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Takotsubo cardiomyopathy:A comprehensive review

World Journal of Cardiology 2022年第6期14卷 355-362页

作者： Walker Barmore Himax Patel sean harrell Daniel Garcia Joe B Calkins Jr Department of Internal Medicine Augusta University Medical CenterAugustaGA 30912United States Department of Cardiovascular Medicine Augusta University Medical CenterAugustaGA 30912United States

Takotsubo cardiomyopathy(TCM),also known as stress cardiomyopathy,occurs in the setting of catecholamine surge from an acute *** cardiomyopathy mimics acute myocardial infarction in the absence of coronary *** classic feature of TCM is regional wall motion abnormalities with characteristic ballooning of the left *** etiology of the stressor is often physical or emotional stress,however iatrogenic causes of TCM have been reported in the *** our review,we discuss medications,primarily the exogenous administration of catecholamines,and a wide array of procedures with subsequent development of iatrogenic *** is unique in that it is transient and has favorable outcomes in most ***,beta-blockers and ACE-inhibitors have been prescribed in individuals with cardiomyopathy;however,unique to TCM,no specific treatment is required other than temporary supportive measures as this process is ***,no improvement in mortality or recurrence have been reported in patients on these *** aim of this review is to elucidate on the iatrogenic causes of TCM,allowing for prompt recognition and management by clinicians.

关键词： Takotsubo Cardiomyopathy Iatrogenic Heart Failure Myocardial Infarction

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COVID-19 vaccine-associated myocarditis

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World Journal of Cardiology 2022年第7期14卷 382-391页

作者： Michael C Morgan Lavannya Atri sean harrell Wael Al-Jaroudi Adam Berman Division of Cardiology Medical College of GeorgiaAugustaGA 30912United States Baptist Heart Baptist Medical CenterJacksonMS 39202United States Department of Population Health Sciences Medical College of GeorgiaAugustaGA 30912United States

Myocarditis is now recognized as a rare complication of coronavirus disease 2019(COVID-19)mRNA vaccination,particularly in adolescent and young adult *** the authorization of the Pfizer-BioNTech^(TM)and Moderna^(TM)mRNA vaccines targeting the severe acute respiratory syndrome coronavirus-2(SARSCoV-2)spike protein,the Centers for Disease Control and Prevention(CDC)has reported 1175 confirmed cases of myocarditis after COVID-19 vaccination in individuals ages 30 years and younger as of January *** to CDC data in June 2021,the incidence of vaccine-mediated myocarditis in males ages 12-29 years old was estimated to be 40.6 cases per million second doses of COVID-19 mRNA vaccination *** with cases of COVID-19 vaccinemediated myocarditis typically present with acute chest pain and elevated serum troponin levels,often within one week of receiving the second dose of mRNA COVID-19 *** cases follow a benign clinical course with prompt resolution of *** mechanisms of COVID-19 vaccine myocarditis include molecular mimicry between SARS-CoV-2 spike protein and self-antigens and the triggering of preexisting dysregulated immune pathways in predisposed *** higher incidence of COVID-19 vaccine myocarditis in young males may be explained by testosterone and its role in modulating the immune response in *** is limited data on long-term outcomes in these cases given the recency of their *** CDC continues to recommend COVID-19 vaccination for everyone 5 years of age and older given the greater risk of serious complications related to natural COVID-19 infection including hospitalization,multisystem organ dysfunction,and *** study is needed to better understand the immunopathology and long-term outcomes behind COVID-19 mRNA vaccine-mediated myocarditis.

关键词： COVID-19 SARS-CoV-2 mRNA vaccine Myocarditis Pericarditis

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Role of cardiac magnetic resonance imaging in the diagnosis and management of COVID-19 related myocarditis: Clinical and imaging considerations

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World Journal of Radiology 2021年第9期13卷 283-293页

作者： Lavannya Atri Michael Morgan sean harrell Wael AlJaroudi Adam E Berman Division of Cardiology Medical College of GeorgiaAugusta UniversityAugustaGA 30912United States Division of Health Policy Medical College of GeorgiaAugusta UniversityAugustaGA 30912United States Division of Health Economics and Modeling Medical College of GeorgiaAugusta UniversityAugustaGA 30912United States

There is a growing evidence of cardiovascular complications in coronavirusdisease 2019 (COVID-19) patients. As evidence accumulated of COVID-19 mediatedinflammatory effects on the myocardium, substantial attention has beendirected towards cardiovascular imaging modalities that facilitate this *** magnetic resonance imaging (CMRI) is the gold standard for thedetection of structural and functional myocardial alterations and its role inidentifying patients with COVID-19 mediated cardiac injury is growing. Despiteits utility in the diagnosis of myocardial injury in this population, CMRI’s impacton patient management is still evolving. This review provides a framework for theuse of CMRI in diagnosis and management of COVID-19 patients from theperspective of a cardiologist. We review the role of CMRI in the management ofboth the acutely and remotely COVID-19 infected patient. We discuss patientselection for this imaging modality;T1, T2, and late gadolinium enhancementimaging techniques;and previously described CMRI findings in other cardiomyopathieswith potential implications in COVID-19 recovered patients.

关键词： Cardiac magnetic resonance imaging COVID-19 Cardiovascular magnetic resonance Myocarditis Coronavirus Cardiovascular complications

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