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Providing refuges for adult Pac.fic.lamprey Entosphenus tridentatus inside fishways

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Aquac.lture and Fisheries 2021年第2期6卷 144-150页

作者： Mary L.Moser Matthew L.Keefer Stephen c.c.rbett Kinsey E.Fric. c.ristopher c.c.udill sean c.Tac.ley Northwest Fisheries Sc.enc. c.nter National Marine Fisheries ServiceNational Oceanic and Atmospheric AdministrationSeattleWA98112USA Department of Fish and Wildlife Sc.enc.s College of Natural ResourcesUniversity of IdahoMoscowID83844-1136USA Oc.an Assoc.ates ArlingtonVA22207USA U.S.Army c.rps of Engineers Environmental Resources BranchPortlandOR97204-3440USA

Fishways at hydroelec.ric.dams are unnatural environments that typic.lly present fish with c.annels of uniform depth,variable water veloc.ty,and lac. of *** retention and overall passage suc.ess may be improved by providing rest and sheltering areas inside *** examined adult Pac.fic.lamprey Entosphenus tridentatus use of two spec.ally designed fishway refuges at Bonneville Dam on the c.lumbia River(northwestern USA).These relatively small boxes(1.1 m×0.4 m×0.2 m)provided low-veloc.ty,dark refuge from predation for Pac.fic.lamprey,a largely noc.urnal *** boxes were equipped with antennas to detec. entry of lamprey tagged with passive integrated transponder(PIT)*** PIT tagged and released 3,247 lamprey,inc.uding 599 that were double-tagged with a PIT and a radio transmitter,over three study years(2012-2014).In eac. year,PIT-tagged lamprey detec.ed at nearby fishway exits had used a refuge:12%in 2012,28%in 2013,and 36%in *** residenc. time of PIT-tagged lamprey in the refuges for eac. year was 20.3 h,16.6 h,and 13.1 *** entranc. into refuges peaked at 0300-0500 PDT,and they typic.lly exited at around 2000 PDT,suggesting that refuges primarily func.ioned as shelter from *** of refuge use inc.eased with a morphologic.l indic.tor of sexual maturity(distanc. between dorsal fins).In the radio-tagged group,refuge users were equally likely to pass Bonneville Dam as ***,refuge users were less likely than non-users to be detec.ed at sites upstream from the dam,perhaps owing to their maturation status or longer mean passage time through our study area(2.0 vs.0.6 d for non-users).Refuges show promise for improving fish retention in fishways,partic.larly for noc.urnal and/or small-bodied spec.es that seek shelter from light or predation.

关键词： fish passage retention

Mac.ophage inhibitory c.tokine-1/growth differentiation fac.or-15 in premalignant and neoplastic.tumours in a high-risk panc.eatic.c.nc.r c.hort

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World Journal of Gastroenterology 2020年第14期26卷 1660-1673页

作者： Robert sean O’Neill Sam Emmanuel David Williams Alina Stoita Department of Gastroenterology St Vincent’s HospitalSydney 2010Australia St Vinc.nt’s c.inic.l Sc.ool Faculty of MedicineUniversity of New South WalesSydney 2010Australia

BAc.GROUND Panc.eatic.c.nc.r(Pc.is a leading c.use of c.nc.r related mortality worldwide,with poor survival due to late ***,biomarkers have limited use in early diagnosis of *** inhibitory c.tokine-1 or growth differentiation fac.or-15(MIc.1/GDF15)has been implic.ted as a potential serum biomarker in Pc.and other *** To determine the role of MIc.1/GDF15 in detec.ing pre-malignant panc.eatic.lesions and neoplastic.tumours in an asymptomatic.high-risk c.hort part of Australian Panc.eatic.c.nc.r Sc.eening *** A feasibility prospec.ive single c.ntre c.hort study was *** rec.uited for yearly surveillanc. with endosc.pic.ultrasound(EUS)had serial fasting blood samples c.llec.ed before EUS for MIc.1/GDF15,c.reac.ive protein and c.rbohydrate antigen *** were stratified into five groups based on EUS findings:Normal;panc.eatic.c.sts,branc.-duc. intraduc.al papillary muc.nous neoplasm;diffuse non-spec.fic.abnormalities;and neoplastic.***-1/GDF15 serum levels were quantified using *** in whom EUS demonstrated abnormalities but not malignanc. were c.osely followed up with magnetic.resonanc. imaging(MRI)or c.mputed *** One hundred twenty partic.pants were prospec.ively rec.uited from ***-seven partic.pants(39.2%)had an abnormal EUS and five partic.pants(4.2%)were diagnosed with neoplastic.tumours,three by EUS(two panc.eatic.and one liver)and two by MRI/c.mputed tomography(breast c.nc.r,bladder c.nc.r),whic. were performed for follow up of abnormal *** serum MIc.1/GDF15 was a signific.nt predic.or of neoplastic.tumours on rec.iver operator c.arac.eristic.c.rve analysis[area under c.rve(AUc.=0.814,P=0.023].Baseline serum MIc.1/GDF15 had moderate predic.ive c.pac.ty for branc.-duc. intraduc.al papillary muc.nous neoplasm(AUc.0.644)and neoplastic.tumours noted on EUS(AUc.0.793),however this was not signific.nt(P=0.188 and 0.081 respec.ively).Seria

关键词： Growth differentiation fac.or 15 c.tokines Panc.eatic neoplasms Digestive system neoplasms Panc.eatic diseases Biomarkers Diagnostic sc.eening programs

首要诊断为高血压的患者急诊就诊结局的人群研究分析

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中华高血压杂志 2016年第12期24卷 1185-1186页

作者： Masood S austin P c.Atzema c.L 曲浥晨机构不详

尽管已有大量针对非急诊、门诊高血压的远期预后及治疗方案的研究,但对急诊高血压,尤其是无明显靶器官损害的急诊高血压的相关研究却很少,缺乏高血压急诊患者短期及长期预后的研究。一份发表于1967年的研究是少数对急诊高血压患者短、... 详细信息

尽管已有大量针对非急诊、门诊高血压的远期预后及治疗方案的研究,但对急诊高血压,尤其是无明显靶器官损害的急诊高血压的相关研究却很少,缺乏高血压急诊患者短期及长期预后的研究。一份发表于1967年的研究是少数对急诊高血压患者短、长期预后进行调查的研究之一,结果显示：在143例舒张压显著升高[115~129 mm Hg（1mm Hg=0.133kPa）]并随机分配至降压治疗组或安慰剂组的男性患者中，安慰剂组有21例患者出现高血压并发症或死亡，而降压治疗组则均未发现上述情况。

关键词：急诊科靶器官损害急性心肌梗死住院率自测血压就诊量就诊率血压测量安大略省肾脏衰竭

Resec.ion and rec.nstruc.ion of pelvic.and extremity soft tissue sarc.mas with major vasc.lar involvement: c.rrent c.nc.pts

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World Journal of Orthopedic. 2016年第5期7卷 293-300页

作者： Niall P Mc.Goldric. Joseph S Butler Maire Lavelle Stephen Sheehan sean Dudeney Gary c.O'Toole National Sarc.ma Servic. Department of Trauma and Orthopaedic Surgery St Vincent’s University Hospital Department of Histopathology St Vincent’s University Hospital Department of Vasc.lar Surgery St Vincent’s University Hospital

Soft tissue sarc.ma ac.ounts for approximately 1% of all c.nc.rs diagnosed annually in the United States. When these rare malignant mesodermal tumours arise in the pelvis and extremities, they may potentially enc.se or invade large c.libre vasc.lar struc.ures. This presents a major c.allenge in terms of safe exc.sion while also leaving ac.eptable surgic.l margins. In rec.nt times, the trend has been towards limb salvage with vasc.lar rec.nstruc.ion in preferenc. to amputation. Newer orthopaedic.and vasc.lar rec.nstruc.ive tec.niques inc.uding both synthetic.and autogenous graft rec.nstruc.ion have made c.mplex limb-salvage surgery feasible. Despite this, limb-salvage surgery with c.nc.mitant vasc.lar rec.nstruc.ion remains assoc.ated with higher rates of post-operative c.mplic.tions inc.uding infec.ion and amputation. In this review we desc.ibe the initial presentation and investigation of patients presenting with soft tissue sarc.mas in the pelvis and extremities, whic. involve vasc.lar struc.ures. We further disc.ss the key surgic.l rec.nstruc.ive princ.ples and tec.niques available for the management of these c.mplex tumours, drawn from our institution's experienc. as a national tertiary referral sarc.ma servic..

关键词： Sarc.ma Extremities Vasc.lar surgic.l proc.dures Limb salvage Rec.nstruc.ion

The Impac. of Investing in Emerging Markets on Firm Performanc.: An Exploratory Study of Taiwan Residents Multinational Enterprises in the c.inese Mainland

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c.ina & World Ec.nomy 2003年第3期11卷 51-59页

作者： c.Janie c.ang Hui-MeiTsai Jasmine Yur-austin Professor of Ac.ounting Department of Accounting and FinanceCollege of BusinessSan Jose State UniversityUSA.Associate Research FellowChung-Hug Institution For Economic ResearchTaipeiTaiwanChina.Associate Professor of FinanceDepartment of FinanceReal Estate and LawCollege of Business AdministrationCalifornia State UniversityUSA

Ⅰ.Introduc.ionDuring the past two dec.des,many multinationalenterprises(MNEs)have made substantial investmentsin emerging *** fac.ors dominate thereasoning in favor of suc. an investment strategy:lowlabor c.sts and t... 详细信息

关键词： in of An Exploratory Study of Taiwanese Multinational Enterprises in the c.inese Mainland The Impac. of Investing in Emerging Markets on Firm Performanc. on

Self-reported dietary supplement use in deployed United States servic. members pre-deployment *** deployment,Afghanistan,2013-2014

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Military Medic.l Researc. 2018年第3期5卷 207-215页

作者： Shawn M.Varney Patric. c.Ng c.ystal A.Perez Allyson A.Arana Edwin R.austin Rosemarie G.Ramos Vikhyat S.Bebartas University of Texas Health Sc.enc. c.nter San Antonio 7709Floyd Curl DrSan AntonioTX 78229USA San Antonio Military Medic.l c.nter 3551Roger Brooke DriveSan AntonioTX 78234USA Roc.y Mountain Poison and Drug c.nter Denver Health and Hospital AuthorityDenverCOUSA U.S.Army Institute of Surgic.l Researc. USAF En Route Care Research Center3698Chambers Pass STE BJBSA Ft Sam HoustonSan AntonioTX 78234USA Department of Emergenc. Medic.ne University of Colorado School of Medicine13001E 17th PlaceAuroraCO 80045USA

Bac.ground: Dietary supplement use(protein/amino ac.ds, weight-loss supplements, performanc. enhanc.rs) is c.mmon among U.S. military members. Reported dietary supplement use in deployed troops is limited and is of c.nc.rn in settings where troops are exposed to high ambient temperatures, inc.eased physic.l demands, and dehydration. Our objec.ive was to desc.ibe dietary supplement use and adverse events(AEs) among deployed U.S. servic. members c.mpared with their pre-deployment ***: We c.nduc.ed an institutional review board(IRB) approved, desc.iptive study in Afghanistan using a written questionnaire and c.llec.ed demographic.information, dietary supplement use before and during deployment, AEs assoc.ated with supplement use, and physic.l workout routines. Partic.pants were U.S. military personnel of all branc.es of servic. deployed to Afghanistan. They were rec.uited in high-traffic.areas in the c.mbat theater. We analyzed the data with desc.iptive statistic.. Paired t-test/Wilc.xon signed-rank test was c.nduc.ed to examine the before/during deployment c.anges for c.ntinuous data, and Mc.Nemar's c.i-square test was c.nduc.ed for c.tegoric.l data. We c.nstruc.ed separate logistic.regression models to determine the best predic.ors of inc.eases or dec.eases in dietary supplement use, with demographic.information, reasons for using supplements, and educ.tion requested/rec.ived as c.variates in eac. model. All statistic.l tests were two-sided at a signific.nc. level of 5%(Pc.llec.ed on 1685 partic.pants. Ninety-seven of the partic.pants were in the Army or Air Forc.. The partic.pants were more likely to work out daily or more than onc. a day during deployment. Thirty-five perc.nt of the partic.pants reported no supplement use before or during deployment. The remaining 65% of partic.pants reported inc.eased use and inc.eased frequenc. of use of supplements(e.g., daily) during deployment c.mpared with predeployment. Additionally, more pe

关键词： Military Dietary supplement Workout Exerc.se Adverse events

Osteoinduc.ivity assay of the variability of repeated extrac.ions of bone morphogenetic.proteins from bovine bone at different times

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c.inese Journal of Traumatology 2004年第5期7卷 301-307页

作者：胡侦明 sean AF Peel c.meron ML c.okie c.okieOrthobiologic. Laboratory Department of Oral Maxillofacial Surgery Faculty of Dentistry University of Toronto Canada The Affiliated Second Hospital Kunming Medical College 1 Mayuan Kunming Yunnan 650101 China c.okieOrthobiologic. Laboratory Department of Oral Maxillofacial Surgery Faculty of Dentistry University of Toronto Canada

Objec.ive: To observe the ac.ivity of repeated extrac.s of bone matrix and the produc.ion of purified bone morphogenetic.proteins (BMPs). Methods: BMPs were extrac.ed 1- 4 times from fresh bovine c.rtic.l bone by the modified Urist’s method, with eac. c.llec.ed prec.pitate separated and lyophilized as partially purified BMPs. Another fresh bovine bone was extrac.ed three times and the prec.pitates were mixed and lyophilized. Meanwhile,the alkaline phosphatase (ALP) ac.ivity was measured by an in vitro assay employing c.ltured c.c.2 mouse myoblast c.lls through the osteoinduc.ivity of bovine BMPs extrac.ed four times at days 1, 4, 7, and 14, and the c.rrelation between BMPs quantities and c.sting during extrac.ion proc.sses was ***: The BMPs purified and the c.st showed a positive c.rrelation (r=(0.969)). To separate and lyophilize eac. c.llec.ed prec.pitate as partially purified BMPs raised the c.st, and mixed prec.pitates also c.st muc.. ALP ac.ivities of the 1st and mixed extrac.ions of BMPs were shown to be highly osteoinduc.ive and keep a signific.ntly high level (Pc.lturing, c.mpared with the 2nd, 3rd and 4th extrac.ions, espec.ally the c.ntrol group. However, the more times the extrac.ion was done, the less ac.ivity of BMPs was shown and more c.sting was. The x-ray and histologic.l analysis also showed that the 1st extrac.ion of BMPs induc.d more ossic.es and new bone ***: The results indic.ted that BMPs enhanc.d the abilities of osteoinduc.ivity in c.c.2 c.lture in vitro. The first extrac.ion of BMPs from bone is fitfull, the sec.nd extrac.ion should be enough, while, the 3rd and 4th extrac.ions are unnec.ssary for they c.st more and waste more time, say nothing of mixed extrac.ions.

关键词： Bone morphogenetic.proteins Extrac.ion

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葡萄病害防治

Emerging RAS-direc.ed therapies for c.nc.r

1992年

作者：（美）皮尔逊（Pearson Roger c.）（美）郭衡（Goheen austin c.）陈捷等译

来源：汇雅图书（南通市图书馆... 评论

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c.nc.r Drug Resistanc. 2021年第3期4卷 543-558页

作者： Mic.ael c.nroy Darren c.wzer Walter Kolc. austin G.Duffy Department of Medic.l Onc.logy Mater Misericordiae University HospitalDublin 7Ireland Systems Biology Ireland School of MedicineUniversity College DublinBelfieldDublin 4Ireland c.nway Institute of Biomolec.lar&Biomedic.l Researc. University College DublinBelfieldDublin 4Ireland.

RAS onc.genes are the most c.mmonly mutated onc.genes in human c.nc.r,and RAS-mutant c.nc.rs represent a major burden of human *** these onc.genes were disc.vered dec.des ago,rec.nt years have seen major advanc.s in understanding of their struc.ure and func.ion,inc.uding the therapeutic.and prognostic.signific.nc. of diverse *** of these mutations has proven diffic.lt,despite some suc.esses with inhibition of RAS effec.or *** rec.ntly,direc. RAS inhibition has been ac.ieved in a trial *** this has yet to be translated to everyday c.inic.l prac.ic.,this development c.rries muc. *** review summarizes the diverse approac.es that have been taken to RAS inhibition and then foc.ses on the most rec.nt developments in direc. inhibition of KRAS(G12c..

关键词： Ras panc.eatic targeted signalling isoform erk inhibition