate technique,LSm analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE *** NIHSS domains were grouped into six categories using two *** was conducted for each category of the two groupings and the total NIHSS *** Sub-score LSms not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised *** These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging.

关键词： patients score category

Plant recruitment and survival as indicators of ecological restoration success in abandoned pasture land in Nurcoung,Victoria,Australia

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Ecological Processes 2013年第1期2卷 380-392页

作者： Singarayer K Florentine Jessica Gardner Friedrich P Graz sean moloney School of Science Information Technology and Engineering Federation University AustraliaP.O.Box 663Mt.Helen 3353VICAustralia Greening Australia NC2 Building62 Main StreetNatimuk 3409Australia Department of Land management Polytechnic of Namibia13Storch Str.P/Bag 13388WindhoekNamibia Department of Botany James Cook University1James Cook DrTownsville CityQLD 4811Australia

Introduction:One of the major impediments to developing better restoration strategies is the inadequate documentation of past restoration *** 2008,Greening Australia commenced ecological restoration on the Nurcoung property in Victoria to enhance local biodiversity,and in this paper we report on the habitat restoration outcomes in the three Ecological Vegetation Classes(EVC)found on this ***:Permanent sample plots(12×20 m)were randomly established in July 2010 in each of the restoration areas,with 9,10,and 24 plots demarcated in Shallow Sands Woodland(SSW),Heathy Woodland(HW),and Sandstone Ridge Woodlands(SRW),*** plots were prepared to include three seeded *** were assessed for seedling recruitment and survival in may 2010,April 2011,and may *** of individual seedling development included their height and cover,and their location within the ***:Our study shows that interaction between the age of the planted and direct-seeded vegetation and the nature of the EVC significantly affects the composition of plants and the soil surface in that species and,further,that soil cover parameters develop in different ways in the different experimental plots.A SImPER analysis of soil cover parameters shows that most of the variation over the years of restoration is attributable to differences in the amount of bare soil recorded,rather than the amount of leaf-litter cover,and that these changes in soil cover parameters differ between EVCs over the sampling *** direct-seeding study shows that whilst most of the broadcast species were recruited,some species used in the Shallow Sands Woodland,the Heathy Woodland,and the Sandstone Ridge Shrubland did not show evidence of recruitment during the three sampling *** the density of most seedlings increased in subsequent sampling years,the planted species Callitris gracilis,Callitris rhomboidea,Hakea muelleriana,and melaleuca lanceolata did not ***

关键词： soil planted seedling

Operational continental-scale land cover mapping of Australia using the Open Data Cube

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International Journal of Digital Earth 2022年第1期15卷 1715-1737页

作者： Christopher J.Owers Richard m.Lucas Daniel Clewley Belle Tissott sean m.T.Chua Gabrielle Hunt Norman mueller Carole Planque Suvarna m.Punalekar Pete Bunting Peter Tan Graciela metternicht School of Environmental and Life Sciences University of NewcastleCallaghanAustralia Department of Geography and Earth Sciences Aberystwyth UniversityAberystwythUK Commonwealth Scientific and Industrial Research Organisation Land and WaterCanberraAustralia Centre for Geospatial Applications Plymouth Marine LaboratoryPlymouthUK Geoscience Australia SymonstonAustralia Earth and Sustainability Science Research Centre University of New South WalesSydneyAustralia School of Science Western Sydney UniversityRichmondAustralia

To comprehensively support national and international initiatives for sustainable development,land cover products need to be reliably and routinely generated within operational *** with consistent semantics and taxonomies,ensuring confidence in mapping land cover for multiple time periods,facilitates informed decision-making at scales appropriate to multiple policy *** United Nations Food and Agriculture Organisation(FAO)Land Cover Classification System(LCCS)provides a taxonomy that comparable at different scales,level of detail and geographic *** Open Data Cube(ODC)initiative offers a framework for operational continental-scale land cover mapping using analysis-ready Earth Observation *** study utilised the FAO LCCS framework and the Landsat sensor data through Digital Earth Australia(DEA;Australia’s ODC instance)to generate consistent and continent-wide land cover mapping(DEA Land Cover)of the Australian *** Land Cover provides annual maps from 1988 to 2020 at 25 m *** maps were validated with∼12,000 independent validation points,giving an overall map accuracy of 80%.DEA Land Cover provides Australia with a nationally consistent picture of land cover,with an open-source software package using readily available global coverage data and demonstrates a pathway of adoption for national implementations across the world.

关键词： DEA land cover digital earth Australia FAO LCCS landsat sustainable development goals

Can we protect the brain via preconditioning?Role of microRNAs in neuroprotection

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Neural Regeneration Research 2016年第3期11卷 388-389页

作者： sean Quinlan Eva m.Jimenez-mateos Department of Physiology and medical Physics Royal College of Surgeons in Ireland

Preconditioning stimulus：Preconditioning is an adaptive response,whereby a small dose of a harmful substance protects the brain from a subsequent damaging insult（Dirnagl et al.,2009）.The concept of preconditioning was first described in an ischemic heart model,it was observed that brief ischemic episodes protect against a subsequent ischemic insult（murry et al., 1986）.

关键词： subsequent protect harmful brief targeting synaptic stimulus epileptic targeted RNA

XmL by example building E-Commerce applications sean mcGrath.

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From the battlefield to the bladder: The development of thio TEPA

1998年

作者： sean mcGrath.

来源：畅想之星图书光盘版（南... 评论

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World Journal of Clinical Urology 2014年第3期3卷 195-200页

作者： sean m Gallagher Steven H Selman Department of Urology The University of Toledo College of Medicine and Life SciencesToledo OH 43614 United States Department of Urology University of Toledo Medical CenterToledo OH 43614 United States

Effective medications for the treatment of cancer were nonexistent in the early twentieth *** the widespread use of toxic chemical weapons,chlorine and sulfur mustard gas,during the"Great War"led to the first successful chemotherapeutic treatment of cancer *** after the introduction of poisonous gas on the battlefield,reports of the resulting pancytopenia in exposed combatants appeared in the medical *** biologic effect of chemical weaponry on rapidly dividing cells eventually was recognized for its salutary potential in the treatment of *** this potential was appreciated,hundreds of similar compounds were synthesized and evaluated as chemotherapeutic *** such compound,thioT EPA,would eventually open the era of intravesical treatment of urothelial cancer.

关键词： ThioTEPA Bladder cancer Urothelial cancer Intravesical chemotherapy mustard gas mitomycin C

Living Earth:Implementing national standardised land cover classification systems for Earth Observation in support of sustainable development

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Big Earth Data 2021年第3期5卷 368-390页

作者： Christopher J.Owers Richard m.Lucas Daniel Clewley Carole Planque Suvarna Punalekar Belle Tissott sean m.T.Chua Pete Bunting Norman mueller Graciela metternicht Department of Geography and Earth Sciences Aberystwyth UniversityAberystwythCeredigionWalesUK Centre for Geospatial Applications Plymouth Marine LaboratoryPlymouthDevonEnglandUK Geoscience Australia SymonstonACTAustralia Earth and Sustainability Science Research Centre School of BiologicalEarth and Environmental SciencesUniversity of New South WalesSydneyAustralia

Earth Observation(EO)has been recognised as a key data source for supporting the United Nations Sustainable Development Goals(SDGs).Advances in data availability and analytical capabilities have provided a wide range of users access to global coverage analysis-ready data(ARD).However,ARD does not provide the information required by national agencies tasked with coordinating the implementation of ***,standardised,scalable mapping of land cover and its change over time and space facilitates informed deci-sion making,providing cohesive methods for target setting and reporting of *** aim of this study was to implement a global framework for classifying land *** Food and Agriculture Organisation’s Land Cover Classification System(FAO LCCS)provides a global land cover taxonomy suitable to comprehensively support SDG target setting and *** present a fully implemented FAO LCCS optimised for EO data;Living Earth,an open-source software package that can be readily applied using existing national EO infrastructure and satellite *** resolve several semantic challenges of LCCS for consistent EO implementation,including modifications to environmental descriptors,inter-dependency within the mod-ular-hierarchical framework,and increased flexibility associated with limited data *** ensure easy adoption of Living Earth for SDG reporting,we identified key environmental descriptors to provide resource allocation recommendations for generating routinely retrieved input *** Earth provides an optimal platform for global adoption of EO4SDGs ensuring a transparent methodology that allows monitoring to be standardised for all countries.

关键词： Land cover FAO LCCS open data cube sustainable development goals environmental descriptors